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NCT ID: NCT03269474 Enrolling by invitation - Healthy Clinical Trials

Computational Drug Repurposing for EBS

Start date: October 1, 2017
Phase: N/A
Study type: Observational

The study will compare gene expression differences between blistered and non-blistered skin from individuals with EBS, as well as normal skin from non-EBS subjects. State of the art computational analysis will be performed to help identify new drugs that might help EBS wound healing and reduce pain. Researchers will focus on drugs that have already been approved for treatment of other dermatologic or non-dermatologic diseases, and therefore be repurposed for treatment of EBS. Drug development is a very expensive process taking decades for execution. Drug repurposing on the other hand, significantly reduces the cost and shortens the amount of time that is needed to bring effective treatments to clinical use. To date, there is no specific treatment targeting the physiology and immunologic response in EB patients during wound healing. Market availability of repurposed medications will provide EBS patients rapid access to treatments, thus improving their quality of life.

NCT ID: NCT03253835 Enrolling by invitation - Healthy Clinical Trials

Cardiac Blood Flow Patterns Associated With Left Ventricular Myocardial Damage

Start date: November 21, 2013
Phase: N/A
Study type: Observational

Various factors affect the performance of the heart: The contractile properties of myocardial muscle cells are the fundamental devices for translating tension-generation and shortening of the cardiac muscle into pressure-generation and blood volume ejection from the heart into the body. On the other hand, the performance of heart can be analyzed with respect to input and output of blood to/from the hollow cardiac muscle and evaluated in terms of the performance of a pump: With every heartbeat blood is sucked from a low-pressure system (veins) and pumped to the arterial high-pressure system via one-way valves, whereas efficiency, ejected blood volume, blood flow and pressures are linked by hemodynamic laws. Cardiac magnetic resonance (CMR) is the "gold standard technique" to determine cardiac function and muscle mass, as well as for non-invasive diagnosis of myocardial necrosis/fibrosis. Furthermore, new CMR imaging techniques enabling the measurement of myocardial magnetic relaxation times for characterization of myocardial morphology and the acquisition of time-resolved, three-dimensional blood flow velocity fields in the heart and surrounding vessels, represent promising tools for the evaluation of the interaction between myocardial morphology and cardiac function. Aim of this explorative study is to 1. identify myocardial pathology-associated blood flow patterns in the heart and surrounding great vessels, and 2. correlate characteristic blood flow patterns in the heat (existence of vortices, vorticity, vortex formation, propagation dynamics …) with myocardial injuries.

NCT ID: NCT03243448 Enrolling by invitation - Healthy Clinical Trials

Skin Sympathetic Nerve Activity and Sympathetic Tone

Start date: August 1, 2016
Phase: N/A
Study type: Observational [Patient Registry]

There are many sympathetic hyperactivity diseases in the investigators' clinical practice. However, the conventional method to measure the sympathetic nerve activity had many limitations such as clinical application, data interpretation and even therapeutic manipulation. Therefore the investigators would like to develop a non-invasive method to record the sympathetic nerve activity in the investigators' study that can help gathering the sympathetic nerve activity easily in the investigators' daily clinical situation. By the determination of sympathetic nerve activity status, the health caregiver can understand the disease more.

NCT ID: NCT03189849 Enrolling by invitation - Healthy Clinical Trials

Farms, Animals and Adolescents: Reinforcing the Microbiome

Start date: June 2017
Phase: N/A
Study type: Observational

This study will be an observational study of children who attend summer camp at the Heartland Farm Sanctuary (HFS). The investigators are exploring whether time-limited exposure to a traditional farming environment will improve children's overall health and general well-being.

NCT ID: NCT03188302 Enrolling by invitation - Healthy Clinical Trials

Evaluation of New Method for Measuring Stool Consistency

Start date: June 2, 2017
Phase: N/A
Study type: Interventional

This study is designed to validate a new direct method for the measurement of stool consistency, using Texture Analyser. Forty healthy subjects are enrolled in this trial for collection of stool samples. Every stool produced during 2 collection periods of approximately 60 hours each is collected and subjected to the measurement of consistency using Texture Analyser. The stool consistency results are compared with the Bristol Stool Form Scale scores for each stool. The relationships of stool consistency with other stool parameters, bowel habit and sleeping habit are also evaluated.

NCT ID: NCT03160261 Enrolling by invitation - Healthy Clinical Trials

Effect of Exenatide on Cortisol Secretion

Start date: September 7, 2017
Phase: Phase 4
Study type: Interventional

The primary aim of the study is to describe the effect of single dose of 10 micrograms (μg) exenatide given subcutaneously (s/c) on cortisol secretion. Secondary outcomes involve ACTH and glucose levels.

NCT ID: NCT03146520 Enrolling by invitation - Healthy Clinical Trials

Clinical Validation of Stool DNA-based SDC2 Methylation Test for Colorectal Cancer Detection

Start date: December 13, 2016
Phase: N/A
Study type: Observational

Pivotal trials of SDC2 methylation biomarker test in stool DNA to estimate clinical sensitivity and specificity in detection of colorectal cancer.

NCT ID: NCT03127046 Enrolling by invitation - Healthy Clinical Trials

Drug-drug Interaction Between Aceclofenac 200 mg and Esomeprazole 20 mg in Healthy Male Volunteers

Start date: March 31, 2017
Phase: Phase 1
Study type: Interventional

To evaluate the drug-drug interaction between aceclofena and esomeprazole

NCT ID: NCT03076086 Enrolling by invitation - Healthy Clinical Trials

Investigation of Secreted Phosphoproteins and PiP3 (Phosphoinositolphospat 3) in Sputum

Start date: May 12, 2017
Phase: N/A
Study type: Interventional

The aim of this study is to validate two new biomarkers in sputum samples. These are PiP3 (phosphoinositolphospat ) and phosphor proteins, representing important proteins within inflammatory situations of the lung.

NCT ID: NCT03044327 Enrolling by invitation - Healthy Clinical Trials

Development of Novel Non-invasive Inflammometry Following Lipopolysaccharide, Endotoxin (LPS) Challenge in Healthy Volunteers

Start date: February 15, 2017
Phase: N/A
Study type: Interventional

The aim of this study is to further profile and develop the Lipopolysaccharide, endotoxin (LPS) challenge models (both by instillation and inhalation) by investigating the utility of various non-invasive monitoring methods.