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Overweight and Obesity clinical trials

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NCT ID: NCT03367936 Not yet recruiting - Clinical trials for Overweight and Obesity

Promoting Lifestyle Change Via Tailored mHealth Feedback to Improve Health

Start date: January 2018
Phase: N/A
Study type: Interventional

The overall purpose of this randomized clinical trial is to examine the effect and efficacy of the individualized, real-time, smartphone-based feedback of diet and physical activity self-monitoring on subsequent weight-control behaviors, weight loss outcomes and sustainability of patient engagement. Participants will be randomized into one of 2 groups: (1) Self-Monitoring -similar to what many people do on the participant's own, subjects will self-monitor diet, physical activity using Fitbit and weight using a Bluetooth-enabled scale, and (2) Self-Monitoring +Feedback-participants will self-monitor as described for the Self-Monitoring group but also will receive tailored Feedback messages. The Self-Monitoring +Feedback participants will receive up to 4 daily discrete pop-up Feedback messages on the participant's smartphone delivered at random times during waking hours and tailored to content of recorded entries in the subjects' smartphone-based diaries and a weekly summary Feedback message about the participant's weight.

NCT ID: NCT03367598 Completed - Clinical trials for Overweight and Obesity

Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness

Start date: January 1, 2008
Phase: N/A
Study type: Observational

The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.

NCT ID: NCT03364205 Completed - Obesity Clinical Trials

Solution Focused Approach in Adolescents (SFA)

Start date: September 2, 2013
Phase: N/A
Study type: Interventional

Aims-objectives: This study assessed the effect of the Solution Focused Approach (SFA) interview technique on overweight/obese adolescents' nutrition-exercise attitudes and behaviors. Background: Obesity is a serious health problem for all age groups, particularly adolescents; therefore, it is important for adolescents to develop healthy nutrition habits, acquire exercise behaviors. Unless healthy nutrition-exercise behaviors are acquired, obesity can develop in adolescence, continue in adulthood. Focusing on solutions can be effective for overweight/obese adolescents to develop healthy nutrition-exercise behaviors. Design: A pretest-posttest randomized-controlled trial design was used. Methods: The study included 32 overweight/obese adolescents (16 for intervention group, 16 for control group) aged12-13 years who attended a health center, met the inclusion criteria. The SFA interview technique was applied to the intervention group. Eight solution-focused interviews were conducted with each adolescent at two-week intervals (interview length 30 to 45minutes). For each group, anthropometric, metabolic measurement follow-ups were conducted in the first and sixth months. The data were evaluated using independent samples t-test, Mann-Whitney U, Wilcoxon test respectively for normally, non-normally distributed variables. The categorical variables were compared using chi-square test. The value p<0.05 was accepted to be statistically significant.

NCT ID: NCT03354377 Not yet recruiting - Clinical trials for Overweight and Obesity

Nutritious Eating With Soul (The NEW Soul Study)

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

This study addresses two challenges seen among African American (AA)participants during previous weight loss and dietary interventions aimed at reducing cardiovascular disease (CVD) risk: poor weight loss results and high attrition rates. We will target both of these challenges by using a randomized design to compare a plant-based dietary intervention (vegan diet) vs. an omni diet and by focusing on culturally-tailored food choices for AA adults living in the South. Therefore, the objective of our study is to conduct a culturally-tailored, randomized trial examining how a vegan diet affects CVD risk factors and weight as compared with an omni diet. Our study will randomize overweight AA adults (n=130) to follow one of two different diets (vegan or omni) for 24 months. We will accomplish our objectives and test our hypotheses by following two specific primary aims: Primary Aims: Using a randomized design, determine the impact at 12 months of two different, culturally tailored diets (n=65 omni and n=65 vegan) on changes in: 1. Risk factors for CVD, including LDL cholesterol and blood pressure; and 2. Body weight. Secondary Aim 3. Examine long-term changes in CVD risk factors and body weight at 24 months.

NCT ID: NCT03353220 Not yet recruiting - Clinical trials for Overweight and Obesity

Predictors of Lorcaserin-Induced Weight Loss

Start date: December 18, 2017
Phase: Phase 4
Study type: Interventional

This two-phase study aims to explore ways to predict who will respond well to the weight loss drug lorcaserin and to understand the mechanisms that develop which limit drug efficacy. Subjects will be recruited for a 5-week crossover study (phase 1) with lorcaserin and placebo followed by treatment with lorcaserin for 24 weeks (phase 2).

NCT ID: NCT03352869 Recruiting - Clinical trials for Polycystic Ovary Syndrome

Research of Exenatide for Overweight/Obese PCOS Patients With IGR

Start date: November 28, 2017
Phase: Phase 4
Study type: Interventional

Compare the therapeutic effects of exenatide, metformin and their combination for 3 months on reproductive and metabolic improvements of overweight/obese PCOS patients with impaired glucose regulation.

NCT ID: NCT03351426 Recruiting - Clinical trials for Overweight and Obesity

Neuromodulation With Transcranial Direct Current Stimulation (tDCS) to Control Excess Weight

Start date: September 1, 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to examine the effects of noninvasive neuromodulation with transcranial direct current stimulation (tDCS) aimed at enhancing the excitability of the left prefrontal cortex in middle-aged women with excess body weight. This is a randomized, parallel, double-blind study with a duration of 4 weeks. Outcome measures will include changes in performance in a computerized task assessing executive functions, subjective measures of food craving and appetite and changes in body weight.

NCT ID: NCT03344133 Recruiting - Clinical trials for Overweight and Obesity

Effect of Exercise Programme on Gut Microbiota, CVD Risk Factors and Appetite Regulation in Overweight Women

Start date: September 16, 2015
Phase: N/A
Study type: Interventional

Evidence suggests that gut microbiota contributes to the development of atherosclerosis and therefore CVDs. Exercise has been extensively reported to be protective against CVDs due to modification of body fatness, metabolic risk factors and cardio-respiratory fitness. It remains unclear whether impact of exercise on CVD risk can be at least in part explained by changes in the microbiota. It also remains to be investigated whether modification of appetite and appetite hormones due to participation in exercise are related to changes in the gut microbiota composition. Therefore, this study will be conducted in overweight, healthy, sedentary women and will investigate the effect of a 4-week moderate intensity exercise programme on gut microbiota composition and metabolic activity, plasma concentrations of fasting and postprandial lipids, glucose, insulin and inflammatory markers, fasting and postprandial gut appetite hormones, subjective appetite measures and cardio-respiratory fitness.

NCT ID: NCT03337828 Active, not recruiting - Clinical trials for Overweight and Obesity

Effect of Two Alcohol-free Beers With Different Carbohydrates Composition on Lipids and Glucose Metabolism

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

This a controlled, double-blind, randomized, cross designed study to determine the effect of an alcohol-free beer with low glycemic index carbohydrates (isomaltulose) and a resistant maltodextrin, comparing to an alcohol-free beer with regular composition, on glycemic metabolism (glucose, glycated hemoglobin, insulin and HOMA index) in subjects with recently diagnosed diabetes mellitus and overweight or obesity. 44 subjects were randomized to consume for 10 weeks: a) two alcohol-free beers with regular carbohydrates composition per day; b) two alcohol-free beers with modified carbohydrates composition per day. Those subjects randomized to begin with A beer during 10 weeks will change to B beer during the second phase for 10 weeks and vice versa. There is a 4-8 weeks wash-out period between two phases.

NCT ID: NCT03337139 Recruiting - Obesity Clinical Trials

FitLink: Improving Weight Loss Maintenance by Using Digital Data to Provide Support and Accountability

Start date: November 2017
Phase: N/A
Study type: Interventional

Most adults in the U.S. are overweight or obese and find maintenance of weight loss difficult. This study is designed to aid in the development of a lifestyle modification program that can facilitate weight loss maintenance, without requiring long-term visits to a clinic for maintenance treatment.