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NCT ID: NCT03250598 Recruiting - Healthy Clinical Trials

Study to Evaluate the Pharmacokinetics, Safety, and QTc Effect of AG-348 in Healthy Subjects of Japanese Origin and Non-Asian Origin

Start date: August 9, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this Phase I, single-dose, open-label trial is to evaluate the pharmacokinetics, safety, and effect on QTc interval of AG-348 in healthy, adult Japanese and Non-Asian subjects. The study plans to evaluate 3 cohorts of a single oral dose of AG-348 in Japanese and Non-Asian subjects. Pharmacokinetic sampling will take place serially at specified times during conduct of the study.

NCT ID: NCT03250039 Recruiting - Healthy Clinical Trials

Absorption, Metabolism, Excretion and Absolute Bioavailability

Start date: July 10, 2017
Phase: Phase 1
Study type: Interventional

This study will investigate the absorption, metabolism and excretion of 14C-PF 04965842 and characterize plasma, fecal and urinary radioactivity and identify any metabolites, if possible, of 14C PF-04965842 in humans. In addition, this study will provide a better understanding of the pharmacokinetic disposition of PF-04965842 by obtaining intravenous (IV) clearance and delineating the extent of oral absorption (absolute bioavailability (F) and fraction absorbed (Fa)).

NCT ID: NCT03248609 Recruiting - Healthy Clinical Trials

Glycemic Index of Table Grape Varietals

Start date: July 31, 2017
Phase: N/A
Study type: Interventional

Investigate the postprandial glycemic responses of healthy individuals when consuming commercially available table grape varietals or grape juice, compared to a standard amount of glucose.

NCT ID: NCT03247673 Recruiting - Healthy Clinical Trials

To Demonstrate Similarity of Pharmacokinetics and Evaluate Safety of CT-P16, EU-Approved Avastin and US-licensed Avastin

Start date: August 7, 2017
Phase: Phase 1
Study type: Interventional

This study is a Phase 1 Randomized, Double-blind, Three-arm, Parallel Group, Single-dose Study to compare the PK, safety and immunogenicity of the proposed biosimilar test product CT-P16 with EU-approved Avastin and US-licensed Avastin after a single IV infusion of 5mg/kg of each product to healthy male subjects

NCT ID: NCT03246581 Recruiting - Healthy Clinical Trials

Two-period 21 Day Cross-over Study to Compare the Pharmacokinetics of Tiotropium From Two Inhalers

Start date: July 13, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the absorption of a test inhalation product with the reference product in healthy volunteers.

NCT ID: NCT03235778 Recruiting - Healthy Clinical Trials

A Phase I Clinical Study Trial of Felbinac Trometamol Injection in China

Start date: July 17, 2017
Phase: Phase 1
Study type: Interventional

1. To evaluate the tolerances of healthy subjects treated with Felbinac Trometamol Injection on multiple dose and single dose 2. To evaluate the pharmacokinetic characteristics in healthy subjects treated with Felbinac Trometamol Injection on multiple dose and single dose

NCT ID: NCT03233282 Recruiting - Healthy Clinical Trials

EEG Monitoring for PERFormance Anticipation

Start date: May 30, 2013
Phase: N/A
Study type: Interventional

Identify, characterize and then validate electrophysiological markers linking electrophysiological cerebral activity and performance in cognitive and physical fatigability in humans. To do this, noninvasive explorations of electroencephalography (EEG) and magnetoencephalography (MEG) will be carried out under two conditions of different experiments, the first one that induces a cognitive fatigability and the second one that induces physical fatigability.

NCT ID: NCT03224897 Recruiting - Healthy Clinical Trials

Effects of Transcranial Direct Current Stimulation Over the Left VLPFC on Cognitive Reappraisal

Start date: April 6, 2017
Phase: N/A
Study type: Interventional

This study aims to investigate the role of the left ventrolateral prefrontal cortex (VLPFC) on cognitive reappraisal, using the reinterpretation strategy. For this purpose, we will produce direct disturbance to the activity of this area through anodal and cathodal transcranial direct current stimulation during a reinterpretation task. A double-blind randomized sham-controlled trial will be conducted. 60 healthy volunteers will be allocated into three groups. Each group will receive one type of stimulation (anodal, cathodal or sham) while accomplishing a cognitive task on reinterpretation using images from the International Affective Pictures System (IAPS). The task consists in applying a given emotional regulation condition (downregulate, upregulate or maintain emotions) to a series of images and ranking the intensity of the emotional arousal felt after doing this procedure to each picture. The effects of tDCS on the subjective evaluation of emotional arousal after reinterpretation in each group will be compared.

NCT ID: NCT03224325 Recruiting - Healthy Clinical Trials

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Escalating Multiple Doses of TAK-831 in Healthy Participants

Start date: July 21, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and tolerability of TAK-831 when administered as multiple oral doses at escalating dose levels in healthy participants.

NCT ID: NCT03223649 Recruiting - Healthy Clinical Trials

Break It Up: A Study Evaluating Breaking Up Daily Sedentary Behavior in Youth

Start date: July 26, 2017
Phase: Phase 2
Study type: Interventional

Background: Some studies have found that people can better process sugars when they take walking breaks. Studies have also found that children's attention and memory may improve after exercise. It is not known if short walking breaks have the same effects. Researchers want to study if breaking up sitting with walking for 6 days helps children s bodies use sugars and improves concentration. Objectives: To learn if breaking up sedentary (low-activity) time with short walking breaks over 6 days affects how children s bodies use sugar. To learn if breaking up sedentary time changes children s attention, memory, feelings, activity, or eating. Eligibility: Children ages 7-11 in general good health Design: Participants will be screened with: - Medical history - Physical exam - Fasting blood tests. On 2 out of 7 total study visits, participants cannot eat or drink after 10 p.m. the night before. - Full-body X-ray - EKG (Electronic signals that record heart function through stickers) - Treadmill exercise. Heart, blood pressure, and oxygen will be monitored. - Questions about the child s health, socialization, and activity, and parent s education and economic status - Picture vocabulary test - Dietician meeting (Questions about eating habits) Participants will have visits on 6 consecutive days. Over that time, they will wear 2 devices to monitor blood sugar and activity (even while at home). Participants will have 5 after-school visits. These include: - Health check - Snack plus food for the next 24 hours - Activity monitored - 3-hour sitting tests. Participants will do non-active things. Some will have 3-minute walks every 30 minutes. - Cognitive tests and questions about mood and anxiety are given on days #1 & 5. Participants will fast before the last visit in the morning. They will have: - 9 blood draws by IV catheter. Participants will drink sugar water. - Sitting test - Activity monitored - Meal (food buffet)