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Coronary Artery Disease clinical trials

View clinical trials related to Coronary Artery Disease.

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NCT ID: NCT05700877 Recruiting - Clinical trials for Cardiovascular Diseases

Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes

STENO INTEN-CT
Start date: January 26, 2023
Phase: Phase 4
Study type: Interventional

The investigators intend to perform a landmark study to answer whether a combined CVD screening and treatment strategy is beneficial for patients with type 2 diabetes (T2DM) without known cardiovascular disease (CVD) The investigators aim to answer the following main research questions: Do screening detected high-risk patients benefit of intensified medical treatment? Is it safe to de-intensify medical treatment among patients with a screening detected low risk of CVD? Does a CVD screening and treatment program improve patient reported health status? Cardiovascular risk remains high in patients with T2DM but unevenly distributed. Our current risk stratification strategies are far from optimal leading to both under- and over-treatment of patients. In recent years, noninvasive imaging of subclinical coronary artery disease by cardiac CT has improved considerably. This allows for easily accessible evaluations of coronary atherosclerosis burden and composition - exceptionally strong imaging biomarkers of future cardiovascular disease. An increasing amount of data suggests that cardiac CT may permit better risk stratification in patients with T2DM. At the same time, the pharmaceutical treatment of T2DM has changed with several new and expensive drug classes, each individually documented to reduce the risk for new or recurrent cardiovascular events. Thus, these new drugs may improve outcome in high-risk patients, whereas they may be wasteful and only lead to side effects in low-risk patients. In the Inten-CT study, the investigators combine these two pivotal developments. The investigators intend to improve risk stratification of patients with T2DM by use of cardiac CT and, based on this knowledge, the investigators wish to investigate if upgraded medical treatment in the high-risk population is beneficial and if de-intensified treatment in the low-risk population is safe. As a secondary aim, the investigators wish to investigate if such a strategy improves patient reported health status. These aims are in agreement with one of the important health indicators from The Danish College of General Practitioners: "We find and treat the patients and let the healthy stay healthy". The investigators intend with this strategy to improve not only cardiovascular outcome among patients with T2DM, but also their quality of life. The Inten-CT study is an investigator-initiated open-label event-driven randomized controlled trial including patients with T2DM stratified according to screen detected coronary artery calcification. The investigators expect inclusion of 7300 patients in 2 years and a mean follow-up period of 5 years.

NCT ID: NCT05699629 Recruiting - Clinical trials for Myocardial Infarction

Prospective Coronary Heart Disease Cohort

Start date: January 21, 2022
Phase:
Study type: Observational

To evaluate the biomarkers for the prognosis of coronary heart disease, patients with coronary heart disease will be recruited and followed up for at least 2 years.

NCT ID: NCT05698732 Not yet recruiting - Clinical trials for Ischemic Heart Disease

Coroflex® ISAR NEO PMCF Study y ( rEPIC07 )

rEPIC07
Start date: February 1, 2023
Phase:
Study type: Observational

International, Multicenter, prospective, non-randomized, post-market clinical follow-up (PMCF) study to confirm and support the clinical safety and performance of Coroflex® ISAR NEO coronary stent system to meet EU Medical Device regulation (MDR) requirements in all the CONSECUTIVE patients treated with Coroflex® ISAR NEO coronary stent system sirolimus eluting stent.

NCT ID: NCT05698719 Recruiting - Clinical trials for Percutaneous Coronary Intervention

Validation of vFFR as Compared to FFR to Guide Revascularization of Non-culprit Lesions in STEMI Patients

Start date: June 22, 2022
Phase:
Study type: Observational

This prospective multicenter observational cohort study is designed to study the diagnostic performance of acute-setting angiography-based FFR (e.g. vFFR) for the physiological assessment of intermediate non-culprit lesions in STEMI patients, with acute-setting FFR and acute-setting NHPR (e.g. RFR) as the reference standards.

NCT ID: NCT05697120 Enrolling by invitation - Clinical trials for Coronary Artery Disease

Long-term Effects of Individualized Follow-up With an App for One Year

Start date: February 2023
Phase:
Study type: Observational

The aim of this study is to examine the long-term (3-5 year post intervention) effects post individualized follow-up with an app for one year, compared to a control group that received usual care on factors related to healthy behaviour in patients post-CR.

NCT ID: NCT05696990 Recruiting - Clinical trials for Coronary Artery Disease

3/7 Resistance Training Method in Cardiac Rehabilitation

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen uptake (Peak Vo2) and leg strength (assessed Isokinetic). The investigators hypothesize that resistance training exercise with induced a high stress metabolic is more important exercise with induced than a lower stress metabolic.

NCT ID: NCT05695716 Not yet recruiting - Clinical trials for Coronary Artery Disease

CSI Percutaneous Ventricular Assist Device (pVAD) Second in Human Study

Start date: February 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to collect data on safety and device performance on the CSI pVAD System used to support hemodynamic stability during HR-PCIs to inform device design and finalization.

NCT ID: NCT05695547 Not yet recruiting - Clinical trials for Coronary Arteriosclerosis

VR Education in Patients Undergoing Coronary Angiography

Start date: January 25, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to compare standard education with VR augmented education in patients undergoing selective coronary angiography.

NCT ID: NCT05695287 Completed - Clinical trials for Coronary Artery Disease

The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery

Start date: January 22, 2021
Phase: Phase 1
Study type: Interventional

Abstract Anaesthetic support for cardiac surgery significantly influences the course of the intraoperative period and the success of the postoperative period. Total intravenous anaesthesia and inhalation anaesthesia are the traditional methods of anaesthesia in cardiac surgery. However, there are few studies assessing the effectiveness of surgical aggression protection in cardiac surgery. Objectives: To study the effectiveness of body protection against surgical aggression by TIVA and inhalational anaesthesia in cardiac surgery. Materials and methods. The examination and treatment data of 89 patients were included in the study. All patients underwent coronary artery bypass grafting, mitral valve replacement/plasty, aortic valve replacement cardiopulmonary bypass conditions. The patients were divided into 2 groups according to the type of disease: the first (1) group with coronary heart disease. The second (2) group with valvular heart disease. There were 65 patients in the first group and 22 in the second. Both groups were divided into 3 subgroups according to the type of anaesthesia: patients anaesthetised with propofol, with sevoflurane, with isoflurane.

NCT ID: NCT05694065 Not yet recruiting - Clinical trials for Ischemic Heart Disease

Functional Assessment by UFR in Patients With Suspected Ischemic Heart Disease (FEATURE)

Start date: January 30, 2023
Phase:
Study type: Observational

Investigating the diagnostic accuracy of online Ultrasonic Flow Ratio (UFR) assessment to identify hemodynamically significant coronary stenosis in patients with suspected ischemic heart disease using angiography-derived fractional flow reserve (FFR) as a reference standard.