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Obesity clinical trials

View clinical trials related to Obesity.

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NCT ID: NCT03762395 Not yet recruiting - Obesity Clinical Trials

Anti Inflammatory Lipid Mediators in Asthma

ALMA
Start date: December 2018
Phase: Phase 2
Study type: Interventional

The main purpose of this Phase 2 double blind, placebo controlled crossover clinical study is to demonstrate the efficacy and safety of CXA-10 in obese adult asthmatics. Obesity induces a chronic systemic inflammatory state characterized by impaired adipokine signaling, pro-inflammatory cytokine responses, inflammatory cell activation and enhanced generation of oxidative inflammatory mediators. This impacts the lung, increasing the severity of asthma and its exacerbations. This research will evaluate how a synthetic nitro-fatty acid (CXA-10, 10-nitro-octadec-9-enoic acid) suppresses the systemic and airway inflammation that contributes to the obese asthmatic phenotype. Current data support the pleiotropic signaling actions of CXA-10 to induce adaptive signaling actions that beneficially modulate adipokine and cytokine expression and inhibit systemic and pulmonary inflammation. The investigators hypothesize that CXA-10 induced signaling responses will alleviate obesity-related airway hyperreactivity in obese adult asthmatics.

NCT ID: NCT03760861 Not yet recruiting - Obesity Clinical Trials

First-in-man Trial of the Magnetic-controlled Balloon Inflation Mechanism of a Novel Ingestible Weightloss Microcapsule

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The objective of this study is to demonstrate the ease of deployment of a novel magnetically-controlled ingestible weight loss microcapsule* and the functionality of the magnetically controlled inflation of the balloon within the stomach.

NCT ID: NCT03758638 Not yet recruiting - Obesity Clinical Trials

Healthy Eating and Active Living Taught at Home (HEALTH) Dissemination & Implementation (D&I)

HEALTH D&I
Start date: January 2019
Phase: Phase 3
Study type: Interventional

This project evaluates the effectiveness of an evidence-based intervention (HEALTH) to prevent weight gain and promote weight loss when disseminated and implemented in real-world settings, through Parents as Teachers. To enhance the impact of HEALTH, the study also evaluates implementation outcomes from the training curriculum (implementation strategy) and external validity when HEALTH is implemented within this national home visiting organization. This partnership has potential for significant impact on obesity and chronic diseases such as cardiovascular disease and diabetes.

NCT ID: NCT03756961 Not yet recruiting - Obesity Clinical Trials

Effects of an Opioid Sparing Care Pathway for Patients Undergoing Obesity Surgery

OS-PCC
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The opioid consumption has exploded in the western world 1, and for some patient populations such as obese patients, patients with sleep apnoea or patients undergoing cancer treatment, opioid-sparing/ opioid-free strategies could have positive effects on outcomes. Studies suggest that opioids could have opioid-induced immunosuppression, induce chronic post-operative pain syndrome and hyperalgesia in addition to the more well-known side effects such as respiratory depression, nausea, bladder, and bowel dysfunction. Hence, new studies are needed on the impact of person-centered care programs that combine pharmaceutical and non-pharmaceutical strategies to reduce the adverse short and long-term effects of opioid therapy.

NCT ID: NCT03752762 Not yet recruiting - Obesity, Childhood Clinical Trials

SPOON:Sustained Program for Improving Nutrition - Mexico

SPOON-Mexico
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The primary goal of this study is to assess the impact of an innovative strategy to prevent undernutrition and obesity in early childhood in children 0-24 months in Mexico. This study is designed to evaluate the impact of promoting adequate infant an young child feeding practices and the use of SQ-LNS (Small Quantity Lipid-Based Nutrient Supplements) on the nutritional status of infants and young children. The study will be conducted in peri-urban areas of Tepic, Nayarit in Mexico in conjunction with the Hospital Infantil de México Federico Gómez and the Nayarit Secretariat of Health.

NCT ID: NCT03749746 Not yet recruiting - Obesity Clinical Trials

Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia

HH4NM
Start date: December 2018
Phase: N/A
Study type: Interventional

Preeclampsia causes devastating maternal and neonatal morbidity and mortality with a high recurrence risk and a rapid, occult progression to cardiovascular disease after delivery. There is a critical need for effective interventions to reduce these risks. This is a pilot randomized controlled trial of a novel postpartum lifestyle intervention compared to women who take home blood pressure measurements and women with usual care who are overweight and obese in the first year after preeclampsia. The investigators hypothesize that the intervention will lead to improved weight loss and blood pressure in the first year postpartum, which has broad implications for future pregnancy and long-term cardiovascular health.

NCT ID: NCT03743844 Not yet recruiting - Obesity Clinical Trials

Psychosocial Intervention for Women With Mood Disorders Seeking Treatment for Obesity

Start date: November 2018
Phase: N/A
Study type: Interventional

Women with mood disorders are vulnerable to the negative consequences associated with obesity, and face considerable challenges with adherence to behavioral weight management interventions. Strategies are needed to support the psychological well-being of this population, and improve adherence to weight-related treatment. The goal of this preliminary study is to determine the acceptability of a group-based compassion-focused psychoeducational intervention among women with mood disorders who are attending a behavioral weight management program.

NCT ID: NCT03743792 Not yet recruiting - Obesity Clinical Trials

Acute Raspberry Intake on Metabolic Control and Cognitive Function

Start date: December 2019
Phase: N/A
Study type: Interventional

The purpose of this project is to determine whether restoring the post-prandial metabolic/inflammatory balance via supplementation with raspberries results in improved cognitive performance, and if these enhancements are mediated through improvements in vascular function.

NCT ID: NCT03733132 Not yet recruiting - Obesity Clinical Trials

Metformin Effect on Brain Function in Insulin Resistant Elderly People

Start date: November 2018
Phase: Phase 2
Study type: Interventional

Alzheimer's disease (AD) and other forms of dementia are rapidly increasing with the aging of the population, and show a clear preponderance among people with insulin resistance. Metformin, an insulin sensitizer, is being examined in clinical trials as an anti-aging drug. However, very little objective data is available regarding metformin's effect on the brain, a major organ affected by aging.

NCT ID: NCT03730792 Not yet recruiting - Obesity Clinical Trials

Success & Health Impacts For Transit Drivers During Onboarding

SHIFTOnboard
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The project is a cluster randomized controlled trial of an occupational health intervention for newly hired bus operators. Transit authorities will be randomized to intervention and usual practice conditions and new bus operators will be recruited to participate in a two year study. Intervention participants will complete a program designed to prevent weight gain while also supporting early adjustment and job success. Control participants will experience standard or usual practice working conditions.