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NCT ID: NCT05205967 Recruiting - Cancer Clinical Trials

REFLECTION: A Clinical Practice Learning Program for Galleri

Start date: August 23, 2021
Phase:
Study type: Observational [Patient Registry]

REFLECTION is a prospective cohort study that will enroll approximately 35,000 patients who have opted to be screened with Galleri, a blood-based, multi-cancer early detection (MCED) test as part of their routine medical care. The purpose of the study is to understand the performance of the test in clinical settings and the impact on patients and healthcare providers.

NCT ID: NCT05203614 Recruiting - Cancer Clinical Trials

Positive Activities for Asian American Cancer Patients and Caregivers

Start date: November 30, 2021
Phase: N/A
Study type: Interventional

Positive Activities for Asian American Cancer Patients and Caregivers

NCT ID: NCT05203250 Recruiting - Cancer Clinical Trials

Longitudinal Registry Including Patients Treated With Heavy Particles

Start date: June 4, 2021
Phase:
Study type: Observational [Patient Registry]

The purpose of this registry is to collect retrospective and prospective standardized data of patients treated with particle therapy, either with protons or carbon ions, at the National Center for Oncological Hadrontherapy (CNAO) based in Pavia. By keeping track of the patients treated, it will allow the investigators to periodically analyze and evaluate data collected of daily clinical activity. This will help gathering more information on the results of particle therapy and will provide the basis for in depth evaluation of patients' outcome with respect to the delivered treatment.

NCT ID: NCT05197348 Recruiting - Cancer Clinical Trials

Spanish Meaning-Centered Psychotherapy for Cancer

Start date: January 2, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to verify the efficacy of the Spanish adaptation of Meaning-Centered Psychotherapy for Spanish participants with cancer in a randomized control trial.

NCT ID: NCT05187845 Recruiting - Cancer Clinical Trials

Geriatric-oncological Study on Quality of Life and Independence After Radiotherapy

GOLD-I
Start date: February 1, 2021
Phase:
Study type: Observational

Elderly patients * with multiple comorbidities are underrepresented in most radio-oncology studies. In times of individualized therapy and when weighing up oncological over- or under-therapy, this observational study is a step towards the implementation of established geriatric instruments and concepts in radiation oncology. As part of the initial outpatient consultation on radiotherapy, the quality of life of patients older than 70 years before the start of therapy is assessed using the EORTC QLQ-C30 and ELD14 questionnaires. Furthermore, a geriatric screening is carried out using the G8 questionnaire. The geriatric screening carried out in routine clinical practice with little effort is used to filter out patients with no risk of increased vulnerability - these participants do not require any further examinations.

NCT ID: NCT05181826 Recruiting - Cancer Clinical Trials

Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer

ELITE
Start date: May 21, 2019
Phase:
Study type: Observational

To acquire blood samples from subjects for various purposes, including: i) determining the sensitivity and specificity of select DNA methylation markers for the detection of various types of cancer, ii) identifying benign conditions that may induce false positive or false negative results, and iii) defining the effects of potential interfering substances, such as chemotherapy drugs.

NCT ID: NCT05176743 Recruiting - Cancer Clinical Trials

Food Insecurity in Oncology

FIOnc
Start date: August 30, 2021
Phase: N/A
Study type: Interventional

This trial will examine the feasibility and preliminary effectiveness of providing unconditional cash transfers to food insecure female breast and gynecologic cancer patients. Approximately one-third of cancer survivors report food insecurity, characterized by limited access to adequate food for active, healthy living because of a lack of money and other resources. Unconditional cash transfers offer direct monetary assistance that can be used to meet immediate food or other financial needs and may positively impact health care resource utilization and health-related quality of life.

NCT ID: NCT05170347 Recruiting - Cancer Clinical Trials

oGVHD After Bone Marrow Transplantation: a Territory-wide Cohort

Start date: April 30, 2021
Phase:
Study type: Observational [Patient Registry]

Allogeneic Haematopoietic stem cell transplantation (HSCT) is an effective treatment for all array of blood or blood-producing organ disorders. Graft-versus-host-disease (GVHD) occurs as a result of an overactive immunological system against normal host tissues. It can happen in the liver, skin, mucosal surface of the eye, gastrointestinal tract, and genitalia. Ocular GVHD occurs in 30-70% of patients after HSCT. It mainly affects the ocular surface, including the conjunctiva and cornea. In severe cases, multiple clinical manifestations can lead to painful non-healing corneal ulcers, secondary infections, and visual loss. oGVHD can be debilitating and severely impact patients' quality of life. However, there are no widely accepted guidelines available for prevention and management. In collaboration with the Department of Haematology of Queen Mary Hospital, the investigators set out to establish a territory-wide cohort of patients receiving HSCT. Primarily, the investigators aim to establish the population-based epidemiology of oGVHD and understand the natural history and the long-term ophthalmic outcomes of oGVHD via this study.

NCT ID: NCT05163028 Recruiting - Cancer Clinical Trials

A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations

Start date: December 13, 2021
Phase: Phase 1
Study type: Interventional

A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS or EGFR mutations to determine the maximum tolerated dose and recommended Phase II dose of HBI-2376 and characterize its pharmacokinetic profile.

NCT ID: NCT05162807 Recruiting - Cancer Clinical Trials

Intervention to Improve Caregiver Palliative Care Knowledge and Attitudes

Start date: December 19, 2021
Phase: N/A
Study type: Interventional

This randomized clinical trial will assess whether a psychoeducational intervention will improve palliative care knowledge and attitudes among caregivers of individuals with cancer. The psychoeducational intervention entails viewing a video introducing palliative care and its purpose, structure, benefits, and efficacy.