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NCT ID: NCT05201794 Not yet recruiting - Dengue Clinical Trials

A Study of JNJ-64281802 for the Prevention of Dengue Infection

Start date: July 29, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the prophylactic effect of JNJ-64281802 with respect to the prevention of laboratory-confirmed dengue virus (DENV) infection up to last day of dosing among participants who have no evidence of current DENV infection at baseline.

NCT ID: NCT05130944 Recruiting - Stress Clinical Trials

Feasibility of Community Psychosocial Intervention for Women

Start date: September 9, 2021
Phase: N/A
Study type: Interventional

The purpose of the current protocol is to describe a cluster randomized feasibility trial examining the integration of a scalable stress management intervention into Entre Nosotras ('among/between us'), a community-based psychosocial intervention for migrant and host community women in Ecuador and Panamá. Specifically the study aims to: 1. Explore the relevance, acceptability, and feasibility of integrating a stress management intervention into community-based participatory women's group 2. Examine the feasibility of conducting a fully-powered cluster randomized controlled trial evaluating the effectiveness and implementation of integrating a stress management intervention into a community-based participatory women's group as compared to community-based participatory women's groups alone.

NCT ID: NCT05091437 Not yet recruiting - Pulmonary Nodules Clinical Trials

DOUBLED - Doubling Outcomes by Lung Cancer Early Diagnosis

DOUBLED
Start date: October 15, 2021
Phase:
Study type: Observational

Early diagnosis of LC in the asymptomatic stage through intentional screening programs and/or incidental pulmonary nodule identification and follow-up are known to improve outcomes significantly. There are large gaps in the screening and early detection of LC, especially in LMIC - driven by multifactorial aspects, including a variety of socioeconomic and infrastructural factors, mainly due to limitations in the required network of specialized human resources and technical capacity. Identifying LC at an early stage allows for treatment that is more likely to be curative, thereby improving survival. The present study aims to characterize the lung nodule journey in different hospitals/clinics across Latin America, describing the use of health resources, time to diagnosis, stage at diagnosis, and time to treatment depending on the source of nodule identification in two different cohorts (retrospective and prospective).

NCT ID: NCT05068479 Recruiting - Presbyopia Clinical Trials

Safety & Efficacy of the Laser Scleral Microporation Procedure

Start date: April 9, 2021
Phase: N/A
Study type: Interventional

A new minimally invasive procedure for treating presbyopia is being evaluated to determine if there is improvement in near and intermediate vision after treatment

NCT ID: NCT04980391 Recruiting - Clinical trials for Respiratory Syncytial Virus Infections

A Study on the Safety and Immune Response to an Unadjuvanted RSV Maternal Vaccine, in High Risk Pregnant Women Aged 15 to 49 Years and Infants Born to the Vaccinated Mothers

Start date: August 3, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety, reactogenicity and immune response of a single intramuscular dose of the respiratory syncytial virus (RSV) maternal vaccine compared to placebo, when administered in the second or third trimester of pregnancy in women, 15 to 49 years of age (YOA), with high risk pregnancies and in the infants born to the vaccinated mothers.

NCT ID: NCT04962880 Recruiting - Clinical trials for Castration-resistant Prostate Cancer

HRR Prevalence in LatAm PROSPECT Study

PROSPECT
Start date: April 21, 2021
Phase:
Study type: Observational

Determine the prevalence of homologous recombination repair (HRR) gene mutations in participants with mCRPC in Latin America (LatAm) between February 2021 and January 2022.

NCT ID: NCT04951349 Completed - Covid19 Clinical Trials

Safety and Efficacy of Intranasal Application of GX-03 as a Treatment and Prevention for COVID-19.

Start date: January 21, 2021
Phase: Phase 2
Study type: Interventional

Phase 2b clinical trial to evaluate the safety and efficacy of intranasal application of GX-03 as a treatment and prevention for COVID-19.

NCT ID: NCT04864652 Recruiting - Clinical trials for Obstructive Sleep Apnea of Adult

Safety and Dosing Study of the CHILLS Cryotherapy for the Treatment of OSA

ARCTIC-1
Start date: November 30, 2020
Phase: N/A
Study type: Interventional

ARCTIC-1 is a safety and dosing study to evaluate procedure tolerability in patients with clinically diagnosed moderate or severe OSA.

NCT ID: NCT04847024 Completed - Clinical trials for Caesarean Section; Pain

Parecoxib vs. Dexketoprofen for the Management of Pain After Cesarean Section.

Start date: July 1, 2019
Phase: N/A
Study type: Interventional

Although it is known that parecoxib and dexketoprofen are commonly used in successful post-operative pain relief, there are very few studies that compare these two agents in their individual applications and/or combined with neuraxial analgesia with opioids and even less in post-cesarean section pain, as well as the evaluation of the side effects and their impact on the patient's functionality. For this reason, in order to approach this answer, we sought to perform this study in patients undergoing elective or emergency cesarean section in our institution, who meet the inclusion criteria, using the Visual Analog Pain Scale at 12 hrs and 24 hrs post surgery and evaluating the aforementioned side effects, comparing in one arm of the study Parecoxib + acetaminophen vs Dexketoprofen + acetaminophen in the other arm, randomizing the patients in both groups using a double-blind configuration.

NCT ID: NCT04841577 Active, not recruiting - Clinical trials for Respiratory Syncytial Virus Infections

A Study on the Immune Response and Safety Elicited by a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a Vaccine Against Influenza in Adults Aged 60 Years and Above

Start date: April 27, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the immunogenicity, safety and reactogenicity of the RSVPreF3 OA investigational vaccine when co-administered with the seasonal quadrivalent influenza vaccine (FLU-QIV) in adults aged 60 years and above compared to separate administration of the vaccines.