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NCT ID: NCT03703388 Not yet recruiting - Healthy Clinical Trials

The Safety and Intake Rate of a Natural Compound Arctigenin in Healthy Men

Start date: January 15, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this research study is to determine if consuming arctigenin, a natural compound from a Chinese herb called Arctium lappa (commonly called greater burdock), is safe, and to measure the intake level of arctigenin in blood. Arctigenin is being studied by researchers for potential health benefits such as helping to lower the risk of inflammation and cancer. A human study has been done measuring the uptake of arctigenin into blood after consumption of the herb extract containing arctigenin, and found no toxicity. Studies in mice demonstrated that consumption of arctigenin in pure form at a safe level is highly effective in inhibition of prostate cancer growth. Therefore, this study is designed to evaluate the safety and uptake rate of pure arctigenin in humans, which may be potentially used in the future for prostate cancer prevention.

NCT ID: NCT03702673 Not yet recruiting - Healthy Clinical Trials

Compare the Pharmacokinetic of K-877 Controlled Release (CR) and Immediate Release (IR) Tablets in Healthy Adults.

Start date: October 5, 2018
Phase: Phase 1
Study type: Interventional

A study to compare the pharmacokinetics of 3 types of K-877 controlled release tablets with a current normal K-877 tablet in healthy adult subjects.

NCT ID: NCT03700515 Not yet recruiting - Healthy Clinical Trials

Exosome Proteomics to Detect EPO

Start date: October 15, 2018
Phase: N/A
Study type: Interventional

The role of exosomes in cell signalling has only recently been appreciated and is a hugely exciting and rapidly growing area, and combined with LC-MS/MS proteomics, can overcome traditional barriers to proteomics in doping applications. To our knowledge, no research has yet been undertaken to explore whether the highly promising combination of exosome proteomics has utility for rhEPO detection. The applications are extensive; the diagnostic value of differentially regulated proteins could be further validated against the existing IEF EPO WADA accredited tests using samples collected during this study, used to study altitude hypoxia versus exogenous EPO administration (WADA current targeted research 2017), investigated as a platform approach to ESA and HIF agents more generally, as well as facilitate development of direct ELISA high throughput tests.

NCT ID: NCT03697889 Not yet recruiting - Healthy Clinical Trials

A Study to Assess Bioquivalence Between a Novel Naproxen Sodium 275 mg Film-coated Tablet and Nalgesin Naproxen Sodium 275 mg Film-coated Tablet in Healthy Adult Volunteers

Start date: November 4, 2018
Phase: Phase 1
Study type: Interventional

This is a research study designed to evaluate the rate and extent of absorption of Naproxen from a novel Naproxen sodium tablet and Nalgesin naproxen sodium 275 mg.

NCT ID: NCT03696459 Not yet recruiting - Healthy Clinical Trials

A Study to Evaluate the Effect of JNJ-53718678 on the Cardiac Repolarization Interval in Healthy Adult Participants

Start date: October 3, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the effect of JNJ-53718678 on QT interval corrected for heart rate (QTc) changes using exposure response analysis in healthy adult participants (Part 2).

NCT ID: NCT03695198 Not yet recruiting - Healthy Clinical Trials

A Study of LY3361237 in Healthy Participants

Start date: October 26, 2018
Phase: Phase 1
Study type: Interventional

The purposes of this study are to determine: - The safety of LY3361237 and any side effects that might be associated with it. - How much LY3361237 gets into the blood stream and how long it takes the body to remove it in healthy participants. Participants will be admitted to the clinical research unit (CRU) for 4 overnight stays. The study will last about 12 weeks for each participant, not including screening.

NCT ID: NCT03693391 Not yet recruiting - Healthy Clinical Trials

A Study to Investigate Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA Gamma 8) Receptor Occupancy of JNJ-64140284 With Newly Developed Transmembrane AMPA Receptor Regulatory Protein (TARP)-Gamma 8 Positron Emission Tomography (PET) [18F]JNJ-64511070 in Healthy Men

Start date: October 1, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to measure the blocking of [18F]JNJ-64511070 binding in the brain at the time after administration of a drug when the maximum plasma concentration is reached; when the rate of absorption equals the rate of elimination (tmax) of JNJ-64140284 and determine the exposure/receptor interaction of JNJ-64140284 in healthy male participants following single oral dose administration of JNJ-64140284.

NCT ID: NCT03692949 Not yet recruiting - Healthy Clinical Trials

A Study of LY3451838 in Healthy Participants

Start date: December 2018
Phase: Phase 1
Study type: Interventional

The study has two parts. In Part A, single increasing doses of LY3451838 will be administered intravenously (into a vein). In Part B, a single dose of LY3451838 will be administered subcutaneously (just under the skin).

NCT ID: NCT03690453 Not yet recruiting - Healthy Clinical Trials

Effect of Ivermectin Metabolites on Mosquito Survival

Start date: October 3, 2018
Phase: Phase 4
Study type: Interventional

This clinical trial will be designed to capture the full duration of mosquito-lethal effect of single dose Ivermectin to aid efforts to characterize metabolites with mosquito-lethal effect. Ivermectin and its metabolites likely have antiparasitic properties against asexual and sexual stage Plasmodium parasites that will be investigated with plasma samples from this study. This is an open-label pharmacokinetic study. Ten healthy subjects will be admitted in the inpatient ward to receive a single oral dose of IVM (400 µg/kg). Another 10 healthy subjects will be donate blood up to 40 ml each times for 3 times. There is no drug administration for these volunteers. The total duration for each subject's participation in the study is approximately 2 months.

NCT ID: NCT03682380 Not yet recruiting - Healthy Clinical Trials

A Study of Seltorexant (JNJ-42847922) After Single-Dose Administration in Healthy Participants

Start date: October 1, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the rate and extent of absorption (relative bioavailability) of seltorexant Phase 3 test formulation(s) relative to a reference Phase 2b tablet formulation dosed 3 hours after evening meal (semi-fasted condition) and to assess the effect of a high-fat/high-calorie meal, timing of the meal on the rate and extent of absorption of seltorexant in healthy male and female participants.