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Pain, Postoperative clinical trials

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NCT ID: NCT04929665 Recruiting - Pain, Postoperative Clinical Trials

Thoracic Paravertebral Block, Erector Spinae Block, and in Combined Paravertebral-erector Spinae Block

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

Video-assisted thoracic surgery (VATS) has become a common procedure in thoracic surgery. Severe postoperative pain may be encountered in patients undergoing VATS. Analgesic methods such as thoracic paravertebral block (TPVB), intercostal block and erector spina block (ESB) are widely used for VATS. Among these methods, ultrasound (US) guided TPVB is the most preferred method. Generally, comparisons are made between ESB and TPVB in studies and the analgesic effect is evaluated. However, no research could be found in the literature combining ESB and TPVB. The mechanisms of regional analgesia techniques used after thoracic surgery operations are also different from each other. Therefore, it may be possible to obtain a more effective analgesic effect in patients by combining the mechanism of action of TPVB and ESB, as in the multimodal analgesia method. This study seeks to evaluate the effect of TPVB, ESB and combined TPVB-ESB pain after VATS.

NCT ID: NCT04928521 Recruiting - Postoperative Pain Clinical Trials

Erector Spinae Plane (ESP) Block With 20 ml Versus 30 ml in Cardiac Surgery

Start date: June 1, 2021
Phase: N/A
Study type: Interventional

Even though erector spinae plane (ESP) block is shown to be efficient in cardiac surgery, it is still controversial how much volume is necessary for efficient analgesic effect for sternotomy and drain tube pain relief. This study aims to investigate the optimal local anesthetic volume (20 mL versus 30 mL) with ESP block for open-heart cardiac surgery.

NCT ID: NCT04926454 Recruiting - Pain, Postoperative Clinical Trials

Efficacy of Adding Dexmedetomidine as an Adjuvant to Bupivacaine in TAP Block and Caudal Block

Start date: September 22, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

This study compares the efficacy of Dexmedetomidine as an adjuvant to Bupivacaine in Ultrasound Guided Transversus Abdominis Plane Block versus Caudal Block for post-operative analgesia in children undergoing congenital inguinal hernia repair especially to provide prolonged post-operative analgesia and decrease opioid consumption.

NCT ID: NCT04924439 Completed - Pain, Postoperative Clinical Trials

Effects of Reflexology on Postpartum Pain, Fatigue, Sleep Quality and Lactation

Start date: January 1, 2020
Phase: N/A
Study type: Interventional

The aim of this research is to determine the effect of foot reflexology applied to primiparous women who had cesarean section in the postpartum period on pain, fatigue, sleep quality and lactation. This research is a randomized controlled trial. The study was conducted in Şanlıurfa, which has the highest fertility rate in Turkey.

NCT ID: NCT04924010 Recruiting - Breast Cancer Clinical Trials

Effect of Perioperative CBT on Chronic Persistent Postsurgical Pain Among Breast Cancer Patients

Start date: May 31, 2021
Phase: N/A
Study type: Interventional

Chronic persistent post-surgical pain (CPSP) is defined as pain at or near the site of surgery persisting for 3 months or more after the date of surgery. The incidence CPSP in Europe is up to 50% at 3 months and 12% at 12 months, but the incidence varies depending on surgical procedure [Fletcher D et al]. In Breast surgery, one of the most commonly performed surgical procedures for cancer [Kehlet H et al], CPSP has been observed in 20-30% of patients at 6 months after surgery, making this group among the highest risk of developing CPSP [Spivey TL et al & Weiser TG et al]. Clinical developments that could mitigate the development of CPSP after breast cancer surgery would potentially yield multiple benefits in terms of reducing future healthcare utilization, associated costs [Spivey Tl et al], and improving their physical and mental health. Several predictive factors for CPSP have been identified, the most important being chronic pre-operative pain, high intensity of acute postoperative pain, and several psychological factors [Vranceanu A-M et al]. Of these psychological factors, pain catastrophizing has emerged as one of the strongest predictors of pain severity and disability among individuals with a range of pain presentations and CPSP [Leung L & Wade Jb & Wildeman TH]. Catastrophizing is described as a maladaptive psychological coping strategy involving an exaggerated reaction to anticipated or actual pain. It can involve mental rumination, magnification of the perceived danger or threat associated with pain, and feelings of helplessness in relation to what can be done [Leung L et al]. A recent systematic review on psychological interventions undergoing major elective abdominal surgery concluded catastrophization can have a direct influence on the neuropathophysiological mechanisms underlying pain experiences and can improve pain and psychological outcomes, after surgery [Villa G et al]. In recent years, there has been a growing number of studies investigating the potential impact of perioperative psychological interventions in a variety of patient groups. A recent systematic review and meta-analysis of observational studies concluded that psychological predictors may have a significant association with chronic postsurgical pain, including catastrophization, although this conclusion is limited by the heterogeneity of study designs and methods used [Giusti et al]. To our knowledge, no randomized controlled trial has been done to date, investigating the influence of perioperative psychological interventions on CPSP in patients undergoing breast cancer surgery.

NCT ID: NCT04921540 Recruiting - Quality of Life Clinical Trials

Ingrown Toenails : Surgery Only Versus Surgery + Chemical Cauterization With TCA

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

Ingrown toenail is a very common disease in the general population that touches young adults. There are lots of treatments from local care of pedicure to surgery with matricectomy. Gold standard of symptomatic and painful ingrown toenail is the simple surgery with matricectomy and with suture or directed healing pad. For many years chemical cauterisation with phenolic acid is used, a method with very few relapses and with a more simple pad. However, because of a lack of information about this phenolic acid, the pharmaceutical laboratory withdrew it from the market. The new method to replace phenolic acid is trichloroacetic acid, used mainly in cosmetics for peeling. This method was already compared to phenolic acid and showed equal results with fewer laps of application and a low cost. The comparison between acid trichloroacetic method and the gold standard surgery was never done and will be the goal of this study. It's an open, non randomised, comparative, multicentric (2 centers) study with two groups : common surgery and surgery with chemical cauterisation For this study the investigators will compare between the two groups : gain of quality of life at one month after surgery, difference of pain between before, one week and one month after surgery, the occurrence of adverse events and number of relapses at one year.

NCT ID: NCT04920669 Recruiting - Postoperative Pain Clinical Trials

Dexmedetomidine in Erector Spinae Block in Postoperative Analgesia

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

60 female patients scheduled for breast cancer surgeries, allocated in 3 groups for erector spinae block with bupivacaine and erector spinae block with dexmedetomidine added to bupivacaine and control group. During anesthesia: total intraoperative fentanyl required will be recorded. After surgery the first time of request for analgesic will be recorded. after request of analgesia all patients will be connected to PCA device containing morphine solution, the amount of morphine consumed during the first 24 hours will be recorded.

NCT ID: NCT04919317 Completed - Pain, Postoperative Clinical Trials

Combination Dexamethasone and Bupivacaine Pain Control in Reduction Mammaplasty

Start date: September 29, 2017
Phase: Phase 2
Study type: Interventional

The addition of dexamethasone to non-liposomal bupivacaine in perineural blocks has been shown to enhance pain control and prolong the time until first request for postoperative narcotics in the fields of orthopedic, thoracic, and gynecologic surgery. This has not been investigated in any types of breast surgery. The investigators assessed if the combination of dexamethasone to bupivacaine in the preoperative field block prior to bilateral breast reduction surgery resulted in improved pain control relative to bupivacaine alone.

NCT ID: NCT04917510 Not yet recruiting - Postoperative Pain Clinical Trials

Evaluating the Efficacy of Erector Spinae Block in Routine Hip Arthroscopy

Start date: July 2021
Phase: N/A
Study type: Interventional

The aim of this project is to evaluate the efficacy of preoperative erector spinae blocks in arthroscopic hip surgery. This will be a prospective randomized controlled trial.

NCT ID: NCT04916418 Not yet recruiting - Clinical trials for Coronary Artery Disease

Postoperative Pain Relief With Transversus Thoracis Muscle Plane Block After Cardiac Surgery

Start date: June 2021
Phase: Phase 4
Study type: Interventional

This study aims to investigate the effect of transversus thoracis muscle plane block (TTP), using repeated boluses of ropivacaine via catheter, on postoperative pain and oxycodone consumption after elective cardiac surgery with sternotomy.