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Obesity clinical trials

View clinical trials related to Obesity.

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NCT ID: NCT02556138 Suspended - Obesity Clinical Trials

Endoscopic Intragastric Balloon Placement for Weight Loss in Liver Transplant Waitlist Candidates

Start date: September 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether the ORBERA Intragastric Balloon is a safe and effective means for weight loss and improved metabolic disease in patients with cirrhosis requiring liver transplantation.

NCT ID: NCT02486380 Suspended - Clinical trials for Obesity Hypoventilation Syndrome

Simplus and Eson Evaluation in Obesity Hypoventilation Syndrome (NZ)

Start date: July 2015
Phase: N/A
Study type: Interventional

This investigation is to evaluate the performance, comfort and ease of use of the Simplus and Eson masks amongst Obesity Hypoventilation Syndrome (OHS) patients in an overnight study.

NCT ID: NCT02191501 Suspended - Obesity Clinical Trials

Endoscopic Suturing of the Gastric Pylorus to Delay Gastric Emptying and Treat Obesity

Start date: March 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to demonstrate the efficacy and safety of endoscopic suturing of the gastric pylorus to delay gastric emptying and treat obesity.

NCT ID: NCT01962857 Suspended - Obesity Clinical Trials

Effect of 4 Weeks of Shuttle Run Training on Insulin Sensitivity in Sedentary Men

Start date: October 2013
Phase: N/A
Study type: Interventional

A number of studies have shown that short duration, high intensity interval training can improve health-related outcomes, such as insulin sensitivity and cardiorespiratory fitness. However, these often use specialized equipment, such as cycle ergometers, which makes it difficult to roll these interventions out for wide-scale use in the general population. This study aims evaluate the effects of a high intensity shuttle running intervention on insulin sensitivity, fitness and related cardiometabolic risk factors in men who are currently inactive. Participants will be randomized into intervention (4 weeks of shuttle running) and control groups. We hypothesize that the shuttle running programme will result in improved insulin sensitivity, fitness and increased fat oxidation at rest compared with the control group.

NCT ID: NCT01859104 Suspended - Obesity Clinical Trials

Feasibility of Use of BariCare App in Pre-transplant Population

Start date: September 2015
Phase: N/A
Study type: Interventional

This current study aims to evaluate the efficacy of engagement modules in assisting patients who are candidates for renal and liver transplantation make significant lifestyle modifications. With the help of the Center for Innovation (CFI), a smartphone app (Android and iOS compatible) has been created to assist in both educating and engaging patients to develop and maintain healthy lifestyle modifications. Our goal is to create a cost-effective, smartphone-based platform that serves to not only efficiently educate but to also verify competence and keep our patients engaged.

NCT ID: NCT01824680 Suspended - Obesity Clinical Trials

Effect of a Physical Activity Program on the Hormonal Regulation of Food Intake

Start date: October 2012
Phase: N/A
Study type: Interventional

The primary purpose of this protocol is to assess the hormonal regulation of satiety by an intense exercise before and after a 3 month physical activity program. Hormones assessed are: leptin, grhélin, Cholecystokinin, Glucagon-Like-Peptid-1 (GLP-1), PYY. It is well known that in overweight adults and children also, an intense physical exercise diminish the food intake relatively to the total energy expenditure and this effect is persistent after a 6 weeks physical activity program. Our hypothesis are: a diminution of food intake after the intense physical exercise and a persistent diminution of food intake after the 3 month physical activity program, an augmentation of levels of GLP-1 and PYY during the intense exercise before and after the physical activity program, a diminution of the level of GLP-1 and leptin before and after the physical activity program

NCT ID: NCT01815216 Suspended - Obesity Clinical Trials

Effect of Gastric Bypass Surgery on Brain Responses

Start date: March 2013
Phase: N/A
Study type: Interventional

After obesity surgery gastric bypass (GBP) patients usually lose more than 50% of its former preponderance in relative short time (~ 2 years). But knowledge of the underlying biological mechanisms of decline in body weight is still inadequate. This project intends to examine patients' background activity in the brain (i.e. "the resting state activity") and brain volume using MRI both before and one year after surgery.

NCT ID: NCT01387126 Suspended - Obesity Clinical Trials

Effects of a High Viscosity Dietary Fibre, as Part of a Medically Supervised Weight Management Program

Start date: n/a
Phase: Phase 3
Study type: Interventional

The aim of this study is to investigate whether the supplementation of a medically supervised weight management program with a novel fibre supplement, improves body weight, body composition, and laboratory measurements in overweight and obese individuals. All subjects will participate in the medical weight management program however the intervention group will have 5 grams of a novel fibre supplemented to each meal while the control group will not.

NCT ID: NCT01351753 Suspended - Obesity Clinical Trials

Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity

Start date: March 2011
Phase: Phase 2
Study type: Interventional

Obesity is common (>30% of US adults), contributes to substantial morbidity and mortality, but is difficult to treat. Partly this is due to the transient, arduous and modest nature of lifestyle interventions. Partly it is due to the limited efficacy and safety problems of existing pharmacotherapy. Only one drug, orlistat, is approved for long-term use in obesity; but its effects on weight are relatively small. There are drugs that have been approved for other diseases but which also reduce weight. One promising approach to treating obesity is combination therapy with orlistat and one or more of these other agents. The investigators propose an innovative approach to developing new therapies for obesity coupling the use of combination therapy with rigorous assessment of cardiovascular safety. Vascular function is a quantitative surrogate clinical endpoint that has been strongly and independently linked to future cardiovascular events. Our hypothesis is that combination pharmacotherapy will reduce weight and improve vascular function in obese human subjects. The co-primary endpoints will be weight and vascular function.