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Prostate Cancer clinical trials

View clinical trials related to Prostate Cancer.

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NCT ID: NCT04541030 Active, not recruiting - Prostate Cancer Clinical Trials

Integrated Genomic Prostate Score With MRI Targeted Prostate Biopsies

Start date: September 2, 2020
Phase:
Study type: Observational

Background: Prostate cancer is one of the most common cancers in men. For some men, their cancer is monitored. Others have surgery to remove the prostate. Focal therapy is another treatment option. It treats the areas of cancer selectively, which leaves the rest of the prostate intact. This can help lessen side effects. Men who get focal therapy must be chosen carefully. The Oncotype DX Genomic Prostate Score (GPS) assay tests biopsy samples for certain cancer-related genes. It then then gives a score from 1 to 100 to predict the likelihood of poor outcomes. The GPS is used to choose men for focal therapy. Researchers want to test the GPS further. Objective: To assess how GPS may be useful when used with MRI to improve how men are chosen for focal therapy of prostate cancer. Eligibility: Men age 18 and older who had NCCN low or intermediate risk prostate cancer and had MRI and radical prostatectomy at the Urologic Oncology Branch, National Cancer Institute and collaborating centers. Design: This is a multisite study. It will review data and samples that were collected in the past. Samples and images from up to 277 participants will be used. Tumor tissue will be tested with the GPS. Data such as age at diagnosis, race, biopsy results, and pathology results will be merged with the GPS results. Data will be entered into an in-house electronic system. It will be password protected. All data will be kept in secure sites that comply with NIH security standards....

NCT ID: NCT04500080 Active, not recruiting - Prostate Cancer Clinical Trials

Feasibility and Safety of Physical Exercise in Men With Prostate Cancer

PCa_Ex
Start date: November 1, 2020
Phase: N/A
Study type: Interventional

Prostate cancer (PCa) is among the most widespread in the male population and represents 19% of all cancers diagnosed from the age of fifty, in Italy. Androgen deprivation therapy (ADT) and Radiotherapy (RT) are used for increase survival. However, both therapies are associated with significant side effects, such as fatigue, loss of muscle mass and strength, cognitive decline that together lead to an increase risk of accidental falls and fractures. Guidelines for cancer survivors recommend Physical Exercise (PE) as a strategy to reduce several side effects of therapies. However, most people living with cancer do not meet current exercise recommendations. Indeed, an effective PE program requires the application of long-term, moderate to high intensity activity. Thus it may be difficult to implement this type of recommendation in patient with PCa. Therefore, this study aims to develop an experimental PE intervention testing their feasibility and safety and the patients' satisfaction, aimed at improving the health conditions of the patients with PCa receiving ADT and RT. Furthermore, long-term falls and fracture events will be monitored.

NCT ID: NCT04489745 Active, not recruiting - Prostate Cancer Clinical Trials

Stereotactic Body Radiotherapy (SBRT) for Localized Prostate Cancer

Start date: December 2016
Phase: Phase 2
Study type: Interventional

This is a trial of 5 fraction SBRT combined with androgen deprivation therapy for patients with localized high-risk or unfavorable intermediate risk prostate cancer

NCT ID: NCT04428203 Active, not recruiting - Prostate Cancer Clinical Trials

Epidiolex (CBD) in Patients With Biochemically Recurrent Prostate Cancer

Start date: August 3, 2020
Phase: Phase 1
Study type: Interventional

The purpose of this phase I/Ib study is to determine the safety profile of Epidiolex (CBD oil) in biochemically recurrent prostate cancer patients. The study consists of a dose escalation part and dose expansion part. The dose expansion part of the study will use the maximum tolerated dose (MTD) determined in the dose escalation part to assess the activity, safety and tolerability of the investigational product in patients with biochemically recurrent prostate cancer after localized therapy with either surgery or radiation.

NCT ID: NCT04374240 Active, not recruiting - Prostate Cancer Clinical Trials

A Clinical Trial of AdNRGM Plus CB1954 in Prostate Cancer

AdUP
Start date: March 19, 2013
Phase: Phase 1
Study type: Interventional

This is an open label, non-randomised, phase I, sequential group trial which will explore the safety and tolerability of ascending doses of AdNRGM, in combination with CB1954. Five groups of 3 patients each will be treated with escalating doses of AdNRGM (10^10, 3x10^10, 10^11, 3x10^11, 10^12 vp) followed 2 days later by intravenous CB1954 at a fixed dose (24mg/m^2). To ensure the coverage of the whole prostate the vector will be delivered by multiple, template-guided trans-perineal injections using an adaptation of standard prostate brachytherapy technique. Dose escalation will be dependent on safety and tolerability; at each dose-level, if dose-limiting toxicity (DLT) is seen in one patient, the cohort will be expanded to a maximum of 6 patients. If DLT is then observed in a second patient at that dose, no further patients will be recruited and the previous (lower) dose-level will be defined as the maximum tolerated dose (MTD). If DLT is seen in 0/3 or just 1/6 patients, dose escalation may continue.

NCT ID: NCT04307056 Active, not recruiting - Prostate Cancer Clinical Trials

Evaluation of HIFU in TREATMENT OF LOCALIZED PROSTATE CANCER and OF RECURRENCE AFTER RADIOTHERAPY

HIFI
Start date: April 1, 2015
Phase: N/A
Study type: Interventional

to compare the efficacy of HIFU treatment with standard treatment in two situations: 1. as first-line cancer treatment, HIFU is compared to radical prostatectomy. 2. for patients with recurrence after external beam radiotherapy, HIFU treatment is compared to radical prostatectomy.

NCT ID: NCT04305925 Active, not recruiting - Prostate Cancer Clinical Trials

Focal Laser Ablation of Prostate Cancer

Start date: March 16, 2020
Phase: N/A
Study type: Interventional

The primary objective of this study is to evaluate the safety and feasibility of Magnetic-Resonance(MR)-ultrasound image fusion-guided transrectal-based focal laser ablation (FLA) of prostate cancer using the Orion System, an investigational laser-based interstitial irradiation/thermal soft-tissue ablation system. Safety and feasibility will be determined by analyzing the number, type, and severity of adverse events.

NCT ID: NCT04299997 Active, not recruiting - Prostate Cancer Clinical Trials

Evaluation of the PI-RADS v2.1 Score Using Multiple Readers

MULTI
Start date: September 1, 2019
Phase:
Study type: Observational

The interpretation of prostate multiparametric MRI (mpMRI) is difficult and requires expertise. As a result, it suffers from substantial inter-reader variability. The so-called Prostate Imaging Reporting and Data System (PI-RADS) scoring system has been launched in 2012 to try and standardise prostate mpMRI interpretation. It is a 5-level score that assesses the likelihood that suspicious focal prostatic lesions seen on mpMRI are clinically significant prostate cancers. Despite the use of semi-objective criteria for each category of the score, the inter-reader reproducibility of the first two versions (PI-RADS v1 launched in 2012 and PI-RADS v2 launched in 2015) was moderate at best, even for experienced readers. The last version (PI-RADS v2.1) has been launched in March 2019 in an effort to improve the inter-reader reproducibility. This version has not been evaluated yet. The purpose of our study is to evaluate the accuracy and inter-reader reproducibility of the PI-RADS v2.1 score on a large set of 163 prostate MRIs using 20 readers of varying experience. Twenty readers (14 seniors and 6 juniors) from 7 different institutions and with varying experience in prostate mpMRI accepted to participate to the study. Reader will assess the dataset independently and will be blinded to the other readers' results. They also be blinded to clinical and biochemical data.

NCT ID: NCT04292041 Active, not recruiting - Prostate Cancer Clinical Trials

Fasting Mimicking Diet in Prostate Cancer and Metabolic Syndrome

Start date: January 15, 2019
Phase:
Study type: Observational [Patient Registry]

This is a prospective observational cohort study of patients with prostate cancer who have a metabolic syndrome. The study aims to evaluate the role of intermittent fasting (fasting mimicking diet) in these patients. The primary end point is metabolic health and the secondary endpoint is quality of life.

NCT ID: NCT04290611 Active, not recruiting - Prostate Cancer Clinical Trials

a Vigibase Pharmacovigilance Study of ENzalutamide Drug-induced neurotoxicitY

VENDY
Start date: January 1, 2019
Phase:
Study type: Observational

Enzalutamide may lead to various adverse reactions. This study investigates reports of different neurological toxicities in the World Health Organization's (WHO) global database of individual safety case reports (VigiBase).