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Obesity clinical trials

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NCT ID: NCT03460834 Enrolling by invitation - Obesity Clinical Trials

Asthma and Obesity: Observational

Start date: May 1, 2016
Phase: N/A
Study type: Observational

Obesity is associated with poor asthma control and greater healthcare utilization and costs. In this study the researchers will examine the biologic and behavioral interrelationships between these conditions and their impact on outcomes. Towards this end, the researchers will conduct an observational prospective cohort study of 400 obese asthmatic patients treated at institutions in New York City and Denver, and develop and pilot test educational and counseling modules that take an integrated approach to asthma and obesity self-management support.

NCT ID: NCT03450655 Enrolling by invitation - Visceral Obesity Clinical Trials

Cardio Training of Older Adults With Central Obesity

Start date: February 9, 2018
Phase: N/A
Study type: Interventional

Given the increasing prevalence of obesity, there is an urgent need to find better strategies to promote physical activity in the community. The present study will invite 70-year-olds with central (abdominal) obesity to participate in a 10-week aerobic exercise program. Participants will be randomly assigned to one of two equally large groups. The first group will complete the exercise program in instructor-led groups. The second group will complete the program at home with the help of an on-line video.

NCT ID: NCT03430154 Enrolling by invitation - Clinical trials for Haemophilia A, Haemophilia B, Obesity

Awareness, Care, and Treatment In Obesity Management of Patients With Hemophilia (ACTION) to Inform Hemophilia Obesity Patient Empowerment (HOPE)

Start date: December 1, 2017
Study type: Observational

An online web-based cross-sectional survey in which participants will complete a distinct questionnaire for patients with hemophilia and obesity (PwHO) and/or their carers/spouses/partners, or a distinct questionnaire for healthcare professionals. Each questionnaire consists of more than 100 items including pre-coded (multiple choice) closed-ended questions, yes/no questions and rating scales. It is estimated that this one-off survey will take approximately 45-60 minutes to complete. As a cross-sectional study, there will be no treatment of patients.

NCT ID: NCT03407833 Enrolling by invitation - Obesity Clinical Trials

Physiologic and Functional Adaptations of Insulin Sensitive Tissues

Start date: February 13, 2018
Phase: N/A
Study type: Observational

The long-term goal is to understand the mechanisms of intestinal nutrient sensing and signal relays to insulin sensitive tissues (adipose, skeletal muscle, liver) in humans. The investigators hypothesize that human tissue biopsies (from obese surgery and non-surgery subjects as well as lean controls) can be used to understand the molecular mechanisms underlying intestinal nutrient sensing and signal relay in humans. The investigator will obtain tissue specimens from obese patients during scheduled upper endoscopies, colonoscopies and scheduled metabolic and bariatric surgeries. The investigator will obtain tissue specimens from lean patients during scheduled endoscopies and colonoscopies. A blood sample (4mL) will be obtained concurrent with these procedures. From metabolic and bariatric surgery subjects blood and tissues (liver, adipose, small intestine, omentum, skeletal muscle) will be collected at the time of surgery. Stool will be obtained preoperatively and at various time points after surgery.

NCT ID: NCT03396302 Enrolling by invitation - Obesity Clinical Trials

Lifestyle On-line Intervention in Patients With Obesity and Hypertension

Start date: January 22, 2018
Phase: N/A
Study type: Interventional

This study aims to describe a totally self-applied online program to promote healthy lifestyles (nutritional education and exercise practice) for obese participants with hypertension. Participants will be recruited from users of a hypertension unit of a public hospital and will be randomized into two groups: experimental group and control group (treatment as usual). The experimental program (3 months) will be composed by 8 modules aimed for promoting healthy eating habits and increase physical activity. Assessment will include: body composition (BMI), blood pressure, glucose metabolism variables, and physical activity level (measured with accelerometers). Design: Randomized Controlled Trial.

NCT ID: NCT03378765 Enrolling by invitation - Obesity Clinical Trials

Gut Microbiota, Short Chain Fatty Acids, and Adiposity Across The Epidemiological Transition

Start date: January 2, 2018
Phase: N/A
Study type: Observational

The objective of this study is to define associations between gut microbiota, SCFAs and obesity in populations spanning the epidemiologic transition, and explore mechanisms by which these factors may independently and collectively influence the development of obesity. The central hypothesis of this study is that the composition of gut microbiota drives SCFA production which in turn influences obesity risk at the population-level.

NCT ID: NCT03364335 Enrolling by invitation - Obesity Clinical Trials

The Effect Of NS-0200 and NS-0300 Versus Placebo on Weight In Obesity

Start date: January 8, 2018
Phase: Phase 2
Study type: Interventional

This is a 24-week study to evaluate the effects of two fixed-dose combinations of leucine and sildenafil or two fixed-dose combinations of leucine, sildenafil and metformin compared to placebo. The primary objective of this study is to evaluate the percentage change in body weight in subjects from Baseline/Visit 2 (Day 1) to Study Termination/Visit 8 (Day 168/Week 24).

NCT ID: NCT03355092 Enrolling by invitation - Obesity Clinical Trials

The vBlocT2D Study

Start date: February 23, 2018
Phase: N/A
Study type: Interventional

Overall aim: To demonstrate that weight loss through vBloc Therapy in combination with usual care will achieve better glycemic control for patients with obesity and type 2 diabetes than usual care alone. Duration: Participants will be asked to participate in a 12 month study that involves a baseline visit and research follow-up visits at 3, 6, 9, and 12 months. Sample Size: 60 participants will be enrolled in the study. Of these, 30 will be randomized to vBloc therapy and 30 will be randomized to usual care.

NCT ID: NCT03334669 Enrolling by invitation - Obesity Clinical Trials

Family-centered Obesity Prevention: Communities for Healthy Living (CHL)

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

The Communities for Healthy Living (CHL) program is a family-focused intervention to promote healthy lifestyle behaviors including diet and physical activity among children (age 3-to 5-years) and their families, enrolled in Head Start.

NCT ID: NCT03324906 Enrolling by invitation - Obesity Clinical Trials

Effects of Transcranial Direct Current Stimulation (tDCS) on Individuals With Prader-Willi Syndrome

Start date: May 8, 2017
Phase: N/A
Study type: Interventional

Prader-Willi Syndrome (PWS) is a multisystemic genetic disease characterized by hypotonia, mental retardation, hyperphagia, and uncontrollable hunger due to hypothalamic dysfunction, caused by dysregulation of genes located in chromosome 15q11-q13. The goal of this study is to evaluate the effects of Transcranial Direct Current Stimulation (tDCS) on hyperphagia and behavior in PWS. Forty children and adolescents (11-24 years) with clinical and cytogenetic-molecular diagnosis of Prader-Willi syndrome will be assessed before and after 10 tDCS session with: Food Craving Questionnaire (FCQ), Aberrant Behavior Checklist (ABC), Dykens hyperphagia questionnaire. Caregivers self-reported the participant's behaviors at home and, lately, they will be categorized and quantified. tDCS will be applied for 20 minutes with electrodes of 25cm2 wrapped in cotton material soaked in saline solution. The anode at the left dorsolateral prefrontal cortex (F3) and the cathode at the contralateral area (F4). Children from 11-12 years will receive a current of 1mA; above 13 years, 2mA.