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Breast Cancer clinical trials

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NCT ID: NCT04845256 Recruiting - Breast Cancer Clinical Trials

Evaluation of SOMAVAC 100 Sustained Vacuum System

Start date: May 1, 2021
Study type: Observational

The purpose of this research study is to compare the effectiveness of the Somavac 100 Sustained Vacuum System versus manual section bulbs after immediate breast reconstruction.

NCT ID: NCT04842812 Recruiting - Breast Cancer Clinical Trials

Engineered TILs/CAR-TILs to Treat Advanced Solid Tumors

Start date: January 1, 2021
Phase: Phase 1
Study type: Interventional

Tumor infiltration lymphocytes (TILs) have been harvested from advanced cancer patients and constructed to knockout PD1 gene and express scFvs against both PD1 and CTALA4 and CARs against various antigens, followed by transfusion into the patients. The safety, tolerance, and preliminary clinical efficacy of the TILs will be evaluated.

NCT ID: NCT04842240 Recruiting - Breast Cancer Clinical Trials

Comparison of Patient Reported Outcome Measures Using the BREAST-Q Questionnaire in Patients Undergoing Pre Versus Sub-pectoral Implant Based Immediate Breast Reconstruction.

Start date: September 1, 2019
Study type: Observational

The PROM Q study aims to compare patient reported outcome measures (PROMs) in patients undergoing mastectomy and immediate implant based breast reconstruction (IBR). This is the commonest form of breast reconstruction and current advances in surgical technology have led to increasing number of patients having implants placed above the pectoral muscle (pre-pectoral), rather than below it (sub-pectoral). This has important benefits for patients including shorter surgery time, quicker recovery, and avoidance of animation deformity (visible muscle twitching of the reconstructed breast) as the pectoral muscle is not divided to cover the implant. However, potential disadvantages include rippling effect as the implant is covered by the skin and subcutaneous tissue only, as well as potentially higher risk of capsule (scar tissue) formation. By utilising a validated questionnaire (BREAST-Q), we will assess for any difference in PROMs between the two groups of patients. The results will provide valuable information for future patients when making an informed decision about their reconstruction options. This questionnaire study will include consecutive patients undergoing mastectomy and immediate IBR for breast cancer as well as for risk reduction at Leeds Teaching Hospitals NHS Trust. The study participants will undergo either pre- or sub-pectoral IBR based on their informed discussion with the clinical team. This is a non-randomised observational study.

NCT ID: NCT04841928 Recruiting - Breast Cancer Clinical Trials

Optimizing Psychological Treatment for Pain After Breast Cancer: A Pilot Study

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

The present study is a pilot study that aims to evaluate the feasibility, validity, and preliminary efficacy of three psychological treatment components for pain after breast cancer, which will be evaluated in a larger trial following completion of the present pilot study.

NCT ID: NCT04841252 Recruiting - Breast Cancer Clinical Trials

Classification of Breast Masses Based on Visco-elastic Properties Using SAVE Method

Start date: December 19, 2012
Study type: Observational

The purpose of this research is to conduct a clinical study to evaluate the efficacy of a noninvasive and quantitative tool for classification/diagnosis of breast masses. The main objective of this proposal is to test the SAVE (Sub-Hertz Analysis of Visco-Elasticity) method on a patient population of sufficient size to determine the sensitivity and specificity for malignant-benign discrimination of breast masses.

NCT ID: NCT04837820 Recruiting - Breast Cancer Clinical Trials

The Effect of Acupuncture on Cancer-Related Cognitive Difficulties

Start date: April 6, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test whether acupuncture can improve cognitive difficulties and insomnia in survivors of breast cancer. Researchers will compare the effects of real acupuncture with those of placebo acupuncture and wait-list acupuncture. This study will also look at insomnia's link to cognitive difficulties.

NCT ID: NCT04834570 Recruiting - Breast Cancer Clinical Trials

Breast Cancer Survivors: Main Physical and Psychosocial Problems After Completion of Treatment

Start date: October 5, 2020
Study type: Observational

Breast cancer directly affects women physically, psychologically and socially in the process of diagnosis, treatment and post-treatment. Despite the improvement in conventional breast cancer treatments that led to longer disease-free survival, many patients still suffer from physical, psychological, social and spiritual problems after treatment. The neglect of physical and psychosocial problems faced by patients who are between 1 and 2 years after the end of treatment negatively impacts the quality of life of this population.

NCT ID: NCT04834154 Recruiting - Breast Cancer Clinical Trials

Mental Health Disparities in Spanish Speaking Latina Breast Cancer Patients

Start date: March 15, 2021
Phase: N/A
Study type: Interventional

The purpose of the study is to:Translate a mindfulness program into Spanish for Latina patients with breast cancer.Train a community health worker to facilitate the mindfulness program. Determine if this program is culturally acceptable and feasible, and Obtain pilot data on the program's effectiveness in reducing anxiety and depression

NCT ID: NCT04832594 Recruiting - Breast Cancer Clinical Trials

Using AI to Select Women for Supplemental MRI in Breast Cancer Screening

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

This is a prospective clinical trial aiming to determine the ability of an AI pipeline to identify women who would benefit from supplemental MRI in terms of decreasing the number of cancers having a significantly delayed detection

NCT ID: NCT04829643 Recruiting - Breast Cancer Clinical Trials

Axillary Staging in Early Breast Cancer: SNB vs PET/MRI

Start date: July 3, 2020
Phase: N/A
Study type: Interventional

The gold standard of surgical treatment for patients with early breast cancer (BC) is breast conservation and sentinel node biopsy (SNB). Ongoing randomized trials are evaluating to omit surgery at all when axillary imaging is negative. However, the available diagnostic tools still have several limitations in accuracy. Combining the specificity of PET, with the superior sensitivity of MRI, hybrid PET/MRI might be a non-invasive, one-stage, operator-independent imaging method to accurately define nodal status and, whenever negative, might replace surgery for axillary staging. The project includes patients with <3 cm BC without overt nodal involvement who will undergo PET/MRI prior to surgery. The primary aim is to compare the staging power between SNB and PET/MRI in detecting axillary lymph node macrometastases (>2 mm). Additionally, general concordance and diagnostic accuracy of PET/MRI vs SNB, eventual correlation with BC molecular subtypes and MRI findings will be evaluated.