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NCT ID: NCT04524416 Recruiting - Ocular Hypertension Clinical Trials

MINIject Global Long-Term Follow-up Study

STAR-GLOBAL
Start date: August 5, 2020
Phase:
Study type: Observational

The study will assess the long-term (up to 5 years) safety and performance in patients with open-angle glaucoma uncontrolled by topical hypotensive medications who had previously been implanted with a MINIject glaucoma implant.

NCT ID: NCT04215991 Recruiting - Clinical trials for Gram-negative Bacterial Infections

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Pediatric Participants

Start date: February 19, 2020
Phase: Phase 2
Study type: Interventional

The primary objectives of this study are to assess the safety, tolerability, and pharmacokinetics (PK) of cefiderocol after single-dose administration in hospitalized pediatric participants 3 months to < 12 years of age with suspected or confirmed aerobic Gram-negative bacterial infections and after multiple-dose administration in hospitalized pediatric participants 3 months to < 18 years of age with suspected or confirmed complicated urinary tract infection (cUTI), hospital-acquired bacterial pneumonia (HABP), or ventilator-associated bacterial pneumonia (VABP).

NCT ID: NCT03988439 Recruiting - Psoriasis Clinical Trials

A Safety and Pharmacokinetics Study of IDP-118 Lotion in Pediatric Participants With Plaque Psoriasis

Start date: March 24, 2021
Phase: Phase 4
Study type: Interventional

This study is to evaluate the safety, the systemic exposure, and the hypothalamic-pituitary-adrenal (HPA) axis suppression potential for topically applied IDP-118 lotion in pediatric participants with moderate to severe plaque psoriasis.

NCT ID: NCT03987763 Recruiting - Psoriasis Clinical Trials

A Safety and Pharmacokinetics Study of IDP-122 Lotion in Pediatric Participants With Plaque Psoriasis

Start date: October 22, 2019
Phase: Phase 4
Study type: Interventional

This study is to evaluate the safety, the systemic exposure of halobetasol propionate (HP), and the hypothalamic-pituitary-adrenal (HPA) axis suppression potential for topically applied IDP-122 lotion in pediatric participants with moderate to severe plaque psoriasis.

NCT ID: NCT03616678 Recruiting - Clinical trials for Functional Mitral Regurgitation

VenTouch OUS Feasibility Study

Start date: March 25, 2019
Phase: N/A
Study type: Interventional

This is a prospective, multi-center, single-arm study to evaluate safety and efficacy of the VenTouch System for treatment of subjects with functional MR.

NCT ID: NCT03178552 Recruiting - Clinical trials for Non-Small Cell Lung Cancer

A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

B-FAST
Start date: September 22, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

This is a phase 2/3, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in combination in participants with unresectable, advanced or metastatic NSCLC determined to harbor oncogenic somatic mutations or positive by tumor mutational burden (TMB) assay as identified by two blood-based next-generation sequencing (NGS) circulating tumor DNA (ctDNA) assays.

NCT ID: NCT03169803 Recruiting - Heart Failure Acute Clinical Trials

Cardiac Output Autonomic Stimulation Therapy for Acute Heart Failure (COAST-AHF)

Start date: May 19, 2017
Phase: N/A
Study type: Interventional

A feasibility study to investigate the safety and performance of the NeuroTronik Cardiac Autonomic Nerve Stimulation (CANS) Therapy System

NCT ID: NCT03129672 Recruiting - Bone Neoplasm Clinical Trials

Distal Tibia Sarcoma Treatment Using Allograft Arthrodesis of the Ankle

Start date: May 20, 2014
Phase:
Study type: Observational

The study show the clinical results of limb salvage for primary malignant bone tumor of the distal tibia using block excision of the tumor and reconstruction with allograft arthrodesis with different methods of fixation (plates or intramedullary nail system)

NCT ID: NCT02843594 Recruiting - Cataract Clinical Trials

A Study to Assess the Clinical Outcomes of Surgical Phaco Segmentation Techniques in Patients Undergoing Cataract Surgery

Start date: August 2016
Phase: Phase 4
Study type: Interventional

The purpose of this research study is to evaluate the clinical outcomes of different cataract surgical techniques for lens fragmentation in subjects undergoing routine cataract surgery.

NCT ID: NCT02016924 Recruiting - HIV Infections Clinical Trials

Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV

Start date: January 16, 2014
Phase: Phase 2/Phase 3
Study type: Interventional

The goal of this clinical study is to learn more about the safety and dosing of study drugs, cobicistat-boosted Atazanavir (ATV/co), cobicistat-boosted darunavir (DRV/co) and emtricitabine/tenofovir alafenamide (F/TAF), in children (age ≥ 4 weeks to < 18 years) with HIV.