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Breast Cancer clinical trials

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NCT ID: NCT05498311 Recruiting - Breast Cancer Clinical Trials

Breast Cancer With Intraoperative Radiotherapy Followed by Hypofractionated External Beam Radiotherapy

IORT_BREAST
Start date: October 20, 2016
Phase: Phase 2
Study type: Interventional

To evaluate cosmetic outcomes after conservative surgery for breast cancer with INTRABEAM followed by hypofractionated external beam radiotherapy

NCT ID: NCT05498155 Not yet recruiting - Breast Cancer Clinical Trials

Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer

OlympiaN
Start date: September 9, 2022
Phase: Phase 2
Study type: Interventional

This study to learn more about olaparib and olaparib plus durvalumab combination therapy and also to better understand the studied disease, breast cancer, and associated health problems. Olaparib is a type of drug called a PARP (poly [adenosine diphosphate-ribose] polymerase) inhibitor. PARP inhibitors can destroy cancer cells that are not good at repairing DNA damage. Olaparib is also approved by US Food and Drug Administration (FDA), European Medicines Agency (EMA) and in other countries for treating women with BRCA-mutated, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. Durvalumab is a type of anticancer drug called immunotherapy that targets cancer cells by blocking the signal that prevents the immune system from seeing the cancer cell. Your immune system can then attack and kill the cancer cells. Durvalumab is approved by the FDA and the EMA for the treatment of patients with locally advanced non-small cell lung cancer after receiving chemoradiation therapy and extensive-stage small cell lung cancer in combination with chemotherapy. Some parts of this study are experimental, which means that durvalumab and the combination of olaparib and durvalumab are still in the development stage for the treatment of breast cancer, and they are not approved for treatment of breast cancer, except for use in research studies like this.

NCT ID: NCT05496829 Recruiting - Breast Cancer Clinical Trials

IMPACT Trial: Intervention to iMProve AdherenCe Equitably

Start date: August 31, 2021
Phase: N/A
Study type: Interventional

To determine the efficacy of a multicomponent adherence intervention among participants with early-stage breast cancer on endocrine therapy and at least one oral cardiovascular disease (CVD) medication on adherence to endocrine therapy and to CVD medication at 24 weeks assessed by self-report using the Domains of Subjective Extent (DOSE)-Nonadherence questionnaire and also by pharmacy fill data assessed in the electronic health record (EHR).

NCT ID: NCT05496101 Not yet recruiting - Clinical trials for Breast Cancer Female

CLI and FAR for Intraoperative Margin Assessment

CLI-FAR
Start date: October 30, 2022
Phase: Phase 2
Study type: Interventional

This study is a prospective, single arm interventional study to evaluate the diagnostic accuracy of intraoperative Cerenkov luminescence imaging (CLI) plus flexible autoradiography (FAR) using the LightPath® Imaging System for intraoperative tumour margin assessment compared to post-operative standard-of-care histopathology in women undergoing breast-conserving surgery for breast cancer.

NCT ID: NCT05491694 Not yet recruiting - Breast Cancer Clinical Trials

To Evaluate the Efficacy of Toripalimab Combined With Chemotherapy After HIFU Induction in the Treatment of Early Triple-negative Breast Cancer

HIFU
Start date: September 1, 2022
Phase: Phase 2
Study type: Interventional

To investigate the efficacy and safety of terbinumab combined with chemotherapy (epirubicin + cyclophosphamide → nab-paclitaxel + carboplatin) in neoadjuvant therapy of triple-negative breast cancer after HIFU.

NCT ID: NCT05491395 Recruiting - Breast Cancer Clinical Trials

Hypofractionated Radiotherapy in Breast Cancer Patients With Prosthetic Reconstruction

PROMART
Start date: June 27, 2022
Phase: N/A
Study type: Interventional

RATIONALE: Radiotherapy (RT) can be indicated to patients submitted to breast-conserving surgery, but, despite the benefits, adjuvant RT can cause contracture generated by tissue fibrosis in patients with immediate prosthetic reconstruction, which could cause prosthesis loss. The biological explanation of this outcome is not fully understood, but recent advances in the analysis of patient-derived blood can contribute to establishing a connection of molecular alterations related to this clinical outcome. There is not a consensus about using hypofractionated RT schemes for patients with BCS and breast reconstruction since no studies had investigated the reasons why some patients lose the prosthesis. PURPOSE: This study will evaluate G3 toxicity rate in breast cancer patients with immediate prosthetic reconstruction, submitted to hypofractionated radiotherapy, analyzing capsular contracture, leakage, infection, and bad positioning in order to demonstrate the noninferiority of Hypo-RT with the conventional RT. Additionally, the molecular profile of blood samples will be investigated in order to find biomarkers related to inflammations processes and response to treatment.

NCT ID: NCT05491226 Not yet recruiting - Breast Cancer Clinical Trials

Reinvigorating TNBC Response to Immunotherapy With Combination Myeloid Inhibition and Radiation

Start date: October 1, 2022
Phase: Phase 2
Study type: Interventional

This is an open-label prospective, single institution, Phase II study of pembrolizumab in combination with radiation therapy and CSF-1R inhibition in patients with high-risk TNBC. The primary objective is to assess the pathologic complete response (pCR) rate where pCR is defined as the absence of invasive disease in the breast and lymph nodes at the time of standard of care (SOC) treatment. Secondary objectives include evaluating the change in tumor infiltrating lymphocytes (TILs), safety and tolerability of the combination, progression-free survival, event-free survival, overall survival, and node clearance.

NCT ID: NCT05491057 Not yet recruiting - Breast Cancer Clinical Trials

Treatment Patterns of Neratinib in HER2+ EBC in China

Start date: September 30, 2022
Phase:
Study type: Observational

This is a multicenter, open-label, single-arm, non-interventional study to investigate the treatment patterns of Neratinib in HER2-positive early-stage breast cancer in China

NCT ID: NCT05490433 Not yet recruiting - Breast Cancer Clinical Trials

Robot-assisted vs. Open Nipple-sparing Mastectomy With Immediate Breast Reconstruction

ROM
Start date: October 2022
Phase: N/A
Study type: Interventional

The purpose of the study: It provides the highest level of evidence ever studied on the use of robotic surgical systems during breast surgery for breast cancer treatment, and aims to reveal the clinical significance of successive breast reconstruction(immediate breast reconstruction, IBR) at the same time as robotic assisted papillary preservation mastectomyRobot-assisted nipple-sparing mastectomy, RNSM)

NCT ID: NCT05489679 Not yet recruiting - Breast Cancer Clinical Trials

A Study of AC682 In Chinese Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer

Start date: September 1, 2022
Phase: Phase 1
Study type: Interventional

This clinical trial is evaluating AC682 in participants with estrogen receptor positive/human epidermal growth factor 2 negative (ER+/HER2-) locally advanced or metastatic breast cancer. The main goals of this study are to: 1. To evaluate the safety and tolerability of AC682 2. To evaluate the pharmacokinetic of AC682 3. To evaluate the preliminary anti-tumor activity of AC682