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Filter by:This study will investigate the test-retest reliability of transcranial magnetic stimulation (TMS) -evoked potentials (TEPs) as measured by electroencephalography (EEG), using three different TMS protocols over five different brain regions in healthy volunteers. The goal is to compare the test-retest reliability of single pulse, inhibitory and excitatory TMS protocols as well as two distinct targeting approaches. The main questions to answer are: 1. This study will investigate whether the test-retest reliability of TEPs differ across TMS protocols. 2. This study will investigate whether the test-retest reliability of TEPs differ between individualized and non-individualized targeting approaches.
The main purpose of this study is to evaluate the safety and immunogenicity of three dosage levels (low, medium, high) of the bivalent combination respiratory syncytial virus (RSV)/human metapneumovirus (hMPV) virus-like particle (VLP) candidate vaccine (IVX-A12), compared to placebo, when administered as a single-dose regimen in healthy older adults 60 to 75 years of age.
A Randomized, Double-blinded, Partial-open, Placebo and Active-controlled, Single and Multiple Dose-escalation Phase 1 Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of ID120040002 in Healthy Volunteers
The aim of this randomized controlled study, which included pre-test, posttest and perseverance test, was to determine the effect of game-based learning on nursing students' knowledge levels about blood transfusion, to determine the permanence level of learning and satisfaction with the training method. The fundamental question it aims to answer is: •Does the blood transfusion training given to nursing students by the board game playing method have an effect on the level of knowledge, the permanence of the information and satisfaction with the training method? Participants will participate in an educational activity related to blood transfusion. The researchers will compare whether the blood transfusion training given to nursing students with the board game playing method is effective or not with the text-reading method.
The goal of this randomized controlled including pretest, posttest and persistence test study is to examine the effect of creative drama method on student nurses' knowledge and skill levels related to postmortem care, learning permanence and satisfaction with the training method. The main question it aims to answer are: •Is the postmortem care training given to nursing students with the creative drama method effective on the level of knowledge and skills, the permanence of knowledge and skills and satisfaction with the training method? Participants will participate in an educational activity related to postmortem care. Researchers will compare it with the classical education method to see if postmortem care training given to nursing students with the creative drama method is effective.
The main objectives of this trial are to investigate safety, tolerability and pharmacokinetics (PK) of BI 765423 in healthy male subjects following intravenous administration of single rising doses.
The goal of this clinical trial is to evaluate the effect of Product X on facial skin of middle-aged women in Malaysia. The main questions it aims to answer are: 1. The effect of Product X on skin hydration of middle-aged women in Malaysia. 2. The effect of Product X on skin elasticity of middle-aged women in Malaysia. 3. The effect of Product X on skin wrinkle of middle-aged women in Malaysia. 4. To observe any adverse effect occurrence with the use of Product X. Participants will used Product X for 8 week and the skin assessment will be carried out at baseline, week 2, 4 and week 8.
This study is the first clinical study with PF-07328948. The safety, tolerability, and plasma pharmacokinetics and pharmacodynamics of PF-07328948 after administration of escalating, single, oral doses will be evaluated.
The goal of this clinical trial is to test the Caregiver Interaction Profile (CIP) training program (Helmerhorst et al., 2017) promoting the relational quality between professional caregivers and children in daycare. The main questions it aims to answer are: - Does the CIP training program, compared to no training, improve the relational quality between daycare providers and children in daycare? - Does the CIP training program, compared to no training, foster children's social, emotional, and language development? Daycare providers assigned to the "training group" will participate in the CIP training program, which uses video-recorded interactions between the daycare providers and children in daycare to give feedback on the relational quality as observed in the videos. Daycare providers assigned to the "waiting list control group" will initially not take part in the training program but will receive the training after the study is finished. All daycare providers' daily interactions with the children in daycare will be filmed before and after the training in order to see if there has been a change in relational quality for the daycare providers in the training group (compared to the control group). Daycare providers in the training and control groups will also fill out questionnaires about the social, emotional, and language development of the children in their care. Researchers will compare daycare providers (and the children in their care) in the "training group" to daycare providers (and the children in their care) in the "control group" to see if the relational quality in the training group improves more than that in the control group as a result of the CIP training, and how that impacts the social, emotional, and language development of children.
The goals of this clinical study are to characterize and compare the safety, tolerability, blood levels of UPB-101 when given to healthy Japanese and non-Japanese non-East Asian (NJNEA) adults. Eligible participant will be assigned to one of the 4 planned dosing treatment groups. Treatment groups 1, 2 and 3 will consist of Japanese adults who will be administered a single subcutaneous (SC) dose of UPB-101 (at 3 different strengths). Treatment group 4 will consist of NJNEA participants who will receive a single SC dose of UPB-101. All treatment groups will enroll and run in parallel.