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Breast Cancer clinical trials

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NCT ID: NCT04872738 Not yet recruiting - Covid19 Clinical Trials

Patient Experiences With the COVID-19 Vaccination After Breast Cancer Treatment

Start date: May 1, 2021
Phase:
Study type: Observational

This study aims to elicit patient experiences, choices, and side effects associated with the COVID-19 vaccine after breast cancer surgery. Lymph node swelling is a known and common side effect of both the Moderna and Pfizer COVID-19 vaccines. This is the body's normal reaction to the vaccine. It is worrisome that lymph node swelling after the vaccine mimics that found in breast cancer which has spread to the lymph nodes. This side effect will cause worry and anxiety amongst patients as a result. For patients who have had lymph node removal (axillary lymph node dissection or sentinel lymph node biopsy) and are at risk of lymphedema, we are concerned that the lymph node swelling may tax the lymphatic system and incite lymphedema in those at risk or worsen it in those with BCRL. Fear of lymphedema is high in this population and we need to better understand what risk, if any, lymph node swelling after the COVID-19 vaccine imparts to BCRL risk.

NCT ID: NCT04871854 Recruiting - Breast Cancer Clinical Trials

Evaluating Tocilizumab for Sever COVID-19 Infection in Breast Cancer vs. Non Cancer Pateints

Start date: April 26, 2021
Phase: Phase 2
Study type: Interventional

To compare evaluating Clinical outcomes for patients treated with Tocilizumab for sever COVID-19 infection in breast cancer patients versus non cancer patients

NCT ID: NCT04871139 Recruiting - Breast Carcinoma Clinical Trials

An Imaging Technology, Contrast-Enhanced Mammography, in Predicting Breast Cancer

Start date: April 8, 2021
Phase: N/A
Study type: Interventional

This clinical trial examines a new imaging technology, contrast-enhanced mammography, in predicting breast cancer. Contrast-enhanced mammography is similar to standard mammography, but it includes an intravenous (by vein) injection of iodine-based contrast, which makes tissue and blood vessels more visible in scans. Contrast-enhanced mammography may work better in detecting cancer in the breast that is not seen on other imaging tests and may help doctors find the most suspicious areas of the breast to biopsy, which could increase the chances of finding breast cancer.

NCT ID: NCT04868812 Active, not recruiting - Clinical trials for Breast Cancer Female

Histological Modifications of Postmenopausal Vaginal Mucosa After Repeated Carbon Dioxide (CO2) Laser Treatment

REPLAMOD
Start date: December 3, 2019
Phase: N/A
Study type: Interventional

To assess the long-term histological and clinical efficacy of MonaLisa Touch procedure for the management of the Genitourinary Syndrome of Menopause (GSM) in postmenopausal female patients.

NCT ID: NCT04867096 Recruiting - Breast Cancer Clinical Trials

Supervised Exercise, Sleep in Patients With Non Metastatic Breast Cancer

FATSOMCAN
Start date: May 2021
Phase: N/A
Study type: Interventional

Insomnia affects about 60% of the patients treated with radio-chemotherapy, a percentage twice higher compared to that observed in the general population. This sleep disorder increases cancer-related fatigue (CRF), the side effect most often reported by patients. Conversely, it is well accepted that adapted physical activity (APA) improves tolerance to treatment, decreases the risk of recurrence, increases survival, and reduces CRF. The present study aims to evaluate, in non-metastatic breast cancer patients, the composition and architecture of sleep by ambulatory polysomnography and to verify the effects of an APA rehabilitation program (3 times a week during 12 weeks), on the quality and quantity of sleep, daytime sleepiness. The biological markers: melatonin and body temperature will be studied to better understand the chronobiological mechanisms of the sleep-wake rhythm. Finally, the physiological responses to exercise, pain, CRF and finally quality of life will be studied at the beginning, at the end of the program and at a distance from it. Improved sleep-wake rhythm by a physical activity may reduce CRF, prevent recurrence and comorbidities.

NCT ID: NCT04865549 Completed - Breast Cancer Clinical Trials

Sentinel Node After Neoadjuvancy In Node-Positive Breast Cancer

SANA
Start date: June 1, 2016
Phase: N/A
Study type: Interventional

The status of the axillary lymph nodes is one of the main prognostic factors in breast cancer (BC). SLNB is currently the standard staging method for patients with clinically node-negative (cN0) breast cancer. In patients with a positive SLN and in those with affected lymph nodes at the beginning (cN+), LND is the standard of treatment.

NCT ID: NCT04864405 Not yet recruiting - Breast Cancer Clinical Trials

Evaluating the Dose Timing (Morning vs Evening) of Endocrine Therapy and Its Effects on Tolerability and Compliance

Start date: June 2021
Phase: Phase 4
Study type: Interventional

Endocrine therapy is an established treatment for hormone receptor-positive breast cancer, but can cause significant side effects with deterioration in quality of life. The side effects of all forms of endocrine therapy are well recognized and can lead to treatment non-persistence or non-compliance. Chronotherapy, also called chronotherapeutics, is defined as the administration of a medication in coordination with circadian rhythm in order to minimize side effects and yield a greater efficacy. The investigators propose to perform a pragmatic, multi-centre, open-label, randomized clinical trial to establish the optimal timing (morning vs. evening) of administering endocrine therapy based on side effects and benefits in early stage breast cancer patients.

NCT ID: NCT04863443 Recruiting - Breast Cancer Clinical Trials

Nonlinear Elasticity Mapping of Breast Masses

Start date: July 24, 2014
Phase:
Study type: Observational

This proposed technique, called "Nonlinear Elasticity Mapping (NEM)", is an innovative approach to estimate (i.e., linear and nonlinear) elasticity to provide complementary and relevant information for identification and characterization of breast masses. The proposed technique includes imaging the (nonlinear) elasticity parameter in a quantitative manner and measuring two new and relevant parameters. These parameters, together with linear elasticity, are used to differentiate breast masses. The first parameter is the nonlinearity of the elasticity.

NCT ID: NCT04862585 Not yet recruiting - Breast Carcinoma Clinical Trials

Safely Stopping Pre-medications in Patients With Breast Cancer Who Are Receiving Paclitaxel

Start date: June 1, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

This phase II/III trial investigates the difference in rates of infusion hypersensitivity reaction in patients with breast cancer who are receiving paclitaxel alone or in combination with other cancer drugs which require parenteral rescue medication after stopping standard pre-medications (dexamethasone, diphenhydramine, famotidine/cimetidine/ranitidine), compared to continuing premedications. Paclitaxel is a drug used to treat breast cancer, ovarian cancer, and autoimmune deficiency syndrome (AIDS)-related Kaposi sarcoma. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic agent. However, there are side-effects and toxicities associated with repeat exposure to this pre-medication regimen. With prolonged use of paclitaxel, especially during weekly regimens, patients are exposed to repeat doses of drugs that prevent hypersensitivity reactions. Side effects include, but are not limited to, insomnia, gastritis, fluid retention, weight gain, mood changes and immune suppression. The information gained from this study may positively influence clinical practice and help researchers develop methods to safely stop pre-medications.

NCT ID: NCT04862429 Not yet recruiting - Breast Cancer Clinical Trials

Biopsy of Calcifications Under Contrast Enhancement Guide (BoCCE)

BoCCE
Start date: July 2021
Phase: N/A
Study type: Interventional

Calcification clusters are 30-40% of recalls in mammographic screening, but have a low positive predictive value (~15%) for ductal cancer in situ (DCIS) or invasive cancer. These calcifications often need histological assessment with stereotaxic guided biopsy (Mammotome). With extended calcifications, choosing the best area to biopsy may be challenging. The main objective of this 1:1 randomized controlled clinical trial is to compare the accuracy of the CESM guide (study arm with biopsy under CESM guidance) with the traditional Mammotome (control arm with biopsy under stereotactic guidance) in conducting the biopsy in the area of greatest malignancy/grade of the lesion, using as gold-standard the histological exam of the operating piece. Women recalled with indication to perform stereotactic biopsy for clusters of suspicious calcifications on mammography (BIRADS R3 or R4 or R5) not mass-associated will be included. Anticipated sample size is 100 women per arm.