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Breast Cancer clinical trials

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NCT ID: NCT04842240 Recruiting - Breast Cancer Clinical Trials

Comparison of Patient Reported Outcome Measures Using the BREAST-Q Questionnaire in Patients Undergoing Pre Versus Sub-pectoral Implant Based Immediate Breast Reconstruction.

PROM-Q
Start date: September 1, 2019
Phase:
Study type: Observational

The PROM Q study aims to compare patient reported outcome measures (PROMs) in patients undergoing mastectomy and immediate implant based breast reconstruction (IBR). This is the commonest form of breast reconstruction and current advances in surgical technology have led to increasing number of patients having implants placed above the pectoral muscle (pre-pectoral), rather than below it (sub-pectoral). This has important benefits for patients including shorter surgery time, quicker recovery, and avoidance of animation deformity (visible muscle twitching of the reconstructed breast) as the pectoral muscle is not divided to cover the implant. However, potential disadvantages include rippling effect as the implant is covered by the skin and subcutaneous tissue only, as well as potentially higher risk of capsule (scar tissue) formation. By utilising a validated questionnaire (BREAST-Q), we will assess for any difference in PROMs between the two groups of patients. The results will provide valuable information for future patients when making an informed decision about their reconstruction options. This questionnaire study will include consecutive patients undergoing mastectomy and immediate IBR for breast cancer as well as for risk reduction at Leeds Teaching Hospitals NHS Trust. The study participants will undergo either pre- or sub-pectoral IBR based on their informed discussion with the clinical team. This is a non-randomised observational study.

NCT ID: NCT04841928 Recruiting - Breast Cancer Clinical Trials

Optimizing Psychological Treatment for Pain After Breast Cancer: A Pilot Study

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

The present study is a pilot study that aims to evaluate the feasibility, validity, and preliminary efficacy of three psychological treatment components for pain after breast cancer, which will be evaluated in a larger trial following completion of the present pilot study.

NCT ID: NCT04841252 Recruiting - Breast Cancer Clinical Trials

Classification of Breast Masses Based on Visco-elastic Properties Using SAVE Method

SAVE
Start date: December 19, 2012
Phase:
Study type: Observational

The purpose of this research is to conduct a clinical study to evaluate the efficacy of a noninvasive and quantitative tool for classification/diagnosis of breast masses. The main objective of this proposal is to test the SAVE (Sub-Hertz Analysis of Visco-Elasticity) method on a patient population of sufficient size to determine the sensitivity and specificity for malignant-benign discrimination of breast masses.

NCT ID: NCT04841148 Not yet recruiting - Breast Cancer Clinical Trials

Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

PALAVY
Start date: May 2021
Phase: Phase 2
Study type: Interventional

This clinical trial will assess the safety and early efficacy of Hydroxychloroquine or Avelumab, with or without Palbociclib, in early-stage ER+ breast cancer patients who are found to harbor disseminated tumor cells (DTCs) in the bone marrow after definitive surgery and standard adjuvant therapy.

NCT ID: NCT04839835 Enrolling by invitation - Breast Cancer Clinical Trials

Anxiety on the First Day of Chemotherapy

Start date: November 1, 2020
Phase: N/A
Study type: Interventional

investigating chemotherapy anxieties

NCT ID: NCT04838756 Enrolling by invitation - Breast Cancer Clinical Trials

Mammography Screening With Artificial Intelligence (MASAI)

MASAI
Start date: April 12, 2021
Phase: N/A
Study type: Interventional

The purpose of this randomized controlled trial is to assess whether AI can improve the efficacy of mammography screening, by adapting single and double reading based on AI derived cancer-risk scores and to use AI as a decision support in the screen reading, compared with conventional mammography screening (double reading without AI).

NCT ID: NCT04837820 Recruiting - Breast Cancer Clinical Trials

The Effect of Acupuncture on Cancer-Related Cognitive Difficulties

Start date: April 6, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test whether acupuncture can improve cognitive difficulties and insomnia in survivors of breast cancer. Researchers will compare the effects of real acupuncture with those of placebo acupuncture and wait-list acupuncture. This study will also look at insomnia's link to cognitive difficulties.

NCT ID: NCT04837677 Not yet recruiting - Breast Cancer Clinical Trials

A Study of PRT1419 in Patients With Advanced Solid Tumors

Start date: April 15, 2021
Phase: Phase 1
Study type: Interventional

This is a Phase 1 dose-escalation study of PRT1419, a myeloid cell leukemia 1 (MCL1) inhibitor, in patients with advanced solid tumors. The purpose of this study is to define the dosing schedule, maximally tolerated dose and/or estimate the optimal biological dose to be used in subsequent development of PRT1419.

NCT ID: NCT04837248 Not yet recruiting - Breast Cancer Clinical Trials

Design and Evaluation of the Effects of a Physical Therapy Program With Digital Support in Patients With Breast Cancer

Start date: May 1, 2021
Phase: N/A
Study type: Interventional

Breast cancer surgery usually results in reduced range of motion of the shoulder joint, weakness of the musculature and altered scapular kinematics during movement. These factors limit activities of daily living, so rehabilitation exercises help to restore function after shoulder surgery. Women with breast cancer often have a life conditioned by the sequelae or morbidity secondary to the treatment of the disease and, despite the high cure rate, many patients are unable to regain their initial quality of life. Cancer therapies can leave physical, psychological and psychosocial sequelae, which may manifest themselves or persist even years after the end of treatment. For all these reasons, patients who have undergone cancer treatment need physical rehabilitation as well as psychological and social care to support them in their new stage of life, and to optimise the rehabilitation programme, it is necessary to identify each patient's individual needs, The digital support proposed in this study enables the development of a physiotherapy programme for patients with breast cancer in a situation of health crisis, which includes providing assistance, information, accompaniment, help and treatment to these patients in a comprehensive way, based on the biopsychosocial model.

NCT ID: NCT04837209 Not yet recruiting - Breast Cancer Clinical Trials

Radiation, Immunotherapy and PARP Inhibitor in Triple Negative Breast Cancer

NADiR
Start date: April 2021
Phase: Phase 2
Study type: Interventional

This research study is looking to see whether the combination of Dostarlimab and Niraparib plus Radiation Therapy (RT) is safe and effective in participants with metastatic triple negative breast cancer. The names of the study treatment involved in this study are: - Dostarlimab - Niraparib - Radiation Therapy (RT), which is given per standard of care.