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NCT ID: NCT03778801 Completed - Healthy Clinical Trials

Kinesiophobia in Patients With Fibromyalgia Syndrome and Chronic Neck Pain

Start date: October 1, 2018
Study type: Observational

Kinesiophobia which is described as fear of movement reduces physical activity levels and increases the risk of chronic pain. We consider that kinesiophobia levels were higher in patients with fibromyalgia syndrome and chronic neck pain so that physical activity levels were lower in this patients groups. Because there are not enough studies, we aimed to evaluate kinesiophobia and physical activity levels in this patients.

NCT ID: NCT03773432 Completed - Healthy Clinical Trials

Influence of Meal Schedule: Gender Differences

Start date: August 13, 2018
Phase: N/A
Study type: Interventional

Gender differences in the effect of meal schedule will be studied in a parallel design (10 women and 10 men). In two separate days a probe meal (290 stewed beans, 35 g bread, 100 mL water; 549 Kcal) will be administered in the afternoon, i.e. conventional schedule, and in the morning, i.e. unconventional schedule. The effect of meal schedule will be measured as the differences between the responses on both study days. Participants will be instructed to eat standard dinner the day before and to consume standard breakfast at home the day of the afternoon test. Studies will be conducted in a quiet, isolated room with participants siting on a chair. Perception will be measured at 5 min intervals 10 min before and 20 min after ingestion and at 10 min intervals up to 60 min after the probe meal.

NCT ID: NCT03758482 Completed - Healthy Clinical Trials

Biological Response to Meal Ingestion: Gender Differences

Start date: June 25, 2018
Phase: N/A
Study type: Interventional

Aim: to determine the effect of gender on the sensory and metabolomic responses to a standard probe meal. Participants (12 men and 12 women) will be instructed to eat a standard dinner the day before, to consume a standard breakfast at home after overnight fast, and to report to the laboratory, where the test meal will be administered 4 h after breakfast. Studies will be conducted in a quiet, isolated room with participants sitting on a chair. Participants will ingest a standard probe meal (750 Kcal). Perception of homeostatic sensations (hunger/satiation, fullness) and hedonic sensations (digestive well-being, mood) will be measured at 5 min intervals 10 min before and 20 min after ingestion and at 10 min intervals up to 60 min after the probe meal. Heart rate variability, blood pressure and body temperature were measured before and after the meal. Blood samples for metabolomic analysis were taken before and 30 min after the meal.

NCT ID: NCT03758339 Completed - Healthy Clinical Trials

A Study of the Absorption, Metabolism, and Excretion of Tucatinib in Healthy Participants

Start date: December 30, 2017
Phase: Phase 1
Study type: Interventional

This study will look at how a drug (tucatinib) leaves the body and what happens to tucatinib while it is still in the body. Healthy participants will get one dose of tucatinib by mouth. Patients will be monitored for 8-14 days after they take the dose of tucatinib.

NCT ID: NCT03753477 Completed - Healthy Clinical Trials

Clinical Trial to Investigate the Efficacy and Safety of DWJ1351

Start date: December 22, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the safety and pharmacokinetic characteristics of combination of amlodipine, olmesartan and rosuvastatin and DWJ1351 in healthy male volunteers

NCT ID: NCT03752359 Completed - Healthy Clinical Trials

Whey Protein Supplementation and Resistance Training in Older Women With Sarcopenic Obesity.

Start date: March 13, 2017
Phase: N/A
Study type: Interventional

The main purpose of the present study was to investigate the effects of whey protein following resistance training on body composition, muscular strength, functional capacity, and plasma-metabolism biomarkers in older women with sarcopenic obesity.

NCT ID: NCT03752229 Completed - Healthy Clinical Trials

Capillary Blood Volume and Pain Perception Obtained in a Process of Puncturing With Different Safety Lancets

Start date: December 8, 2017
Phase: N/A
Study type: Interventional

The study was a randomized, single blind, uni-center pivotal study in male and female healthy volunteers, to determine capillary blood volume and pain perception obtained in a process of puncturing with different safety lancets. A group of three hundred (300) Caucasian male and female Subjects was randomized (aged > 18 to < 65 years old) who were in good physical and mental condition. The Subjects had 4 (four) fingers (two fingers from each hand) lanced each with a different type of safety lancet. Overall, 4 (four) different safety lancets were investigated per each Subject. Overall, 48 (forty eight) different safety lancets (4 different safety lancets per one Subject) were investigated, the capillary blood volume and pain were measured.

NCT ID: NCT03747341 Completed - Healthy Clinical Trials

Buprenorphine-Fentanyl Interaction Study

Start date: March 22, 2018
Phase: Phase 1
Study type: Interventional

An increase in overdose deaths has been attributed to widespread access to fentanyl and carfentanyl. The study is designed to determine if buprenorphine can change the respiratory depression response to intravenous (IV) fentanyl.

NCT ID: NCT03745443 Completed - Healthy Clinical Trials

Efficacy of Recruitment Maneuver in Pediatric Patients Under General Anesthesia

Start date: January 20, 2017
Phase: N/A
Study type: Interventional

During general anesthesia lung collapses and atelectasis occurs. Preservation of atelectasis can cause pulmonary disfunction. The goal of safe anesthesia is to protect the lungs intraoperatively. Positive end-expiratory pressure (PEEP) is distending pressure that prevents alveolar collapse during mechanical ventilation and is a part of recruitment maneuver that is often used in patients on mechanical ventilation. Overall effect of PEEP is improvement in lung function. PEEP can have adverse effects on hemodynamics. The objective of this study was to assess the effect of step up and down PEEP titration on lung function and hemodynamics in healthy preschool children during general anesthesia. One group of children was ventilated with constant PEEP. the other was submitted to PEEP titration. Changes in lung compliance, gas exchange and hemodynamic status were documented as well as any unwanted effects.

NCT ID: NCT03741621 Completed - Healthy Clinical Trials

Viscosity of Fibre Predicts Cholesterol-lowering in Healthy Individuals

Start date: January 1992
Phase: Phase 2
Study type: Interventional

To investigate the role of fibre viscosity (low, medium, high) in lowering cholesterol in healthy individuals