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NCT ID: NCT03246282 Suspended - Pain Clinical Trials

Feasibility of Polychromatic Light Emitting Diode System to Reduce Pain

Start date: February 8, 2017
Phase: Early Phase 1
Study type: Interventional

This study uses a prospective non-randomized, non-controlled design. One Hundred Fifty (150) subjects presenting with pain will be enrolled into a single treatment group The purpose of the study is to evaluate the feasibility of PLEDS for PIV catheter light delivery for pain reduction, through change between baseline average pain and final average VAS score. The absence of a control group is based on the following reason: The purpose of this investigation is to further the understanding of the feasibility of PLEDS for PIV catheter light delivery for pain management. Further, the results of this investigation will be used (internally only) to determine if subject-perceived reductions in pain warrant proceeding with more controlled, targeted and possibly randomized studies.

NCT ID: NCT02465008 Suspended - Pain Clinical Trials

Analgesic Effect of Levobupivacaine in Breast Augmentation

Start date: n/a
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine whether levobupivacaine is effective in the acute postoperative pain treatment in periprosthetic breast augmentation

NCT ID: NCT02205229 Suspended - Pain Clinical Trials

Compounded Pain Preparation Absorption Study

Start date: August 2014
Phase: N/A
Study type: Observational [Patient Registry]

Single center, prospective, observational study to assess serum concentration of ingredients used in multi-ingredient, topical compounded medications from Medimix Specialty Pharmacy.

NCT ID: NCT01863940 Suspended - Pain Clinical Trials

Continuous Infusion of Local Anesthetic for Post-operative Pain Control in Ukraine

Start date: August 2013
Phase: N/A
Study type: Interventional

Ukraine is a newly sovereign country in Eastern Europe with a large burn population. With the collapse of the Soviet Union, burn programs have become decentralized and resources for maintaining facilities have dwindled. Patients frequently present with debilitating burn injuries and often do not receive necessary treatment secondary to limited resources and cost of treatment. The investigators have established an annual medical mission, outreach clinic and telemedicine relationship with hospitals and burn centers in Ukraine in an effort to improve burn care. One focus is post-operative pain control. The investigators have noticed a pattern of anxiety with children from the Ukraine surrounding dressing changes which they believe this is secondary to inadequate pain control in the immediate post-operative period including the initial dressing changes. The goal is to provide wound catheters with a continuous infusion of procaine in an attempt to reduce the pain experienced in the early post-operative period and specifically with dressing changes. There will be 200 participants, 12-65 years old who are receiving reconstructive plastic procedure with split-thickness skin grafts from lateral thigh in the study. 100 will receive the standard pain management Analgin/Metamizole 1 g IM; Ketorolac 3%- 30 mg IM regimen and 100 will receive wound catheters with continuous procaine infusion for 48 hours with the standard Analgin/Metamizole 1 g IM; Ketorolac 3%- 30 mg IM available for breakthrough pain. Pain scores will be assessed prior to dressing change, during dressing changes and at 30 minutes and 1 hour after dressing change.

NCT ID: NCT01268670 Suspended - Pain Clinical Trials

The Addition of Oral Analgesics to LET During Laceration Repair

Start date: July 2012
Phase: N/A
Study type: Interventional

Background Approximately 30 million children are treated in emergency departments each year in the United States, of which two to three million are children presenting with lacerations. Topical numbing medication is the standard of care in children with regard to pain control during laceration repair. While topical numbing medications are effective, children often require further pain control during laceration repair in the form of an injected numbing medication, which in itself is painful. No evidence currently exists regarding the concurrent use of oral pain medications to combat laceration procedural pain. Research Question Does the addition of ibuprofen or oxycodone to lidocaine, epinephrine, and tetracaine (LET) topical anesthetic provide more effective pain control than LET alone during laceration repair? Design This is a double-blinded, randomized-controlled study. Methods Subjects in all three groups will receive topical anesthetic. In addition to topical anesthetic, two groups of children will receive either of two oral analgesics, ibuprofen or oxycodone, while the third group will receive a placebo.

NCT ID: NCT01094912 Suspended - Pain Clinical Trials

Procedures of Locoregional Analgesia and Quality of Life in Palliative Care Units

Start date: April 2010
Phase: N/A
Study type: Interventional

Number of patients in mobile palliative care units have pain of both nociceptive and neuropathic origin. In certain cases, procedures of locoregional analgesia can be helpful. The Purpose of this study is to evaluate the impact of techniques of locoregional analgesia in a palliative population

NCT ID: NCT00873743 Suspended - Pain Clinical Trials

Analgesia and Antihyperalgesia of Tramadol and Acetaminophen Per Oral After Caesarean Section

Start date: October 2008
Phase: N/A
Study type: Observational

The aim of this study is to evaluate quality of patient-controlled peroral analgesia after cesarian section using the combination of tramadol and acetaminophen. Research hypothesis is that the combination reduces pain at leg rising more than tramadol alone.

NCT ID: NCT00822926 Suspended - Pain Clinical Trials

Subcutaneous Botulinum Toxin for Cutaneous Allodynia - Enriched Responder Trial

Start date: January 2009
Phase: N/A
Study type: Interventional

Superficial injection of Botulinum toxin has been advocated for cosmetic purposes but has also been reported to be helpful for some pain conditions. The investigators have observed prolonged profound analgesia following subcutaneous superficial injection of Botulinum Toxin Type A (BTA) in patients with certain types of neuropathic pain. the investigators propose to study if addition of BTA extends pain relief compared to placebo when injected subcutaneously into areas of cutaneous allodynia (the property that a normally non-noxious stimulus is perceived as painful).

NCT ID: NCT00747669 Suspended - Pain Clinical Trials

Pharmacokinetic Study of Synera™ in Neonates and Infants

Start date: September 2008
Phase: Phase 4
Study type: Interventional

This study will measure the amount of lidocaine and tetracaine in the blood after a 30 minute application of Synera.

NCT ID: NCT00637364 Suspended - Pain Clinical Trials

High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain

HIFU Pancreas
Start date: March 2008
Phase: Phase 1/Phase 2
Study type: Interventional

This is an open-label, non-randomized, single-center, therapeutic trial in patients with AJCC Stage III or IV pancreatic cancer with tumor related abdominal and/or back pain to evaluate the safety of high intensity focused ultrasound therapy using the FEP-BY02 HIFU system for palliation of pancreatic cancer-related pain. Patients meeting all eligibility criteria without any exclusion criteria will be offered an opportunity to participate in the study. After obtaining informed consent a baseline history, physical examination, laboratory studies, and any additional imaging studies needed will be performed. The major theoretic risk to the patient with this procedure is the development of acute pancreatitis. If acute pancreatitis were to develop, it should become clinically evident by day 3 following HIFU ablation. Therefore, the initial phase of this pilot study is designed to allow a sufficient interval between HIFU treatments to identify whether this theoretic risk will manifest clinically. Previous clinical experience in China suggests that HIFU of pancreatic tumors is safe without risk of developing severe acute pancreatitis. Patients treated with HIFU will have approximately 15-20% of the tumor volume treated per session. The first 5 patients (feasibility study) will receive their first HIFU treatment followed by a 3-5 day interval for observation. Following the feasibility study the results will be reviewed with the FDA. If no serious adverse events are encountered, and the FDA agrees with continuing the study, then the next 5 patients will be treated with an interval of 2-3 days between each treatment. If no serious adverse events are encountered in this group, then the next group of 5 patients will be treated at intervals of 1-2 days between each treatment.