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HIV Infections clinical trials

View clinical trials related to HIV Infections.

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NCT ID: NCT03767465 Recruiting - Cancer Clinical Trials

Treatment With Immunological Checkpoint Inhibitors of HIV-infected Subjects With Cancer

PembroHIV
Start date: October 26, 2018
Phase:
Study type: Observational

It has been reported that peripheral and lymph node resident Cluster of Differentiation 4 (CD4)+ T cells expressing Programmed cell death protein 1 (PD-1) contribute to Human Immunodeficiency Virus (HIV) persistence during Antiretroviral Therapy (ART). In HIV-infected individuals, PD-1 expression on CD4+ T cells correlates with HIV disease progression, and loss of HIV-specific CD4+ T cell function can be reversed in vitro by PD-1 blockade. There are only a limited number of case reports describing the evolution of HIV-infected patients with concurrent oncological disease treated with immunological checkpoint inhibitors. However, this case provides very limited information on the effect of pembrolizumab on the HIV reservoir. Here, the investigators aim at describing changes in the HIV reservoir and in the HIV-specific immunity in HIV-infected patients on ART who receive immunological checkpoint inhibitors for the treatment of cancer, especially for metastatic melanoma.

NCT ID: NCT03767374 Recruiting - HIV Infections Clinical Trials

Risk-factors for Multidrug-resistant Bacteria Colonization Among Patients at High Risk of STIs

BMR-IST
Start date: May 11, 2018
Phase:
Study type: Observational

The aim of this study is to identify risk factors and prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria colonization among patients at high risk of STIs

NCT ID: NCT03763942 Not yet recruiting - HIV Infections Clinical Trials

HealthMindr App to Increase Pre-exposure Prophylaxis (PrEP) Uptake and Retention Among Men Who Have Sex With Men (MSM)

Start date: January 2019
Phase: N/A
Study type: Interventional

This study is a randomized controlled clinical trial of a theoretically based mobile app, HealthMindr, to increase pre-exposure prophylaxis (PrEP) uptake among men who have sex with men (MSM) to prevent human immunodeficiency virus (HIV). Participants in the intervention arm will receive access to the HealthMindr app, with information about PrEP and other HIV prevention methods in addition to provider locators. Participants randomized to the control arm will receive standard of care. The primary aim for this study is to assess PrEP uptake in the intervention arm compared to the control arm.

NCT ID: NCT03760458 Not yet recruiting - HIV Infections Clinical Trials

The Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less Than 12 Years of Age

Start date: February 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to examine the pharmacokinetics, safety, and tolerability of abacavir/dolutegravir/lamivudine dispersible and immediate release tablets in HIV-1-infected children less than 12 years of age.

NCT ID: NCT03758625 Recruiting - HIV Infections Clinical Trials

Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional Cure

DC-HIV04
Start date: November 30, 2018
Phase: Phase 1
Study type: Interventional

This study will be done in people living with HIV to see if an investigational vaccine made from a person's own white blood cells is safe and tolerated. This study will also look at the body's immune response to the vaccine and evaluate four different methods of making the vaccine to see which method may result in better immune responses.

NCT ID: NCT03755986 Completed - HIV Infections Clinical Trials

Performance and Usability Evaluation of the Atomo HIV Self-Test

Start date: October 2016
Phase: N/A
Study type: Interventional

The study seeks to enroll 501+ patients to use a HIV self testing device to test for HIV in a blood sample drawn by finger prick. The purpose of the trial is to assess the usability of the device by providing participants with video and written instructions on how to correctly obtain a result from the device.

NCT ID: NCT03754803 Recruiting - HIV Infections Clinical Trials

Description of Real World Antiviral Effectiveness and Sustainability of the 2-Drug Regimen Dolutegravir + Lamivudine in Untreated and Pre-treated Patients in Routine Clinical Care in Germany

URBAN
Start date: November 13, 2018
Phase:
Study type: Observational

This is a prospective, non-interventional, multi-center study, in subjects with clinical indication of Human Immunodeficiency Virus (HIV)-1 infection. The aim of the study is to generate the real world evidence for the use of DTG+3TC in routine clinical care in Germany to supplement data obtained from controlled clinical trials. Approximately, 300 treatment naïve and pre-treated HIV-1 positive subjects will be enrolled in the study. The observation period for the study will be 3 years. Data will be collected from routine clinical care via electronic data capture (EDC) system.

NCT ID: NCT03753867 Not yet recruiting - HIV Infections Clinical Trials

RA Effect on Cell Surface Molecules in Vivo

Start date: January 7, 2019
Phase: Phase 1
Study type: Interventional

This study will follow a group of healthy male participants for about 18 weeks to see the effect of taking Acitretin on their immune cells

NCT ID: NCT03747003 Active, not recruiting - Clinical trials for Erectile Dysfunction

Gonadal Function in Young to Middle Aged HIV-infected Men

Start date: May 15, 2013
Phase:
Study type: Observational

HIV infection is associated to premature decline of serum testosterone. However, prevalence and biochemical characterization of hypogonadism in HIV-infected men are still to be well defined. HIV-infection is strongly associated to erectile dysfunction in men, but preliminary data suggest that it is poorly associated with serum testosterone in this context.

NCT ID: NCT03746600 Not yet recruiting - HIV/AIDS Clinical Trials

Technological Intervention for Reducing Alcohol Use Among People Living With HIV/AIDS

TRAC
Start date: January 2019
Phase: N/A
Study type: Interventional

While advances in medication have led to greatly improved outcomes for people living with HIV/AIDS, less than one-third of all people living with the disease are adherent enough to their medication to achieve viral suppression. Alcohol consumption has been shown to have a significant effect on HIV medication adherence, so the proposed research will aim to reduce alcohol use among people living with HIV/AIDS through a technology-driven intervention. This eight-session intervention will be delivered using a combination of videoconferencing, smart phones, and Bluetooth-enabled breathalyzers for monitoring of alcohol consumption, with an overall goal of reducing alcohol use, mitigating adherence issues, and achieving optimal prevention and treatment responses for people living with HIV/AIDS.