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NCT ID: NCT03953196 Recruiting - Healthy Clinical Trials

A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants

Start date: April 8, 2019
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to characterize the immune response in vivo using approved vaccines and antigen challenges to stimulate the immune system.

NCT ID: NCT03952715 Recruiting - Healthy Clinical Trials

Can Training Increase Reporting Accuracy and Study Power in Human Pain Trials

Start date: April 17, 2018
Phase: N/A
Study type: Interventional

In previous studies, results of both the Focused Analgesia Selection Test (FAST) procedure, a method to assess pain-reporting accuracy, and the Evoked Pain Training (EPT) procedure, aimed to improve pain-reporting accuracy, correlated with the placebo response. The objectives of the current project were to determine if EPT (1) increases pain reporting accuracy and (2) affect the placebo response in experimental pain study.

NCT ID: NCT03950999 Recruiting - Healthy Clinical Trials

Experimental Pain Reporting Accuracy and Placebo Response

Start date: August 13, 2017
Phase: N/A
Study type: Interventional

Good clinical care relies on precise evaluation of patients' conditions. Chronic pain and other neurological and psychiatric diagnoses pose challenges because their assessment depends on subjective patient-reported outcome measures (PROs). The investigators have recently developed the Focused Analgesia Selection Task (FAST), a method that allows assessing pain reporting accuracy. Preliminary results suggest that those who more accurately report their pain show diminished placebo response. The underlying mechanisms for this observation cannot be explained by current theories. Therefore, the investigators have conducted a pilot study to further characterize this relation in healthy population.

NCT ID: NCT03949712 Recruiting - Healthy Clinical Trials

Pediatric Transcranial Static Magnetic Field Stimulation to Improve Motor Learning

PSTIM
Start date: March 30, 2018
Phase: Phase 1
Study type: Interventional

Non-invasive brain stimulation (NIBS) is a safe, painless way to improve brain function. It is used for many conditions, including to help children with disabilities. However, it can be challenging to apply NIBS in very young children and infants. A new, simple form of NIBS called transcranial static magnetic field stimulation (tSMS) is a promising tool for early brain stimulation. tSMS in adults has been shown to be safe, tolerable and have the desired effects on brain activity when applied to the motor cortex of the brain. However, how tSMS affects on motor function is not understood. This research will use tSMS to target the motor cortex which is responsible for voluntary movement. The study will determine if tSMS can improve motor learning in healthy children. It is hypothesized that application of tSMS on the right motor cortex will decrease excitability of the motor cortex and will lead to improved motor learning in the right hand. tSMS has the potential to become a safe, inexpensive, home-based way to enhance personalized rehabilitation for disabled children.

NCT ID: NCT03937206 Recruiting - Healthy Clinical Trials

Evaluation of the Pharmacokinetics, Safety and Effects of NutriterraTM in Healthy Adults

Start date: May 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The blood lipid profile plays a role in health and disease states and is affected by many genetic and lifestyle factors. On the more extreme side, hyperlipidemia (a condition characterized by hypertriglyceridemia, hypercholesteremia, or both) is a risk factor for coronary heart disease (CHD) 1. CHD is the most common form of cardiovascular disease (CVD); it is characterized by arterial obstructions or blockages, and is a leading cause of heart attacks and strokes 2. Specifically, blood lipids including triglycerides (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and the ratio of TC: high density lipoprotein (HDL) cholesterol, are key modifiable risk factors for CHD. Hyperlipidemia is thought to be caused or promoted by sedentary lifestyle, obesity, or uncontrolled type 2 diabetes 2. Therefore, lifestyle factors, like the modification of dietary lipids to maintain a healthy blood lipid profile are warranted. There are many beneficial effects of omega-3 fatty acids in terms of cardiovascular disease and the nervous system in general, as well as emerging research on DHA supplementation in acute brain and spinal cord injury. Demand for dietary omega-3's, either through increased fish consumption or through DHA supplementation, is expected to increase, particularly as the baby boomer population adds to the ranks of senior citizens concerned about and/or susceptible to health issues such as dementia and Alzheimer's Disease. Availability of EPA and DHA in circulation is an important parameter in understanding biologic properties of fatty acids. The purpose of this study is to evaluate the pharmacokinetic characteristics of ascending doses of NutriterraTM, as measured by plasma levels of total EPA, DHA, DPA and ALA under fed conditions. In addition, after a two-week (minimum) washout period, subjects will take product for 16 weeks to evaluate effects on cardiovascular markers as a measure of efficacy.

NCT ID: NCT03935022 Recruiting - Healthy Clinical Trials

Rice Anthocyanin Bioavailability in Humans

Start date: March 6, 2019
Phase: N/A
Study type: Interventional

Aims of the project 1. To determine the rice anthocyanin content via high-performance liquid chromatographycoupled to mass spectrometry, HPLC-MS 2. To study the oral bioavailability of anthocyanins in healthy volunteers after the intake of a serving (80 g) of black rice (Venere and Artemide varieties). 3. To determine the plasma biokinetics parameters of rice anthocyanins via spectrophometric determination and high-performance liquid chromatographycoupled to mass spectrometry, HPLC-MS.

NCT ID: NCT03934710 Recruiting - Healthy Clinical Trials

Mood Effects of Serotonin Agonists Extended

MESA-E
Start date: April 20, 2019
Phase: Phase 1
Study type: Interventional

In this study we are examining the effects of repeated very low doses of serotonin agonists on mood individuals with negative mood.

NCT ID: NCT03934632 Recruiting - Healthy Clinical Trials

The Impact of Leg Immobilization on Postabsorptive and Postprandial Muscle Protein Breakdown in Healthy Young Males

Start date: April 2019
Phase: N/A
Study type: Interventional

The present study will seek the quantify the simultaneous muscle protein synthesis and breakdown response with and without amino acid provision in humans following 2 days of immobilisation.

NCT ID: NCT03934502 Recruiting - Healthy Clinical Trials

Effect of Meal Composition and Timing on Evobrutinib Bioavailability

Start date: April 16, 2019
Phase: Phase 1
Study type: Interventional

This study will evaluate the Pharmacokinetics (PK) of the Phase II tablet formulation of Evobrutinib under fasted conditions, within 30 minutes after start of a light meal, one hour prior to start of a low-fat meal, and 2 hours after start of a low-fat meal.

NCT ID: NCT03934203 Recruiting - Healthy Clinical Trials

This Study in Healthy Men and Women Tests Whether BI 409306 Has an Effect on the ECG (Thorough QT Study)

Start date: May 9, 2019
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to assess the effect of BI 409306 on the QT/QTc interval in healthy male and female volunteers as measured by the QTcF change from baseline compared with placebo. Secondary objectives are to show the assay sensitivity of the trial, by reproducing the typical effect of the positive control moxifloxacin on the QT/QTc interval, and to assess the effect of BI 409306 on heart rate.