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NCT ID: NCT05705440 Recruiting - Clinical trials for Respiratory Syncytial Virus Infections

A Follow-up Study to Describe the Safety of Study Participants Who Received RSVPreF3 Maternal Vaccination (Any Dose) or Controls From Previous RSV MAT Studies During Any Pregnancy Conceived Post Vaccination/Control

Start date: February 7, 2023
Phase: Phase 3
Study type: Interventional

The purpose of this follow-up study is to describe the safety in subsequent pregnancies in participants who were previously administered the RSVPreF3 maternal vaccine or control during any prior RSV MAT study. The study participants enrolled in this follow-up study received RSVPreF3 maternal vaccination (any dose) or controls during the following prior RSV MAT studies: RSV MAT-001 (NCT03674177), RSV MAT-004 (NCT04126213), RSV MAT-010 (NCT05045144), RSV MAT-011 (NCT04138056), RSV MAT-009 (NCT04605159), RSV MAT-012 (NCT04980391) and RSV MAT-039 (NCT05169905). No intervention will be administered in this study. The exposure was the intervention (either RSVPreF3 vaccine or control) received by the study participants in the above-mentioned prior RSV MAT studies.

NCT ID: NCT05654467 Recruiting - Poliomyelitis Clinical Trials

Study of a Novel Type 3 Oral Poliomyelitis Vaccine in Panama

Start date: December 5, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this clinical trial is to assess the safety and tolerability (primary objective), immunogenicity (primary and secondary objectives), fecal shedding of vaccine viruses (secondary objective) and the potential for neurovirulence of shed virus (secondary objective) of a novel oral polio type 3 vaccine, nOPV3, as compared to Sabin monovalent type 3 vaccine controls (mOPV3), in healthy young children (192 subjects), infants (860 subjects), and neonates (480 subjects).

NCT ID: NCT05583344 Recruiting - Clinical trials for Nonalcoholic Fatty Liver Disease

Phase 2b Study of GSK4532990 in Adults With NASH

HORIZON
Start date: January 2, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to measure improvements in liver fibrosis and inflammation with GSK4532990 compared with placebo in participants with NASH and advanced fibrosis on biopsy (F3 or F4). The study duration will be up to 76 weeks including the screening period. The treatment duration will be up to 52 weeks.

NCT ID: NCT05567757 Recruiting - Clinical trials for End Stage Renal Disease

Initial Safety Study of the TRUE AVC in Hemodialysis Access (TRUE AVC I Study)

Start date: October 4, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

Prospective, nonrandomized, single-arm, single-center, open-label, initial safety study in subjects requiring hemodialysis. Subjects will be followed with physical evaluation and ultrasound vessel imaging at days 15, 29, 57 and weeks 12, 26. Extended follow up on patent conduits only at weeks 52 and 104.

NCT ID: NCT05447988 Recruiting - Breast Cancer Clinical Trials

Motiva Flora Tissue Expander PMCF

Start date: December 14, 2020
Phase: N/A
Study type: Interventional

The Motiva Flora® Tissue Expander clinical study (hereafter Motiva Flora® TE study) is a 6-month, open-label, prospective, multicentre post-marketing follow-up study designed to confirm the Safety and Effectiveness/Performance of Motiva Flora® TE in breast reconstruction surgery. The study will include 136 women, planned for staged breast reconstruction, in 6 countries (Spain, Belgium, France, Costa Rica, Chile and Panama). Breast tissue expansion and the final breast implant will be performed using devices from the Motiva Flora® TE catalogue.

NCT ID: NCT05404490 Recruiting - Pain, Postoperative Clinical Trials

Efficacy of Bupivacain Local Infiltration for the Management of Pain During Cesarean Section

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

This study aims to evaluate the effect of local administration of bupivacain in the cesarean section incision for postoperative pain control, using the visual analogue pain scale (VAS) and assessing the need for rescue analgesia after surgery.

NCT ID: NCT05363761 Recruiting - Hypertension Clinical Trials

Arterial Ablation for the Treatment of Type 2 Diabetes Mellitus and Its Comorbidities

NECTAR III
Start date: April 19, 2022
Phase: Phase 1
Study type: Interventional

This study is assess the safety and performance of the Neurotronic Infusion catheter for treatment of patients with Type 2 Diabetes (T2DM) and hypertension.

NCT ID: NCT05317728 Recruiting - Cataract Clinical Trials

Clinical Study of a Fluid Accommodating Intraocular Lens (IOL) Design

Start date: March 31, 2023
Phase: N/A
Study type: Interventional

The purpose of this clinical study is to evaluate the surgical, refractive, and visual outcomes with implantation of an investigational intraocular lens (IOL).

NCT ID: NCT05201794 Recruiting - Dengue Clinical Trials

A Study of JNJ-64281802 for the Prevention of Dengue Infection

Start date: February 22, 2023
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the prophylactic effect of JNJ-64281802 with respect to the prevention of laboratory-confirmed dengue virus (DENV) infection up to the last day of dosing among participants who have no evidence of current DENV infection at baseline.

NCT ID: NCT05067283 Recruiting - Clinical trials for Advanced Solid Tumors

A Study of MK-1084 in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

Start date: December 17, 2021
Phase: Phase 1
Study type: Interventional

This is a study evaluating the safety, pharmacokinetics, and efficacy of MK-1084 alone, and MK-1084 plus other combination therapies in participants with advanced solid tumors with identified kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation.