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Prostate Cancer clinical trials

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NCT ID: NCT05558241 Not yet recruiting - Prostate Cancer Clinical Trials

Micro-UltraSound In Cancer - Active Surveillance

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

This study will compare the two imaging modalities (MRI and micro-ultrasound) during Active Surveillance of prostate cancer (PCa). Progression to clinically significant PCa will be assessed by first taking micro-US targeted samples (while blinded to MRI results), followed by MRI targeted samples, finishing with 12 systematic biopsy cores. The primary goal is to determine if microUS is non-inferior to MRI for the detection of ≥GG2 PCa at confirmatory biopsy. This study will also collect blood samples from participants to be used for future biomarker studies.

NCT ID: NCT05558007 Not yet recruiting - Prostate Cancer Clinical Trials

Safety and Efficacy Evaluation of BZ371A Topically Applied on Prostatectomized Patients

Start date: March 2023
Phase: Phase 2
Study type: Interventional

To determine efficacy, safety and tolerabiltiy of topically applied BZ371A in patients that experienced RP, in combination with daily tadalafil compared to placebo.

NCT ID: NCT05557604 Recruiting - Prostate Cancer Clinical Trials

Sbrt±sTad for Unfavorable iNtermediate rIsk/High Risk Prostate caNcer

Start date: February 2, 2021
Phase: Phase 2
Study type: Interventional

This is a prospective, open, randomized phase II trial.

NCT ID: NCT05555017 Not yet recruiting - Prostate Cancer Clinical Trials

Tracer-Guided Surgery for Recurrent Prostate Cancer

Start date: November 2022
Phase: Phase 2
Study type: Interventional

ADT with or without robot-assisted PSMA-radioguided surgery for patients with recurrent prostate cancer.

NCT ID: NCT05553327 Recruiting - Prostate Cancer Clinical Trials

Impact of a Multimodal Prehabilitation Program Before Robotic-assisted Radical Prostatectomy.

Start date: May 31, 2022
Phase: N/A
Study type: Interventional

The aim of the study is to verify whether a multimodal prehabilitation programme prior to robotic radical prostatectomy contributes to a faster recovery of quality of life after surgery, to better functional results (including erectile function and continence) and to less perioperative anxiety. Single center randomized clinical trial including prostate cancer patients undergoing robotic-assisted radical prostatectomy at the Hospital Clínic de Barcelona. Patients will be randomized into two groups, one receiving multimodal prehabilitation and the other a control group. Multimodal prehabilitation consists of improving the functional and mental capacity of an individual to cope with a significant stressor, in this case surgery. The design of our prehabilitation program, lasting 4 weeks prior to surgery, consists of three parts; physical state, nutritional state and mental health. In the case of physical condition, a series of supervised and "home-based" exercises (aerobic and functional) will be carried out in addition to specific pelvic floor exercises. The nutritional status will be evaluated by a nutritionist. Diet guidelines will be given and if there are deficiencies they will be supplemented. Regarding mental health, a visit will be made with a psychologist and group and online therapies will be offered. The outcomes will be evaluated before starting the prehabilitation program, at the end of it (just before surgery) and at 4, 8 and 16 weeks after surgery. The outcomes include variables on physical, nutritional and mental state, health-related quality of life (HRQoL), and continence and erectile function.

NCT ID: NCT05549024 Recruiting - Breast Cancer Clinical Trials

68Ga-RM26-RGD PET/CT Imaging in the GRPR and αvβ3 Positive Tumor Patients

Start date: August 16, 2022
Phase: Early Phase 1
Study type: Interventional

Based on the high expression of specific receptors on the surface of diseased tissues and neovascularization, noninvasive targeted molecular imaging can be used to visualize lesions in vitro by combining specific ligands labeled with short half-life isotopes. In this study, a novel dual-target imaging agent 68Ga-RM26-RGD was used for clinical study of tumor PET/CT imaging to further verify its clinical application value.

NCT ID: NCT05547061 Recruiting - Prostate Cancer Clinical Trials

A Phase 1/2 Clinical Trial to Evaluate the Safety, Tolerability, Dosimetry, and Anti-tumor Activity of Ga-68-NGUL / Lu-177-DGUL in Patients With Metastatic Castration-resistant Prostate Cancer (mCRPC) Refractory to Standard Therapy

Start date: April 12, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

This clinical trial is an open-label, single-arm, single-center, escalation (Phase 1 Part B only), rater-blind (Phase 2 only), phase 1/2 trial to evaluate the diagnostic validity/safety of Ga-68-NGUL and efficacy/safety of Lu-177-DGUL on the anti-tumor activity that aims to simultaneously evaluate diagnostic and therapeutic validity.

NCT ID: NCT05540782 Recruiting - Prostate Cancer Clinical Trials

A Study of Cognitive Health in Survivors of Prostate Cancer

Start date: September 8, 2022
Study type: Observational

The purpose of this study is to collect information that may help the researchers understand the relationship between prostate cancer survivors' experiences of cancer-related cognitive dysfunction (CRCD) and their other conditions (co-morbid factors), including anxiety, depression, and insomnia. The researchers will also find out how additional things may contribute to CRCD, including social factors, the characteristics of participants' prostate cancer, and the type of cancer treatment or other medications they received.

NCT ID: NCT05540392 Recruiting - Prostate Cancer Clinical Trials

An Acupuncture Study for Prostate Cancer Survivors With Urinary Issues

Start date: September 9, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to test whether acupuncture can improve nocturia in prostate cancer survivors. This is the first time acupuncture is being studied for nocturia in prostate cancer survivors. Researchers will see if acupuncture is a practical treatment option for prostate cancer survivors with nocturia. The study will also look at the effect acupuncture has on nocturia and other symptoms prostate cancer survivors experience such as insomnia, hot flashes, anxiety, depression, tiredness (fatigue), sexual dysfunction, and cognitive (mental) difficulties.

NCT ID: NCT05539677 Recruiting - Prostate Cancer Clinical Trials

Biobank and Register of Patients With Agresive Tumors for Translational and Analytical Research

Start date: September 1998
Study type: Observational [Patient Registry]

The investigators will collect biosamples of patient blood and tumour tissue for further immunological analysis of blood cell subpopulations, immunosupressive factors concentration, HLA expression an lymphocytes and tumour tissue, and and cancer testis antigenes expression on tumour cells, as well as clinical data on patient's stage, therapy, response and demographics. Possible prognostic and predictive dynamic biomarkers will be discovered for individualisation of treatment strategies