Obesity Clinical Trial
Official title:
Longitudinal Cohort Study of Dallas County Residents to Identify Novel Determinants of Atherosclerotic Heart Disease: The DHS 2
The Dallas Heart Study (DHS-1) is a large, multi-ethnic, population-based epidemiological
study designed to identify determinants of atherosclerotic heart disease (ASHD) in a
representative United States (US) urban environment. This study completed enrollment in
2003.
Our objective is to pinpoint factors contributing to progression:
1. from health to ASHD risk;
2. from ASHD risk to subclinical ASHD; and
3. from subclinical to clinical ASHD.
Identification of the critical factors in these transitions will enable targeted
implementation of appropriate therapy to interdict before clinical ASHD develops.
Early medical intervention in asymptomatic individuals at risk is the most effective
strategy to combat atherosclerotic heart disease (ASHD). The major roadblock to effective
ASHD prevention is that conventional tools to assess ASHD risk are inadequate and new
methods are needed to identify susceptible individuals before the disease process is
established. Other successful public-health screening programs have incorporated direct
imaging procedures (e.g. mammography, colonoscopy); yet in ASHD, direct imaging of the
vasculature has not been incorporated into the risk stratification algorithms.
The Dallas Heart Study (DHS-1) is a large, multi-ethnic, population-based epidemiological
study designed to identify determinants of ASHD in a representative US urban environment.
This study completed enrollment in 2003.
In DHS-2 we will transform the Dallas Heart Study from a cross-sectional health survey
(DHS-1) into a longitudinal cohort study (DHS-2). We will perform state-of-the-art
cardiovascular (CV) imaging coupled to biomarkers, genetic markers and classical ASHD risk
factors. We will repeat the detailed clinical phenotyping performed between 2000-2003 to
capture interval changes in ASHD risk and disease burden. Our objective is to pinpoint
factors contributing to progression:
1. from health to ASHD risk;
2. from ASHD risk to subclinical ASHD; and
3. from subclinical to clinical ASHD.
Identification of the critical factors in these transitions will enable targeted
implementation of appropriate therapy to interdict before clinical ASHD develops.
;
Observational Model: Cohort, Time Perspective: Prospective
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