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NCT ID: NCT03506399 Not yet recruiting - Healthy Clinical Trials

A Study of Lanabecestat in Healthy Female Participants Taking Oral Contraceptive

Start date: June 14, 2018
Phase: Phase 1
Study type: Interventional

The study will evaluate the effect of oral contraceptive (birth control pill) on the blood level of lanabecestat when both are given together. Side effects will be monitored and documented. This study will last up to 27 days for each participant, not including screening. Screening is required within 42 days prior to first dose.

NCT ID: NCT03506282 Not yet recruiting - Healthy Clinical Trials

Does Listening to Music Alter the Running Mechanics?

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether in healthy subjects listening to music while running influences the ground pressure forces, the vertical loading and, overall, the running biomechanics.

NCT ID: NCT03505567 Not yet recruiting - Healthy Clinical Trials

Study to Compare Kowa OCT Bi-μ and the Optovue iVue 100

OCT
Start date: April 2018
Phase: N/A
Study type: Interventional

This study is a prospective comparative study to gather pilot agreement and precision data in normal subjects, subjects with glaucoma, and subjects with retinal disease.

NCT ID: NCT03505151 Not yet recruiting - Healthy Clinical Trials

This Study in Healthy Men and Women Tests How the Body Takes up BI 409306

Start date: April 27, 2018
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to investigate the absolute bioavailability of BI 409306. The secondary objective is the evaluation and comparison of several pharmacokinetic parameters for the different treatments.

NCT ID: NCT03504306 Not yet recruiting - Healthy Clinical Trials

Validation of Ventriject Determined Maximal Oxygen Uptake

Start date: April 23, 2018
Phase:
Study type: Observational

This study aims to validate the use of the Ventriject product to estimate VO2 max, through a non-physically active test using ECG, echoseismography and echosonography.

NCT ID: NCT03503825 Not yet recruiting - Healthy Clinical Trials

[Tc-99m]-RPI-087 as an Imaging Marker in Osteoarthritis of the Knee Compared to Healthy Volunteers

Start date: May 7, 2018
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to test the safety and tolerability of T-087. The study will enroll 6 healthy volunteers (HVs) and 6-18 subjects with KOA. All eligible subjects will receive an intravenous injection of the radioactive investigational product (T-087), followed by SPECT/CT imaging of the knees and blood tests and clinical assessments for safety monitoring. Healthy volunteers will also have their whole body imaged and have extra blood drawn to determine where T-087 goes in the body. These additional procedures will be done on the same day as the ip administration, and repeated the following day. All subjects will have a final follow-up phone call within 2- 3 business days following the ip administration.

NCT ID: NCT03502707 Not yet recruiting - Healthy Clinical Trials

A Study to Evaluate the Safety and Immunogenicity for Regimen Selection of Ad26.RSV.preF and/or RSV preF Protein Combinations Followed by Expanded Safety and Concomitant Influenza Vaccine Administration in Adults Aged 60 Years and Older

Start date: May 11, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study for: Cohort 1 and Cohort 2: to assess the safety and reactogenicity of the intramuscular one- and two-dose regimens, with a booster at Month 12 and to select a regimen for Cohort 3. Cohort 2 and part of Cohort 1: to assess respiratory syncytial virus (RSV) neutralizing antibody levels of all regimens containing RSV pre-fusion (preF) protein compared to the one-dose adenovirus serotype 26 respiratory syncytial virus pre-fusion (Ad26.RSV.preF) regimen. Cohort 3: to demonstrate the non-inferiority of the concomitant administration of the selected regimen and seasonal influenza vaccine versus the administration of seasonal influenza vaccine alone in terms of humoral immune response expressed by the geometric mean titers (GMTs) of hemagglutination inhibition (HI) antibody titers against the influenza vaccine strains 28 days after the administration of influenza vaccine, using a non-inferiority margin of 2 for the GMT ratio (control group/co-administration group) and to assess the safety and reactogenicity of the selected regimen administered separately or concomitantly with seasonal influenza vaccine, and a booster at Month 12, and to compare the safety and reactogenicity of the co-administration group with that of the seasonal influenza vaccine + placebo group.

NCT ID: NCT03500679 Not yet recruiting - Healthy Clinical Trials

A Study to Evaluate Safety and Immunogenicity of the ExPEC4V Clinical Trial Material After a Single Intramuscular Dose and a Second Dose 6 Months Later in Healthy Participants Aged 18 Years and Older

Start date: May 3, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety/reactogenicity of the ExPEC4V clinical trial material (CTM) after the first vaccination and to evaluate the immunogenicity of the ExPEC4V CTM, as measured by the enzyme-linked immunosorbent assay (ELISA), 14 days after the first vaccination (on Day 15).

NCT ID: NCT03499106 Not yet recruiting - Healthy Clinical Trials

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Inhibitor Praliciguat (IW-1973) in Healthy Volunteers

Start date: April 12, 2018
Phase: Phase 1
Study type: Interventional

The primary objective of the study is to evaluate the effect of itraconazole (a potent cytochrome P450 isoenzyme [CYP]3A inhibitor) on the pharmacokinetics of IW-1973.

NCT ID: NCT03494907 Not yet recruiting - Healthy Clinical Trials

A Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult Participants

Start date: April 11, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the effects of single dose seltorexant on QT/QTc intervals and electrocardiogram (ECG) morphology at therapeutic and supratherapeutic exposures in healthy adult participants.