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Obesity clinical trials

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NCT ID: NCT03704064 Recruiting - Obesity Clinical Trials

Behavioral Weight Loss and Stigma Reduction

Start date: October 2018
Phase: N/A
Study type: Interventional

This is a randomized controlled trial to test the effects on long-term weight loss of a novel stigma-reduction intervention combined with standard BWL treatment, as compared to BWL alone. Participants will be a total of 104 men and women seeking weight loss, ages 18 years and older, with a body mass index (BMI) of 30 kg/m2 or above (or 27 kg/m2 or above with an obesity-related comorbidity), a history of experiencing weight bias, and elevated levels of WBI. Participants will attend a screening visit in which they will complete a behavioral evaluation with a psychologist and a medical history that will be reviewed by a nurse practitioner or physician. Questionnaires assessing experiences and internalization of weight bias, with confirmation by interviewer assessment during the behavioral evaluation, will be used to determine whether participants meet criteria for having high levels of WBI. Eligible consenting participants will be randomly assigned to the standard BWL intervention (n = 52) or the stigma + BWL intervention (n = 52). All participants will attend weekly, 90-minute group meetings for 20 weeks (20 visits). In the stigma + BWL treatment group, 60 minutes will be devoted to BWL and 30 minutes to weight stigma. In the standard BWL treatment group, the additional 30 minutes will be devoted to sharing recipes and food preparation tips. Following 20 weeks of weight loss treatment, participants will attend group meetings focused on weight loss maintenance, monthly from weeks 21-46 (6 visits), and every-other-month from weeks 47-72 (3 visits). Maintenance sessions in the stigma + BWL group will continue to incorporate discussion of WBI and stigma-related barriers to physical activity. Assessments - which include questionnaires, blood draws, and measurements of body weight and physical activity - will occur at baseline and weeks 20, 46 (no blood draw this week), and 72. Weight will be measured at every group meeting for clinical purposes.

NCT ID: NCT03699228 Recruiting - Obesity Clinical Trials

China Health Big Data

China biobank
Start date: December 1, 2017
Phase:
Study type: Observational

In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. The aim of this study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.

NCT ID: NCT03699059 Recruiting - Obesity Clinical Trials

The wEight Management in Renal Transplant Online Study (ExeRTiOn)

ExeRTiOn
Start date: May 31, 2018
Phase: N/A
Study type: Interventional

The primary aim of this project is to create an online weight management tool (Physical activity, weight management and cognitive behavioral therapy) to prevent significant weight gain following kidney transplantation. Designing the online interactive weight management resource for kidney transplant patients will involve patient and health care professional input through Qualitative methodology such as 'Think-Aloud' interviews and one-to-one semi-structured interviews. This online resource will be called "exertion" and will be created by the research team, with technical support from the Software Company (SPIKA). Results from this study will refine the resource, and lead to a study application for a randomized controlled feasibility trial where we plan to test the "exertion" online application. Therefore this project has potential to influence clinical practice for kidney transplant recipients. It will allow patients, who may not have routine access to physio or dietetic input to address weight gain with support. A study flow chart summarizing the project can be found below.

NCT ID: NCT03698955 Recruiting - Obesity Clinical Trials

Low-Fat Vegan Diet Versus a Mediterranean Diet on Body Weight

Start date: October 2018
Phase: N/A
Study type: Interventional

This randomized, cross-over trial aims to assess changes in body weight, plasma lipids, insulin sensitivity, and postprandial metabolism with a low-fat, plant-based diet and a Mediterranean diet, both followed for 4 months.

NCT ID: NCT03695289 Recruiting - Obesity Clinical Trials

Interactive Obesity Treatment Approach (iOTA) for Obesity Prevention in Serious Mental Illness

iOTA-SMI
Start date: July 5, 2018
Phase: N/A
Study type: Interventional

The proposed project aims to pilot and adapt a scalable and sustainable interactive obesity treatment approach (iOTA) program for adults with serious mental illness (SMI). The project consists of 2 arms: the iOTA SMI arm and the Health Education Control Group arm. The investigators hypothesize that participants in the iOTA intervention group will show favorable change in BMI compared to participants in the Health Education Control group, and participants in the iOTA intervention group will show favorable change in self efficacy with respect to healthy eating and activity compared to those in the Health Education Control group.

NCT ID: NCT03693430 Recruiting - Obesity Clinical Trials

Two-year Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity

STEP 5
Start date: October 5, 2018
Phase: Phase 3
Study type: Interventional

This study will look at the change in body weight from the start to the end of the study. Researchers will compare the weight loss in people taking semaglutide (a new medicine) to people taking "dummy" medicine. In addition to taking the medicine, participants will also have talks with study staff about healthy food choices, how the participant can be more physically active and what participants can do to lose weight. Participants will either get semaglutide or "dummy" medicine - which treatment the participant gets is decided by chance. Participants will need to take 1 injection once a week. The study medicine is injected with a thin needle in a skin fold in the stomach, thigh or upper arm. The study will last for about 2 years. The participants will have 19 clinic visits and 15 phone calls with the study doctor.

NCT ID: NCT03687411 Recruiting - Obesity Clinical Trials

An Ultrasound Guided Automated Spinal Landmark Identification With Real-time Neuraxial Needle Insertion System

ULTRA-SINE
Start date: May 24, 2018
Phase: N/A
Study type: Interventional

Neuraxial ultrasonography has been shown a safe and effective technique to enhance the overall success rate of lumbar puncture and reduce the number of injection attempts. However, the current blind palpation landmark technique is known to be highly inaccurate and may increase the risk of multiple insertion attempts, patient suffering and complication rates such as spinal cord injury. Various clinical studies have confirmed the effectiveness of ultrasound imaging compared with the traditional palpation method. However, none of the present system can achieve real-time guidance. The overall aim of this proposal is to develop an ultrasound guided automated spinal landmark identification with real-time neuraxial needle insertion system to improve patient safety and efficacy of neuraxial procedure needle insertion success. This will be achieved in 2 phases of technology development and clinical trial phases. The investigators will recruit 20 subjects in a prospective cohort study to investigate the spinal needle first attempt success rate as a clinically relevant outcome. The secondary aim is to develop an automated spinal landmark identification algorithm using image processing to identify spinal landmarks in 50 obese patients within 12 months. The investigators have set out objectives for regulatory development, technical disclosure and transfer of developed technology to industry partner at the end of the project.

NCT ID: NCT03683888 Recruiting - Obesity Clinical Trials

Healthsnap on Epicardial Adipose Tissue Study

HEATS
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The purpose of this research study is to learn about the effectiveness of HealthSnap assessment, to reduce epicardial fat thickness. Excessive epicardial fat is associated with higher risk of developing diabetes and heart diseases. HealthSnap Assessment is a simple, quick and not invasive tool that will provide the patient with a personalized information nutritional and exercise plan.The use of HealthSnap in the clinical practice has not been evaluated, yet.

NCT ID: NCT03678701 Recruiting - Obesity Clinical Trials

Protein Supplementation and Fat Mass Loss

Start date: September 24, 2018
Phase: N/A
Study type: Interventional

Investigators examined the associations between whey protein supplementation before meals with energy balance and body composition.

NCT ID: NCT03678246 Recruiting - Obesity Clinical Trials

Low Skill Fibreoptic Glottis View in Obese Patients: Ramp vs Supine Sniffing Air Position

Start date: July 13, 2018
Phase: N/A
Study type: Interventional

Aims: The investigators are employing a feasibility study to determine whether fibreoptic view of the glottis (vocal cords) during low skill fibreoptic intubation (FOI) via a laryngeal mask airway (LMA) in obese and severely obese patients is appropriate and feasible for future full-scale research. Obese, and severely and morbidly patients in Asia are classed as body mass index (BMI) of ≥ 30, ≥35 and ≥40 kg/m2, respectively.