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Preeclampsia clinical trials

View clinical trials related to Preeclampsia.

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NCT ID: NCT03903393 Recruiting - Preeclampsia Clinical Trials

Serum LncRNAs as Early Potential Biomarkers for the Prediction of Preeclampsia

Start date: March 31, 2019
Phase:
Study type: Observational

To identify lncRNAs differentially expressed at early stages of gestation in the serum of pregnant women, who later developed severe preeclampsia (sPE) in the third trimester of pregnancy compared to women with normal pregnancy .

NCT ID: NCT03891498 Not yet recruiting - Preeclampsia Clinical Trials

The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia

Start date: March 2019
Phase: N/A
Study type: Interventional

100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes

NCT ID: NCT03891394 Not yet recruiting - Preeclampsia Clinical Trials

Human Epididymis Protein 4 in Women With Severe Preeclampsia / HELLP Syndrome

Start date: April 1, 2019
Phase:
Study type: Observational

Pre-eclampsia seems to be associated with a four to five times increase risk of later microalbuminuria and CKD which might suggest a possible direct renal damage from pre-eclampsia

NCT ID: NCT03888170 Not yet recruiting - Pregnancy Clinical Trials

The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity

Start date: April 2019
Phase:
Study type: Observational

The investigators seek to describe the composition, architecture, and electrical conduction properties of the human uterine myometrial artery and their impact on vascular reactivity upon exposure to hypertensive stress. Non-pregnant women and pregnant women with and without hypertensive complications will be studied to evaluate the influence of these states on the myometrial arteries. Vascular over-reactivity and disruption of the normal pregnancy-associated physiologic changes of relaxed vascular tone possess the potential for non-compensated blood flow to the uterus and placenta that is insufficient to meet the metabolic demands of a growing placenta. With an understanding of these changes, the research team will be able to propose basic mechanistic changes of pathologic myogenic tone that may ultimately be investigated as potentially modifiable processes to reduce the development and/or severity of these pregnancy complications (gestational hypertension, preeclampsia, eclampsia, small for gestational age, intrauterine growth restriction and intrauterine fetal demise. ).

NCT ID: NCT03838965 Not yet recruiting - Preeclampsia Clinical Trials

The Effects of Labor Stages and Interventions on Hemodynamic Measures During and After Childbirth ( Epidural, Rupture Membranses Cesarean Sections and Preeclampsia) With Noninvasive Sensors.

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

The Effects of Labor Stages and Interventions on Hemodynamic Measures During and After Childbirth ( Epidural, Rupture Membranses Cesarean Sections and Preeclampsia) With Noninvasive Sensors.

NCT ID: NCT03824119 Recruiting - Preeclampsia Clinical Trials

Postpartum NSAIDS and Maternal Hypertension

Start date: December 11, 2018
Phase: Phase 4
Study type: Interventional

Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the postpartum period. NSAIDs remain part of standard postpartum care in women with hypertensive disease. The objective of this study is to determine whether postpartum standard care withholding NSAID use is associated with a clinically significant reduction in postpartum hypertension in women with pregnancy induced hypertension. The investigators hypothesize that women with pregnancy induced hypertensive disease will be half as likely to have blood pressure elevation of 150/100 mmHg in the first 24 hours postpartum. This study is an open label randomized trial of women with antepartum hypertension. Women will be randomized to receive standard postpartum care or standard postpartum care without NSAIDs. Blood pressure measurements and patient outcomes will be recorded. The study period will begin at the time of delivery and will end at the time of hospital discharge.

NCT ID: NCT03801447 Recruiting - Preeclampsia Clinical Trials

Biomarkers and Preeclampsia Outcomes

REPORTS
Start date: April 1, 2018
Phase:
Study type: Observational

Prospective, observational, monocentric, non-interventional study.

NCT ID: NCT03749746 Recruiting - Obesity Clinical Trials

Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia

HH4NM
Start date: January 26, 2019
Phase: N/A
Study type: Interventional

Preeclampsia causes devastating maternal and neonatal morbidity and mortality with a high recurrence risk and a rapid, occult progression to cardiovascular disease after delivery. There is a critical need for effective interventions to reduce these risks. This is a pilot randomized controlled trial of a novel postpartum lifestyle intervention compared to women who take home blood pressure measurements and women with usual care who are overweight and obese in the first year after preeclampsia. The investigators hypothesize that the intervention will lead to improved weight loss and blood pressure in the first year postpartum, which has broad implications for future pregnancy and long-term cardiovascular health.

NCT ID: NCT03735433 Recruiting - Preeclampsia Clinical Trials

The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia

Start date: January 15, 2019
Phase: Phase 4
Study type: Interventional

Low dose aspirin (LDA) is used for preeclampsia (PE) prevention in high risk women, but the precise mechanism and optimal dose is not known. Evidence in the non-obstetric literature suggests AR may be more common among patients with a high body mass index (BMI). Recent unpublished data showed that LDA substantially lowers TxB2 levels regardless of BMI, but rates of complete platelet inhibition are lower in women with BMI ≥40. This data suggests that higher doses of ASA may be necessary in obese women. Therefore we plan determine if use of 162mg compared to the traditional 81mg ASA decreased rates of preeclampsia in women considered high risk for developing preclampsia.

NCT ID: NCT03726177 Recruiting - Preeclampsia Clinical Trials

Aspirin for Prevention of Preeclampsia

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Prophylaxis with low-dose aspirin has been recommended to prevent preeclampsia, the rationale being that hypertension and abnormalities of coagulation in this disease are caused in part by an imbalance between vasodilating and vasoconstricting prostaglandins. Low-dose aspirin therapy inhibits thromboxane production more than prostacyclin production and therefore should protect against vasoconstriction and pathologic blood coagulation in the placenta. Initially, several single-center trials, mostly among women at increased risk for preeclampsia, demonstrated a substantial reduction in the risk of proteinuric hypertension as well as reductions in the incidences of preterm birth, infants small for gestational age, and perinatal death,