Stroke Clinical Trial
Official title:
An International Prospective Registry on Concomitant Use of Oral Anticoagulants and P2Y12 Inhibitors in Patients With Atrial Fibrillation or Heart Valve Prosthesis Undergoing Coronary Revascularisation.
The optimal antithrombotic therapy for patients with atrial fibrillation (AF) with a
CHA2DS2-VASc score ≥1 with concomitant acute coronary syndrome (ACS) or revascularisation by
percutaneous coronary intervention (PCI) with stenting, is still unknown. For these patients
current North American and European guidelines recommend a triple therapy strategy, including
vitamin K antagonists (VKA), aspirin and clopidogrel. A major drawback of this triple therapy
strategy is a significant increase in the risk of major bleeding. Furthermore, the ommitance
of aspirin and the introduction of more potent P2Y12 inhibitors as well as the non-vitamin K
oral anticoagulants (NOAC), created numerous new antithrombotic treatment strategies for
these patients with overlapping conditions. To date, evidence on the risks and benefits of
these new antithrombotic treatment strategies is lacking.
The WOEST 2 Registry aims to improve medical care for patients with AF and/or a heart valve
prosthesis ánd undergoing coronary revascularisation through a better understanding of their
demographics, antithrombotic management and related in-hospital and long-term outcomes. The
WOEST 2 Registry will provide data to support benchmarking of antithrombotic treatment
patterns and patient outcomes.
Objective: To assess the different management patterns and related in-hospital and long-term
safety and efficacy outcomes of combined use of chronic oral anticoagulation and a P2Y12
inhibitor in patients with atrial fibrillation and/or a heart valve prosthesis undergoing
coronary revascularisation.
The WOEST 2 Registry is a prospective, international, multi-centre, non-interventional,
cohort study designed to recruit an unselected cohort of patients with atrial fibrillation
and/or a heart valve prosthesis undergoing coronary revascularisation.
Trial overview
Name : WOEST 2 REGISTRY
Target for enrollment : 2200 patients
Time frame for inclusion : within 72 hours after index PCI or coronary artery bypass grafting
(CABG)
Follow-up : 24 months
Visits : 30 days, 12 and 24 months after index PCI or CABG
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