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NCT ID: NCT03251924 Not yet recruiting - Cancer Clinical Trials

A Dose Escalation and Combination Immunotherapy Study to Evaluate BMS-986226 Alone or in Combination With Nivolumab or Ipilimumab in Patients With Advanced Solid Tumors

Start date: August 28, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to investigate BMS-986226 administered alone or in combination with nivolumab or ipilimumab.

NCT ID: NCT03248635 Not yet recruiting - Cancer Clinical Trials

Questionnaire Pre-Test Study

Start date: August 23, 2017
Phase: N/A
Study type: Observational

Background: The Division of Cancer Epidemiology and Genetics does research into the causes of cancer and ways to prevent it. It uses data from questionnaires. Sometimes, pre-testing a questionnaire with a group of volunteers can help researchers find errors in it and learn ways to improve it. Objectives: To test a questionnaire for problems that might cause response errors and to develop ideas for improving it. To test how long it takes people to complete it. Eligibility: Adults ages 35-75. Volunteers both with and without a history of tobacco use and with or without a family history of cancer are needed. Design: Participants will be screened with a phone call. Participants will be told what background data to bring to the 1 study visit. An interviewer will give the participants the questionnaire. It will be done with pen and paper. It will take about 1 hour. There will be multiple-choice and open-ended questions. They will be about lifestyle, medical, and environmental factors. Some of the questions will be about possibly illegal or highly sensitive behaviors. Participants will note any questions that they find hard to answer for any reason. They will be asked to answer the best they can, but they can skip any question that they prefer not to answer. The personal data of participants will be deleted when the study is done. The interviewer will observe participants while they do the questionnaire. He or she will look for things like long pauses and confusion. Participants will discuss the exam with the interviewer after they finish. This will take about 1 hour.

NCT ID: NCT03247309 Not yet recruiting - Cancer Clinical Trials

TCR-engineered T Cells in NSCLC and HNSCC Patients (ACTengine)

ACTengine
Start date: August 31, 2017
Phase: Phase 1
Study type: Interventional

This clinical research study investigates IMA201 which is composed of special immune cells (T cells, also called T lymphocytes) being genetically modified by introduction of a tumor-antigen specific T cell receptor (TCR) to fight against cancer. Patients that choose to take part in this study have advanced cancer where there is no (further) standard treatment for their cancer available OR current treatments are not tolerated. The main purpose of this clinical research study is to confirm the safety of IMA201 and to define the highest safe dose of IMA201 cells to give to patients. The study will also investigate what the specific side effects of this treatment are, and to see whether this therapy shows clinical activity in patients with their advanced cancer.

NCT ID: NCT03247283 Recruiting - Cancer Clinical Trials

Pharmacokinetics and Metabolism Study in Healthy Male Participants

Start date: July 19, 2017
Phase: Phase 1
Study type: Interventional

Phase 1 Phamacokinetic and metabolism study of BMS-986205 in healthy males

NCT ID: NCT03245411 Active, not recruiting - Cancer Clinical Trials

Assessment of Multi-Level Interventions to Improve Adherence to Oral Medications in Cancer Patients

Start date: July 20, 2017
Phase: N/A
Study type: Interventional

Einstein Medical Center in Philadelphia serves a diverse group of the patient population. The majority of patients have a diverse cultural background, low literacy, and poor social-economic status. Medication adherence for chronic medical problems is in a range of 40-70%. Medication adherence among patients on oral anti-cancer therapy is not studied in detail. The main objective is to study medication adherence to oral anticancer agents in patients with low literacy and poor socio-economic status.

NCT ID: NCT03244202 Recruiting - Cancer Clinical Trials

Evaluation of a Decision Aid for Incidental Genomic Findings

Start date: September 12, 2016
Phase: N/A
Study type: Interventional

Health care providers (HCP) are increasingly using genomic sequencing (GS) to target treatment for patients. However, GS may incidentally reveal inherited risks for thousands of current and future diseases. Guidelines recommend HCP inform patients of incidental GS results. No decision aid (DA) exists to guide patients' decisions about which incidental GS results they wish to learn. This study will evaluate whether the DA followed by genetic counselling (GC) reduces decisional conflict compared to GC alone in a randomized controlled trial (RCT) with 128 patients with a family history of cancer, who have had a negative genetic test and may eligible for GS. A qualitative component with a subset of participants (n=40) will explore patients' preferences for the types of incidental results they wish to receive and their decision making process.

NCT ID: NCT03243578 Completed - Cancer Clinical Trials

Relationship Between Dietary Protein Intake and Fatal and Non-fatal Health Outcomes

Start date: April 2007
Phase: N/A
Study type: Observational

The aim of the current study was to clarify the relationship between protein intake and health by using a very large, general population cohort study, UK Biobank, to study the associations between reported protein intake (expressed in g/day, g/kg/day and % of total energy intake) and three health outcomes (all-cause mortality, incidence CVD and cancer).

NCT ID: NCT03243188 Not yet recruiting - Cancer Clinical Trials

Palliative Care in General Practice: Cancer Patient/Carer Experience

Start date: October 2017
Phase: N/A
Study type: Observational

Study Title: Palliative care in general practice: cancer patients' and carers' experience of their GP's role Study Design: Qualitative interview study Study Participants: Adult patients with cancer and palliative care needs, accompanied by their carers Planned Sample Size: Up to 30 interviews with patients +/- their carers Planned Study Period: October 2017 - December 2018 Research Question: What experience do adults with cancer, and carers, have of their GP's involvement in palliative care provision?

NCT ID: NCT03242109 Completed - Diabetes Clinical Trials

The Moli-sani Study

Start date: March 1, 2005
Phase: N/A
Study type: Observational

Cardiovascular disease and malignancies account for more than 70% of all causes of mortality and morbidity in Italy. There is a subtle balance between genetic determinants and lifestyle, that often defines the line between health and sickness. So far studies aiming at identifying risk factors have mainly come from Northern Europe and the USA. It was to understand this balance between genetics and environmental determinants better, and to tailor appropriate preventive strategies for Italian and other Southern European populations, that the Moli-sani study was launched, transforming a small Italian region into a large scientific laboratory: the "Molise lab". Each participant received a thorough medical check-up at no cost to either him/her or the national health service, resulting in thousands of hours of free public health care. With a completely computerized system, Moli-sani is a "paperless" study, in which researchers and participants communicate using recently developed technologies such as mobile phone text messages (SMS). The biological data bank (the "MoliBank") is one of the largest in Europe. Paying particular attention towards innovation and new technologies, the Moli-sani study has placed itself at the cutting edge of a new paradigm crossing research and prevention

NCT ID: NCT03240341 Not yet recruiting - Cancer Clinical Trials

Influence of PARAmedical Interventions on Patient ACTivation in the Cancer Care Pathway

PARACT
Start date: September 1, 2017
Phase: N/A
Study type: Interventional

The aim is to implement the Patient Activation Measure in paramedical practices as a tool to measure activation of patients in cancer care