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NCT ID: NCT03190980 Recruiting - Pain Clinical Trials

Oral Glucose in Pain Alleviation Among Term Neonates

Start date: May 1, 2017
Phase: N/A
Study type: Interventional

Background: It was long believed that newborns could not experience pain. As it is now documented that newborns have all the necessary systems to perceive pain, pain management can no longer be ignored. Pharmacologic agents are not recommended in neonates for pain relief in minor procedures and still there is debate regarding the efficacy of oral glucose, in different strengths, on alleviation of pain among neonates. Aim: The objective of this study is to assess the efficacy and safety oral administration of glucose, in different concentrations, on pain relief in full term neonates undergoing heel prick test. Methods: The investigators will conduct a prospective, randomized, double blind placebo controlled trial to investigate the effect of glucose solution on alleviating the pain of heel prick test in around 360 healthy full term newborns who will be randomly allocated to one of three groups (around 120 neonates in each group): First group will receive 5% glucose, second group will receive 30% glucose and third group will receive sterile water as a placebo, 2 minutes prior to the procedure. Specially trained nurses will take turns to carry out blood sampling. Neonatal pain will be assessed by the Neonatal Infant Pain (NIPS) as well as by duration of crying, changes in heart rate, respiratory rate and oxygen saturation.

NCT ID: NCT03188003 Recruiting - Pain Clinical Trials

Lumbo-pelvic Mobilization and Stabilization With Pilates Method in Low Back Pain and Movement Functionality

Start date: June 2017
Phase: N/A
Study type: Interventional

Lumbar pain is one of the most common injuries being the cause of morbidity in the individual generating occupational disability with strong personal, social and economic impact. As one of the methods of treatment, Pilates is a method that has good results for the management of this dysfunction. However, it is not known exactly which approach Pilates can bring better results for this population. Therefore, the purpose of this study is to compare the effects of two types of Pilates method interventions on non-specific chronic low back pain. A blinded randomized clinical trial, will be held. 32 patients divided randomly into two groups will be assessed, the Mobilization Pilates (MP) and the Stabilization Pilates (SP). Both groups will be formed by individuals of both sexes and aged 21 to 41 years with chronic low back pain. Both groups will receive 10 sessions of Pilates Methods twice a week, with each session taking an average of 50 minutes, therefore the MP will focus on a lumbo-pelvic mobilization exercises approach and the SP will focus on lumbo-pelvic stabilization exercises approach. At the beginning and end of the 5 weeks the individuals are evaluated to verify the presence of pain and disability with VAS of pain and Oswestry Questionnaire, and also with the Functional Movement Screen. Data will be analyzed statistically.

NCT ID: NCT03184740 Recruiting - Pain Clinical Trials

Physical Performance and Analgesic Effects of tDCS in Primary Dysmenorrhea

Start date: June 2017
Phase: N/A
Study type: Interventional

Technological advances and non-invasive techniques to modulate brain function have been developed, including transcranial Direct Current Stimulation (tDCS). Basically, electrodes are placed on the brain regions to stimulate or inhibit it. Subsequently, a continuous electrical current (0.4-2 mA) is imposed, for a period of 3-20 minutes, to modify cortical excitability. Few are the research groups that work on the topic of primary dysmenorrhea and the use of tDCS as the focus of study. Preliminary studies associated the use of tDCS with pain reduction, but the outcomes of physical and behavioral function needs further investigation.

NCT ID: NCT03182933 Recruiting - Pain Clinical Trials

Liposomal Bupivacaine Versus Standard Bupivacaine in the Adductor Canal for Total Knee Arthroplasty

Start date: May 30, 2017
Phase: Phase 4
Study type: Interventional

Study will evaluate the effect of liposomal bupivacaine versus standard bupivacaine on physical therapy measures and pain scores as well as opiate consumption.

NCT ID: NCT03176199 Recruiting - Pain Clinical Trials

A Study to Compare the Titration Efficacy and Safety of Control-released Oxycodone and Immediate-released Oxycodone in Patients With Moderate to Severe Cancer Pain

Start date: September 1, 2016
Phase: Phase 4
Study type: Interventional

This study is to evaluate the efficacy and safety of a titration method by selects 10 mg control-released (CR) oxycodone tablet as background drug in combined with immediate-released (IR) oxycodone, compared to conventional titration method with immediate-released (IR) oxycodone in patients with moderate to severe cancer pain in Taiwan.

NCT ID: NCT03176121 Recruiting - Pain Clinical Trials

Study Evaluating Safety and Tolerability of Oxycodone in Patients With Moderate to Severe Cancer Pain

STOP Pain
Start date: October 31, 2016
Phase: Phase 4
Study type: Interventional

This study is to evaluate the safety and tolerability of oxycodone control-released (CR) and/or immediate-released (IR) use in patients with moderate to severe cancer pain in a 3-months period in Taiwan.

NCT ID: NCT03169127 Recruiting - Pain Clinical Trials

Clinical Pharmacogenetic of Ibuprofen After Lower Third Molar Surgeries

Start date: April 1, 2016
Phase: Phase 4
Study type: Interventional

The present clinical trial randomized will be to assess the link between the different haplotypes of CYP2C8 and CYP2C9 genes and the clinical efficacy of ibuprofen after lower third molar extractions. Onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth opening and wound healing at the 7th postoperative day were evaluated. For this purpose, 200 healthy volunteers underwent removal of one lower third molar, under local anesthesia with articaine 4% (1:200,000 adrenaline) will be genotyped and phenotyped for these genes and their postoperative records with all data collected will be compared with the haplotypes found in the Brazilian population.

NCT ID: NCT03157882 Recruiting - Pain Clinical Trials

Pediatric Pain Assessment in the Emergency Department

Start date: October 2016
Phase: N/A
Study type: Observational

To examine pediatric pain assessment in the Emergency Department

NCT ID: NCT03155516 Recruiting - Pain Clinical Trials

Effect of Good Pain Management (GPM) Ward Program on Moderate to Severe Cancer Pain Patients

GPM
Start date: August 30, 2016
Phase: N/A
Study type: Interventional

This study aims to set up a standardized cancer pain ward - known as the Good Pain Management (GPM) Ward with streamlined assessment and management procedures to act as a pain management model. In particular, it will enforce regular pain assessment from and throughout hospital admission, and treatment protocols introducing the use of strong-opioids in moderate cancer pain patients, following National Cancer Care Network (NCCN) Adult Cancer Pain Guidelines. The GPM ward will be compared against current-practice controlled ward.

NCT ID: NCT03153813 Recruiting - Pain Clinical Trials

Capsaicin Patches In Knee Osteoarthritis In Obese Patients

CHILI-OB
Start date: July 2015
Phase: Phase 3
Study type: Interventional

To assess the efficacy and safety of high concentration capsaicin patches in pain due to osteoarthritis (OA) of the knee in patients with obesity