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Chronic Pain clinical trials

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NCT ID: NCT03845816 Recruiting - Chronic Pain Clinical Trials

Evaluation of Attachment, Self-compassion and Coping Strategies in Chronic Pain Patients

Start date: December 14, 2018
Study type: Observational

Compare the self-compassionate score by type of attachment, "safe" or "insecure", in chronic pain patients.

NCT ID: NCT03842709 Not yet recruiting - Chronic Pain Clinical Trials

Non-Opioid Pramipexole and Pain

Start date: March 2019
Phase: Early Phase 1
Study type: Interventional

The long-term goal of this proposal is to identify non-opioid drugs that harness endogenous anti-inflammatory mechanisms resulting in the suppression of proinflammatory cytokines such as IL-1ß providing a novel approach to treat chronic pain in people while lacking potential for addictive side effects. Specific Aim I: pramipexole blocks the activation of NLRP3 and consequent production and release of the proinflammatory cytokines IL-1ß, IL-6 and TNF-α, and increases production of the anti-inflammatory cytokine interleukin-10 (IL-10). The goal of Aim I (Phase I) experiments is to examine the specific anti-inflammatory mechanisms of pramipexole on PAMP, DAMP and opioid stimulated immune cells, THP-1 cells will be used. Specific Aim II: pramipexole treatment will provide therapeutic benefit to patients experiencing suboptimal pain relief from current standard therapy with concurrent reduction of TLR4-NLRP3-cytokine expression in peripheral blood mononuclear cells. The goal of Aim II (Phase II) will be to determine the therapeutic benefit of pramipexole for pain, which is a repurposing of this FDA-approved drug with a good safety profile. 1.2. Our overarching hypothesis is that pramipexole will control clinical pain by suppressing the activation of the TLR4-NLRP3-IL-1ß pathway and prevent IL-1ß release from peripheral immune cells. These findings have provided the current impetus to examine pain therapeutic drugs targeting immune-related factors either upstream or downstream of IL-1ß signaling.

NCT ID: NCT03841604 Not yet recruiting - Clinical trials for Idiopathic Parkinson Disease

Effect of Safinamide on Parkinson's Disease Related Chronic Pain

Start date: February 28, 2019
Phase: Phase 4
Study type: Interventional

This is a Phase IV, international, multicentre, randomised, double-blind, placebo controlled study in IPD patients, experiencing motor fluctuations and PD related chronic pain while on stable doses of levodopa (L-Dopa). Participants will be randomized 2:1 to receive either active or placebo

NCT ID: NCT03837080 Recruiting - Chronic Pain Clinical Trials

Nutrition Intervention for Chronic Pain Patients

Start date: January 28, 2019
Phase: N/A
Study type: Interventional

The primary objective of the study is to determine the effectiveness of nutrition education (individual and group) on the intensity of pain in patients suffering from chronic pain. The secondary goal is to determine whether there is a change in the status of the patient's nutrition, their quality of life, quality of life, and other indicators of the psychophysical condition of the patient.

NCT ID: NCT03831581 Completed - Pain, Postoperative Clinical Trials

Evaluation of Dermatomal Distribution in the Erector Spinae Plane (ESP) Block

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Interventional study that evaluate dermatomal distribution and its demographic determinants in patients who underwent to Erector Spinae Plane (ESP) block

NCT ID: NCT03827174 Not yet recruiting - Chronic Pain Clinical Trials

Return to Work in Patients With Chronic Pain and Opioid Treatment

Start date: February 2019
Phase: N/A
Study type: Interventional

This study aims to evaluate whether a vocational behaviour change ability programme has any additional effect on return to work compared with return to work coordination only in persons with chronic pain and pharmacological treatment with opioids.

NCT ID: NCT03824860 Not yet recruiting - Chronic Pain Clinical Trials

Yoga for Painful Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized-Controlled Study

Start date: March 28, 2019
Phase: N/A
Study type: Interventional

This research study will examine the feasibility of conducting an eight-week yoga intervention for individuals with chronic painful chemotherapy-induced peripheral neuropathy.

NCT ID: NCT03823729 Recruiting - Chronic Pain Clinical Trials

Elosan Efficacy Study (EES)

Start date: July 18, 2018
Phase: N/A
Study type: Interventional

The "Elosan Cabin" is a closed, electrically insulated, biocompatible cabin for the short-term application of electrostatic high voltage in patients with chronic pain, especially those with rheumatic diseases. Patients assigned to the Elosan group (group A) will have 8 sessions in the Elosan cabin, with an interval of 3 to 4 days between sessions. Patients assigned to the control group (group B) will have no treatment except for the continuation of their prescribed pain medication and pain therapy.

NCT ID: NCT03821194 Not yet recruiting - Pain, Chronic Clinical Trials

The Effect of Chronic Pain Relief Over Knee Joint Area by Gua Sha Therapy

Start date: January 25, 2019
Phase: N/A
Study type: Interventional

Objective: A randomized, single-blind, controlled clinical trial is conducted to evaluate the effect of gua sha on the relief of chronic knee joint area pain, and to investigate the association between local skin surface and core temperature changes with chronic pain relief over knee after gua sha. Also, we want to observe the changes before and after gua sha in the local tissues of the knee joint area. We expect to provide more insights into the relevant mechanism of gua sha and relieving pain in chronic knee joint area and establish a complementary therapy for chronic knee joint pain. Materials and Methods: In this study, a total of 40 chronic knee joint pain participants will be recruited in the eligible conditions. After agreeing into the clinical study and signing the informed consent form, they will be randomized assigned into the treatment group (20 persons) and control group (20 people). Both groups will be tested for total of 12 days. For treatment group, 2 times of gua sha method will be applied within 12-day test period, the treatments will be on the first day and the fourth day respectively. The control group will be applied 2 times of hot pack method at same period intervals during the 12 days. Both groups will be measured the surface and core temperature of the applied site before and after each method. The visual analog scale (VAS) and the lower extremity functional scale (LEFS) and SF-12 quality of life questionnaire will be performed before and after the test. Ultrasound scans of knee will be performed before and after the test. After the data collection is completed, the analysis is performed in SPSS version 24. Student's t-test and one-way ANOVA methods will be used, with P<0.05 as a significant result. Expected results: To establish the positive effect of gua sha therapy to relieve the chronic knee joint pain, and use data and images to infer the mechanism of gua sha therapy on relieving chronic knee joint pain.

NCT ID: NCT03819738 Recruiting - Epilepsy Clinical Trials

fMRI in Deep Brain Stimulation

Start date: March 24, 2017
Phase: N/A
Study type: Interventional

With fMRI, we want to understand the mechanisms of brain neuromodulation in (dys)functional brain circuits, to obtain knowledge on involved brain networks in DBS.