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Cancer clinical trials

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NCT ID: NCT04270916 Suspended - Cancer Clinical Trials

Prevalence and Impact on QoL From Ototoxicity in Cancer Survivors

Start date: February 3, 2020
Study type: Observational

This study will involve collaborating with oncologists in the post-chemotherapy follow-up appointments. The participants who wish to consent to this study will then answer 3 short questionnaires (THI, HHIA and SF-36) about hearing loss, tinnitus and quality of life. The audiologist or the researcher, under the supervision of an audiologist, will then perform a simple, non-invasive hearing test on the participant. Should the participant have a hearing loss, they will be advise to seek help from their General Practitioner.

NCT ID: NCT04097353 Suspended - Cancer Clinical Trials

Improving Health Behaviors for Pediatric Cancer Survivors

Start date: May 1, 2017
Phase: N/A
Study type: Interventional

The objective of this study is to examine the efficacy of Harvesting Hope for Kids (HH4K), a biobehavioral intervention delivered in the context of a university-based, cancer survivor garden, to increase produce intake and physical activity in survivors and caregivers.

NCT ID: NCT03959046 Suspended - Cancer Clinical Trials

GIST in Hematopoietic Stem Cell Transplantation/Bone Marrow Transplantation

Start date: May 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the efficacy of using GIST language when speaking to patients about bone marrow and hematopoietic stem cell transplantation.

NCT ID: NCT03919214 Suspended - Hypertension Clinical Trials

Hypertension Management in Cancer Patients

Start date: December 10, 2019
Phase: N/A
Study type: Interventional

The investigators propose to leverage new technology using the Qardio app for iPhone and Android devices to automatically upload blood pressures, using a well-validated blue tooth blood pressure monitor (QardioArm), directly into the Duke electronic health record system (EPIC). Further, the investigators propose to develop an automated EHR (electronic health record) messaging system utilizing the home blood pressures that will be sent to the participant's PCP, with copies to the participant and the primary oncologist. This is a 12-week prospective non-randomized implementation study. 40 patients who are 18-74 years old who fall under the following criteria will be screened: 10 women with Stage 1-III breast cancer who are receiving either an anthracycleine of antiHER2 therapy, 10 men with prostate cancer on ADT, 10 individuals with CLL on ibrutinib therapy, and 10 individuals who are hematopoietic stem cell transplantation (HSCT) survivors. In Phase 1 (Weeks 1-4) of the study, participants will self-monitor their blood pressure using the QardioArm wireless upper arm blood pressure monitor 3 times per week. In Phase 2 (Weeks 5-12), the investigators will implement the auto-messaging system triggered by an abnormal weekly average systolic or diastolic blood pressure. The investigators will adapt the conceptual framework of Muldoon and colleagues whereby home blood pressure monitoring is combined with office blood pressures to optimize data for the primary care provider's clinical decision making. {Participants will be asked to complete a paper survey, upon enrollment, that will include life chaos and medication adherence questions. There will also be an end-of-study feedback survey (usability and acceptability questions through REDCap) for both the participants and their primary care providers. This is an implementation study with a descriptive analysis. The data generated from the study will be used in future studies, including testing of different interventions aimed at optimizing blood pressure control among patients on active cancer therapy. This study presents no greater than minimal risk to the subjects and adverse events are not anticipated.

NCT ID: NCT03574194 Suspended - Breast Cancer Clinical Trials

Methionine-Restricted Diet to Potentiate The Effects of Radiation Therapy

Start date: June 12, 2018
Phase: N/A
Study type: Interventional

A diet consisting of a reduced quantity of the essential amino acid methionine sensitizes cancer cells to radiation therapy and reduces metastasis formation and disease progression in mice. However, to date, dietary restriction of methionine has not been tested in combination with radiation therapy in humans as a strategy to improve patient outcomes.

NCT ID: NCT03082612 Suspended - Cancer Clinical Trials

Overcoming Psychological Distress Through Hymns

Start date: June 28, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the feasibility and acceptability of an intervention designed to reduce psychological distress among African Americans during treatment for cancer. This knowledge will inform a larger test of an intervention tailored to decrease the psychological distress experienced among African Americans diagnosed with late-stage cancers. Study participants will take part in 4 data collection sessions and also asked to view and provide feedback on audio- or video recorded vignettes of African Americans use of hymns to reduce psychological distress during the diagnosis and treatment for cancer. Participants will also be asked to complete interviews at the 4 time periods which will include open-ended, semi-structured interviews, and structured interview questions. This study addresses the need to understand the ways in which narrated messages of hope through hymns and African American religious song in particular, reduce psychological distress.

NCT ID: NCT02469129 Suspended - Cancer Clinical Trials

PET Imaging of PARP Activity in Cancer

Start date: March 2015
Phase: Early Phase 1
Study type: Interventional

The purpose of this research study is to determine the feasibility of using positron emission tomography (PET) imaging technology to image cancer with [18F]FluorThanatrace ([18F]FTT), a new radioactive tracer compound that has been developed that images poly(ADP-ribose) polymerase 1 (PARP-1) activity.

NCT ID: NCT01604863 Suspended - Cancer Clinical Trials

A Study of HGS1036 in Combination With Chemotherapy in Subjects With Advanced Solid Malignancies

Start date: June 2012
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to determine the maximally tolerated dose (MTD) of HGS1036 when used in combination with the standard chemotherapeutic regimens paclitaxel plus carboplatin, cisplatin plus etoposide, or docetaxel.

NCT ID: NCT01050725 Suspended - Cancer Clinical Trials

Pilot Study of Biomarkers for Radiation Therapy

Start date: November 2009
Phase: N/A
Study type: Observational

The purpose of this study is to determine whether specific assays of DNA damage repair proteins can be used in patients undergoing radiation therapy. The ultimate goal of this research is to develop clinically useful biomarkers from blood samples that could be used to customize radiation treatment for individuals, leading to reduced side effects and improved outcomes.

NCT ID: NCT00523094 Suspended - Cancer Clinical Trials

Vibration Response Imaging (VRI) in Patients That Are Candidates for Undergoing Pulmonary Operation Procedure

Start date: September 2007
Phase: N/A
Study type: Observational

The primary objective of this study is to estimate the accuracy of the pre-operative VRI quantitative results versus the gold standard pre-operative perfusion scan. The secondary objective is to assess the correlation of the predicted post-operative lung function with the observed post-operative lung function (forced expiratory volume in 1 second [FEV1] and diffusing capacity of the lung for carbon monoxide [DLCO]) in patients who underwent surgical resection.