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Prostate Cancer clinical trials

View clinical trials related to Prostate Cancer.

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NCT ID: NCT05615909 Completed - Prostate Cancer Clinical Trials

PRO-MR-RT Systematic Patient-reported Outcomes to Pelvic Online MRgRT

Start date: November 19, 2020
Phase:
Study type: Observational

In 2018 the Unity MR-linac was approved for treating patients with online magnetic resonance (MR)-guided radiotherapy. With the MR-linac it is possible to get real-time MR images with high soft tissue contrast, adapt the radiotherapy plan and subsequently irradiate at each treatment fraction. Patients with prostate cancer is one of the patient groups referred for this new treatment and potentially they will benefit with decreased margins around the tumour and increased local tumor control rates. The acute toxicity is important when evaluating treatment tolerability. A prospective longitudinal observation of the acute treatment toxicity to online MR-guided radiotherapy is therefore essential in the evaluation of this new technology. Patient-reported outcomes (PRO) are disease symptoms and treatment toxicity reported directly by patients themselves without clinician interpretation. Several studies have indicated that clinicians tend to underreport the incidence and severity of patient symptoms, thus a systematic use of PROs in clinical trials can provide valuable evidence to the clinicians. As online MR-guided radiotherapy (MRgRT) is a new technology there is limited research worldwide on patient-reported symptoms and quality of life. The objective of this study is therefore to prospectively investigate the patient-reported acute toxicity and changes in quality of life during and after online MR-guided radiotherapy.

NCT ID: NCT05605171 Completed - Prostate Cancer Clinical Trials

Posterior Urethrovesical Anastomotic Reconstruction in Comparison to Conventional Urethrovesical Anastomosis

Start date: March 19, 2014
Phase: N/A
Study type: Interventional

Urinary incontinence post radical prostatectomy is a well-recognized complication regardless of approach, with a potential negative impact on health-related quality of life. Although 12-month continence rates range from 85-95% in the literature, few patients are continent in the early postoperative period. It has been suggested that posterior reconstruction of the Denonvilliers' musculofascial plate, also known as the Rocco stitch, may improve early return to urinary continence, though clinical equipoise remains.

NCT ID: NCT05589558 Completed - Prostate Cancer Clinical Trials

Prospective Comparison of the Four Biopsy Methods for Prostate Cancer Detection

Start date: October 1, 2020
Phase: N/A
Study type: Interventional

The aim of this study is to compare clinically significant prostate cancer detection rate by the 4 biopsy methods: TRUS-guided, cognitive, fusion and transperineal template mapping biopsy. It is recommended to combine MRI-guided biopsy with systematic (TRUS-guided or transperineal template mapping biopsy) biopsy for high yield of prostate cancer diagnosis. Nevertheless, it remains unclear which biopsy combination is more precise for prostate cancer detection.

NCT ID: NCT05573789 Completed - Prostate Cancer Clinical Trials

Tumor Molecular Profiling in Patients With Prostate Cancer

Start date: January 1, 2018
Phase:
Study type: Observational

The aim of the study was to evaluate the prevalence, the prognostic and predictive value of gene alterations in unselected patients with prostate cancer. Patients with histologically confirmed prostate cancer, treated at Hellenic Cooperative Oncology Group (HeCOG)-affiliated departments, were included. The presence of gene alterations was assessed using the ForeSENTIA® Prostate panel developed by NIPD Genetic.

NCT ID: NCT05506735 Completed - Prostate Cancer Clinical Trials

The Role of the Seven Sweeps in the Prevention of the Prostate Cancer Among Those With a Positive Family History

PSA
Start date: May 1, 2022
Phase:
Study type: Observational

The seven sweeps is a recommended act performed by men after urinating in order to be confident that no urine is left in the urethra, and its not compulsory to perform. It is performed by the following way: after urinating, the anus is first purified if it has become impure; then, the middle finger of the left hand is slid three times from the anus up to the scrotum; then, the thumb is placed on the penis and the forefinger is placed under the penis, and the thumb and forefinger are pulled three times along the penis up to the point of circumcision; finally, the end of the penis is pressed three times.

NCT ID: NCT05447637 Completed - Prostate Cancer Clinical Trials

PROCLAIM: Germline Genetic Testing for Prostate Cancer Patients

Start date: November 1, 2019
Phase:
Study type: Observational [Patient Registry]

This registry is for men who have prostate cancer and have had multigene panel hereditary testing. The registry will gather data on genetic testing results and how that information may change physician treatment or follow up recommendations. It will also gather data on the patient's experience with genetic testing, through a post-test survey to be completed 60-90days after results have been received and discussed with their provider.

NCT ID: NCT05423431 Completed - Prostate Cancer Clinical Trials

Retrospective Evaluation of a Commercially Available Hydrogel Spacer (BP-009)

Start date: November 9, 2020
Phase:
Study type: Observational

Dosimetry efficacy of the hydrogel spacer.

NCT ID: NCT05399940 Completed - Prostate Cancer Clinical Trials

The Relationship Between Serum PSA Levels and WBC, Delta Neutrophil Index (DNI) and Other Hematological Parameters

Start date: January 1, 2018
Phase:
Study type: Observational [Patient Registry]

Purpose: To find the correlation between hemogram parameters and Delta Neutrophil Index(DNI) and Serum PSA in patients presenting with the diagnosis of acute prostatitis. Material-Metod: Serum PSA levels and hemogram parameters of patients who came to the urology outpatient clinic in January 2018 and May 2022 and were diagnosed with prostatitis were collected retrospectively.

NCT ID: NCT05381311 Completed - Prostate Cancer Clinical Trials

Survey Based Discrete Choice Experiment Study in Prostate Cancer (DECIDER) Study

Start date: September 3, 2021
Phase:
Study type: Observational

The purpose of this study is to quantify and publish participants' relative preferences for outcomes of chemotherapy and novel oral hormonal agents when added to androgen deprivation therapy (ADT) for participants with locally-advanced and metastatic hormone-sensitive prostate cancer (mHSPC). This study will also quantify the importance of administration factors related to convenience relative to treatment outcomes.

NCT ID: NCT05354427 Completed - Prostate Cancer Clinical Trials

Retrospective Evaluation of Commercial Spacers in Prostate Cancer Patients

CLP-10095
Start date: June 18, 2020
Phase:
Study type: Observational

Assessment of efficacy and safety of implantable spacers when used to reduce the radiation dose delivered to the organs at risk in prostate cancer patients undergoing radiotherapy.