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NCT ID: NCT03295370 Enrolling by invitation - Pain Clinical Trials

Electrical Stimulation of Accessory Spinal Nerve in Cortical Activation and Autonomic Response in Healthy Subjects

Start date: June 13, 2017
Phase: N/A
Study type: Interventional

This randomized, crossover sham controlled trial with sham intended to study the effect of electrical stimulation on peripheral nerve (spinal accessory nerve) with acupuncture needle in healthy subjects aims to access the effect o electrical stimulation of accessory spinal nerve in cortical activation, muscular perfusion and autonomic response in healthy subjects. Participants will be assessed through measure changes in cortical activation, local muscular peripheral perfusion and autonomic responses before and after intervention and intervention-sham, and crossed after a period of wash-out. The design aims to contribute to assessment of one electroacupuncture's techniques by measuring some of the physiological effects caused by peripheral stimulation.

NCT ID: NCT03272139 Enrolling by invitation - Pain Clinical Trials

Interscalene Block Versus Superior Trunk Block

STB
Start date: September 28, 2017
Phase: Phase 4
Study type: Interventional

Sparing the phrenic nerve by administering ultrasound-guided low volume superior trunk block (STB) and interscalene block (ISB) for arthroscopic shoulder surgery (labral repair, stabilization, rotator cuff repair).

NCT ID: NCT03227614 Enrolling by invitation - Pain Clinical Trials

Friends/Family in the Abortion Procedure Room (FAIR)

FAIR
Start date: July 18, 2017
Phase: N/A
Study type: Interventional

This study aims to explore patient, support person, and health care providers' experience and satisfaction with social support in the abortion procedure room. Although some providers do allow a support person in the abortion procedure room, no study has formally examined the effects of this practice. If this study demonstrates higher patient satisfaction and lower perceptions of pain and anxiety levels in patients who have social support in the in-clinic abortion procedure room, this could change standard procedures in the in-clinic abortion procedure room, allowing for more positive patient experiences.

NCT ID: NCT03207360 Enrolling by invitation - Pain Clinical Trials

Pain Coping Skills and Meaning-Centered Intervention

Start date: November 17, 2017
Phase: N/A
Study type: Interventional

The proposed study seeks to develop and test a novel psychosocial pain management intervention for patients with advanced cancer. It is hypothesized that the intervention will demonstrate feasibility, acceptability, and preliminary efficacy. The first aim is to develop a combined pain coping skills training and meaning-centered psychotherapy intervention. The second aim is to test the intervention's feasibility and acceptability as well as preliminary efficacy for improving primary outcomes (i.e., pain, pain interference, and meaning in life) and secondary outcomes. Two efficacious, theory-driven interventions will be integrated to address pain management by teaching pain coping skills with a novel emphasis on enhancing a sense of meaning in life. Participants will be patients with advanced cancer and moderate-to-severe pain. The study will be conducted in two phases. Phase I of the study will be intervention development. The intervention content will be guided by theory and mentoring from a team of leading experts in pain management and meaning-centered psychotherapy. Initial intervention content will be further informed by interviews with patients with advanced cancer. Content will then be refined through an iterative patient testing process. Phase II of the study will be a single-arm pilot trial testing the intervention. The intervention will be delivered in-person and consist of four, 45-to-60 minute therapy sessions. Study measures will be collected at baseline (0 weeks), immediately post-intervention (5 weeks), and 4-weeks post-intervention (9 weeks).

NCT ID: NCT03099252 Enrolling by invitation - Pain Clinical Trials

Caring for Babies: A Study of Ontario Maternal-Newborn Hospitals on the Effectiveness of Parent-targeted Education

ONesiE
Start date: October 12, 2017
Phase: N/A
Study type: Interventional

Newborn infants have blood work procedures for newborn screening and bilirubin testing in their first days of life that cause pain, distress and physiological changes. Breastfeeding (BF), skin to skin care (SSC), or giving small amounts of sweet solutions (sucrose or glucose) with or without a pacifier, effectively and safely reduce pain and distress in newborn infants during painful procedures. However, studies of neonatal pain management practices in Ontario and throughout Canada demonstrate inconsistent use of these strategies. There is a clear need for developing and testing acceptable parent-targeted interventions, alongside health care provider-targeted knowledge translation (KT) interventions, to support parents' involvement in comforting their infants during painful procedures. To address this knowledge to action (KTA) gap, Denise Harrison's Be Sweet to Babies team developed the BSweet2Babies video, which demonstrates the effectiveness of BF, SSC, and sucrose during infant bloodwork and how parents can use and advocate for these pain management strategies. This study will evaluate the effectiveness of a parent-targeted and mediated KT strategy, the BSweet2Babies video, when shown to parents of newborns prior to newborn screening or bilirubin testing, on subsequent use of the three pain reduction strategies during the blood test. The target sample size for the study is 20 hospitals. Following consent, hospitals will be randomized to one of two groups: the intervention group (showing parents the BSweet2Babies video prior to their baby's newborn screening blood test) or the control group (no education or information provided). Hospitals in the intervention group will show all parents the 5 minute BSweet2Babies video before newborn bloodwork. BORN Information System (BIS) data will subsequently be analyzed to evaluate the use of BF, SSC and sweet solutions. The investigators hypothesize that hospitals randomized to the BSweet2Babies video will have a higher rate of use of BF, SSC or sucrose as measured by the systematically collected Better Outcomes Registry & Network (BORN) Ontario pain data elements during newborn screening or bilirubin testing, compared to hospitals randomized to usual Health Care Provider (HCP)-targeted education.

NCT ID: NCT03070054 Enrolling by invitation - Pain Clinical Trials

LIA in Hip Arthroscopy Patients

Start date: June 2016
Phase: Early Phase 1
Study type: Interventional

The investigator's are conducting a randomized, blinded study to determine if the extra-capsular local infiltration analgesic (LIA) administration of 20ml 0.25% bupivacaine-epinephrine can improve the postoperative pain management of hip arthroscopy patients. Participants will be randomly assigned to the LIA group or non-LIA group prior to surgery. Participants, anesthesiologists and PACU nurses will be blinded to group assignment, however the surgeon administering the LIA will be unblinded.

NCT ID: NCT02933814 Enrolling by invitation - Pain Clinical Trials

Liposomal Bupivacaine in Ambulatory Hand Surgery

Start date: November 2017
Phase: Phase 4
Study type: Interventional

This study is being done to evaluate pain management regimens following ambulatory hand surgery. Improved pain control may be associated with decreased complications, decreased pain scores, decreased opioid dependence, improved patient comfort and satisfaction, and reduced healthcare costs. Liposomal bupivacaine is an FDA-approved local anesthetic. There will be two groups. One group will receive liposomal bupivacaine. One group will not. The results will be compared. Patients will be over the age of 18 ambulatory hand surgery. Approximately 40 subjects will participate in this study at LLU.

NCT ID: NCT02902770 Enrolling by invitation - Pain Clinical Trials

Intravenous Lidocaine and Ketorolac for Pain Management

Start date: October 2016
Phase: Phase 4
Study type: Interventional

The literature regarding analgesic modalities, their combinations and routes of administrations for patients with pain related to renal colic is expanding. NSAID's (IV ketorolac) and opioids (morphine) constitutes the mainstay of treatment of renal colic either alone or in combinations. Despite their synergism and analgesic superiority when administered together, both classes of these medications possess a set of unfavorable side effects that limit their use. Emerging data of the use of IV lidocaine for patients with renal colic demonstrated good analgesic efficacy and safety profile. However, none of the trials directly compared lidocaine to ketorolac or the combination of both as viable options in patients unable to tolerate or to have serious contraindications to opioids. We designed a double-blinded, randomized, controlled trial to evaluate analgesic efficacy, safety and feasibility of non-opioid analgesics and their combinations in patients with renal colic. The hypothesis and proposed study will try to determine if a combination of IV lidocaine and reduced dose of IV ketorolac is superior to either drug alone and if this non-opioid analgesic modality is effective for controlling pain of renal colic origin.

NCT ID: NCT02897934 Enrolling by invitation - Breast Cancer Clinical Trials

CWI and Discharge After Breast Cancer Surgery

Start date: August 2016
Phase: N/A
Study type: Observational

The objectives of this work are threefold: 1. To evaluate the analgesic efficacy of CWI in women discharged within 23 hours of major breast cancer surgery 2. To evaluate objective indices of patient recovery following anaesthesia and surgery in a 23 hour model of care 3. To evaluate patient satisfaction with their care pathway

NCT ID: NCT02752854 Enrolling by invitation - Pain Clinical Trials

Pain Threshold Measurements in High and Low Altitude Among Healthy Volunteer Adults: A Comparative Study

Start date: April 2015
Phase: N/A
Study type: Observational

one measurement of pain threshold in high altitude and in low altitude using pressure algometer and Situational pain scale.