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Acute Coronary Syndrome clinical trials

View clinical trials related to Acute Coronary Syndrome.

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NCT ID: NCT03439449 Recruiting - Clinical trials for Acute Coronary Syndrome

Computerized Medical History Taking for Acute Chest Pain

Start date: May 1, 2017
Phase: N/A
Study type: Observational [Patient Registry]

The aim is to determine the additional value of computerized, patient-entered medical histories for the management of patients presenting at the emergency department with chest pain.

NCT ID: NCT03434483 Not yet recruiting - Diabetes Clinical Trials

The Microbiome as a Target for Precision Medicine in Atherosclerosis

Start date: February 25, 2018
Phase: N/A
Study type: Observational [Patient Registry]

Cardiovascular diseases are the main cause of death in industrialized countries. Among them, atherosclerosis has the highest prevalence and constitutes a common pathological pathway responsible for the majority of cases of chronic ischemic heart disease, acute myocardial infarction, heart failure and cerebrovascular disease. Classic studies have confirmed well-established etiopathogenic factors of atherosclerosis based on genetic and immunological components and environmental modifying agents such as diet and exercise. But in addition, recent experimental studies have shown that dysbiosis (alteration of the microbiota) may be an additional factor that participates in the onset and progression of atherosclerosis. The objective of this study is to identify the potential interactions between changes in the microbiota, changes in the immune status, and the instability and progression of atherosclerosis.

NCT ID: NCT03429517 Not yet recruiting - Clinical trials for Dyslipidemia Associated With Acute Coronary Syndrome

Changes in Triglycerides, HDL-C and Cholesterol in ACS Patients

Start date: May 1, 2018
Phase: N/A
Study type: Observational

Background Changes in high-density lipoprotein cholesterol and triglyceride levels have been linked to residual cardiovascular risk, whereas non-high density lipoprotein levels have been shown to be more predictive of cardiovascular risk than are low-density lipoprotein cholesterol levels. We aimed to investigate the impact of high density lipoproteins, triglyceride, and non-high density lipoproteins levels on acute coronary syndrome risk with on-target low density lipoproteins levels.

NCT ID: NCT03421873 Recruiting - Clinical trials for Myocardial Infarction

Effectiveness and Safety of a Clinical Assessment and 0h/1h Troponin Rule-Out Protocol

Start date: February 1, 2018
Phase: N/A
Study type: Observational

Chest pain is a common presenting complaint at the Emergency Department (ED). Many of these patients undergo lengthy assessments in the ED or are admitted which contributes to ED and hospital crowding as well as a substantial health care burden. The now commonly used high-sensitivity cardiac troponin assays enable faster rule-out of acute myocardial infarction (AMI). The European Society of Cardiology (ESC) recommend the use of a 0h/1h high-sensitivity cardiac troponin T (hs-cTnT) protocol, but all studies so far have been observational. The safety and effectiveness of the protocol when implemented in routine care is thus unknown. The aim of this study is to determine the safety and effectiveness of the ESC 0h/1h hs-cTnT protocol, supplemented with clinical assessment and ECG, when implemented in routine care.

NCT ID: NCT03419325 Recruiting - Clinical trials for Coronary Artery Disease

A Genomic Approach for Clopidogrel in Caribbean Hispanics

Start date: January 17, 2018
Phase: N/A
Study type: Interventional

Clopidogrel is a prescription medicine used to minimize blood clot formation in patients with cardiovascular disease, particularly those undergoing heart catheterization and stroke. A substantial amount of medical evidence has proven that patients with stroke or heart diseases can benefit from this medicine. However, significant variability in such expected benefits has been found among individuals receiving Clopidogrel, with some patients not having the benefit of reduced complications and adverse cardiovascular events. Prior studies have demonstrated a significant association between certain variants on patient's genes (e.g., CYP2C19) and poor response to Clopidogrel and, therefore, major adverse cardiovascular events. Variation in other genes and other factors such as platelet activation, weight, diabetes mellitus (a medical condition that produces high blood sugar), concomitant use of other drugs and smoking status have also been proposed to be related with the same adverse outcomes. In this study the investigators would like to determine a possible association between these genes and the response to the medication among Caribbean Hispanic cardiovascular patients on Clopidogrel. In other population, it is known that patients with certain genetic variants have lower or magnified response to this medication when compared to those individuals taking the same dose and not carrying the genetic variations. However, a fundamental gap remains in understanding whether the genomic diversity of Caribbean Hispanics accounts for the observed high inter-individual variability of clinical outcomes to preventive dual antiplatelet therapy (DAPT) with Clopidogrel.

NCT ID: NCT03414996 Active, not recruiting - Clinical trials for Acute Coronary Syndrome

High-intensity Interval Training in Patients With Post-acute Coronary Syndrome

Start date: January 1, 2011
Phase: N/A
Study type: Interventional

To date, no studies have evaluated the safety or efficiency (improvement of maximal oxygen uptake [VO2peak]) of a high-intensity interval training (HIIT) program in post-acute coronary syndrome (post-ACS) patients. Heart rate variability (HRV) and recovery (HRR), QT dispersion (QTd) and ventricular arrhythmias are all indices associated with an increased risk of cardiac death. HIIT has been shown to improve these risk markers and be safe in coronary heart disease patients but not yet in post-ACS patients which are considered more at risks. The aim of this study was to compare a HIIT program to a moderate-intensity continuous exercise training (MICET) program on HRV, HRR, QTd parameters and occurrence of ventricular arrhythmias in post-ACS patients.

NCT ID: NCT03414190 Recruiting - Clinical trials for Cardiovascular Disease

Impact of Text Messages to Promote Secondary Prevention After Acute Coronary Syndrome

Start date: November 29, 2017
Phase: N/A
Study type: Interventional

The study is a two-arm, parallel, randomized clinical trial. The purpose of the study is to evaluate the effectiveness of automated mobile phone text message-based intervention for secondary prevention after acute coronary syndrome hospitalization. Text messages will include information about lifestyle modifications, medication adherence and cardiovascular risk factor control. The participants will be randomized into intervention and control groups in a 1:1 ratio. The intervention group will receive 4 pre-designed and semi-personalized text messages per week in addition to usual care for 6 months, while the control group will receive usual care.

NCT ID: NCT03413423 Recruiting - Clinical trials for Acute Coronary Syndrome

Post Acute Cardiac Event Smoking (PACES) Study

Start date: January 29, 2018
Phase: N/A
Study type: Interventional

Summary of the Project : Quitting smoking following acute coronary syndrome (ACS) can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and independently predicts mortality. Thus, a single, integrated treatment for both smoking and depression could be highly effective in reducing post-acute coronary syndrome mortality. Behavioral Activation (BA) is a well established treatment for depression and has recently shown promise as a treatment for smoking cessation. The investigators systematically developed an intervention integrating gold standard smoking cessation counseling with existing BA based mood management techniques for post-ACS smokers; Behavioral Activation Treatment for Cardiac Smokers (BAT-CS). Objective: For this R01 the investigators will evaluate the efficacy of using a single, integrated treatment that targets both depressed mood and smoking (BAT-CS).

NCT ID: NCT03413410 Recruiting - Clinical trials for ACS - Acute Coronary Syndrome

A Multi-Center Study on the Metoprolol Optimal Dosing Pathway of Metoprolol Application in Chinese Patients With Acute Coronary Syndrome

Start date: December 20, 2017
Phase: N/A
Study type: Interventional

This study is to test the feasibility and tolerability of the metoprolol optimal dosing pathway by observing the percentage of patients achieving target dose followed the pathway on ACS patients during hospitalization.

NCT ID: NCT03402711 Recruiting - Clinical trials for Acute Coronary Syndrome

Registry of Bleeding Risk in Real World Chinese Acute Coronary Syndrome Patients-II

Start date: December 14, 2017
Phase: N/A
Study type: Observational [Patient Registry]

The present study was designed to observe the incidence of bleeding events and characteristics of bleeding and exploratively analyse bleeding related biomarkers and gene polymorphisms in ACS patients undergoing PCI.