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HIV Infections clinical trials

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NCT ID: NCT03746457 Completed - Alcohol Consumption Clinical Trials

Alcohol and ART Adherence in India

RISHTA
Start date: May 10, 2015
Phase: N/A
Study type: Interventional

The focus of this project was to reduce alcohol consumption among male "persons living with HIV" (PLHIV) on antiretroviral treatment (ART) at government hospitals in urban Maharashtra, India and factors associated with both these outcomes including depression, stigma, social support networks, quality of life and health status. The project consisted of three phases; formative research, implementation of multilevel interventions and analysis of process and outcome data. The project utilized a crossover design to compare outcomes of individual interventions and the sequences of intervention.

NCT ID: NCT03742375 Recruiting - Clinical trials for Human Immunodeficiency Virus

Quantitative HPV Genotyping in Screening of Anal Intraepithelial Neoplasia in HIV-positive Patients

GAIN
Start date: August 1, 2018
Phase: N/A
Study type: Interventional

The pathophysiology from anal HPV infection to Anal Intraepithelial Neoplasia is less well understood than cervical HPV infection. In cervical screening programs it is well accepted that the sole presence of a high-risk HPV strain (irrespective of number of viral particles) is sufficient to justify further investigation and treatment. The investigators hypothesize that in anal HPV infection not only the presence but the extent of HPV infection (single genotype viral load) or combination of different HPV genotypes (cumulative viral load) is of importance in determining the risk of anal dysplasia.

NCT ID: NCT03739996 Not yet recruiting - HIV Infections Clinical Trials

Long-Acting Cabotegravir Plus VRC01LS for Viral Suppression in HIV-1-Infected Adults

Start date: January 31, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and antiviral activity of long-acting cabotegravir (CAB LA) plus the broadly neutralizing monoclonal antibody, VRC-HIVMAB080-00-AB (VRC01LS), in HIV-1-infected adults with suppressed plasma viremia.

NCT ID: NCT03735849 Not yet recruiting - HIV Infections Clinical Trials

Evaluating the Safety and Pharmacokinetics of VRC-HIVMAB075-00-AB (VRC07-523LS) in the Sera and Mucosae of Healthy, HIV-Uninfected Adult Participants

Start date: January 15, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and pharmacokinetics of a human monoclonal antibody (VRC07-523LS) in the sera and mucosae of healthy, HIV-uninfected adults.

NCT ID: NCT03732625 Not yet recruiting - HIV Infections Clinical Trials

Neuropsiquiatric Evolution After Introduction of Raltegravir QD in Substitution of Dolutegravir: NEAR QD Study

NEARQD
Start date: January 2019
Phase: Phase 4
Study type: Interventional

Open, multicenter, non randomized, single arm, pilot trial.

NCT ID: NCT03730311 Not yet recruiting - HIV Infections Clinical Trials

Phase Ib Study of Safety, Tolerability and Pharmacokinetics of Elpida Once Weekly in Healthy Volunteers

Start date: December 2018
Phase: Phase 1
Study type: Interventional

A randomized, placebo-controlled, once weekly dose for four weeks, double blind study in Healthy HIV-Uninfected Volunteers (6 active; 2 placebo) with 40 mg and 80 mg in parallel followed by 120 mg after DSMB approval.

NCT ID: NCT03729778 Recruiting - HIV Infections Clinical Trials

Impact of HIV-1 and Aging on Mucosal Vaccine Responses

Start date: January 18, 2017
Phase: Phase 4
Study type: Interventional

The purpose of this study is to learn more about both HIV-1 infection and advancing age, alone and in combination, and their association with increased risk of serious infection and impaired response to the Prevnar 13 vaccine.

NCT ID: NCT03727932 Completed - HIV Infections Clinical Trials

VioOne HIV Profile Supplemental Assay

Start date: January 3, 2018
Phase: N/A
Study type: Interventional

Assessment of the sensitivity, specificity and reproducibility of the VioOne HIV Profile Supplemental Assay

NCT ID: NCT03719664 Not yet recruiting - HIV-1-infection Clinical Trials

Albuvirtide and 3BNC117 as Long-Acting Maintenance Therapy in Virologically Suppressed Subjects

ABL
Start date: November 2018
Phase: Phase 2
Study type: Interventional

The study is an adaptive, phase 2, multicenter, three-part study to establish the dosage, safety and antiviral activity of combination therapy with albuvirtide (ABT) and 3BNC117 as long-acting maintenance therapy in virologically suppressed subjects with HIV-1 infection.

NCT ID: NCT03719521 Not yet recruiting - HIV Infection Clinical Trials

Community Based Interventions to Improve HIV Outcomes in Youth: a Cluster Randomised Trial in Zimbabwe

CHIEDZA
Start date: January 2019
Phase: N/A
Study type: Interventional

A cluster randomised trial to determine the impact of an integrated community-based package of HIV services incorporating HIV testing, linkage to care and ongoing adherence support, combined with sexual and reproductive health (SRH) services and general health counselling for 16 to 24 year olds on population level HIV viral load in a high HIV prevalence setting.