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Myocardial Infarction clinical trials

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NCT ID: NCT03772743 Not yet recruiting - Clinical trials for Myocardial Infarction

Functional Assessment in Elderly MI Patients With Multivessel Disease

Start date: February 2019
Phase: N/A
Study type: Interventional

Elderly patients presenting with myocardial infarction (MI) and multivessel disease are the highest risk population with the worst prognosis. No trial has ever been designed to optimize their outcome. The actual real-life standard of care is, in the best of the cases, culprit only revascularization. However, real-life registries show that outcome of MI elderly patients treated with this strategy is far from being optimal with at least a 15% rate of cardiac death or myocardial infarction at 1 year. To date, studies on this population have been focused on devices (bare metal stent vs biodegradable drug eluting stent) or on dual antiplatelet regimen (long vs short) and no study was focused on evaluating if complete revascularization is able to improve the prognosis in these patients. The contemporary complete revascularization is represented by a functionally-driven revascularization that recently showed to significantly reduce myocardial infarction rate and outperformed an angio-complete revascularization. Thus, our hypothesis is that a functionally-driven complete revascularization in elderly patients with MI and multivessel disease may improve prognosis compared to the actual standard of care in these patients, namely culprit only revascularization. Being a "strategy" trial, we identified the patient-oriented composite endpoint (POCE) as primary outcome of interest (all cause death, any MI, any stroke, any revascularization).

NCT ID: NCT03771937 Completed - Clinical trials for Myocardial Infarction

The Effect of Education and Telephone Follow-up Intervention

Start date: April 3, 2016
Phase: N/A
Study type: Interventional

In this parallel randomized controlled trial (n = 33/group), the control group received routine care, while the intervention group received a telephone follow-up intervention, which consisted of a pre-discharge education program and three telephone follow-up sessions based on the Roy Adaptation Model.

NCT ID: NCT03764241 Not yet recruiting - Clinical trials for ST Segment Elevation Myocardial Infarction

Treatment of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant

Start date: April 1, 2019
Phase: Phase 3
Study type: Interventional

Left ventricular thrombus is a common complication subsequent to ST-segment elevation myocardial infarction (STEMI) that related to increased embolic events. This study aims to assess the efficacy and safety outcomes of Rivaroxaban on the treatment of post-STEMI left ventricular thrombus.

NCT ID: NCT03763968 Recruiting - Clinical trials for ST-segment Elevation Myocardial Infarction

Multicentre REtrospective StuDy of Treatment and OUtComes in STEMI Patients in Fujian Province

Start date: January 1, 2014
Study type: Observational

This is a multicentre observational study planned to gather follow up data for a period of 1 year in order to understand the treatments and outcomes of ST-segment elevation myocardial infarction(STEMI) and improve medical care quality in Fujian province for China. Consecutive patients who were admitted and diagnosed with STEMI between January 2014 December 2018 were conducted at five regional representative hospitals in Fujian province, which included the Fujian Provincial Hospital,Longyan First Hospital, the affiliated hospital of putian university,the Second Affiliated Hospital of Fujian Medical University and Mindong Hospital of Ningde City.

NCT ID: NCT03760796 Recruiting - Clinical trials for Coronary Artery Disease

Myocardial Infarction, COmbined-device, Recovery Enhancement Study

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

Unplanned readmissions after hospitalization for acute myocardial infarction (AMI) are among the leading causes of preventable morbidity, mortality, and healthcare costs. Digital health interventions (DHI) could be an effective tool in promoting self-management, adherence to guideline directed therapy, and cardiovascular risk reduction. A DHI developed at Johns Hopkins—the Corrie Health Digital Platform—includes the first cardiology Apple CareKit smartphone application, paired with an Apple Watch and iHealth Bluetooth-enabled blood pressure cuff. Corrie targets: (1) self-management of cardiac medications, (2) self-tracking of vital signs, (3) education about cardiovascular disease through articles and animated videos, and (4) care coordination that includes outpatient follow-up appointments. In this prospective study, STEMI or type 1 NSTEMI patients are being enrolled to use the Corrie Digital Health Platform beginning early during participants' hospital stay. Enrollment sites include Johns Hopkins Hospital, Johns Hopkins Bayview Medical Center, Massachusetts General Hospital, and Reading Hospital. The primary objective is to compare time to first readmission within 30 days post-discharge among patients with the Corrie Digital Health Platform to patients in the historical standard of care comparison group.

NCT ID: NCT03753269 Not yet recruiting - Clinical trials for ST Segment Elevation Myocardial Infarction

Early Intracoronary Administration of Fasudil in the Primary PCI of ST-segment-Elevation Myocardial Infarction

Start date: July 1, 2019
Phase: Phase 4
Study type: Interventional

The study aims to evaluate whether an early intracoronary administration of Fasudil Hydrochloride during primary PCI of STEMI can improve epicardial and myocardial perfusion as well as clinical outcomes.

NCT ID: NCT03752515 Recruiting - Clinical trials for Coronary Artery Disease

A Registry Study on Genetics and Biomarkers of Acute Coronary Syndrome

Start date: June 2, 2015
Study type: Observational

This is a national registry study to determine genetics risk factors and serial biomarkers of Acute Coronary Syndrome.

NCT ID: NCT03750760 Not yet recruiting - Clinical trials for Myocardial Infarction

Early Alirocumab to Reduce LDL-C in Myocardial Infarction

Start date: January 2019
Phase: Phase 4
Study type: Interventional

The EARLY trial is a phase IV, investigator initiated, international, multicentre study that will investigate if early use of alirocumab 150mg plus atorvastatin 80mg (enhanced care) will have a greater effect than atorvastatin 80mg (standard care) on the reduction of LDL-C at 2-weeks after a myocardial infarction (MI), in patients who start treatment within 24 hours of symptom onset. A secondary goal is to assess the effects of enhanced care when compared to standard care which is either atorvastatin alone or atorvastatin plus ezetimibe, (the latter added at 4 weeks if LDL-C is ≥ 70mg/dL (1.8mmol/L), on the proportion of patients achieving an LDL-C goal of < 50mg/dL (1.29 mmol/L) at 7 weeks after an MI.

NCT ID: NCT03749694 Completed - Clinical trials for Acute Myocardial Infarction

Investigating Temporal Improvements in Survival Following ST-elevation Myocardial Infarction.

Start date: January 1, 2004
Study type: Observational [Patient Registry]

The aim of the study was to use data from the Myocardial Ischaemia National Audit Project (MINAP) to investigate whether temporal improvements in survival were associated with changes in patients' baseline clinical risk or use of guideline-indicated treatments for the management of STEMI, and to determine the extent to which associations explained the temporal improvements in survival.

NCT ID: NCT03745742 Completed - Clinical trials for Myocardial Infarction

Post Myocardial Infarction's Rehabilitation Guided by Heart Rate Variability

Start date: March 1, 2016
Phase: N/A
Study type: Interventional

Cardiac rehabilitation reduces morbidity and mortality after myocardial infarction (MI) and improve the sympathovagal balance. The autonomic nervous system (ANS) can be explored by the variation of heart rate (HRV). The HRV is a fatigue marker and guides the athletes training programs. A smartphone app can measure the HRV via a heart rate monitor. The main study objective is to compare the effect on the functional capacities of a re-training adapted to the HRV compared to a standard program in the post-MI The secondary objective is to compare the patients' quality of life according to the rehabilitation program and to validate the HRV smartphone app. This is a prospective, multicenter study. Post-MI patients treated with angioplasty with a LVEF> 40% are randomized into 2 groups: HRV (re-training adapted to HRV daily: 10W decrease or increase in workload according to the HRV) or control (continuous training in SV1). Patients underwent a cardiopulmonary test, a walking test (TM6) and a SF36 questionaries' at the entrance and exit. The taking of HRV was done every morning in a standardized way via the smartphone app during the 20 re-training sessions.