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A study in healthy male and female adult volunteers to determine the potential of CCP-020 (Diacerein 1%) Topical Ointment to induce a photoallergic skin reaction using a controlled photopatch testing procedure.
This Phase 1 study is designed to determine the photoirritation potential of CCP-020 (Diacerein 1%) when application is followed by light exposure.
Single center, randomized, controlled, evaluator blinded, within-subject comparison study to evaluate the irritation potential of CCP-020 (Diacerein 1%) topical ointment on normal skin.
The purpose of this study was to examine the effects of THC on the retrieval of emotional and neutral memories in healthy young adults.
Four basic taste perceptions and relationship with caries are poorly investigated in children as compared to adults. The aim of this study was to evaluate salty, sweet, bitter and sour taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors.
The purpose of this study was to determine how two doses of lasmiditan affected the heart in healthy participants. The study also evaluated how much lasmiditan got into the blood stream and how long it took the body to get rid of it. Information about side effects was collected. The study lasted a maximum of 46 days for each participant, not including screening.
In a cross-over study the investigators evaluate the effects of natural (Panmol-B-Complex) versus synthetic vitamin B complexes to identify the bioavailability of distinct vitamins as well as long-term effects. The primary hypothesis for this study: "Natural Vitamin B-complexes are as effective as synthetic Vitamin B-complexes or better." For this reason 30 subjects (18 to 65y; BMI >19 to <29) were recruited for this study. The study population was divided into 2 groups of each 15 subjects in a cross-over trial. Vitamin supplementation consisted of Thiamine (2,77mg), Riboflavin (3,53mg), Niacin (40,32mg), Pantothenic acid (15,12mg), Pyridoxine (3,53mg), Biotin (0,13mg), Folic acid (0,50mg) and Cobalamin (6,3µg) per day in both groups. Blood samples are taken at baseline - 1.5h after vitamin supplementation - 4h - 7h - 6 weeks - wash out phase I (2 weeks); start cross-over: baseline - 1.5h after vitamin supplementation - 4h - 7h - 6 weeks - washout phase II (6 weeks). In case of main target criteria Thiamin, Riboflavin, Pyridoxine, Folic acid and Cobalamin were measured in serum as well as total peroxides, peroxidase-activity, total antioxidant status and polyphenols.
This is a single-Center, Randomised, 4-Period, Phase 1 Study to Evaluate the Pharmacokinetics, Safety and Tolerability, and Effect of Food on Pharmacokinetics following Single Doses of MIV-711 Capsule and Tablet Formulations in Healthy Volunteers
The core region is prescribed as a box which is formed from abdominal muscles at the front, paraspinals and glutueal muscles on the back, diaphragm on the roof, oblique abdominal muscles on sides and hip joint and pelvic girdle at the base. With the activation of these muscles, both trunk stabilization is ensured and movement that emerges in the distal segments is supported by power generation and transfer. The location of the center of gravity in the space changes frequently with the movement of the body segments. Postural adjustments that required to restore the impaired balance due to this displacement of center of gravity, consist of lumbal stabilization with the activation of the core muscles. The upper extremity is a body part with a wide variety of abilities. With the same basic anatomical structures, the arms, forearms, hands and fingers may function differently. The upper extremity is the primary tool that people use to manipulate the environment. Therefore, mobility comes to the forefront rather than stability in the upper extremity. On the upper extremity, the most vital component in the transition from high-level mobility to functionality is the hand. The continuity of the kinetic chain is necessary for these functions to be carried out with biomechanical and kinesiologically correct patterns. The kinetic chain is a system that allows different body parts to produce coordinated power and collect and transfer it to the final connection point through muscle activity and body position. It is necessary to provide body stabilization by a strong core in order to achieve power transfer between the extremities and the trunk with the minimum loss of power due to this system. Core stabilization is defined as a prerequisite for the consist of movements involving the upper limb through regional biomechanical stabilization and power generation, transfer and control along the kinetic chain. The aim of this study planned in line with the available information is to investigate the effect of core stabilization exercises applied for 6 weeks on body balance and hand functions.
During the last pandemic influenza antivirals were prescribed both as prophylaxis and treatment. However, adherence rates were suboptimal. This study assessed the effect of theory-based and evidence-based health messages, which promoted the use of antivirals as prophylaxis for pandemic influenza, on intentions to use antivirals. Using hypothetical scenarios, the investigators tested whether written health communications about pandemic flu and recommended preventative medication (i.e. a prophylactic treatment with antivirals) had an effect on study participants' beliefs about the pandemic flu and the advice received, and their intention to adhere to the recommendation. In particular, the investigators assessed the behavioural impact of health messages presented in four different linguistic formats, defined by a 2×2 (agency assignment × attribute framing) factorial design. The originality of this study relies on the attempt to maximise the behavioural impact of written health messages by combining the agency assignment and attribute framings, which have never been tested together, and by systematically targeting specific predictors of adherence intentions through these messages. The findings of this study may be used to improve the behavioural impact of health communications to the general public in case of a pandemic flu outbreak in the UK.