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Hypertension clinical trials

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NCT ID: NCT03511313 Recruiting - Clinical trials for Primary Hypertension

Renal Denervation With Sterile Irrigated Deflectable Ablation Catheter Used in Renal Artery in Primary Hypertension

Start date: April 11, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the safety and efficacy of renal denervation with sterile irrigated deflectable ablation catheter used in renal artery in primary hypertension in China.

NCT ID: NCT03506724 Recruiting - Preeclampsia Clinical Trials

Response to Anti-hypertensives in Pregnant and Postpartum Patients

Start date: September 11, 2017
Phase: Phase 4
Study type: Interventional

In this study, the investigators will evaluate the blood pressure response to nifedipine and labetalol in pregnant and postpartum patients, who present with hypertensive disease in pregnancy with severe range blood pressure defined as greater than 160/110. These anti-hypertensives are first line therapy for management of severe range blood pressures in pregnancy and postpartum by the American Congress of Obstetricians and Gynecologist (ACOG). In addition at the Mount Sinai West site, the investigators will also analyze the ADRB1 and similar genes involved in beta blockade, genes involved in calcium channel blockade and other genes implicated in blood pressure response among pregnant and postpartum patients receiving labetalol and nifedipine. This analysis will be used to determine if a pharmacogenetic association exists between variant alleles in these receptors in the pregnant and postpartum population.

NCT ID: NCT03503383 Recruiting - Clinical trials for Hypertension With Pregnancy

Evaluation of Psychological Status in Pregnant Women Complaining of Hypertension With Pregnancy

Start date: March 1, 2018
Study type: Observational [Patient Registry]

This study is a case controlled study comparing mental health status and some psychological impacts between two groups of patients first group is pregnant women without any other medical disorder during pregnancy,the second group is pregnant women complaining of hypertension with pregnancy.

NCT ID: NCT03496792 Recruiting - Blood Pressure Clinical Trials

The Venous Distension Reflex and Orthostatic Hypertension

Start date: December 11, 2017
Phase: N/A
Study type: Interventional

This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).

NCT ID: NCT03496623 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Patients With PH Due to COPD

Start date: May 2018
Phase: Phase 3
Study type: Interventional

This is a multicenter, randomized, double-blind, placebo-controlled, 30-week, adaptive cross-over study, with a Treatment Period of approximately 26 weeks under the Original Design or, if applicable, a 17-week parallel study, with a Treatment Period of approximately 14 weeks under the Contingent Design.

NCT ID: NCT03496207 Recruiting - Clinical trials for Pulmonary Arterial Hypertension

A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH)

Start date: June 2018
Phase: Phase 2
Study type: Interventional

Study A011-09 is designed to assesses the efficacy and safety of sotatercept (ACE-011) relative to placebo in adults with pulmonary arterial hypertension (PAH). Eligible participants will receive study treatment for 6 months in the double-blind Treatment Period, and then will be eligible to enroll into an 18-month Extension Period during which all participants will receive sotatercept. All treated patients will be also undergo follow-up period after last treatment.

NCT ID: NCT03489005 Recruiting - Heart Failure Clinical Trials

Effect of BIA 5 1058 on Cardiac Repolarization

Start date: April 2018
Phase: Phase 1
Study type: Interventional

The purpose is to evaluate the effect of single therapeutic (400 mg) and supratherapeutic (1200 mg) doses of BIA 5-1058 on the time-matched change from baseline in placebo-adjusted interval corrected (QT) for heart rate (HR)

NCT ID: NCT03484364 Recruiting - Hypertension Clinical Trials

Engaging Native Hawaiian/Pacific Islanders and Activating Communities to Take Steps (ENACTS)

Start date: June 15, 2018
Phase: N/A
Study type: Interventional

Our Specific Aims are: 1. At the individual level, to compare within-person change in BP and secondary outcomes between the intervention and control groups. 2. At the family level, to evaluate ENACTS' effects on BP and secondary outcomes as within-person change in family members who provide primary support, and as mean change in other adult family members who are not directly engaged in the intervention. 3. At the policy level, to evaluate the intervention's ability to influence grocery store policy on clearly identifying foods that are low in sodium or high in potassium, some of which might not be easily identified with existing labels (e.g., fresh produce). ENACTS combines empirically supported elements of existing programs, thus increasing its probability of success. It aligns with the American Heart Association's call for multilevel prevention.

NCT ID: NCT03480217 Recruiting - Clinical trials for Hypertension,Essential

Implementing Hypertension Screening Guidelines in Primary Care

Start date: April 2, 2018
Phase: N/A
Study type: Interventional

The goal of this study is to use a cluster-randomized design (1:1 ratio) among 8 primary care clinics affiliated with New York-Presbyterian Hospital to test the effectiveness of a theory-informed multifaceted implementation strategy designed to increase the uptake of the 2015 United States Preventive Services Task Force (USPSTF) hypertension screening guidelines. The primary outcome is the ordering of out-of-office blood pressure testing, either ambulatory blood pressure monitoring (ABPM) or home blood pressure monitoring (HBPM), by primary care clinicians for patients with newly elevated office blood pressure (BP), as recommended by the 2015 guidelines.

NCT ID: NCT03479697 Recruiting - Hypertension Clinical Trials

HIRREM for Stage 1 Primary Hypertension

Start date: June 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to determine that effects of an intervention called High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), on Stage 1 Primary Hypertension (systolic BP 130-139, and/or diastolic BP 80-89).