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NCT ID: NCT03731767 Recruiting - Healthy Clinical Trials

The Effect of a Talocrural Thrust Manipulation on Lateral Ankle Ligament Integrity in a Subgroup of Healthy Individuals

Start date: October 20, 2018
Phase: N/A
Study type: Interventional

Measure the effect of a common used ankle manipulation on ligament length in the ankle.

NCT ID: NCT03730935 Recruiting - Healthy Clinical Trials

Respiratory Muscle Endurance Training in Healthy Elderly

Start date: November 2018
Phase: N/A
Study type: Interventional

Prevalence of hypertension in the elderly is high. Given that hypertension is the leading cause of cardiovascular disease worldwide, safe and efficacious treatment options for this condition are highly desired. Apart from medication, changes in lifestyle are recommended to lower blood pressure, such as an increase in physical exercise. However, whole-body exercise is not feasible for all. Mobility disabilities, for example, increase sharply with age and are already common in middle age. For this population, it is necessary to have alternative, non-invasive interventions with similar effects on blood pressure. One such intervention might be respiratory muscle endurance training (RMET), but the effects on blood pressure are currently unknown. The primary aim of this project is therefore to investigate the effects of RMET over the course of several weeks on resting blood pressure in healthy elderly. The secondary aim of the project is to evaluate the effects of RMET on uphill exercise performance in healthy active elderly given that elderly experience structural and functional changes of the lungs potentially affecting exercise performance. Finally, since prevalence of subjective sleep complaints is also high in the elderly, the present study will also investigate the effects of RMET on sleep quality.

NCT ID: NCT03728101 Recruiting - Healthy Clinical Trials

Drug Interaction Study of Simvastatin and Dabigatran

Start date: November 16, 2018
Phase: Phase 1
Study type: Interventional

The aim of the study is to evaluate the effect of simvastatin on the pharmacokinetics and pharmacodynamics of dabigatran in healthy male adults

NCT ID: NCT03726671 Recruiting - Healthy Clinical Trials

Choline Nutritional Status: Development of a Biomarker Panel

Start date: November 2018
Phase: N/A
Study type: Interventional

People who eat diets low in choline should deplete their choline (Cho) stores, and measurements of Cho pool size using isotope dilution should reflect this depletion. Investigators will identify a biomarker panel that correlates well with measured Cho pool size across the range of different degrees of depletion.The investigators propose that, as body stores of Cho diminish, cells and organs will reach the point when metabolism/function in the cell is altered, and that this will result in a progression of changes in biomarkers that reflect Cho status.

NCT ID: NCT03725462 Recruiting - Healthy Clinical Trials

Evaluation of Electrophysiological Signal Measured by Smart Textile CE-marked

Start date: October 16, 2017
Phase: N/A
Study type: Interventional

The aim is to evaluate the performance of Cardioskin and Neuronaute, two connected medical devices CE-marked, manufactured by Bioserenity. It's an open monocentric comparative clinical study, where subjects will test the Cardioskin device and/or the Neuronaute device.

NCT ID: NCT03725241 Recruiting - Healthy Clinical Trials

Effects of Glutathione on Immunity in Individuals Training for a Marathon

Start date: October 29, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to determine the effects of glutathione supplement on the immune cell response and symptomatology of upper respiratory health, and antioxidant capacity in healthy people in exercise-induced model.

NCT ID: NCT03723746 Recruiting - Healthy Clinical Trials

A Study to Evaluate the Safety and Tolerability of JNJ-67670187 in Healthy Participants

Start date: October 25, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of single and multiple day dose of JNJ-67670187 compared to placebo.

NCT ID: NCT03723733 Recruiting - Healthy Clinical Trials

Compensatory Brain Mechanisms for Amygdala-associated Cognitive Dysfunction: Potential Role of the Cortical Mirror Neuron System

Start date: July 2016
Study type: Observational

Identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional MRI.

NCT ID: NCT03723434 Recruiting - Healthy Clinical Trials

Physiology of Interregional Connectivity in the Human Brain

Start date: May 31, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to understand the physiology of connectivity between cortical regions in the human brain in healthy participants and in patients with white matter lesions. Specifically, the investigators will examine the effects of paired associative stimulation (PAS) which consists in delivering brief (< 1 ms) current pulses separated by a short millisecond-level time interval ("asynchrony") to two cortical areas. The used techniques are all non-invasive and considered safe in humans: transcranial magnetic stimulation (TMS), electroencephalography (EEG), magnetic resonance imaging (MRI), and functional MRI (fMRI). Based on prior literature in animals and human studies, it is hypothesized that PAS may increase or decrease effective connectivity between the stimulated areas depending on the asynchrony value. The main outcome measure is source-resolved EEG responses evoked by single-pulse TMS; this is a more direct measure of neuronal changes occurring at the targeted cortical area than motor evoked potentials (MEPs) or sensor-level EEG responses used in previous studies.

NCT ID: NCT03722641 Recruiting - Healthy Clinical Trials

Evaluation of Postprandial Glycaemia in a Healthy Population After Intake of Milk and Oat Based Products

Start date: October 4, 2018
Phase: N/A
Study type: Interventional

The objective of this study is to investigate the effect on postprandial glycaemia in a healthy population after intake of milk and oat based products.