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Overweight and Obesity clinical trials

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NCT ID: NCT06311487 Not yet recruiting - Healthy Clinical Trials

Time and Nutrient-Dependent Effects of Aerobic Exercise on Metabolism in Adults (TANDEM Study)

TANDEM
Start date: March 2024
Phase: N/A
Study type: Interventional

This study plans to learn more about metabolic responses to aerobic exercise at different times of the day (morning or evening) under fasting versus fed conditions.

NCT ID: NCT06305650 Not yet recruiting - Clinical trials for Overweight and Obesity

Probiotic Influence on Obesity-Related Lipidemia

Start date: March 20, 2024
Phase: N/A
Study type: Interventional

This study aims to investigate the effects of Bifidobacterium breve BBr60 on key health indicators in overweight and obese adults. Specifically, it will assess the probiotic's impact on body composition metrics such as BMI, body fat percentage, WHR, and BMR. The inclusion criteria for participants are a BMI of ≥28 kg/m^2, targeting individuals who stand to benefit significantly from metabolic and body composition improvements.

NCT ID: NCT06302231 Not yet recruiting - Obesity Clinical Trials

Effects of Time-restricted Eating and Aerobic Exercise Training in Women With Overweight and Obesity

Start date: March 2024
Phase: N/A
Study type: Interventional

Time-restricted eating (TRE) is a dietary approach that aims to increase fasting time and decrease the eating window. Promising TRE effects on weight loss and improvements in some cardiometabolic risk factors have been reported in studies in animals and humans. However, the impacts of TRE combined with aerobic exercise training in individuals with overweight and obesity have been insufficiently investigated. Additionally, aerobic training performed in a fasted state appears to promote physiological adaptations that may improve the metabolic health in individuals with overweight and obesity. The present study investigates the effects of 8 weeks of TRE associated with aerobic training in a fasted state versus a fed state on body composition and cardiometabolic parameters in women with overweight and grade 1 obesity.

NCT ID: NCT06282952 Not yet recruiting - Clinical trials for Overweight and Obesity

NEwborn Infant of a Mother With Obesity - Fecal Microbiome Transplantation, RCT

NEMO-FMT
Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to investigate the differences in microbiota, height and weight between infants born by cesarean section to obese mothers and randomized to receive fecal microbiota transplant after birth. The main questions it aims to answer are: - Could fecal transplant be used improve gut microbiota and prevent overweight or obesity. - Is the source of colonization a modifiable factor and can it be changed by using an early fecal microbiota transplant.

NCT ID: NCT06280625 Recruiting - Clinical trials for Overweight and Obesity

The Effect of the Inclusion of Soybean Flour on Glycemic Responses

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

Foods that release glucose rapidly, leading to spikes in blood sugar and insulin (known as high glycemic index foods), generate lower satiety responses than foods with low glycemic index. High glycemic index foods are also linked to an increased risk of developing diabetes. The partial replacement of carbohydrates in rich staple foods with soy flour has the potential to reduce glycemic response and improve satiety. In many regions of Latin America, as well as in the Middle East and North Africa (MENA) regions, bread is the staple source of calories, but it is a relatively poor source of balanced nutrition. Bread enriched with soy flour could provide higher dietary protein while moderating blood glucose (and insulin) spikes, which can help reduce insulin resistance and metabolic diseases. The results of this study could provide government and private human nutritionists with the evidence they need to formulate soy flour into bread, corn tortillas, and arepas for schools and homes.

NCT ID: NCT06277232 Not yet recruiting - Clinical trials for Overweight and Obesity

Nutrition Care in Patients Living With Chronic Pain

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

The investigators' purpose is to develop and test the feasibility, usability, and satisfaction of the Diet4painrelief app as a platform for implementing nutrition care in a specialist pain rehabilitation clinic. The Diet4painrelief will consist of two components: a) a screening tool for nutrition status b) an individually tailored behavior change program aiming to improve the dietary habits and behaviors of patients living with chronic pain. The study is planned to include 20 patients with complex chronic pain and non-optimal BMI (underweight or overweight/obesity) to examine the feasibility and outcomes of evidence-based Interdisciplinary Pain Rehabilitation Program (IPRP) integrated with nutrition care. The Diet4painrelief includes a screening tool to assess basic nutritional status as well as their intake of key unhealthy and healthy foods and drinks (through three 24hour-dietary recordings or food diary). Thereafter, the patients receive a personalized behavior change program for dietary optimization. The investigators will design and adapt 6 modules in the digital platform (Diet4painrelief app) based on the International Association for the Study of Pain (IASP) recommendations (6 aspects about 'nutrition and pain') and Sweden's food culture. Clinical outcomes using patient-reported data on socio-demographics, pain aspects, psychometric data, physical disability, and quality of life will be measured at three occasions: first appointment (Pre-IPRP), immediately after completing the rehabilitation program (Post-IPRP), and at a 12-month follow-up (FU-IPRP). Blood samples will be taken to identify biomarkers at the same occasions that provide objective information on metabolic and nutritional abnormalities and further to evaluate the effect of the dietary intervention on changing of pain rehabilitation outcomes.

NCT ID: NCT06273072 Not yet recruiting - Asthma Clinical Trials

Metformin IN Asthma for Overweight and Obese Individuals (MINA)

Start date: May 1, 2024
Phase: Phase 2
Study type: Interventional

This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.

NCT ID: NCT06269159 Recruiting - Clinical trials for Overweight and Obesity

The Power of 24-hour: Co-designing Intervention Components

Start date: September 5, 2023
Phase:
Study type: Observational

Most of the existing lifestyle interventions in adults with overweight or obesity focus on one movement behavior in isolation (i.e. moderate to vigorous physical activity (MVPA)). However, recent research suggests to incorporate all movement behaviors performed in one day to explore the possible synergistic health effects of targeting more than one behavior. Moreover, more optimal 24-hour movement behavior compositions are related with better cardiometabolic health. Literature shows that adults with obesity have less optimal 24-hour compositions (8-9). Therefore it would be of interest to discover the needs related to an optimal 24-hour movement behavior intervention for a group of adults with overweight and obesity using co-design to develop an intervention. This study will conduct a concept mapping protocol to explore the needs to of people with overweight and obesity to change their sedentary behavior into more physical activity as well to include the opinion of health care providers (HCP are physiotherapists) on the needs of their patients.

NCT ID: NCT06268262 Recruiting - Clinical trials for Overweight and Obesity

Surgical-imaging Research on Obesity (SIRO)

Start date: March 1, 2023
Phase:
Study type: Observational

The global obesity epidemic is well established, and is an important public health issue. The previous researches had applied the clues that obesity is a kind of systemic disease. The investigators hypothesized that a serious alteration of the body systems will occur after bariatric surgery, which may shed light on the mechanisms of obesity. Thus, the research aims to combine the imaging and surgery to investigate the alterations of the body that induced by obese and alterations after surgery.

NCT ID: NCT06256653 Not yet recruiting - Obesity Clinical Trials

Assess the Effect of a Whole Fruit Powder on Gut Microbiome Function on Overweight & Obese Adults

Start date: February 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to evaluate the effect of freeze-dried blueberry powder on the gut microbiome in overweight and obese adults. The main question[s] it aims to answer are: - Does the supplementation of freeze-dried blueberry powder reduce the risk of obesity or lower the weight of people with a high BMI? - Does freeze-dried blueberry powder alter the gut microbiome function? Participants will; - Mix one sachet of Study Product (freeze-dried blueberry powder/placebo) into breakfast/dessert/yoghurt daily for 56 days during the intervention phase. - Partake in 4 site visits over the 14-week period, including an initial screening visit and a follow-up visit after the intervention phase. Researchers will compare the effect of freeze-dried blueberry powder with a placebo in a population comprising overweight and obese adults to see if the gut microbiome is altered and if there is a change in body composition.