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Breast Cancer clinical trials

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NCT ID: NCT05203029 Recruiting - Clinical trials for Breast Cancer Survivors

Effectiveness of Aerobic Exercises and Laughter Yoga Compared With Yoga in Anxiety/Depression Levels in Breast Cancer

Start date: January 5, 2022
Phase: N/A
Study type: Interventional

90% of breast cancer survivors experience cancer-related fatigue which decreases the physical activity. Moreover, due to the cancer treatments depression and anxiety will be happened. Previous studies showed the effect of physical activity on reduction of depression and anxiety; therefore the aim of this study is to evaluate the effectiveness of aerobic exercises and laughter yoga compared with yoga in anxiety and depression levels in breast cancer survivors.

NCT ID: NCT05201963 Recruiting - Breast Cancer Clinical Trials

Erector Spinae Plane Block Versus Serratus Anterior Block on Post Mastectomy Pain Syndrome

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Breast cancer is the most common malignancy among females. Nearly 40-60% of breast surgery patients experience severe acute postoperative pain, with severe pain persisting for 6-12 months in almost 20-50% of patients (post mastectomy pain syndrome) which is defined according to International Association for the Study of Pain (IASP) as pain which persists more than 3 months after mastectomy/lumpectomy affecting the anterior thorax, axilla, and/or medial upper arm. Regionale anesthesia is one of the strategies with the potential to prevent the development of chronic pain following breast surgery. We hypothesize that erector spinae plane block is going to be more effective than serratus anterior plane block in the prevention of postmastectomy pain syndrome.

NCT ID: NCT05200078 Recruiting - Breast Cancer Clinical Trials

Deep Inspiration Breath-hold Radiotherapy for Left-sided Breast Cancer

Start date: September 1, 2021
Phase:
Study type: Observational

Postoperative breast radiotherapy (RT) has been associated with increased risk of heart toxicity. However, there is a lack of knowledge for radiation-induced early cardiovascular injury, especially for hypofractionated RT. This study aims to prospectively detect and predict early clinical or subclinical cardiac events in women undergoing adjuvant RT for breast cancer.

NCT ID: NCT05192278 Recruiting - Breast Cancer Clinical Trials

Comparison of Different Volumes Spread of Erector Spinae Block in Post Mastectomy Pain Syndrome Management

Start date: December 12, 2021
Phase: Phase 2
Study type: Interventional

Cancer breast is one of the most common tumors among women and surgery is still the key for its management and cure. Post-mastectomy pain control is crucial as acute postoperative pain is a significant factor in the development of persistent chronic pain in the form of post-mastectomy pain syndrome. Post-mastectomy pain syndrome (PMPS) is a common complication after breast cancer surgery and is often challenging to manage. It is estimated that PMPS occurs in 20%-44% of patients after breast surgery. Adequate pain control for PMPS has become one of the most important goals and recently can achieve by multiple tools including multimodal analgesia and regional techniques. Erector spinae block (ESB) is one of the new described regional techniques. Although its mechanism is not clear, the published data agree that it is promising block for chronic and acute pain and its simplicity and safety compared with thoracic epidural or bilateral paravertebral blocks. ESB can be performed using a superficial approach between the large rhomboid muscle and the erector spinae muscle or the deep method beneath the erector spinae. The use of the ESPB for chronic pain has recently expanded for various neuropathic pain conditions. Also, it reported with several volumes range from 10 to 30 ml of total volume.

NCT ID: NCT05190770 Recruiting - Breast Cancer Clinical Trials

A Study of Oleogel-S10 Gel for the Treatment of Radiation Dermatitis in People With Breast Cancer

Start date: December 15, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is find out whether Oleogel-S10 is an effective treatment for radiation dermatitis when it is used in combination with a standard wound treatment cream called triamcinolone. Oleogel-S10 has shortened the healing time for other types of skin wounds such as burns. Triamcinolone is a cream that is frequently used to treat moderate to severe skin conditions such as skin irritation caused by poison ivy, eczema, sunburn, and rashes.

NCT ID: NCT05189535 Recruiting - Clinical trials for Breast Cancer Female

"Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"

Start date: October 3, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of this study is to evaluate the effect of pentoxifylline 400 mg twice daily administration on the prevention of paclitaxel-Induced peripheral neuropathy in breast cancer patients.

NCT ID: NCT05187338 Recruiting - Breast Cancer Clinical Trials

Triplex Checkpoint Inhibitors Therapy for Advanced Solid Tumors

Start date: November 1, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

This trial is designed to investigate the safety, response rates and survival outcomes of patients with advanced solid tumors by infusion of CTLA4, PD1 and PDL1 antibodies combination through venous (IV), artery (IA) or intra-tumor (IT).

NCT ID: NCT05180851 Recruiting - Breast Cancer Clinical Trials

Safety and Efficacy of Recombinant L-IFN Adenovirus Injection in Relapsed/Refractory Solid Tumors Clinical Study

YSCH-01
Start date: November 30, 2021
Phase: Early Phase 1
Study type: Interventional

This is an open-label, dose escalation study of the safety and tolerability of Recombinant L-IFN adenovirus injection(YSCH-01) when administered via intratumoral injection in patients with advanced solid tumors. The purpose of this study is to assess the safety and tolerability of Recombinant L-IFN adenovirus injectionand to determine the recommended phase 1 dose for further study. The study will also evaluate antitumor activity, objective response rate, pharmacokinetics and virus shedding of Recombinant L-IFN adenovirus injection

NCT ID: NCT05180656 Recruiting - Breast Cancer Clinical Trials

Feasibility of a Remotely-Delivered Yoga Intervention on Cognitive Function in Breast Cancer Survivors

Start date: December 13, 2021
Phase: N/A
Study type: Interventional

The purpose of this pilot study is to assess the feasibility of a remotely-delivered yoga intervention for breast cancer survivors.

NCT ID: NCT05180474 Recruiting - Breast Cancer Clinical Trials

Research Trial to Study Safety of GEN1047 (DuoBody®-CD3xB7H4) in Participants With Malignant Solid Tumors

Start date: December 13, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

The drug that will be investigated in the study is an antibody, GEN1047. Since this is the first study of GEN1047 in humans, the main purpose is to evaluate safety. Besides safety, the study will determine the recommended GEN1047 dose to be tested in a larger group of participants and assess preliminary clinical activity of GEN1047. GEN1047 will be studied in a broad group of cancer patients, having different kinds of solid tumors. All participants will get GEN1047. The study consists of two parts: Part 1 tests increasing doses of GEN1047 ("escalation"), followed by Part 2 which tests the recommended GEN1047 dose from Part 1 ("expansion").