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Cancer clinical trials

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NCT ID: NCT05181826 Recruiting - Cancer Clinical Trials

Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer

Start date: May 21, 2019
Study type: Observational

To acquire blood samples from subjects for various purposes, including: i) determining the sensitivity and specificity of select DNA methylation markers for the detection of various types of cancer, ii) identifying benign conditions that may induce false positive or false negative results, and iii) defining the effects of potential interfering substances, such as chemotherapy drugs.

NCT ID: NCT05176743 Recruiting - Cancer Clinical Trials

Food Insecurity in Oncology

Start date: August 30, 2021
Phase: N/A
Study type: Interventional

This trial will examine the feasibility and preliminary effectiveness of providing unconditional cash transfers to food insecure female breast and gynecologic cancer patients. Approximately one-third of cancer survivors report food insecurity, characterized by limited access to adequate food for active, healthy living because of a lack of money and other resources. Unconditional cash transfers offer direct monetary assistance that can be used to meet immediate food or other financial needs and may positively impact health care resource utilization and health-related quality of life.

NCT ID: NCT05171426 Completed - Cancer Clinical Trials

Incidental Cancer in Familial Adenomatous Polyposis

Start date: January 1, 2018
Study type: Observational

Colectomy is life-saving in patients with familial adenomatous polyposis (FAP) because cancer development is inevitable in individuals with this disease. In this study, we aimed to determine the incidence of incidental malignancy in surgical specimens from patients who underwent colectomy for FAP. Prophylactic colectomy should be performed in patients with FAP, as colorectal cancer transformation is inevitable in these individuals. The possibility of incidental cancer identified via histopathological analysis of colectomy specimens should be kept in mind in these patients.

NCT ID: NCT05170347 Recruiting - Cancer Clinical Trials

oGVHD After Bone Marrow Transplantation: a Territory-wide Cohort

Start date: April 30, 2021
Study type: Observational [Patient Registry]

Allogeneic Haematopoietic stem cell transplantation (HSCT) is an effective treatment for all array of blood or blood-producing organ disorders. Graft-versus-host-disease (GVHD) occurs as a result of an overactive immunological system against normal host tissues. It can happen in the liver, skin, mucosal surface of the eye, gastrointestinal tract, and genitalia. Ocular GVHD occurs in 30-70% of patients after HSCT. It mainly affects the ocular surface, including the conjunctiva and cornea. In severe cases, multiple clinical manifestations can lead to painful non-healing corneal ulcers, secondary infections, and visual loss. oGVHD can be debilitating and severely impact patients' quality of life. However, there are no widely accepted guidelines available for prevention and management. In collaboration with the Department of Haematology of Queen Mary Hospital, the investigators set out to establish a territory-wide cohort of patients receiving HSCT. Primarily, the investigators aim to establish the population-based epidemiology of oGVHD and understand the natural history and the long-term ophthalmic outcomes of oGVHD via this study.

NCT ID: NCT05166694 Not yet recruiting - Cancer Clinical Trials

Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether a consultation with a Personalized Therapeutics Clinic, or PTC, will help participants lower the risk for side effects (drug-drug interactions and drug-gene interactions) when taking many medications and help providers improve prescribing decisions for participants. A PTC is a clinical that will test your genes to gather information about your health that may help guide prescribing advice and offer you new information about your prescriptions. Doctors leading this study will look for variations (differences) in your genes that may suggest that you are at greater risk of having side effects or a greater chance of benefiting from certain medications. Individuals in this study will participate for roughly 9 months.

NCT ID: NCT05164016 Not yet recruiting - Cancer Clinical Trials

Evaluating Immune Response to COVID-19 Vaccines in Patients With Cancer, Transplant or Cellular Therapy Recipients

Start date: February 2022
Study type: Observational

This study is being done because the investigators would like to learn more about how well the COVID-19 vaccine works in participants with cancer or those who have received a transplant or cellular therapy. Primary Objective Assess the immunogenicity to COVID-19 vaccination in patients with cancer and/or transplant and cellular therapy (TCT) recipients. Secondary Objectives - Evaluate the antibodies response to COVID-19 vaccination in immunocompromised patients. - Evaluate the T cell response to COVID-19 vaccination in immunocompromised patients. Exploratory Objectives - Assess incidence and severity of COVID-19 infections by 6 months following immunization with a SARS CoV-2 vaccine. - Assess the durability immune response to COVID-19 vaccination. - Assess the immunogenicity of COVID-19 vaccination in immunocompetent children and adolescents without cancer and have not undergone transplant or received cellular therapy.

NCT ID: NCT05163028 Recruiting - Cancer Clinical Trials

A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations

Start date: December 13, 2021
Phase: Phase 1
Study type: Interventional

A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS or EGFR mutations to determine the maximum tolerated dose and recommended Phase II dose of HBI-2376 and characterize its pharmacokinetic profile.

NCT ID: NCT05163015 Not yet recruiting - Cancer Clinical Trials

Impact of Oncogeriatric Consultation on Quality of Life of Patients Aged 75 and More With Cancer

Start date: February 3, 2022
Study type: Observational

Among patients with cancer, 6 in 10 are over 65 years of age. In order to improve quality of life of aged cancer patients, the oncogeriatric consultation has been created. Oncogeriatric consultation aim to help oncologists determine the best solutions to combine therapy and quality of life. Factors influencing quality of life of cancer patients have been studied previously. However, these studies always focus on one specific cancer.

NCT ID: NCT05162807 Recruiting - Cancer Clinical Trials

Intervention to Improve Caregiver Palliative Care Knowledge and Attitudes

Start date: December 19, 2021
Phase: N/A
Study type: Interventional

This randomized clinical trial will assess whether a psychoeducational intervention will improve palliative care knowledge and attitudes among caregivers of individuals with cancer. The psychoeducational intervention entails viewing a video introducing palliative care and its purpose, structure, benefits, and efficacy.

NCT ID: NCT05162404 Not yet recruiting - Cancer Clinical Trials

Video Education to Improve Rural Cancer Care Delivery

Start date: January 15, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to understand if a video-based education program delivered on a tablet device will improve care coordination experiences for patients with cancer living in rural areas.