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NCT ID: NCT05204290 Not yet recruiting - Cancer Clinical Trials

A Pilot Study of Combined Decompressive Spine Radiosurgery and Pembrolizumab

Start date: April 2022
Phase: Early Phase 1
Study type: Interventional

The purpose of this research study is to find out what effects (good and bad) Pembrolizumab and radiosurgery have on participants with high-grade epidural disease of the spine.

NCT ID: NCT05201014 Not yet recruiting - Cancer Clinical Trials

Cancer Survivor Cardiomyopathy Detection

CASCADE
Start date: January 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to improve the cardiovascular care of adult cancer survivors. The goal is to obtain the data necessary to plan and develop a nation-wide network of a screening program that can help provide cost-effective and long-term monitoring.

NCT ID: NCT05192837 Not yet recruiting - Cancer Clinical Trials

Preoperative Smoking Cessation in Patients Undergoing Surgery

PORTICO
Start date: April 1, 2022
Phase: N/A
Study type: Interventional

Background: At present, effectively implementing smoking cessation programs in the health care system constitutes a major challenge. A unique opportunity to initiate smoking cessation focuses on smokers scheduled for surgery. These patients are not only highly motivated to quit smoking but also likely to benefit from a reduction in postoperative complications which may translate into a decrease of costs. Nevertheless, surgical patients are not routinely informed about the benefits of preoperative smoking cessation. Potential reasons for this missed opportunity may be lack of time and training of surgeons and anesthesiologists. We therefore aim to analyse the impact of a preoperative high-intensity smoking cessation intervention on surgical complications up to a 90-day postoperative period in patients of various surgical disciplines. The hypothesis is that preoperative smoking cessation program improves outcomes in smokers undergoing intermediate to high-risk surgery. The primary objective is to compare complications between patients with an institutional multifaceted smoking cessation intervention starting four weeks before surgery compared to patients in the advice only group (control group) within a 90-day postoperative period. The primary endpoint is the Comprehensive Complication Index (CCI®) within 90 days of surgery. Secondary outcomes include length of hospital stay, cost of hospital stay, smoking abstinence, reduction in nicotine consumption. Methods: The present study is a single center, randomized trial with two parallel groups of smokers scheduled for surgery comparing surgery alone and surgery with preoperative smoking cessation. We plan to randomize 251 patients. The primary endpoint is the Comprehensive Complication Index up to a 90-day postoperative period. The secondary endpoints include comparison of smoking abstinence, treatment fidelity, quality of life, mental health, length of stay, costs of care and difference in hospital reimbursement between the two groups. Discussion: The hypothesis is that preoperative smoking cessation program improves outcomes in smokers undergoing surgery.

NCT ID: NCT05186948 Not yet recruiting - Clinical trials for Cancer-related Cognitive Impairment

Development and Validation of a Novel Functional Eye-Tracking Software Application for Cancer-related Cognitive Impairment (CRCI)

Start date: January 20, 2022
Phase:
Study type: Observational

This study aims to develop and validate a sensitive and non-invasive eye-tracking software application.

NCT ID: NCT05166694 Not yet recruiting - Cancer Clinical Trials

Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether a consultation with a Personalized Therapeutics Clinic, or PTC, will help participants lower the risk for side effects (drug-drug interactions and drug-gene interactions) when taking many medications and help providers improve prescribing decisions for participants. A PTC is a clinical that will test your genes to gather information about your health that may help guide prescribing advice and offer you new information about your prescriptions. Doctors leading this study will look for variations (differences) in your genes that may suggest that you are at greater risk of having side effects or a greater chance of benefiting from certain medications. Individuals in this study will participate for roughly 9 months.

NCT ID: NCT05164016 Not yet recruiting - Cancer Clinical Trials

Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients

Start date: February 2022
Phase:
Study type: Observational

This study is being done because the investigators would like to learn more about how well the COVID-19 vaccine works in participants with cancer or those who have received a transplant or cellular therapy. Primary Objective Assess the immunogenicity to COVID-19 vaccination in patients with cancer and/or transplant and cellular therapy (TCT) recipients. Secondary Objectives - Evaluate the antibodies response to COVID-19 vaccination in immunocompromised patients. - Evaluate the T cell response to COVID-19 vaccination in immunocompromised patients. Exploratory Objectives - Assess incidence and severity of COVID-19 infections by 6 months following immunization with a SARS CoV-2 vaccine. - Assess the durability immune response to COVID-19 vaccination. - Assess the immunogenicity of COVID-19 vaccination in immunocompetent children and adolescents without cancer and have not undergone transplant or received cellular therapy.

NCT ID: NCT05163015 Not yet recruiting - Cancer Clinical Trials

Impact of Oncogeriatric Consultation on Quality of Life of Patients Aged 75 and More With Cancer

ONCOGERIA-QDV
Start date: February 3, 2022
Phase:
Study type: Observational

Among patients with cancer, 6 in 10 are over 65 years of age. In order to improve quality of life of aged cancer patients, the oncogeriatric consultation has been created. Oncogeriatric consultation aim to help oncologists determine the best solutions to combine therapy and quality of life. Factors influencing quality of life of cancer patients have been studied previously. However, these studies always focus on one specific cancer.

NCT ID: NCT05162404 Not yet recruiting - Cancer Clinical Trials

Video Education to Improve Rural Cancer Care Delivery

Start date: January 15, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to understand if a video-based education program delivered on a tablet device will improve care coordination experiences for patients with cancer living in rural areas.

NCT ID: NCT05155605 Not yet recruiting - Cancer Clinical Trials

PATHFINDER 2: A Multi-Cancer Early Detection Study

Start date: December 2, 2021
Phase: N/A
Study type: Interventional

This is a prospective, multi-center interventional study of the GRAIL multi-cancer early detection test with return of test results for participants enrolled through healthcare systems in North America. The purpose of this study is to evaluate the safety and performance of the GRAIL multi-cancer early detection test in a population of individuals who are eligible for guideline-recommended cancer screening. In cases with a "cancer signal detected" test result, participants will undergo diagnostic procedures based on the test returned cancer signal origin(s) to determine if they have cancer. The number and types of diagnostic procedures required to achieve diagnostic resolution will be assessed. Participant-reported outcomes will be collected at several time points to assess participants' perceptions about the multi-cancer early detection test. The study will enroll approximately 10,000 participants as defined by eligibility criteria over an anticipated enrollment period of approximately 10 months at up to 30 clinical institutions within North America. Participants will be actively followed for approximately 3 years from the date of their enrollment.

NCT ID: NCT05153447 Not yet recruiting - Cancer Clinical Trials

A Multicomponent Technology Supported Care Delivery for Older Patients With Hematologic Malignancies (The M-Tech Study)

M-Tech
Start date: February 1, 2022
Phase: N/A
Study type: Interventional

This is a randomized controlled trial to assess the feasibility and preliminary efficacy of a multicomponent technology-supported care delivery intervention trial in 110 older patients with hematologic malignancies [acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), multiple myeloma (MM), and diffuse large b-cell lymphoma (DLBCL)] receiving outpatient chemotherapy on treatment-related toxicities, patient-reported outcomes, healthcare utilization, and inflammatory and epigenetic markers.