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Pain clinical trials

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NCT ID: NCT03657810 Active, not recruiting - Pain Clinical Trials

A Controlled Study to Determine the Efficacy and Safety of CL-108 5 mg as a Treatment for Acute Pain and the Prevention of OINV

Start date: August 2, 2017
Phase: Phase 3
Study type: Interventional

To determine the analgesic efficacy of CL-108 5 mg by comparison with placebo and the anti-emetic efficacy of CL-108 5 mg by comparison with hydrocodone 5 mg/acetaminophen 325 mg.

NCT ID: NCT03636386 Active, not recruiting - Clinical trials for Myofascial Trigger Point Pain

Percutaneous Microelectrolysis in the Reduction of Myofascial Trigger Points Pain

Start date: May 23, 2018
Phase: N/A
Study type: Interventional

The aim of the design is to investigate the value of percutaneous microelectrolysis (MEP) as an analgesic technique in myofascial trigger points. This research seeks to evaluate the influence of the polar effects of the cathode on the reduction of the threshold of painful pressure and intensity of pain in the myofascial trigger points of the trapezius muscle. An assessment with algometry and visual analog scale will be made in healthy subjects before applying the intervention. The study will evaluate the changes in kilograms per square centimeter of painful pressure threshold and millimeters of pain in a group exposed to the application to percutaneous microelectrolysis (MEP) compared to another group that will not receive the intervention. Both groups will be provided with a basic treatment of therapeutic ultrasound. The treatment will include three sessions with an interval of 3 days. Subsequently, the researchers will proceed to compare the painful pressure threshold and pain intensity obtained from the algometry test and visual analogue scale in each of the groups, and between groups, before and after the procedure. The changes obtained between sessions will be compared.

NCT ID: NCT03617471 Active, not recruiting - Pain Clinical Trials

Pharmacokinetic Study of Paracetamol in Patients Over 80 Years Hospitalized to an Acute Geriatric Ward

Start date: November 2015
Phase: N/A
Study type: Interventional

The goal of this exploratory study is the characterization of the pharmacokinetic profile of paracetamol in older patients and the specific PK variables associated with plasma exposure in this population.

NCT ID: NCT03551977 Active, not recruiting - Pain Clinical Trials

The Norwegian "iCanCope With Pain" App

Start date: November 28, 2017
Phase: N/A
Study type: Interventional

Background: Research evidence shows that prevalence of pain in adolescents is increasing and is therefore recognized as a growing health problem. Psychological interventions delivered remotely through the internet may reduce intensity or severity of pain among children and adolescents with chronic pain. The iCanCope with Pain program is an existing web- and mobile-based self-management program, which is developed as a multi-center study funded by the Canadian Institutes of Health Research and is based on identified health care needs and current best practices for pain self-management. Objectives: The primary objectives are to describe the translation and cultural adaptation of the Norwegian version of the iCanCope with Pain mobile application and evaluate the effect in an upcoming randomized controlled trail with adolescents with chronic pain. Study sample: 16-19-year-old adolescents with self-declared persistent and/or chronic pain. Recruited from high schools in Southern Norway. Theoretical framework: Cognitive behavioral therapy (CBT) is explained by an integration of behavioral and cognitive theories of human behavior and psychopathology and is often the preferred treatment of choice for adolescents with different health disorders. The theoretical framework of CBT is integrated in the iCanCope with Pain app in terms of five components. The intervention group will receive the app with all five components: (I) symptom trackers for pain, sleep, mood, physical, and social function; (II) goal setting to improve pain and function; (III) coping toolbox of pain self-management strategies; (IV) social support; (V) age-appropriate pain education. The control group will receive the app with only the first self-registration component (I) symptom trackers for pain, sleep, mood, physical, and social function. Methods: Both qualitative and quantitative data will be gathered for evaluating the Norwegian version of the iCanCope with Pain app. Usability testing are assessed in both laboratory settings and in field using observation, interviews and questionnaires, which provide necessary information for an upcoming randomized controlled trail (RCT). Outcomes will in the RCT be measured at baseline (mid-April) and after an 8 weeks intervention (mid-June). The study is part of a PhD project.

NCT ID: NCT03491072 Active, not recruiting - Pain Clinical Trials

Transcutaneous Electric Nerve Stimulation for Pain Relief During Extracorporeal Shock-wave Lithotripsy

Start date: February 20, 2018
Phase: N/A
Study type: Interventional

This study evaluates pain relief during extracorporeal shock-wave Lithotripsy by using transcutaneous electrical nerve stimulation (TENS) and comparing it with fentanyl which is a narcotic analgesic. Half of the participants will receive a primary fentanyl dose together with TENS application, another half will receive a primary fentanyl dose. All patients will receive fentanyl increments if they still complained of pain.

NCT ID: NCT03475082 Active, not recruiting - Pain Clinical Trials

Overcoming Analgesic Tolerance to TENS

OCTTT
Start date: July 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if changing the frequency or intensity of transcutaneous electrical nerve stimulation (TENS) can reduce the development of tolerance to TENS treatment.

NCT ID: NCT03452449 Active, not recruiting - Pain Clinical Trials

Physical Activity, Disability and Quality of Life Before and After Lumbar Spine Surgery

PA-LSS
Start date: June 1, 2017
Phase:
Study type: Observational

To date it is unknown how physical activity levels in adults is limited before and after lumbar spine surgery and if physical activity level is associated with disability and limitations of quality of life. The main objective is to compare physical activity preoperatively and 6 and 12 weeks postoperatively in patients undergoing lumbar spine surgery with norm data. In addition, the investigators will study the association of changes in physical activity, disability and quality of live.

NCT ID: NCT03380949 Active, not recruiting - Pain Clinical Trials

Monitor-Guided Analgesia During General Anesthesia - Part II

MOGADA-II
Start date: December 8, 2017
Phase: N/A
Study type: Interventional

This prospective randomized clinical trial evaluates the effects of a monitor-guided opioid analgesia during general anesthesia. To date no standard-monitoring device exists to specifically reflect the analgesic component of general anesthesia. Quality and safety of general anesthesia are of major clinical importance and should be improved by limiting the opioid analgesic's dosage to the minimum amount needed. The study compares the effects of monitoring nociception during general anesthesia with different innovative techniques in comparison to routine clinical practice.

NCT ID: NCT03377907 Active, not recruiting - Pain Clinical Trials

Pain Alleviation of Forearm Fractures

Start date: December 9, 2017
Phase: N/A
Study type: Interventional

fractures of upper limb induce much pain . A lot of modalities are available to alleviate pain. fracture hematoma block, and intravenous regional anesthesia seem to be cost effective and attractive options

NCT ID: NCT03357484 Active, not recruiting - Pain Clinical Trials

Leukocyte- and Platelet Rich Fibrin (L-PRF) Application in Impacted Mandibular Third Molar Removal Surgery

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

The purpose of this study was to evaluate the influence of leukocyte- and platelet-rich fibrin (L-PRF) on impacted mandibular third molar (IMTM) extraction wound healing, patient postoperative discomfort, and incidence of alveolar osteitis (AO). Thirty patients (18 female, 12 male) who met the inclusion criteria for this split-mouth study underwent bilateral IMTM surgical extractions. Following extraction, randomization was done. One socket received L-PRF, and the other socket served as a regular blood clot control. Postoperatively, the soft tissue healing index (HI), pain according to visual analog scale (VAS), facial swelling using a horizontal and vertical guide, and incidence of AO were evaluated 1, 3, 7, and 14 days after surgery.