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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT05037695 Recruiting - Clinical trials for Coronary Artery Disease

SGLT-2 Inhibitors in Prevention of Post-procedural Renal and Cardiovascular Complications aFter PCI Among Patients With Diabetes Mellitus and Coronary Artery Disease: a Prospective, Randomized, Pilot Study (SAFE-PCI)

SAFE-PCI
Start date: July 21, 2021
Phase: Phase 4
Study type: Interventional

Patients with type 2 diabetes mellitus (DM) have higher risk of major cardiovascular events (MACE) and renal disfunction. The Sodium-glucose cotransporter-2 inhibitors (iSGLT2) reduces hyperglycemia in patients with type 2 DM and have multiple metabolic effects, lowering primary composite cardiovascular outcomes and progression to renal failure. 25% of patients with Stable Ischemic Heart Disease (SIHD) undergoing PCI are diabetics being one of the most prevalent and important risk factors for the development of contrast induced nephropathy (CIN). The occurence of CIN is associated with higher rates of death, loss of renal function, necessity of dialysis and increase of health care costs. In this pilot study we sought to evaluate if the iSGLT2 would prevent periprocedural complications - such as periprocedural CIN and MI - in type 2 DM patients undergoing PCI through the assessment of renal and myocardial biomarkers

NCT ID: NCT05035056 Recruiting - Clinical trials for Coronary Artery Disease

WARRIOR Ancillary Study for CCTA Analysis

Start date: July 1, 2020
Phase: N/A
Study type: Interventional

In this study, quantitative characterization of plaque using coronary computed tomographic angiography (CTA) will be used to determine if women who were treated with intensive medical therapy have a greater reduction in the amount and type of cholesterol plaque compared to women receiving usual care and if this results in beneficial changes in clinical symptoms. The study will provide an understanding of how intensive medical therapy works in providing clinical benefit in women with nonobstructive plaque.

NCT ID: NCT05034224 Recruiting - Clinical trials for Microvascular Coronary Artery Disease

Coronary Sinus Pressure and Microvascular Disease

MACCHUS
Start date: August 23, 2021
Phase: N/A
Study type: Interventional

MACCHUS is a randomized, single-center, controlled, cross-over interventional study in which coronary artery resistances will be measured at baseline and during temporary occlusion of the coronary sinus.

NCT ID: NCT05033964 Not yet recruiting - Clinical trials for Coronary Artery Disease

The DESyne BDS Plus RCT: A Randomized Trial to Assess the Elixir DESyne BDS Plus DES for Treatment of Coronary Artery Lesions

Start date: September 2021
Phase: Phase 2
Study type: Interventional

The DESyne BDS Plus Randomized Clinical Study is a prospective, multi-center, single blind, randomized clinical study. Randomization (1:1; DESyne BDS Plus : DESyne X2) of up to 100 patients (50 in each arm) requiring treatment of up to two de novo coronary artery lesions ≤ 34 mm in length in vessels ≥ 2.25 mm and ≤ 3.5 mm in diameter will be conducted. Clinical endpoints will be assessed at each follow-up point: 3 days or hospital discharge (whichever comes first), 1, 6, and 12 months.

NCT ID: NCT05032937 Not yet recruiting - Clinical trials for Coronary Heart Disease

the Accuracy and Safety of Coronary Artery Contrast-enhanced Magnetic Resonance Imaging With Polysaccharide Superparamagnetic Iron Oxide Nanoparticle

Start date: September 1, 2021
Phase: Phase 1
Study type: Interventional

This is a single-center, prospective, controlled and diagnostic clinical trial which will enroll 30 patients scheduled for coronary angiography in China.Patients will receive contrast-enhanced cardiac magnetic resonance with polysaccharide superparamagnetic iron oxide nanoparticle before percutaneous coronary angiography.In order to evaluate the safety of polysaccharide superparamagnetic iron oxide nanoparticle, patients will detect iron levels in peripheral and tissue before and after the examination.The main indicators of the study are the degree of coronary artery stenosis and the stability of coronary atherosclerotic plaque assessed by contrast-enhanced cardiac magnetic resonance with polysaccharide superparamagnetic iron oxide nanoparticle.

NCT ID: NCT05031520 Recruiting - Clinical trials for Non-Obstructive Coronary Atherosclerosis

PericOronary INflammaTion in Non-Obstructive Coronary Artery Disease

POINT-NOCAD
Start date: July 12, 2021
Phase: N/A
Study type: Interventional

Among patients with ischemic heart disease who are referred for coronary angiography, a substantial proportion have non-obstructive coronary artery disease (CAD). Myocardial infarction (MI) with non-obstructive coronary artery disease (MINOCA) accounts for 5-20% of patients with MI and preferentially affects women. MINOCA pathogenesis is varied and may include atherosclerotic plaque rupture, plaque erosion with thrombosis, vasospasm, embolization, dissection or a combination of mechanisms. Other patients may have clinically unrecognized myocarditis, or takotsubo syndrome masquerading as MI. Among patients referred for coronary angiography for the evaluation of stable ischemic heart disease, non-obstructive CAD is present in up to ~30% of men and ~60% of women. Stable ischemia with non-obstructive coronary arteries (INOCA) may be due to coronary microvascular dysfunction in up to 40% of these patients. Our understanding of mechanisms of MINOCA and INOCA remain incomplete. Coronary inflammation has been hypothesized as a potential mechanism contributing to coronary spasm in MINOCA and microvascular disease in INOCA.

NCT ID: NCT05030818 Not yet recruiting - Clinical trials for Coronary Artery Disease

Cross-over Study of Coronary Risk Factors With a Polypill

POLICROSS
Start date: November 1, 2021
Phase: Phase 4
Study type: Interventional

Open-label, randomized, cross-over study conducted in a single center, applied to patients receiving a polypill with 100 mg of acetyl salicylic acid and different doses of ramipril and atorvastatin for indication of secondary prevention according to clinical practice, with objective of analyzing the level of systolic blood pressure and LDL-cholesterol in the same patient in 2 different periods: one under treatment of 3 months with the polypill and another of 3 months with the components separately.

NCT ID: NCT05028179 Not yet recruiting - Clinical trials for Coronary Heart Disease

PROTEUS: Evaluating the Use of Artificial Intelligence to Support Stress Echocardiography Testing for Heart Disease

PROTEUS
Start date: September 2021
Phase: N/A
Study type: Interventional

PROTEUS is a multicentre, two arm, randomised controlled trial of a medical device to assess the impact of the introduction of EchoGo into the standard care pathway for stress echocardiology.

NCT ID: NCT05027984 Recruiting - Clinical trials for Coronary Artery Disease

Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria at OCT in Patients With ACS

INTERCLIMA
Start date: June 30, 2021
Phase: N/A
Study type: Interventional

The INTERCLIMA (Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria Identified by Optical Coherence Tomography in Patients With Acute Coronary Syndrome) is a multi-center, prospective, randomized trial of optical coherence tomography (OCT)-based versus physiology-based (i.e. fractional flow reserve[FFR]/instantaneous Wave-Free Ratio[iFR]/resting full-cycle ratio[RFR]) treatment of intermediate (40-70% diameter stenosis at quantitative coronary angiography), non-culprit coronary lesions in acute coronary syndrome (ACS) patients undergoing coronary angiography. About 1400 patients with ACS will be randomized into the study at approximately 40 sites worldwide.

NCT ID: NCT05026957 Not yet recruiting - Clinical trials for Cardiac Rehabilitation

A Digitally-Supported Shared Decision Making Approach for Coronary Artery Disease Patients During Cardiac Rehabilitation

SharedHeart
Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Investigating the role of shared-decision making in cardiac rehabilitation