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NCT ID: NCT03800069 Recruiting - Healthy Clinical Trials

Validation of Point of Care Liver Function Tests

Start date: December 3, 2018
Phase:
Study type: Observational

This study is testing the accuracy of a point of care device that tests liver function within 20 minutes. The target population will be any adult who had liver function tests ordered and to be drawn on the same day as enrollment.

NCT ID: NCT03791463 Recruiting - Healthy Clinical Trials

Effect of Food on Pharmacokinetics of Salvianolic Acid A in Healthy Subjects

Start date: December 20, 2018
Phase: Phase 1
Study type: Interventional

This study is an open-label, randomized, cross-over design with two single-dose treatment periods and a washout of at least 3~5 days in between each treatment visit. The study period consists of 3 visits to the study centre: Visit 1 (enrolment), Visit 2 (first single-dose treatment), Visit 3 (second single-dose treatment). Target subject population is healthy subjects aged 18-45 years. Following an overnight fast of at least 10 hours, a single dose of 90mg salvianolic acid A will be administered on 3 separate occasions (fasting, before meal, and after meal) in a randomized crossover fashion with different food restrictions.

NCT ID: NCT03790358 Recruiting - Healthy Clinical Trials

Mood Effects of Serotonin Agonists

Start date: May 1, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the effects of very low doses of serotonergic agonists on depressed mood in human volunteers.

NCT ID: NCT03787186 Recruiting - Healthy Clinical Trials

A Study in Healthy Male Volunteers to Look at How the Test Medicine GLPG1690 is Taken up by the Body When Given by Mouth and Into a Vein as an Injection

Start date: November 9, 2018
Phase: Phase 1
Study type: Interventional

The sponsor wants to investigate how well the test medicine is taken up by the body when given orally (by mouth) as a tablet or capsule and as a solution for infusion (into a vein). The capsule and the solution will be radiolabelled. 'Radiolabelled' means that the test medicine has a radioactive component which helps us to track where the test medicine is in the body.

NCT ID: NCT03785054 Recruiting - Healthy Clinical Trials

Phase 1, Healthy Subject, Safety, Tolerability and Pharmacokinetic Study of mGlu5 NAM HTL0014242

Start date: November 14, 2018
Phase: Phase 1
Study type: Interventional

This is the first time HTL0014242 will be administered to humans. The principal aim of this study is to obtain safety and tolerability data when HTL0014242 is administered orally as single doses to healthy subjects. This information, together with the pharmacokinetics data, will help establish the doses and dosing regimen suitable for future studies in patients

NCT ID: NCT03783221 Recruiting - Healthy Clinical Trials

Effect of Previous Diet

Start date: October 22, 2018
Phase: N/A
Study type: Interventional

Meal ingestion induces digestive responses associated to homeostatic and hedonic sensations. The responses to meal ingestion are modulated by conditioning factors. Single-centre, cross-over, random, open label study comparing the effect of a high-fat/low-residue diet versus low-fat/high residue diet on the responses to meal ingestion. In 20 healthy subjects each diet will be administered during 2 weeks in random order; each diet will be preceded by 2 weeks washout, balanced diet. The aim of the study is to compare the effects of each diet on the responses to comfort and flatulogenic meals, intestinal gas production and digestive sensations.

NCT ID: NCT03782987 Recruiting - Healthy Clinical Trials

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 730357 in the Blood

Start date: January 10, 2019
Phase: Phase 1
Study type: Interventional

The main objective of this trial is to investigate the relative bioavailability of BI 730357 in plasma when given as oral single dose together with multiple oral doses of itraconazole (Test, T) as compared to when given alone as oral single dose (Reference, R)

NCT ID: NCT03781947 Recruiting - Healthy Clinical Trials

A Study of Parenterally-administered Teverelix TFA in Healthy Male Volunteers

Start date: November 19, 2018
Phase: Phase 1
Study type: Interventional

A Phase I, open-label, single centre study investigating the pharmacokinetics, safety and pharmacodynamics of a single dose of teverelix TFA, a gonadotrophin releasing hormone antagonist, via subcutaneous or intramuscular route of administration in healthy male volunteers

NCT ID: NCT03777761 Recruiting - Healthy Clinical Trials

Effects of Tucatinib on Cardiac Repolarization in Healthy Participants

Start date: December 6, 2018
Phase: Phase 1
Study type: Interventional

This study is looking at how the study drug, tucatinib, affects the heart. Tucatinib is being studied as a possible treatment for breast cancer. This study will recruit healthy volunteers. There are 3 parts in the study. Each volunteer will be in all 3 parts. One part will be to take the study drug, the second part will be to take a placebo (pill with no medicine), and the third part will be to take moxifloxacin. The volunteers will only know what part of the study they are in when they take moxifloxacin. For the study drug and placebo parts, volunteers will take 2 pills by mouth for 5 days. For the moxifloxacin part, volunteers will take 1 pill by mouth for 1 day.

NCT ID: NCT03775668 Recruiting - Healthy Clinical Trials

Single Dose Mass Balance Study With C14 - Labeled AAI101 in Healthy Male Volunteers

Start date: November 27, 2018
Phase: Phase 1
Study type: Interventional

This is an open-label, single dose, pharmacokinetic (PK) study conducted at 1 study center in the United States (USA). This study will evaluate the absorption, distribution, metabolism, and elimination (ADME), mass balance, safety, and tolerability of a single dose of intravenously administered 14C-AAI101.