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NCT ID: NCT03316612 Recruiting - Healthy Clinical Trials

The Effect of Vaccinium Myrtillus L. Extract Intake on Human Metabolism

Start date: November 10, 2017
Phase: N/A
Study type: Interventional

Advanced glycation end-products (AGEs) has been linked to ageing, and many metabolic diseases. The findings of previous experiments suggested that the extracts from polyphenol-rich bilberry might inhibit the formation of AGEs. This is a randomized double-blind crossover trial, aims to study the effect of Vaccinium Myrtillus L. natural extracts on AGEs and human metabolism. Firstly, we will investigate the efficacy of Bilberry extracts on lowering the levels of advanced glycation end-products (AGEs). Secondly, we will conduct 16S rRNA sequencing and ultra-high performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) detection to explore the role of bilberry extracts on gut microbiota as well as metabolites.

NCT ID: NCT03315338 Recruiting - Healthy Clinical Trials

First-in-human Study in Healthy Subjects

Start date: September 15, 2017
Phase: Phase 1
Study type: Interventional

This initial Phase I study will evaluate the safety, tolerability, and pharmacokinetic (PK) of single and multiple ascending doses of CORT118335, the effect of concomitant administration with food on exposure to CORT118335, and its pharmacological effect in healthy subjects.

NCT ID: NCT03312816 Recruiting - Healthy Clinical Trials

Effect of Oxidized Plant Sterols on Serum Concentrations of Plant Sterol Oxidation Products

Start date: October 2017
Phase: N/A
Study type: Interventional

The study is a randomised, double-blind, placebocontrolled, parallel dose-response study with four study arms. Sixty subjects will be randomly allocated to consume study products containing varying amounts of plant sterol (PS)oxidation products (POP) or placebo for 6 weeks.

NCT ID: NCT03311191 Recruiting - Healthy Clinical Trials

Quantifying Skin Oxygenation Properties in Normal vs Sun Exposed Skin

Start date: July 17, 2017
Phase: N/A
Study type: Observational

This research study aims to determine if there are differences in oxygen consumption between chronically sun exposed and less sun exposed skin. This study uses a new imaging device that can detection oxygenation properties skin in a non-invasive manner.

NCT ID: NCT03308110 Recruiting - Healthy Clinical Trials

Bioavailability and Food Effect Study of Two Formulations of PF-06650833

Start date: September 11, 2017
Phase: Phase 1
Study type: Interventional

Bioavailability and food effect of 2 formulations of PF-06650833 in healthy volunteers.

NCT ID: NCT03304262 Recruiting - Healthy Clinical Trials

Metaplasticity in the Human Motor Cortex Experimental Design and Comparison of Motor Outcome Measure Sensitivity to Change

Start date: July 18, 2017
Phase: N/A
Study type: Interventional

The overall objective is to validate the methodology of a metaplasticity experimental design by assessing change in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by repetitive transcranial magnetic stimulation (rTMS) in healthy human participants.

NCT ID: NCT03304197 Recruiting - Healthy Clinical Trials

Hydration and Exercise Performance in Cycling

Start date: September 11, 2017
Phase: N/A
Study type: Interventional

This study will evaluate the effects manipulating ingested fluids can have on cycling performance. There will be 4 different conditions.

NCT ID: NCT03303924 Recruiting - Healthy Clinical Trials

Study to Determine and Compare Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam in Healthy Subjects

Start date: August 21, 2017
Phase: Phase 1
Study type: Interventional

This is a Phase 1, multiple dose, open-label pharmacokinetic study conducted in healthy adult male and female subjects to determine and compare plasma, epithelial lining fluid (ELF) and alveolar macrophage (AM) concentrations of ETX2514 and sulbactam in healthy adult subjects after intravenous infusion of ETX2514 1.0 g given concurrently with intravenous sulbactam 1.0 g, administered every 6 hours with each infused over 3 hours, for 3 consecutive doses

NCT ID: NCT03302416 Recruiting - Healthy Clinical Trials

CRF - Nociceptin Receptor Interactions

Start date: June 1, 2016
Phase: Early Phase 1
Study type: Interventional

To determine if [C-11]NOP-1A receptor binding (VT) can be altered by an intravenous hydrocortisone (cortisol) challenge through CRF-NOP interactions

NCT ID: NCT03302078 Recruiting - Healthy Clinical Trials

Relative Bioavailability of BI 1015550 Following Oral Administration Under Fed and Fasted Conditions in Healthy Male Subjects

Start date: October 16, 2017
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to investigate the effect of food on the pharmacokinetics of the oral tablet formulation of BI 1015550 by investigating the relative bioavailability of TF1 under fed and fasted conditions. The assessment of safety and tolerability will be an additional objective of this part.