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NCT ID: NCT03587883 Recruiting - Healthy Clinical Trials

Daily Intake of Cocoa Flavanols and Arterial Stiffness in Humans

Start date: March 23, 2018
Phase: N/A
Study type: Interventional

A randomized, double-masked and cross-over dietary intervention study to investigate the effects of diet supplementation with cocoa flavanols on arterial stiffness in healthy adult human subjects.

NCT ID: NCT03587467 Recruiting - Healthy Clinical Trials

Study on Gut Microbiota in Chronic HBV Infected Patients

HBV
Start date: December 1, 2017
Phase:
Study type: Observational

Hepatitis B Virus(HBV) infection is a common infectious disease affecting up to 2 billion people worldwide. Around 650 thousand people died of liver failure, cirrhosis and primary liver cancer caused by chronic hepatitis B every year. Age is the main factor affecting the chronicity of hepatitis B, while 90% and 25% to 30% of hepatitis b virus(HBV) infection in perinatal and infant period will develop into chronic infection respectively. Whereas the proportion in patients above 5 years old is only 5% to 10%. Intestinal microbiota plays an important role in maintaining nomal physiological function of the intestine and the immune function of the body. It has been found that the disorder of intestinal microbiota is associated with numerous intestinal and parenteral diseases. Recently, the relationship between immune response and intestinal microbiota has been claimed. In a previous study using IMT to treat HBeAg positive chronic hepatits B patients combined with antiviral theraopy, 80% of them has reached HBeAg clearance. Increasing evidence suggests that the gut microbiota has evolved as a new important player in the pathogenesis of hepatitis B virus-induced chronic liver disease. However, the composition and structure alteration of the gut microbiota associated with the stage and progression of HBV infection remains unknown. Hence, we proposed a trial to detected gut microbiota of chronic HBV infected patients high-throughput 16S rRNA gene sequencing to elucidate the microbial influence which contribute to the microbial shift of patient in different stage.

NCT ID: NCT03585205 Recruiting - Healthy Clinical Trials

Neural Indications of Stress-Induced Mental Overload

Start date: October 23, 2017
Phase: N/A
Study type: Interventional

This aim of the current research is to characterize the complex interaction between stress and cognitive workload. Furthermore, we aim to create a functional magnetic resonance imaging (fMRI) inspired Electroencephalogram (EEG) brain-based bio-marker for cognitive load under stress.

NCT ID: NCT03579940 Recruiting - Healthy Clinical Trials

A Study of Lasmiditan in Healthy Japanese and Caucasian Participants

Start date: June 27, 2018
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to evaluate the safety and tolerability of lasmiditan in healthy Japanese and Caucasian participants. The study will also investigate how much lasmiditan gets into the bloodstream and how long it takes the body to get rid of lasmiditan when given to Japanese and Caucasians. The study will last up to 47 days for each participant.

NCT ID: NCT03579030 Recruiting - Healthy Clinical Trials

Safety and PK/PD of RTA 1701 in Healthy Adults

Start date: June 20, 2018
Phase: Phase 1
Study type: Interventional

This first-in-human, Phase 1, single-center study will evaluate single ascending doses (SAD) and multiple ascending doses (MAD) of RTA 1701 conducted in 2 parts. Part 1 (SAD) of this study will be conducted in approximately 56 healthy participants in up to 7 groups. Each group will consist of up to 8 participants who will be randomized in a 3:1 ratio to receive a single dose of RTA 1701 or placebo, respectively. Safety, tolerability, and available pharmacokinetics in each group will be assessed by the Safety Monitoring Committee prior to dose escalation. Part 2 (MAD) of this study will be conducted in approximately 30 healthy participants in up to 3 groups and will commence after safety data for the highest dose in the SAD phase has been evaluated. Each group will consist of up to 10 participants who will be randomized in a 4:1 ratio to receive 14 daily doses of RTA 1701 or placebo, respectively. Safety, tolerability, and available pharmacokinetics will be assessed in each dosing group prior to dose escalation

NCT ID: NCT03577886 Recruiting - Healthy Clinical Trials

Safety and Tolerability of CDX-6114 in Healthy Volunteers

Start date: July 4, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of an oral solution of CDX-6114 when administered as a single dose in healthy volunteers.

NCT ID: NCT03577457 Recruiting - Healthy Clinical Trials

The Interaction Between Oxytocin and Serotonin

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

The primary objective of this study is to identify any interaction between oxytocin and serotonin on neural and behavioral activity related to social reward and decision making by a double-blind, placebo-controlled, between-subject, pharmacological fMRI design

NCT ID: NCT03576144 Recruiting - Healthy Clinical Trials

This Study in Healthy Men Tests How Different Doses of BI 1265162 Are Taken up in the Body and How Well They Are Tolerated.

Start date: July 11, 2018
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to investigate the safety and tolerability of BI 1265162 in healthy male subjects following inhalative administration of multiple rising doses. Secondary objectives is the exploration of the pharmacokinetics (PK) including dose proportionality and time dependency of BI 1265162 after multiple dosing

NCT ID: NCT03574064 Recruiting - Healthy Clinical Trials

Effects of Gut Peptides on Bone Remodeling

KS-3
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

We will investigate effects of gut hormones on bone remodeling.

NCT ID: NCT03571425 Recruiting - Healthy Clinical Trials

The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females

Start date: June 4, 2018
Phase: N/A
Study type: Interventional

The present study will seek to quantify the muscle protein synthetic response to a protein beverage consumed orally or through a nasogastric tube in healthy, young individuals.