Stroke Clinical Trial
Official title:
Stroke and Cerebrovascular Diseases Registry
This is a single institutional registry database for the patients with stroke and cerebrovascular diseases. Stroke is the fifth leading cause of death in the United States. Despite extensive research, most of the patients die or suffer from varying degree of post-stroke disabilities due to neurologic deficits. This registry aims to understand the disease and examine the disease dynamics in the local community.
Stroke is the fifth cause of all-cause mortality in US http://www.cdc.gov/stroke/facts.htm
Early identification and treatment not only prevent mortality but also morbidity. Recent
advancement in the imaging and diagnostic technique and novel therapeutic modalities has
dramatically helped to downgrade stroke from the list of top mortality index in the last 3
years. However, studies determining factors which help predict stroke outcome are still
underway and much work needs to be done in this direction. Many factors currently are used to
predict stroke outcome with varying results, for e.g. NIHSS is a good predictor of stroke
outcome at 3 months; however, the investigators need better predictors, outcome scales or
outcome measures which are easy, reliable and has better specificity and sensitivity.
Acute Brain injury, Transient Ischemic Attack is a special category of a neurological
condition wherein there is an impending devastating outcome if workup is not completed in a
timely fashion. There is an urgent need to do investigations with high-risk patients to
prevent stroke and further mortality and morbidity. The abcd2 score can help us to risk
stratify the TIA and to predict the chances of stroke in this specific cohort. However,
investigators need better identifiers than already present, to improve the patient changes in
secondary prophylaxis of stroke prevention
http://www.stroke.org/sites/default/files/resources/tia-abcd2-tool.pdf?docID
There is also some correlation of clinical and biochemical predictors in subarachnoid,
cerebral venous thrombosis including Hunt and Hess, SAH score, WFNS-SAH grading among others
with variable predictive quality. (Rosen et al; Neurocritical Care; April 2005, Volume 2,
Issue 2, pp 110-118: Subarachnoid hemorrhage grading scales).
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