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Prostate Cancer clinical trials

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NCT ID: NCT04946214 Recruiting - Prostate Cancer Clinical Trials

A Behavioral Health Intervention Using Digital Technology in Radiation Therapy for Prostate Cancer Patients

HIDRATEPRO
Start date: May 26, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to determine how to incorporate a smart water bottle to improve bladder filling for prostate cancer patients undergoing radiation therapy.

NCT ID: NCT04936334 Recruiting - Prostate Cancer Clinical Trials

The Role of 68Ga-PSMA-11 PET in Surgery Guidance in Prostate Cancer

Start date: June 15, 2021
Phase: Phase 2
Study type: Interventional

Obtain PSMA-PET imaging preoperatively and calculate performance for predicting extra-prostatic extension based on whole-mount pathology (gold standard). Quantify the frequency of proper treatment changes directed by PSMA-PET, focusing on appropriate preservation of surrounding structures important for genito-urinary function including: 1) Bladder neck, 2) Nerve bundles, 3) Urethral Sphincter (Figure 4). Directly compare PSMA-PET performance for predicting extra-prostatic extension to standard-of-care assessments. Assess quality of life changes from preoperative baseline.

NCT ID: NCT04892914 Recruiting - Prostate Cancer Clinical Trials

Embr Thermal Device for Hot Flash Management in Prostate Cancer

Start date: May 28, 2021
Phase: N/A
Study type: Interventional

This study is being conducted to evaluate if the Embr thermal device is useful for men who experience hot flashes as a result of prostate cancer treatment.

NCT ID: NCT04891536 Recruiting - Prostate Cancer Clinical Trials

Salvage Cryotherapy for Recurrent Prostate Cancer After Radiation Therapy

CRIOAND2021
Start date: May 1, 2021
Phase: N/A
Study type: Interventional

The main objective of this project is to establish a shared comprehensive and systematic protocol for a multicenter prospective registry of patients undergoing salvage cryoablation of the prostate (SCAP). Our study hypothesis is that SCAP constitutes an effective and safe approach to treat local prostate cancer recurrence after brachytherapy or external beam radiation therapy (EBRT).

NCT ID: NCT04889742 Recruiting - Prostate Cancer Clinical Trials

Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors

HETERERO
Start date: May 10, 2021
Phase: Phase 2
Study type: Interventional

This study investiagates deep-regional or superficial hyperthermia to enhance radiotherapy or chemoradiation in patients that suffer recurrent disease after previous radiotherapy.

NCT ID: NCT04882618 Recruiting - Prostate Cancer Clinical Trials

Use of Indocyanine Green During Pelvic Lymph Node Dissection in Prostate Cancer.

Start date: November 8, 2019
Phase: Phase 4
Study type: Interventional

Standard treatment of local or locally advanced prostate cancer is radical prostatectomy (RRP) surgery. During RRP in certain patients extended lymph node dissection (ELND) is recommended. to detect eligible patients for ELND some nomograms based on clinical factors of them is used. The Briganti nomogram is one of them. If the patient has 7% or more probability on Briganti nomogram, then ELND is recommended. But ELND is complicated surgical procedure and may cause labor lost and cost. It is aimed here to show whether the ICG based fluorescence imaging during laparoscopy may yield higher accuracy to detect metastatic LNs than the conventional ELND?

NCT ID: NCT04879563 Recruiting - Breast Cancer Clinical Trials

Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE Project

ASCAPE
Start date: February 1, 2021
Phase: Phase 2
Study type: Interventional

ASCAPE (Artificial intelligence Supporting CAncer Patients across Europe) is a collaborative research project involving 15 partners from 7 countries, including academic medical centers, SMEs (small and medium-sized enterprises), research centers and universities, aiming to leverage the recent advances in Big Data and AI (Artificial Intelligence) to support cancer patients' Quality of Life (QoL) and health status. Specifically, ASCAPE aims to provide personalized- and AI-based predictions for QoL issues in breast- and prostate cancer patients as well as suggest potential interventions to their physicians. This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 875351.

NCT ID: NCT04873427 Recruiting - Prostate Cancer Clinical Trials

In Situ Clonal Heterogeneity in Prostatic Diagnostic Biopsies

Start date: April 15, 2021
Phase:
Study type: Observational

This is a retrospective, proof of concept study, which aims at reconstructing the cellular heterogeneity of the tumor in multi-needle diagnostic prostate biopsy as well as any biopsy containing potentially pre-malignant tissue, to study its implications in the clinical history of the disease. For each patient, 2 or more samples will be prepared starting from the FFPE diagnostic material. The biopsy used for assigning the Gleason score will be sequenced, together with two or more of the local peri-proximal biopsies with a higher level of differentiation. Samples will undergo Whole Exome Sequencing with an average coverage of 300x at the Wellcome Sanger Institute (WSI, Hinxton, UK). Sequencing data will be analysed for single nucleotide variants, copy number variants and structural variants by using state-of-the-art data analysis pipeline at WSI. 1. Reconstruction of local PCa heterogeneity in multi-needle diagnostic biopsy with different Gleason scores (6-10) using high-coverage whole exome sequencing (WES) and DP-based clonal analysis; 2. Characterization of the relationships between pathological differentiation (Gleason score) and genomics-measured heterogeneity and malignancy features; 3. Assessment of clinical implications of clonal heterogeneity. The study will include an average of 150 prostatic diagnostic biopsies from a cohort of 20 early metastatic PC patients and 20 non-relapsing/non-metastatic patients with indolent malignant disease.

NCT ID: NCT04869462 Recruiting - Prostate Cancer Clinical Trials

DS Titanium Ligation Clip in Urology (Prostatectomy and Nephrectomy)

DOSTILCU
Start date: May 27, 2021
Phase:
Study type: Observational

Prospective, monocentric, single arm, observational PMCF - Study on the Performance and Safety of Double-Shank Titanium Ligation Clip in Urology (Prostatectomy and Nephrectomy)

NCT ID: NCT04867603 Recruiting - Prostate Cancer Clinical Trials

Digital PET/CT Using [Ga-68]PSMA for Characterization of Prostate Lesions

Start date: August 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate a radioactive diagnostic study drug, which is called Gallium-68 Prostate Specific Membrane Antigen ([Ga-68]PSMA) for characterization of prostate abnormalities.