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Coronary Stenosis clinical trials

View clinical trials related to Coronary Stenosis.

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NCT ID: NCT03877848 Not yet recruiting - Coronary Stenosis Clinical Trials

EluNIR Ridaforolimus Eluting Coronary Stent System in Patients at High Bleeding Risk (HBR)- EluNIR HBR Study

Start date: April 2019
Phase:
Study type: Observational [Patient Registry]

The study will enroll approximately 316 subjects with a wide spectrum of PCI indications (stable angina as well as ACS), who are considered to be at high risk of bleeding. Patients will undergo PCI with implantation of the EluNIR stent, followed by shortened duration (1 months in stable patients, and up to 3 months in ACS patients) of DAPT.

NCT ID: NCT03857503 Not yet recruiting - Clinical trials for Coronary Artery Disease

Radiographic Imaging Validation and EvALuation for Angio iFR (ReVEAL iFR)

ReVEAL
Start date: March 2019
Phase:
Study type: Observational

The Philips Angio-iFR medical software device is intended to provide information on the functional significance of a coronary artery lesion to provide guidance on diagnostic decisions similar to that obtained through invasive measures of iFR and FFR. The software application uses the vessel geometry obtained from a coronary angiographic image together with a lumped parameter physiological model to provide the associated iFR and FFR estimates.

NCT ID: NCT03848650 Recruiting - Clinical trials for Left Anterior Descending Coronary Artery Stenosis

The Drift-Reduction for Improved FFR Using Fiberoptic Technology (DRIFT) Study

OPSENS
Start date: June 19, 2018
Phase: N/A
Study type: Interventional

The primary objective of this study is to assess the accuracy, efficacy, and durability of the OpSens Medical OptoWire Deux pressure wire in the assessment of angiographically intermediate proximal left anterior descending coronary artery (LAD) stenoses in clinical practice.

NCT ID: NCT03820492 Not yet recruiting - Coronary Stenosis Clinical Trials

Comparison of Optical Coherence Tomography-derived Minimal Lumen Area, Invasive Fractional Flow Reserve and FFRCT

OPTICO-LM
Start date: April 1, 2019
Phase: N/A
Study type: Interventional

Significant left main (LM) stenosis is associated with a poor prognosis, therefore, adequate judgement of the prognostic significance of LM stenosis is essential to improve patients' prognosis. Recently, fractional flow reserve (FFR) has become widespread practice and carries a Class Ia recommendation to assess functional significance of intermediate coronary stenosis in patients with stable angina. Intravascular ultrasound (IVUS)-derived minimum lumen area (MLA) represents an accurate measure to determine LM significance as shown in multiple studies, while optical coherence tomography (OCT) ,which is a novel intracoronary imaging method with a greater spatial resolution (15μm vs. 100μm), faster image acquisition and facilitated image interpretation, OCT derived-MLA has never been validated against FFR and accordingly, it is not mentioned in the current guidelines for myocardial revascularization. Coronary computed tomography angiography (CTA) has emerged as a noninvasive alternative of coronary angiography with its excellent negative predictive value, while the positive predictive value of CTA is limited. Computational fluid dynamics is an emerging method that enables prediction of blood flow in coronary arteries and calculation of FFR from computed tomography (FFRCT) noninvasively. Noninvasive and accurate assessment of functional significance would bring a great benefit for patients with LM stenosis, however, there are no data to evaluate the diagnostic accuracy of FFRCT for LM stenosis in comparison with FFR and minimal lumen area derived by OCT. This study will investigate the optimal OCT-derived MLA cut-off point and the diagnostic performance of FFRCT for intermediate LM stenosis compared with FFR ≤0.8 as a reference standard.

NCT ID: NCT03815123 Recruiting - Clinical trials for Evaluation of CT in Coronary Artery Stenosis

Register Kardialer Computertomographie

Start date: November 2014
Phase:
Study type: Observational [Patient Registry]

Evaluation of coronary plaques in the CT coronaryangiography.

NCT ID: NCT03815032 Not yet recruiting - Clinical trials for Coronary Artery Disease

Assessing the Accuracy of the OptoWire DeuxTM in a Wire to Wire Comparison

ACCURACY
Start date: January 28, 2019
Phase: N/A
Study type: Interventional

The goal of the ACCURACY study is to assess the differences, if any, in FFR measurements made by the OptoWire Deux FFR guidewire by comparison of simultaneous data of two different OptoWire DeuxTM guidewires (group 1). In addition, the investigators will compare (group 2) the FFR measurements obtained from an OptoWire Deux FFR guidewire and compare it to the FFR measurement by a VERRATA-TM guidewire to assess coronary stenosis in the routine clinical practice.

NCT ID: NCT03788369 Not yet recruiting - Coronary Stenosis Clinical Trials

Evaluation of Effectiveness and Safety of Hybrid Coronary Revascularization

HCR registry
Start date: January 15, 2019
Phase:
Study type: Observational

This study evaluated the effectiveness and safety of Hybrid Coronary Revascularization in real-world practice.

NCT ID: NCT03767621 Not yet recruiting - Clinical trials for Coronary Artery Disease

Concordance Between FFR and iFR for the Assessment of Intermediate Lesions in the Left Main Coronary Artery. A Prospective Validation of a Default Value for iFR

iLITRO
Start date: January 14, 2019
Phase:
Study type: Observational [Patient Registry]

The assessment of Left Main Coronary Artery (LMCA) lesions by means of coronary angiography renders serious limitations. Studies with a limited number of patients have shown that a value of FFR (Fractional Flow Reserve) above 0.80 identify a low risk of events in case of not performing revascularization in patients with intermediate stenosis in the LMCA. Although iFR (Instant wave Free Ratio) has recently been found equivalent to FFR The demonstration of the prognostic utility of iFR in patients with LMCA intermediate lesions could have an important clinical impact and justify its systematic use for the treatment decision in these high-risk patients.

NCT ID: NCT03702764 Recruiting - Atherosclerosis Clinical Trials

Coronary Plaque Geometry and Acute Coronary Syndromes

Start date: February 1, 2019
Phase:
Study type: Observational

The aim of GEOMETRY study is to investigate the correlation between coronary plaque geometric modifications and lesion vulnerability in patients with suspected coronary artery disease referred for cardiac computed tomography angiography (CCTA). Furthermore the study will evaluate the impact of plaque eccentricity and morphology on the rate of major adverse cardiovascular events (MACE) for a 2 years follow-up period.

NCT ID: NCT03702608 Not yet recruiting - Coronary Stenosis Clinical Trials

BIONICS 38 mm Trial EluNIR Ridaforolimus Eluting Coronary Stent System (EluNIR) In Coronary Stenosis Trial

Start date: October 2018
Phase: N/A
Study type: Interventional

This is a prospective, multi-center, single-arm, open-label clinical trial. Clinical follow-up will be performed at 30 days. Follow-up by phone will be performed at 6 months, and 1 year after the procedure. Study Objective is to further assess the safety and efficacy of long (38 mm) Ridaforolimus Eluting Stent - EluNIR.