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Obesity clinical trials

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NCT ID: NCT03197363 Enrolling by invitation - Obesity Clinical Trials

Białystok PLUS - Polish Longitudinal University Study

Bialystok+
Start date: July 2017
Phase: N/A
Study type: Observational

The main goal of study is to provide a unique multidimensional picture of the health of the population with simultaneous optimal standards of sampling, processing and storing of data and biomaterial that will allow discoveries of novel mechanisms in the development and progression of common civilization diseases. In the effect it will improve prevention, diagnosis and treatment.

NCT ID: NCT03191591 Enrolling by invitation - Physical Activity Clinical Trials

The First 1,000 Days Program: Maternal-Child Obesity Prevention in Early Life

Start date: August 9, 2016
Phase: N/A
Study type: Interventional

The First 1000 Days (conception to age 2) is a crucial period for the development and prevention of obesity and its adverse consequences in mother-child pairs and their families. The overall aim of the First 1000 Days program is to work across early-life systems to prevent obesity, promote healthy routines and behaviors, address social determinants of health, and reduce health disparities among vulnerable children and families at the MGH Chelsea and Revere HealthCare Centers, and DotHouse Health. The study aims to simultaneously implement and evaluate an obesity prevention program across early life systems to reduce the prevalence of obesity risk factors within racial/ethnic minority families, close the gap in maternal-child health disparities, and assess and address social determinants of health.

NCT ID: NCT03063606 Enrolling by invitation - Obesity Clinical Trials

Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Specialist Treatment

Start date: June 2017
Phase: Phase 2/Phase 3
Study type: Interventional

This study will test the effectiveness of cognitive-behavioral therapy as a specialist treatment for binge eating disorder (BED) in patients with obesity. This is a controlled test of whether, amongst non-responders to acute treatments, cognitive-behavioral therapy augments on-going blinded pharmacotherapy (either naltrexone/bupropion or placebo), compared with no additional behavioral treatment .

NCT ID: NCT03047005 Enrolling by invitation - Obesity Clinical Trials

Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy

Start date: June 2017
Phase: Phase 2/Phase 3
Study type: Interventional

This study will test the effectiveness and relative efficacy of naltrexone/bupropion medication as a maintenance therapy for the treatment of binge eating disorder (BED) in patients with obesity. This is a controlled test of whether, amongst responders to acute treatments, naltrexone/bupropion medication results in superior maintenance and longer-term outcomes compared with placebo.

NCT ID: NCT03029936 Enrolling by invitation - Obesity Clinical Trials

Obesity-asthma Endophenotype and Diaphragm Mobility in Adolescence

Start date: July 1, 2016
Phase: N/A
Study type: Observational

Obesity and asthma share changes that may begin in the fetal development phase. The endophenotype obesity-asthma presents as main characteristic a pattern of inflammatory response different from the habitual Th2 profile of cytokines. In these obese patients, possible changes in the diaphragm muscle can directly influence the dynamics of pulmonary ventilation significantly. Due to the importance of the diaphragm in pulmonary ventilation, this study will be performed to verify possible alteration in the excursion and diaphragmatic thickness of adolescents with endophenotype obesity-asthma. In parallel, the possible underlying etiopathogenic substrate of this endophenotype will be explored through the dosing of muscle enzymes and inflammatory cytokines and obesity hormones.

NCT ID: NCT03024879 Enrolling by invitation - Healthy Clinical Trials

The Effect of Motilin on the Frequency and Amount of Food Intake

Start date: March 2014
Phase: Phase 4
Study type: Interventional

In this study, the investigators aimed at evaluating the role of motilin in the regulation of food intake. Motilin, a gastrointestinal hormone, is a hunger signal in healthy volunteers and is significantly increased in obese patients. Its role in food intake regulation might contribute to the pathogenesis of obesity.

NCT ID: NCT03012126 Enrolling by invitation - Clinical trials for Overweight and Obesity

Clinical & Community Approaches to Weight Management

CORD 2
Start date: December 2016
Phase: N/A
Study type: Interventional

This project seeks to build on innovative strategies to optimize the care of low-income children with a BMI ≥ 85th percentile. To accomplish this goal, investigators will implement a new clinical-community intervention, theoretically grounded in the Integrated Clinical and Community Systems of Care Model, to address obesity through optimized screening and management known to be effective, e-Referrals, Healthy Weight Clinics, and the YMCA's Healthy Weight and Your Child weight management program (originally known as MEND). The study will examine outcomes for children that matter most to a broad group of stakeholders including parents, clinicians, and public health practitioners as well as inform the care of >7 million children with obesity covered by the Children's Health Insurance Program or Medicaid.

NCT ID: NCT02992106 Enrolling by invitation - Clinical trials for Endothelial Dysfunction

Evolution of Maternal Weight During Pregnancy and Influence on the Endothelial Function in Her Offspring

EFFECTOR
Start date: May 10, 2017
Phase: N/A
Study type: Interventional

The rising worldwide prevalence of obesity and its subsequently rising incidence of concommitant diseases as diabetes and cardiovascular events impose a defiant obstacle for the health care and associated health care costs of future generations. Obese pregnant women are a growing population of interest because their offspring is at risk for childhood obesity, an adverse metabolic and inflammatory profile and possible endothelial dysfunction. However, strong evidence is still lacking regarding the hypotheses on the early origin of these long-term health consequences. Consequently there is no comprehensive data available on the contribution of changing maternal weight through lifestyle interventions or bariatric surgery and an eventual adverse metabolic and endothelial programming of the offspring. The investigators of this study want to provide additional data on the body composition, metabolic and inflammatory state as well as endothelial function of children of obese pregnant women women and compare the outcome with children born from normal weight women. Furthermore, the investigators of this study will stratify the obese pregnant women into 3 groups: women who did not underwent an intervention, women who underwent a weight changing intervention during pregnancy e.g. diet or lifestyle intervention and women who underwent bariatric surgery before pregnancy. The overall aim of the study is to prove that in all the diverse groups of participating children, except the control group, there will be a certain grade of endothelial dysfunction, even if there was a normalization of weight, insulin sensitivity and inflammation before conception or delivery in the mother.

NCT ID: NCT02975258 Enrolling by invitation - Asthma Clinical Trials

Adiposity and Airway Inflammation in HIV-Associated Airway Disease

SHOP
Start date: September 2015
Phase: N/A
Study type: Observational

The goals of this study are to 1) examine the relationships among inflammation, obesity, and asthma in people with HIV and 2) to test if special subtypes of cells or markers are present in the blood and lungs of people with HIV with asthma compared to those without asthma.

NCT ID: NCT02967757 Enrolling by invitation - Obesity Clinical Trials

In-market Utilisation of Liraglutide Used for Weight Management in Europe

Start date: November 30, 2016
Phase: N/A
Study type: Observational

This study is conducted in Europe. The aim of this study is to investigate usage of liraglutide for weight management in clinical practice.