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Pain, Postoperative clinical trials

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NCT ID: NCT05490186 Recruiting - Pain, Postoperative Clinical Trials

Function, Pain, and Alignment Following Knee Replacement for the Treatment of Osteoarthritis

Start date: November 16, 2021
Phase: N/A
Study type: Interventional

There are many factors that can influence patient satisfaction and patient related outcomes following total knee replacement including the surgical alignment of the joint components. Historically, total knee replacements have been performed with an aim aiming to achieve neutral alignment or a mechanical weight axis in the lower extremity . However, only 0.1 % of the population have a pre-surgical anatomical neutral alignment, and therefore the constitutional anatomy of the patient is neglected. There is a growing trend to return patients back their anatomical constitutional alignment after a knee replacement, referred to as Kinematic Alignment using robotics. The aim of this randomized controlled trial is to examine how mechanical alignment and kinematic alignment impacts function, pain, mood and fatigue following TKR for the treatment of osteoarthritis. Outcomes will be measured at 6 week, 6 months, 1 year and 2 years after surgery.

NCT ID: NCT05484648 Not yet recruiting - Post Operative Pain Clinical Trials

Dexamethasone or Dexmedetomidine as Adjunct in Fascia Iliaca Block During Positioning for Sub-arachnoid Block & Post-operative Analgesia After Femur Neck Fracture Surgery: A Randomized Control Trial

Start date: January 1, 2023
Phase: Phase 4
Study type: Interventional

Femur fracture is a common injury occurring in the young due to trauma as well as amongst the elderly due to fall. Reduction and fixation of femur fractures pose a challenge to the anesthesiologist. These fractures are intensely painful as the pain arises from the periosteum and even slight movement can cause muscle forces to angulate and deform the fractured fragments which apart from causing extreme pain also make the reduction of the fracture quite difficult. Sub-arachnoid block (SAB) is a commonly used technique for lower-limb surgeries. It provides excellent surgical anesthesia and is a largely safe and reliable anesthetic technique. However, for femur fracture repair, positioning the patient for SAB not only causes extreme pain but it also makes administration of SAB difficult due to inappropriate position. Another limitation of SAB is its limited duration of action. Hence, conventional pain management modalities which include opioids and NSAIDs are used to manage pain before and during the administration of SAB and during the post-operative period. These conventional pain management drugs are associated with significant adverse effects and should be used with caution especially in the elderly with multiple comorbids. Recently, fascia iliaca block (FICB) has been used not only as part of multi-modal peri-operative analgesic regime for femur fractures but also to provide adequate analgesia for appropriate SAB positioning. FICB fills the plane underneath the fascia iliaca with local anesthetic and acts on the femoral, lateral femoral cutaneous and obturator nerves and thus provides adequate analgesia for femur fractures for up to 24-48 hours. FICB is also associated with less side effects when compared to conventional pain management modalities and provides adequate unilateral analgesia with fewer autonomic and neurological complications when compared with epidural analgesia. Traditionally, local anesthetics have been used for most of the peripheral nerve blocks (PNB), however multiple adjuncts such as opioids, ketamine and clonidine have been used to prolong the duration of action as well as decrease the local anesthetic dosage. Among the adjuncts, dexamethasone has been used to generally favorable results in PNBs. Dexmedetomidine is another promising drug being used as a local anaesthetic adjuvant in peripheral nerve blocks. It is an alpha-2 agonist, which has shown to have prolonged duration of postoperative analgesia when given with LA for peripheral nerve blocks with other beneficial effects such as reducing the opioid consumption. In this study, the investigators compare dexamethasone with dexmedetomidine as an adjunct when combined with ropivacaine in FICB.

NCT ID: NCT05482919 Recruiting - Pain Clinical Trials

The Adolescent Surgery Experience: A Mixed Methods Analysis

Start date: June 14, 2022
Phase:
Study type: Observational

New chronic pain and opioid use are reported as prevalent among adolescents undergoing major surgery; many unanswered questions remain regarding recovery and the anticipated pain trajectory across procedures and the interaction between pain treatment, acute inflammation and new chronic pain. Broadly, the proposed study will characterize the adolescent's postoperative recovery experience, and establish the anticipated pain trajectory across a range of procedures.

NCT ID: NCT05480111 Not yet recruiting - Pain, Postoperative Clinical Trials

The Role of Quadratus Lumborum Blocks Following Minimally Invasive Hysterectomy

Start date: July 27, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare quality of recovery as well as peri-operative systemic opiates use and pain scores in patients undergoing laparoscopic or robotic hysterectomy when local anesthetic versus Quadratus Lumborum nerve block (QL-2) is added to the standard pain management.

NCT ID: NCT05479175 Active, not recruiting - Postoperative Pain Clinical Trials

Evaluation the Effect of Using Preoperative Ibuprofen Versus Low Level Laser Therapy on Inferior Alveolar Nerve Block

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

Acute apical periodontitis (AAP) is an inflammatory condition of the periapical tissues of the periodontium, usually resulting from irreversible pulpitis and pulpal necrosis. Patients with AAP often have moderate to severe pain, which results in the need for emergency treatment. Patients with AAP usually present with dull, throbbing, constant pain; absence of swelling; a negative or delayed positive result on vitality testing; absence of thermal sensitivity of the tooth; and pain on biting or percussion.The treatment of these teeth is root canal treatment. Pain control during root canal treatment is essential for several reasons. First, patients desire and expect that their treatment should be free of discomfort. Second, good intra-operative pain control helps to reduce post-operative pain and simplifies its management. Third, patients will be reluctant to have further root canal treatment in the future if they have had a bad experience as a result of pain during treatment. Hence, pain-free treatment should be every dentist's aim. The amount of pain experienced during treatment is related to the condition being treated teeth with irreversible pulpitis and acute apical periodontitis were significantly associated with more treatment pain than devital teeth and infected canals with apical periodontitis.In another study, molars and teeth with irreversible pulpitis had more intra-operative pain than single-rooted teeth and devital teeth, infected root canals. Local anesthesia is the most common method used for pain control during root canal treatment. However, other strategies can also be employed in some cases such as pre-treatment anti-inflammatory systemic medications, and methods to reduce discomfort associated with injections. The use of pre-operative medication reduce pain and inflammation at the treatment site. Several studies have been performed to investigate the effectiveness of this approach using a variety of drugs such as benzodiazepines, NSAIDs and corticosteroids. The concept of using NSAIDs and corticosteroids as premedication is largely based on reducing the amount of prostaglandin in the inflamed pulp. There have been conflicting results reported for the use of ibuprofen premedication with some studies reporting an increased success rate for local anaesthesia,while others have reported no effects compared with placebo. Recently, low level laser therapy has been used in dentistry for a range of treatments, including reduction of orthodontic pain, symptomatic oral lichen planus cases, healing of maxillofacial defects and prophylaxis of stomatitis. LLLT has begun to be used in endodontic treatments due to its ability to increase wound healing, its role in root canal disinfection, its role in reducing pain and its very limited side effects. However, the pain reduction mechanism of LLLT is not fully understood.

NCT ID: NCT05478382 Not yet recruiting - Postoperative Pain Clinical Trials

Pregabalin is an Effective Treatment for Acute Postoperative Pain Following Spinal Surgery Without Major Side Effects

Start date: October 2022
Phase: Phase 4
Study type: Interventional

The objective of this study is to examine the efficacy and side effect of varying dose of pregabalin for the treatment of postoperative pain after spinal surgery.

NCT ID: NCT05478044 Not yet recruiting - Post Operative Pain Clinical Trials

Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.

Start date: August 2022
Phase: N/A
Study type: Interventional

The study is conducted to evaluate the effect of Ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.

NCT ID: NCT05478005 Not yet recruiting - Pain, Postoperative Clinical Trials

Function and Pain Following Knee Replacement

Start date: August 15, 2022
Phase: N/A
Study type: Interventional

The three common procedure of pain blocking, at the end of the knee replacement, are femoral nerve block, adductor canal block (saphenous nerve) and intra-articular block. Many studies have compared the effectiveness of the different pain block methods in terms of early mobilization, pain level, opioid consumption and the duration of hospitalization. A few studies have addressed the effect of pain blocking methods in term of postoperative functional status, in particle bed functions, while using function performance tests. The objective of the study is to examine whether there is a difference in function and pain level in the acute postoperative stage of knee replacement surgery between the three methods of postoperative analgesia -femoral nerve block, adductor canal block and intra-articular block. The study will include 100 patients in the acute stage after knee replacement surgery, at the Orthopedic department, Galilee Medical Center, Israel. Oxford Knee Score Questionnaire and quadriceps muscle strength will be measured before surgery. On the first and fifth day after surgery, the follow functional tests will be measured: Timed up & Go, Elderly Mobility scale, 5 Times Sit to Stand and the quadriceps muscle strength will be measured. Patients will be asked about the intensity of their pain according to the Numeric Pain Rating Scale three times a day by the nursing staff, and also before and after physiotherapy treatment throughout the days of hospitalization. At the end of the hospitalization, additional data will be collected from the patient file: hospitalization duration, surgery duration, consumption of analgesics, post operative occurrence of falls.

NCT ID: NCT05477303 Recruiting - Pain, Postoperative Clinical Trials

Artificial Intelligence to Evaluate Postoperative Pain Based on Facial Expression

Start date: June 17, 2022
Phase:
Study type: Observational

Patients' subjective complaints about pain intensity are difficult to objectively evaluate, and may lead to inadequate pain management, especially in patients with communication difficulties.

NCT ID: NCT05476718 Not yet recruiting - Post Operative Pain Clinical Trials

Kinesio Taping in Patients After Lumbar Disc Surgery

Start date: July 25, 2022
Phase: N/A
Study type: Interventional

In this study, it will be determined whether Kinesio-tape is an effective and reliable application in reducing pain and maintaining functionality after lumbar disc surgery, and its effect on the rehabilitation process will be evaluated.