Hypertension Clinical Trial
Official title:
Multi-Ethnic Study of Atherosclerosis-Eye Study
To evaluate the relation of retinal microvascular characteristics to subclinical cardiovascular disease, clinical disease, and their risk factors in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
BACKGROUND:
The study further expands and enlarges the findings of the NHLBI-supported Atherosclerosis
Risk in Communities (ARIC) study on the relationship of retinal microvascular disease to the
presence of subclinical and clinical cardiovascular disease among Multi-Ethnic Study of
Atherosclerosis (MESA) participants. ARIC data showed that retinal microvascular changes
were associated with the following findings: markers of persistent hypertensive damage,
markers of inflammation and endothelial dysfunction, magnetic resonance imaging
(MRI)-detected cerebral infarct independent of hypertension, predictive of 3-year incident
stroke independent of hypertension, and predictive of 3-year incident coronary heart disease
in women but not men.
DESIGN NARRATIVE:
The MESA-EYE study is a separate add-on to the Multi-Ethnic Study of Atherosclerosis, a six
regional center 10 year program begun in July 2000. The overall goals of the parent study
are the identification of risk factors for subclinical cardiovascular disease, for
progression of subclinical disease, and for transition of subclinical to clinical
cardiovascular disease. The eye component will tie in with Exam 2 of the main study which
begins August 2002 and runs through January 2004. Retinal photography to document
microvascular changes will be performed on the approximately 6,500 MESA participants at Exam
2. Retinal photography will follow a standardized written protocol similar to that used in
ARIC. Focal arterial narrowing and AV nicking will be classified as definite, questionable,
or none. Data handling will be based on protocols previously used in several other NIH
sponsored clinical trials where eye retinal studies were performed.
The six specific aims of the study are to: (1) determine the relationship of retinal
microvascular characteristics to measures of subclinical CVD through (a) magnetic resonance
imaging of left ventricular function (b) brachial artery ultrasound for flow mediated
endothelial vasodilatation (c) radial artery tonometry measurement of peripheral artery
function (d) magnetic resonance imaging for myocardial perfusion; (2) determine relationship
of retinal microvascular characteristics to clinical CVD, specifically: (a) coronary heart
disease (b) congestive cardiac failure (c) stroke; (3) determine relationship of retinal
microvascular characteristics to CVD risk factors, specifically:(a) development of type 2
diabetes (b) development of hypertension (c) markers of: (I) inflammation (II) hemostasis
(III) fibrinolysis; (4) determine the relation of retinal microvascular changes to
structural and functional disorders of the brain; (5) describe the prevalence of retinal
microvascular abnormalities in different racial/ethnic groups; (6) describe the prevalence
and risk factors of (a) diabetic retinopathy (b) age-related maculopathy.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT04591808 -
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
|
Phase 3 | |
| Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
| Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
| Completed |
NCT05491642 -
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
|
Phase 1 | |
| Completed |
NCT03093532 -
A Hypertension Emergency Department Intervention Aimed at Decreasing Disparities
|
N/A | |
| Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
| Completed |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
| Recruiting |
NCT05976230 -
Special Drug Use Surveillance of Entresto Tablets (Hypertension)
|
||
| Recruiting |
NCT06363097 -
Urinary Uromodulin, Dietary Sodium Intake and Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
|
||
| Completed |
NCT06008015 -
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fed Conditions in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT05387174 -
Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
|
N/A | |
| Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
| Recruiting |
NCT05121337 -
Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension
|
N/A | |
| Withdrawn |
NCT04922424 -
Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men
|
Phase 1 | |
| Active, not recruiting |
NCT05062161 -
Sleep Duration and Blood Pressure During Sleep
|
N/A | |
| Completed |
NCT05087290 -
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR)
|
||
| Not yet recruiting |
NCT05038774 -
Educational Intervention for Hypertension Management
|
N/A | |
| Completed |
NCT05621694 -
Exploring Oxytocin Response to Meditative Movement
|
N/A | |
| Completed |
NCT05688917 -
Green Coffee Effect on Metabolic Syndrome
|
N/A | |
| Recruiting |
NCT05575453 -
OPTIMA-BP: Empowering PaTients in MAnaging Blood Pressure
|
N/A |