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NCT ID: NCT03516630 Completed - Healthy Clinical Trials

Effects of Three Single Oral Doses of Trazodone on the QTc Interval Duration in Healthy Volunteers

Start date: March 20, 2017
Phase: Phase 1
Study type: Interventional

The present study has been designed to evaluate the effect of three doses of trazodone (20, 60 and 140 mg), in comparison to placebo, on the QT/QTc interval of healthy volunteers. Trazodone oral drops 6% formulation has been selected in order to evaluate the three doses using the same formulation, because the lowest available strength for the tablet formulations is 50 mg. According to the E14 guideline on the evaluation of QT/QTc interval prolongation and proarrhythmic potential of antiarrhytmic drugs, a negative control (placebo) and a positive control (moxifloxacin) will also be assessed.

NCT ID: NCT03512821 Completed - Healthy Clinical Trials

A Single-dose, Comparative Bioavailability Study of Two Formulations of Ursodiol 500mg Tablets Under Fed Conditions

Start date: October 1, 2017
Phase: Phase 1
Study type: Interventional

single-dose, comparative bioavailability study of two formulations of ursodiol 500mg tablets under fed conditions

NCT ID: NCT03512808 Completed - Healthy Clinical Trials

A Single-dose, Comparative Bioavailability Study of Two Formulations of Ursodiol 500mg Tablets Under Fasting Conditions

Start date: June 1, 2017
Phase: Phase 1
Study type: Interventional

A single-dose, comparative bioavailability study of two formulations of ursodiol 500mg tablets under fasting conditions

NCT ID: NCT03508635 Completed - Healthy Clinical Trials

CORT125134 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)

Start date: September 2014
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the dose-related safety, tolerability, pharmacokinetics (PK) and pharmacological effects (PD) of CORT125134 and its active metabolite CORT125201 after single and multiple ascending oral doses of CORT125134 in healthy subjects.

NCT ID: NCT03500900 Completed - Healthy Clinical Trials

Vildagliptin on Gastric Accommodation

Start date: March 1, 2016
Phase: N/A
Study type: Interventional

Dipeptidyl peptidase-4 (DPP-4) inactivates glucagon-like peptide-1 (GLP-1). Whether DPP-4 inhibition affects GLP-1 metabolism in vivo and/or food intake remains unknown. The aim of this study is to evaluate the effect of vildagliptin (DPP-4 inhibitor) on gastric accommodation and ad libitum food intake in healthy volunteers (HVs).These effects will be evaluated in two randomized, placebo-controlled, single-blinded trials. Each protocol will include ten volunteers. Protocol 1: Sixty minutes after treatment a nutrient drink (270 kcal) will be intragastrically infused and intragastric pressure (IGP) will be measured for one hour. Protocol 2: 60 min after treatment the participants consume one nutrient drink (300 kcal). Thirty minutes hereafter, the participant will eat ad libitum from a free-choice buffet for 30 minutes. Blood will be collected at several time points to measure active GLP-1 plasma levels.

NCT ID: NCT03494491 Completed - Healthy Clinical Trials

Characterization of Chitin-glucan Fiber Fermentation in Human After a Single Administration

Start date: March 8, 2018
Phase: N/A
Study type: Interventional

The aim of this research study is to characterize the fermentation of chitin-glucan fiber by assessing the volatile compounds released in the breath. For this purpose, an interventional study with control will be performed. After a single administration of 4.5 g of chitin-glucan fiber, the kinetic of production of exhaled volatile compounds (such as H2, methane, SCFAs,…) will be measured during twelve hours. These results will be compared to the exhaled volatile compounds measured during twelve hours after supplementation with 4.5g of maltodextrin (placebo).

NCT ID: NCT03473197 Completed - Healthy Clinical Trials

A 6-Week Study to Evaluate Photoallergic Skin Reaction of CCP-020 (Diacerein 1%) in Healthy Subjects

Start date: January 8, 2018
Phase: Phase 1
Study type: Interventional

A study in healthy male and female adult volunteers to determine the potential of CCP-020 (Diacerein 1%) Topical Ointment to induce a photoallergic skin reaction using a controlled photopatch testing procedure.

NCT ID: NCT03473184 Completed - Healthy Clinical Trials

A 4-Day Study to Evaluate Phototoxicity of CCP-020 (Diacerein 1%) in Healthy Subjects

Start date: December 12, 2017
Phase: Phase 1
Study type: Interventional

This Phase 1 study is designed to determine the photoirritation potential of CCP-020 (Diacerein 1%) when application is followed by light exposure.

NCT ID: NCT03472534 Completed - Healthy Clinical Trials

A 21-Day Study to Evaluate the Skin Irritation Potential of CCP-020 (Diacerein 1%) Topical Ointment in Healthy Subjects Using a Cumulative Irritant Patch Test Design

Start date: January 9, 2018
Phase: Phase 1
Study type: Interventional

Single center, randomized, controlled, evaluator blinded, within-subject comparison study to evaluate the irritation potential of CCP-020 (Diacerein 1%) topical ointment on normal skin.

NCT ID: NCT03471585 Completed - Healthy Clinical Trials

Effects of THC on Emotional Memory Retrieval

TARE
Start date: February 15, 2017
Phase: Early Phase 1
Study type: Interventional

The purpose of this study was to examine the effects of THC on the retrieval of emotional and neutral memories in healthy young adults.