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NCT ID: NCT03876314 Recruiting - Healthy Clinical Trials

The Effect of Physical Activity on Cognition Relative to APOE Genotype

Start date: March 2019
Phase: N/A
Study type: Interventional

Physical activity and Alzheimer's disease (PAAD-2) is a randomized control trial that will assess the effects of exercise on middle-aged (40-65 years) cognitively normal adults who have a heightened risk of Alzheimer's disease (AD) due to family history (FH+). The investigators will also assess the extent to which this effect is moderated by apolipoprotein epsilon-4 (APOE4) carrier status, and will gather critical new experimental evidence on the use of physical activity to improve cognitive performance by persons at the greatest risk of Alzheimer's disease.

NCT ID: NCT03870178 Recruiting - Healthy Clinical Trials

Effects of tDCS on Maximal Isometric Strength and Endurance Test of Trunk Extensors.

Start date: January 2, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Improving trunk muscle strength and endurance is one of the many goals to be achieved in rehabilitation protocols for a variety of health conditions. Cerebral electrical stimulations techniques, such as transcranial direct current stimulation (tDCS) can modulate motor brain areas involved in motor functions. However, their effects on trunk function are lacking. This study aims to investigate the effects of transcranial direct current stimulation (tDCS) on trunk muscle strength and endurance in healthy subjects.

NCT ID: NCT03860597 Recruiting - Healthy Clinical Trials

Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia

Start date: April 1, 2018
Phase: Phase 4
Study type: Interventional

This application seeks to determine if neurophysiological metrics of memantine (MEM)-enhanced early auditory information processing (EAIP) in schizophrenia (SZ) mediate gains in auditory processing fidelity (APF) and auditory learning.

NCT ID: NCT03856008 Recruiting - Healthy Clinical Trials

Effect of Cervical Spinal Stabilization Exercise Programs by Magnetic Resonance Imaging in Healthy Individuals

Start date: February 25, 2019
Phase: N/A
Study type: Interventional

The aim of this study was to investigate the morphological changes in the neck muscles of cervical spinal stabilization exercises focused on flexor and extensor muscles applied to healthy individuals.

NCT ID: NCT03850977 Recruiting - Healthy Clinical Trials

Is There an Association Between Chronic Pancreatitis and Pulmonary Function

Start date: September 1, 2018
Study type: Observational

To evaluate pulmonary function in chronic pancreatitis compared with healthy volunteers and patients with cirrhosis.

NCT ID: NCT03850652 Recruiting - Healthy Clinical Trials

Can Prebiotics Support the Treatment of Mild Iron Deficiency by Iron Supplementation

Start date: March 6, 2019
Phase: N/A
Study type: Interventional

The first aim of this study is to investigate if daily administration of the prebiotic Synergy-1 (a commercial product consisting of oligofructose-enriched inulin) together with a common iron supplement (ferrous sulphate) during 4 weeks, in premenopausal non-anaemic women with low ferritin levels, would mitigate the adverse effects of iron on the gut microbiota. The estimated absorption rate of the ferrous salts is 10-15%, therefore the unabsorbed iron will reach the colon where it could stimulate growth of non-beneficial bacterial species in the intestinal environment. By contrast, prebiotics function by specifically supporting growth of the typically-beneficial microorganism such as bifidobacteria. Inulin-type fructans (ITF) are well recognised in this way. The hypothesis to be tested is that prebiotic consumption will lead to a beneficial shift in the microbiota helping against the dysbiosis associated with iron supplementation.

NCT ID: NCT03849677 Recruiting - Healthy Clinical Trials

Uric Acid Metabolism, Endothelial Function and Oxidative Stress in Vegans and Omnivores.

Start date: March 10, 2019
Study type: Observational

50 vegans and 50 omnivores will be recruited at the Erasme Hospital, Brussels. Hypothesis - Relative induced-hyperuricemia by the vegan diet is not associated with impaired endothelial function if vitamin B12 and folic acid levels are normal. - Quantification of xanthine oxidoreductase (XOR) isoforms varies according to the diet. Omnivores present more xanthine oxidase (XO) than vegans in which the xanthine dehydrogenase (XD) isoform is more prevalent. - The vegan group has more favorable oxidant, metabolic and inflammatory profiles than the omnivore group.

NCT ID: NCT03848962 Recruiting - Healthy Clinical Trials

Collection and Distribution of Biospecimens for Novel Research Uses

Start date: June 30, 2016
Study type: Observational

iSpecimen aims to create a clinical partner network of hospitals, laboratories, academic institutions, and other healthcare organizations ("institutions") capable of providing researchers and educators ("researchers") with annotated biospecimens for use in biomarker discovery and validation; diagnostic test and instrumentation development and validation; therapeutics development; other medical research including the impact that various specimen collection and handling methods and conditions have on research results; and in education such as researcher or physician training (collectively "research").

NCT ID: NCT03848416 Recruiting - Healthy Clinical Trials

A Study of Ixekizumab in Healthy Participants

Start date: January 29, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare three different formulations of ixekizumab. One formulation (Reference) has been approved by the Food and Drug Administration (FDA) and two formulations (Test 1 and Test 2) have not been approved. This study will compare how much of each of the three formulations get into the blood stream. Information about any side effects that may occur will also be collected.

NCT ID: NCT03848403 Recruiting - Healthy Clinical Trials

Study of Ixekizumab in Healthy Participants

Start date: January 29, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the tolerability of injections of each of 3 formulations of ixekizumab using a prefilled syringe. Information about any side effects (including injection site reactions [ISRs]) will be collected.