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NCT ID: NCT03321318 Active, not recruiting - Healthy Clinical Trials

AK-R215 Pharmacokinetic Study Phase I

Start date: July 13, 2017
Phase: Phase 1
Study type: Interventional

An open label, randomized, 2-sequence, 2-period, single-dose cross-over study to evaluate the pharmacokinetics characteristics of AK-R215

NCT ID: NCT03304964 Active, not recruiting - Healthy Clinical Trials

A Phase 1, Pharmacokinetics of the MMP-12 Inhibitor FP-025 After Multiple Oral Ascending Doses in Healthy Subjects

Start date: July 21, 2017
Phase: Phase 1
Study type: Interventional

This is a single-center, phase I study consisting of 2 parts. The first part is a multiple ascending dose (MAD) part with a randomized, double-blind, placebo-controlled design in 3 treatment groups of 8 subjects (6 active; 2 placebo). The second part is a food effect (FE) part with a randomized, open-label, 2-period, 2-way crossover, single dose design in 8 subjects.

NCT ID: NCT03298906 Active, not recruiting - Healthy Clinical Trials

A Study to Assess the Effect of Ticlopidine on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine in Healthy Participants

Start date: September 26, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the effects of ticlopidine on the pharmacokinetics (PK) of intranasally administered esketamine.

NCT ID: NCT03297983 Active, not recruiting - Healthy Clinical Trials

M7583 Relative Bioavailability of Tablet Compared to Powder-in-capsule

Start date: October 9, 2017
Phase: Phase 1
Study type: Interventional

This is a Phase I study consisting of 2 parts: Part 1 aims to investigate the relative bioavailability of tablet formulation (test treatment) and Powder in capsule (PiC) formulation (reference treatment) of M7583 under fasted conditions. The aim of Part 2 is to determine and compare the single dose Pharmacokinetic (PK) profile of M7583 tablet under fasted and fed conditions to assess the food effect.

NCT ID: NCT03295578 Active, not recruiting - Healthy Clinical Trials

Blood Glucose, Cognition and Wellbeing @ Work

Start date: October 2, 2017
Phase: N/A
Study type: Interventional

This randomized controlled pilot study has as a main aim to investigate the relationship between glucose and cognition and wellbeing, as well as food intake in an at-work setting. Additionally, the continuous glucose data collected in the study will be used to investigate the inter- and intraindividual variability in glucose response to foods/meal in a real-life setting. Finally, the study aims to determine if self-monitoring and feedback about food intake and health stimulate individuals to make healthier choices. This study will have two groups, the feedback group and the control group. The study will consist of two self-monitoring periods of two weeks. In between these two self-monitoring periods, the participants in the feedback group will be given feedback on their measurement data. The control group will not get any feedback.

NCT ID: NCT03279393 Active, not recruiting - Healthy Clinical Trials

PPG Project 3 - PET/MRI of the Brain-hematopoiesis-atherosclerosis Axis in PTSD Patients

Start date: March 17, 2017
Phase: Early Phase 1
Study type: Interventional

Project 3 of the PPG grant "Stress and Atherosclerotic Plaque Macrophages A Systems Biology Approach," funded by the NHLBI, examines the relationship between psychosocial stress and atherosclerotic inflammation, cell proliferation and burden using novel PET/MRI. Individuals with post-traumatic stress disorder, trauma controls and healthy controls will be recruited into a two center clinical study. The study team will use functional MRI to examine the relationship between activation of fear circuits in the brain and relate these data to hematopoietic system activation, and vascular inflammation measured by FDG-PET, and atherosclerotic burden measured by MRI.

NCT ID: NCT03262597 Active, not recruiting - Healthy Clinical Trials

"Beverage Hydration Index" of Commercial Therapeutic Beverages

Start date: February 17, 2017
Phase: N/A
Study type: Interventional

The "beverage hydration index" (BHI) assesses the hydration potential of any consumable fluid relative to water. The BHI is a relatively new metric. Our purpose was to assess the BHI of beverages never previously tested, including an amino acid-based oral rehydration solution (AA-ORS), a glucose-containing ORS (G-ORS) and a sports drink (SD) compared to water (control).

NCT ID: NCT03251339 Active, not recruiting - Healthy Clinical Trials

Safety and Immunogenicity of MSB11455 in Healthy Subjects

Start date: August 21, 2017
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to compare the immunogenicity and safety of MSB11455 and Neulasta in healthy adult subjects.

NCT ID: NCT03248609 Active, not recruiting - Healthy Clinical Trials

Glycemic Index of Table Grape Varietals

Start date: July 31, 2017
Phase: N/A
Study type: Interventional

Investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals or grape juice, compared to a standard amount of glucose.

NCT ID: NCT03228446 Active, not recruiting - Healthy Clinical Trials

The Effects of Attentional Filter Training on Working Memory

DIIN
Start date: September 26, 2012
Phase: N/A
Study type: Interventional

The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional control.