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NCT ID: NCT03506399 Withdrawn - Healthy Clinical Trials

A Study of Lanabecestat in Healthy Female Participants Taking Oral Contraceptive

Start date: June 2018
Phase: Phase 1
Study type: Interventional

The study will evaluate the effect of oral contraceptive (birth control pill) on the blood level of lanabecestat when both are given together. Side effects will be monitored and documented. This study will last up to 27 days for each participant, not including screening. Screening is required within 42 days prior to first dose.

NCT ID: NCT03340233 Withdrawn - Healthy Clinical Trials

Understanding the Mechanisms of Diastolic Dysfunction

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

Heart failure is a clinical syndrome marked by breathlessness, even at low levels of exertion, general fatigue, and fluid retention and is estimated to affect 5.1 million people in the United States. Heart failure with preserved ejection fraction (HFpEF) means that the heart pumps enough blood to the body, but patients still have terrible symptoms. It is estimated to account for about 50% of all heart failure cases. Experts agree that impaired filling of the heart, perhaps due to "stiffness" of the heart muscle itself, critically underlies HFpEF. There is currently no clinical technique for measuring heart muscle (myocardial) stiffness; the very definition of "myocardial stiffness" remains poorly established. Consequently, the ability to study the mechanisms that underlie HFpEF is virtually non-existent, and limited treatment options will persist without significant advances. The objective of this project is to use an Equilibrium-Material-Stability (EMS) framework that couples patient-specific clinical MRI and heart pressure data in a computational model of the heart to diagnose changes in myocardial stiffness. The central hypothesis is that the new EMS framework for understanding the mechanisms of diastolic dysfunction in HFpEF will be more sensitive and outperform currently available approaches.

NCT ID: NCT03220867 Withdrawn - Healthy Clinical Trials

Bioequivalence Study of Xian Risperdal Tablets Compared With Gurabo Risperdal Tablets Under Fasting and Fed Conditions in Chinese Healthy Participants

Start date: December 11, 2017
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to assess the bioequivalence of Xian Risperdal compared with Gurabo Risperdal in Chinese healthy participants under fasting and fed conditions.

NCT ID: NCT03131700 Withdrawn - Healthy Clinical Trials

Bioequivalence and Safety Study of Bevacizumab-biosimilar (RPH-001) Compared to Bevacizumab-innovator

Start date: December 2017
Phase: Phase 1
Study type: Interventional

The purpose of this to assess pharmacokinetic bioequivalence between two bevacizumab products, RPH-001 (TRPHARM) and EU sourced Avastin® (Roche), after single IV administration at 5 mg/kg fixed dose.

NCT ID: NCT03130647 Withdrawn - Healthy Clinical Trials

The Effects of Transcranial Focused Ultrasound on Human Motor Learning

Start date: May 15, 2017
Phase: N/A
Study type: Interventional

Transcranial focused ultrasound (tFUS) is a form of neuromodulation that uses a single element transducer to produce highly focused low-intensity acoustic energy that can be used to affect cortical excitability in humans.

NCT ID: NCT03035734 Withdrawn - Healthy Clinical Trials

Evaluate the Bioavailability Between 2 BMS-986141 Formulations in Healthy Participants

Start date: January 25, 2017
Phase: Phase 1
Study type: Interventional

Open label, randomized, 4-period crossover study with single doses of BMS-986141 given to healthy female subjects of non-childbearing potential and healthy males.

NCT ID: NCT02951845 Withdrawn - Healthy Clinical Trials

Study to Investigate the Food Effect and Oral Bioavailability of Tablet Formulations Relative to Suspension Formulation of JNJ-54416076 in Healthy Participants

Start date: November 22, 2016
Phase: Phase 1
Study type: Interventional

The purpose of the study is to assess the oral bioavailability of the two tablet formulations of JNJ-54416076 relative to the suspension formulation and to investigate the effect of a high fat meal on the pharmacokinetics of the tablet formulation in healthy participants.

NCT ID: NCT02897999 Withdrawn - Healthy Clinical Trials

Single and Multiple Dose Evaluation of QBKPN SSI In Healthy Volunteers

Start date: September 2016
Phase: Phase 1
Study type: Interventional

The purpose of this dose-escalation study is to assess the safety and pharmacodynamics of single and multiple doses of QBKPN SSI, administered subcutaneously to healthy adult volunteers

NCT ID: NCT02531009 Withdrawn - Healthy Clinical Trials

Systemic Sclerosis Clinical and Biomarker Study

Start date: December 2015
Phase: N/A
Study type: Observational

The primary objective of the study is to assess the change in systemic sclerosis (SSc)-associated gastrointestinal (GI) tract symptoms over a 1-year period in participants with SSc.

NCT ID: NCT02506010 Withdrawn - Healthy Clinical Trials

Accuracy Validation of a Pulse Oximetry Monitor

Start date: November 2016
Phase: N/A
Study type: Observational

The purpose of this study is to conduct an oxygen saturation (SpO2) accuracy validation comparing prototype pulse oximeter oxygen saturation measurements directly to arterial blood saturation during non-motion conditions over the range of 60-100% SaO2 as measured by Reference CO-Oximetry. Additionally, the prototype pulse oximeter pulse rate measurements will be compared to 3-lead ECG heart rate measurements made via a multi-parameter monitor.