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Coronary Disease clinical trials

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NCT ID: NCT03248674 Not yet recruiting - Clinical trials for Coronary Artery Disease

Diagnostic Performance of Coronary CT Angiography With CT FFR in Kidney Transplantation Candidates

Start date: September 1, 2017
Phase: N/A
Study type: Observational

Patients with chronic kidney disease (CKD) before kidney transplantation require that obstructive coronary artery disease (CAD) is excluded, as cardiovascular complications are the leading cause of mortality in kidney transplant patients. However, in this patient population, the optimal method for the detection of obstructive CAD has not been identified. Noninvasive stress tests such as Dobutamine stress echocardiography or nuclear perfusion study have low diagnostic accuracy. CT fractional flow reserve measurement (CT FFR) is a novel non-invasive (FDA approved) imaging test to identify obstructive CAD. The goal of this project is to evaluate the diagnostic accuracy of CT FFR in the detection of obstructive coronary artery disease in patients with chronic kidney disease before kidney transplantation.

NCT ID: NCT03247608 Recruiting - Clinical trials for Coronary Artery Disease

ConnectedHeartHealth - Heart Failure Readmission Intervention

CHH
Start date: November 2015
Phase: N/A
Study type: Interventional

This is a single-center, pilot study that will evaluate the effectiveness of the AHA science based CarePlans and the Ambio Health technology in improving the risk adjusted 30 day readmissions rate, patient compliance, and biometrics. The study will also be used to assess the feasibility of similar heart failure transition programs in the future.

NCT ID: NCT03239262 Completed - Clinical trials for Coronary Artery Disease

Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation

Start date: July 1, 2012
Phase: N/A
Study type: Interventional

The aim of our study was to investigate, whether enhancement of left atrial cryoablation by ablation of the autonomic nervous system of left atrium leads to influencing the outcomes of surgical treatment of atrial fibrillation in patients with structural heart disease undergoing open-heart surgery.

NCT ID: NCT03237169 Recruiting - Clinical trials for Coronary Artery Disease

Performance of a New REsting Pressure Index During Invasive Angiography Compared To Adenosine Hyperemic FFR

PREDICT
Start date: October 28, 2016
Phase: N/A
Study type: Observational

To test the feasibility and diagnostic accuracy of a new automated pressure derived resting index (Pd/Pamin), using FFR as gold standard, in de novo coronary lesions in which invasive physiological evaluation is warranted.

NCT ID: NCT03236415 Not yet recruiting - Clinical trials for Coronary Artery Disease

Comparative Response to Vascular Injury in Patients With Diabetes Mellitus: An OCT Study of BVS Versus Xience DES

Start date: July 2017
Phase: N/A
Study type: Interventional

Stents are used at centers around the world to unblock the arteries of the heart. These stents are usually made of metal and remain permanently within the blood vessel wall. Newer developments in the stent technology has led to stent scaffolds that can be reabsorbed over time. Patients with diabetes are prone to more complex blockages in the heart arteries which can be more difficult to treat. The purpose of this study is to compare the difference of how arteries heal early when metal stents or resorbable stents are used in patients with diabetes.

NCT ID: NCT03236311 Not yet recruiting - Clinical trials for Microvascular Coronary Artery Disease

A Dose Titration Study to Assess the Effects of SAR407899 in Patients With Microvascular Angina and/or Persistent Stable Angina Despite Angiographically Successful Elective PCI

Start date: September 19, 2017
Phase: Phase 2
Study type: Interventional

The Primary Objective of this study: -To assess the effects of SAR407899 on coronary vasomotor function using the coronary flow reserve (CFR) in patients with microvascular angina and/or persistent stable angina despite angiographically successful elective percutaneous coronary intervention (PCI). The Secondary Objectives of this study are: - To assess the effects of SAR407899 on quality of life using Seattle Angina Questionnaire physical limitation domain (SAQ-PL) in patients with microvascular angina and/or persistent stable angina despite angiographically successful elective PCI. - To assess the safety of SAR407899 in patients with microvascular angina and/or persistent stable angina despite angiographically successful elective PCI with a focus on identified risks such as hypotension and orthostatic hypotension. - To assess SAR407899 plasma concentrations in microvascular angina patients and/or persistent stable angina despite angiographically successful elective PCI.

NCT ID: NCT03235700 Recruiting - Clinical trials for Coronary Artery Disease

Hyperemic Efficacy of IV Adenosine in HFrEF

HF-FFR
Start date: March 1, 2017
Phase: N/A
Study type: Interventional

Little is known about the hyperemic efficacy of IV adenosine as well as safety in patients with heart failure with reduced ejection fraction (HFrEF) because they were excluded from the major FFR studies. We will evaluate the feasibility and hyperemic efficacy of IV adenosine in patients with HFrEF in comparison with IC nicorandil for invasive physiological assessment using a coronary pressure wire.

NCT ID: NCT03235622 Completed - Clinical trials for Coronary Artery Disease

Women Health Cohort for Breast, Bone and Coronary Artery Disease

BBC
Start date: March 2011
Phase: N/A
Study type: Observational

A single center cohort which enrolled women who performed mammography, bone densitometry (DEXA), and coronary CT angiography in Seoul National University Bundang Hospital from March 2011 to February 2013.

NCT ID: NCT03235427 Recruiting - Breast Cancer Clinical Trials

The CAROLE (CArdiac Related Oncologic Late Effects) Study

CAROLE
Start date: June 27, 2017
Phase: N/A
Study type: Observational

CAROLE seeks to evaluate the relationship between chest Radiation Therapy and coronary artery disease. The purpose of CAROLE is to check the heart health of women who received breast cancer treatments in the past and protect them from future heart disease.

NCT ID: NCT03231826 Recruiting - Clinical trials for Coronary Artery Disease

Arrhythmias in Post-Myocardial Infarction Patients

Start date: June 22, 2017
Phase: N/A
Study type: Observational

Patients are screened for significant arrhythmias and other possibly significant ECG-patterns directly after discharge and two weeks after myocardial infarction using wearable devices. The home monitoring data will be linked with extensive data from electronic health records collected before, during hospital stay and after discharge. The purpose of the study is to clarify whether home monitoring of continuous ECG-signals can be used to predict and prevent serious adverse events after myocardial infarction.