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Breast Cancer clinical trials

View clinical trials related to Breast Cancer.

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NCT ID: NCT05170087 Active, not recruiting - Breast Cancer Clinical Trials

Radiomic Analysis for Predicting Treatment Response and Clinical Outcomes in Malignancies

Start date: March 2, 2020
Phase:
Study type: Observational

In this study, the investigators aim to undertake a retrospective analysis of CT and MRI scans for patients undergoing radiation treatment to develop radiomic signatures to predict treatment response and clinical outcomes.

NCT ID: NCT05160324 Active, not recruiting - Breast Cancer Clinical Trials

T1-T2 Breast Cancer: Comparison Between Removal and Preservation of Axillary Lymph Nodes (SINODAR ONE)

SINODAR ONE
Start date: April 14, 2015
Phase: N/A
Study type: Interventional

Italian Multicentric non inferiority two-arm randomized clinical trial to verify that the experimental treatment (omission of axillary lymph node intervention) in the presence of sentinel lymph node metastases does not lead to a significant worsening in survival or in the risk of locoregional recurrence compared to standard treatment (removal of I-II level of axillary lymph nodes).

NCT ID: NCT05137067 Active, not recruiting - Breast Cancer Clinical Trials

A Novel Approach for Alleviating the Side Effects of Chemotherapeutic Agents.

Start date: January 20, 2021
Phase: Phase 2
Study type: Interventional

This study will assess the effectiveness of a natural nutraceutical in treating the known side effects of chemotherapeutic agents in cancer patients.

NCT ID: NCT05118568 Active, not recruiting - Breast Cancer Clinical Trials

Assessment of Lumpectomy Margins With the Histolog Scanner in Comparison With Intraoperative Imaging Techniques

Polarhis
Start date: October 1, 2020
Phase:
Study type: Observational

Study to assess the capability of using the Histolog Scanner, a recent large field-of-view confocal laser scanning medical imaging device for the breast cancer detection in fresh lumpectomy margins.

NCT ID: NCT05089903 Active, not recruiting - Breast Cancer Clinical Trials

Breast Cancer Outreach Among Primary Care Patients

Start date: October 25, 2021
Phase: N/A
Study type: Interventional

This project aims to evaluate different approaches to increase breast cancer screening among primary care patients at Penn Medicine through a centralized screening outreach program. In a pragmatic trial, the investigators will evaluate different approaches to increase completion of screening among eligible patients, including ordering mammograms in bulk prior to outreach, sending personalized text reminders, and endorsing of the communication by the primary care provider.

NCT ID: NCT05062538 Active, not recruiting - Breast Cancer Clinical Trials

Cancer Patient Perspectives During COVID-19

Start date: August 24, 2020
Phase:
Study type: Observational

A web-based survey will be emailed to all adult women diagnosed with invasive breast cancer or ductal carcinoma in situ who have been seen as surgical consultations within the last year (06/01/19-06/01/20).

NCT ID: NCT05009849 Active, not recruiting - Clinical trials for Breast Cancer Patients

Role of Exercise in Breast Cancer Patient Undergoing Treatment

Start date: November 23, 2010
Phase: N/A
Study type: Interventional

Randomized controlled trial to evaluate the impact of yoga on QOL is also powered to evaluate the impact of yoga on survival. Study involves various phases of yoga(divided in three phases: Phase I/II/III) during treatment and survivorship, with a comparative analysis of different time points and the response to yoga, which will help integrating yoga as a complementary modality. Also, this study will help identify the long term and short term effects of this therapy in breast cancer patients and survivors. One of the main differences between yoga and other forms of physical activity is that yoga exercises oppose violent muscle movement and is designed to counteract fatigue through relaxation and breathing. 6 monthly Follow Up will be for 5 years followed by yearly follow up.

NCT ID: NCT04986306 Active, not recruiting - Breast Cancer Clinical Trials

The Validation of Sentinel Lymph Node Biopsy After Neo-adjuvant Chemotherapy in Breast Cancer Patients

Start date: May 20, 2021
Phase:
Study type: Observational [Patient Registry]

Neoadjuvant or primary systemic treatment is increasingly applied in the treatment of operable breast cancer. Down staging of the primary tumor is one of the important goals of neoadjuvant chemotherapy treatment (NCT), thereby permitting breast-conserving treatment without affecting the risk for a local relapse. Complete pathological response (pCR) rates after NCT vary across histological subtypes and can be more than 60% in HER2-positive disease with dual blockade therapy. Down staging of the axilla is also observed in patients initially presenting with metastatic lymph nodes. pCR rates in the axilla vary between 22% and 42% in reported series, again depending on tumor subtype. Omission of axillary lymph node dissection (ALND) can avoid the post-operative morbidity such as lymphedema in the short or long term follow-up. Metastatic lymph node status is hard to be stated as a pCR in the axilla by using physical examination or imaging such as ultrasonography or tomography after complete NCT. Good response to the axilla lymph node causing the difficulty of tissue proof by using core needle biopsy, though the investigator knew that biopsy stands for the definite tool for the confirmation of the residual disease. One proposed method to decrease the false-negative rate (FNR) is clip placement in the positive node at initial diagnosis with confirmation of clipped node resection at surgery. The correlation between the axillary lymph node identified on initial axillary ultrasound and the sentinel lymph nodes (SLNs) identified at surgery has not been fully evaluated. The concordance between percutaneous biopsy and the lymph node resected at the time of SLNB is not 100%. Sometimes, the initial node identified by ultrasound is not one of the SLNs. The impairment of the performance of SLNB might correlated to the alteration of lymphatic flow induced by tissue fibrosis or tumor deposits after NCT. The investigator hypothesized that the clip placement at diagnosis of node-positive disease with removal of the clipped node during SLNB reduces the FNR of SLNB after NCT. Here, we evaluate how often the lymph node containing the clip placed at percutaneous biopsy before chemotherapy was found at surgery to be one of the SLNs, and how often it was found in the nodes retrieved at ALND. In addition, the investigator report the impact of identification of the clipped node within the SLNs on the FNR of SLNB.

NCT ID: NCT04976556 Active, not recruiting - Breast Cancer Clinical Trials

Breast Cancer Detection in Breast Surgical Specimens With the Histolog Scanner, Slide-free Confocal Microscope

Hibiscuss
Start date: June 26, 2019
Phase:
Study type: Observational

Study to assess the capability of physicians (breast surgeons and pathologists) to recognize breast cancer in images of fresh lumpectomies generated with the Histolog Scanner, a recent large field-of-view confocal laser scanning medical imaging device.

NCT ID: NCT04974567 Active, not recruiting - Breast Cancer Clinical Trials

Tear Based Sample Collection Breast Cancer Detection

Start date: April 28, 2021
Phase:
Study type: Observational

This study aims to collect tear samples from 50 women who have been recently diagnosed with breast cancer.