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NCT ID: NCT03801876 Not yet recruiting - Clinical trials for Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

Start date: February 1, 2019
Phase: Phase 3
Study type: Interventional

This trial studies how well proton beam radiation therapy compared with intensity modulated photon radiotherapy works in treating patients with stage I-IVA esophageal cancer. Proton beam radiation therapy uses a beam of protons (rather than x-rays) to send radiation inside the body to the tumor without damaging much of the healthy tissue around it. Intensity modulated photon radiotherapy uses high-energy x-rays to deliver radiation directly to the tumor without damaging much of the healthy tissue around it. It is not yet known whether proton beam therapy or intensity modulated photon radiotherapy will work better in treating patients with esophageal cancer.

NCT ID: NCT03788863 Not yet recruiting - Clinical trials for Relationship Between the Exposure of Glucocorticoids During Pregnancy and Orofacial Cleft Development

A Study to Learn More About the Relationship Between the Development of a Gap in the Upper Lip (Cleft Lip) or in the Roof of the Mouth (Cleft Palate) in Newborns and the Use of Glucocorticoids by the Mother During Pregnancy: a Meta-analysis

Start date: December 28, 2018
Study type: Observational

Glucocorticoids are drugs that have many effects on body metabolism, raise sugar level in the blood, and reduce inflammation. By applying a statistical technique for combining the findings from a systematic literature review (meta analysis), researchers want to learn more about the relationship of the risk to develop a separation in the roof of the mouth (cleft palate) in newborns and contact with glucocorticoids during pregnancy.

NCT ID: NCT03787992 Not yet recruiting - Clinical trials for Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non-small Cell Lung Cancer

Alflutinib Mesylate Versus Gefitinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (FLAGE)

Start date: April 1, 2019
Phase: Phase 3
Study type: Interventional

To assess the efficacy and safety of Alflutinib Mesylate versus Gefitinib in patients with locally advanced or Metastatic Non Small Cell Lung Cancer

NCT ID: NCT03785496 Not yet recruiting - Clinical trials for Histologically Confirmed Unresectable or Metastatic Squamous Cell Carcinoma of the Esophagus Who Failed on Standard Treatment

Phase II Study of PDR001 in Combination With MCS110 in Patients With Squamous Cell Carcinoma of the Esophagus.

Start date: January 2019
Phase: Phase 2
Study type: Interventional

Single arm phase II MCS110 (10mg/kg, IV) and PDR001( 300mg, IV) will be treated every 3 weeks

NCT ID: NCT03780231 Recruiting - Clinical trials for Athletes With Isolated Non-ischemic LGE With no Underlying Labelled Cardiomyopathy

Effect of Intense Sport Practice in Athletes With Non-ischemic Scar

Start date: October 5, 2018
Study type: Observational

The prognostic relevance of isolated non-ischemic LGE (i.e. with no underlying "labelled" cardiomyopathy) is unclear, and current guidelines to not state on the clearance of athlete with this type of findings as regards to competitive or intense sport practice. The principal objective of the study is to evaluate during a five-years follow up, the clinical outcome of athletes with this kind of findings. The secondary objective is the determination of prognostic factors. The management and follow-up of the athletes will be let at the appraisal of each center.

NCT ID: NCT03776422 Active, not recruiting - Clinical trials for Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)

Homeless Youth Study - Stepping Stone 2.0

Start date: December 21, 2017
Phase: N/A
Study type: Interventional

Housing instability is both a cause and consequence of mental health problems. As such youth experiencing housing instability (e.g., homeless or marginally housed) have higher rates of mental health problems.Because of their circumstances, these youth also face significant barriers to mental health care and are therefore less likely to receive the treatment that they need. Mobile technology may offer a novel platform for increasing access to mental health care in this population. The primary goals of this pilot study are to (1) establish the feasibility and acceptability of delivering automated mental health interventions via smartphone technology, (2) examine the extent to which automated mental health interventions delivered via mobile technology improve mental health in homeless, marginally-housed, and exiting foster youth.

NCT ID: NCT03775694 Not yet recruiting - Healthy Clinical Trials

Diffusion MRI-1 Imaging Database

Start date: January 30, 2019
Study type: Observational

The purpose of the dMRI-1 data collection study is to establish a database of clinical images and limited medical history information from patients that have previously received a dMRI scan. All data collected will be de-identified. No safety or effectiveness assessments will be completed.

NCT ID: NCT03774251 Not yet recruiting - Clinical trials for Greater Trochanter Pain Syndrome, Gluteus Medius Tendinopathy, Gluteus Minimus Tendinopathy

A Randomized Controlled Trial of Ultrasound-guided Platelet-Rich-Plasma (PRP) Injection Versus Extracorporeal Shock Wave Therapy (ESWT) for Great Trochanter Pain Syndrome (GTPS) With Gluteus Medius or Minimus Tendinopathy

Start date: January 1, 2019
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to compare the efficacy of ultrasound-guided platelet-rich plasma (PRP) injection versus extracorporeal shock wave therapy for management of refractory Greater Trochanteric Pain Syndrome (GTPS).

NCT ID: NCT03773198 Not yet recruiting - Clinical trials for Patient Requiring Scheduled Conventional Orthopedic Surgical Intervention of the Upper or Lower Limb

Effectiveness of Energy Resonance by Skin Stimulation in the Management of Anxious Patients Who Require Scheduled Orthopaedic Surgery

Start date: January 2019
Phase: Phase 3
Study type: Interventional

The need for a surgical procedure may cause a patient to experience reactive anxiety. This reaction is appropriate if it is of low to moderate intensity. On the other hand, various studies have shown that postoperative awakening is more complicated if the patient experiences major preoperative anxiety. Thus, reducing anxiety could be a tool for preventing chronic pain. For several years now, the investigator's facility has been implementing Energy Resonance through Cutaneous Stimulation (ERCS), a method based on "listening" to the body's vibrations through the fingers on points based on the mapping of meridians in Chinese medicine. ERCS practitioners have noted the benefits of this method, particularly in soothing patients. It therefore seems necessary to detect and manage this anxiety beforehand and ERCS seems appropriate in this situation.

NCT ID: NCT03770312 Not yet recruiting - Clinical trials for Healthy Elderly Individuals With High LDL-cholesterol or Risk of Cardiovascular Disease

Low- and Moderate-intensity Statin and Clinical Outcome of Primary Prevention in Individuals Aged >75 Years: the SCOPE-75 RCT Study

Start date: January 2019
Phase: Phase 4
Study type: Interventional

One of the most effective drug in the primary prevention of cardiovascular disease is statins. The protective effects of statin on developement of cardiovascular disease has been demonstrated in elderly individuals aged over 75 years. Since side effects of statin are more common in elderly individuals than in younger individuals, clinical guidelines recommend that use of low intensity statin is considered in elderly individuals. However, there are few randomized clinical trials evaluating the safety and efficacy of different intensity statins in elderly individuals. This is a multicenter, prospective, randomized clinical trial to compare efficacy and safety between low and high intensity statin for primary prevention of cardiovascular disease in elderly individuals.