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NCT ID: NCT03555305 Not yet recruiting - Healthy Clinical Trials

A Study of LY2963016 in Healthy Chinese Participants

Start date: June 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare a study drug known as LY2963016 with insulin glargine (Lantus) in healthy Chinese participants. Blood samples will be taken to compare how the body handles the drugs and how they affect blood sugar levels. Side effects and tolerability will be documented. The study will last at least 18 days, not including screening. Screening is required within 4 weeks prior to the start of the study.

NCT ID: NCT03555162 Not yet recruiting - Healthy Clinical Trials

Study of the Cerebral Bases of Tool Use and Tool Evolution

TOOLBOX
Start date: July 2018
Phase: N/A
Study type: Interventional

Tool use is considered to be the hallmark of complex cognitive adaptations that humans have achieved trough evolution, that provides an adaptive advantage to the human species. Even if nonhuman species do use tools too, human tool use is much more complex and sophisticated. Besides, only humans can make their tools evolve by improving them. If Man has special abilities for tool use, it has to be grounded in a specific neuroanatomical substrate. Humans and nonhumans share a similar prehension system located within the superior parietal lobe and the intraparietal sulcus. However, there is a human specificity : the surpramarginal gyrus within the left inferior parietal lobe is unique to Man, and could play a central role in tool use and tool evolution. This project aims to study the neural correlates of human tool use with functional Magnetic Resonance Imaging (fMRI), to precise the cognitive mechanisms through which humans are able to use tools. We also wish to study what are the cognitive abilities that allow us to make our tools evolve by improving them, and the neural correlates associated.

NCT ID: NCT03550950 Not yet recruiting - Healthy Clinical Trials

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-64232025 in Healthy Participants

Start date: May 29, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of JNJ-64232025 following single ascending intravenous (IV) study intervention administrations and a single subcutaneous (SC) intervention administration in healthy participants.

NCT ID: NCT03547024 Not yet recruiting - Healthy Clinical Trials

A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol

Start date: June 1, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the effect of JNJ-55308942: 1) high dose at steady state on the single dose pharmacokinetics of a cocktail containing selective probes of cytochrome P450 (CYP) enzymes (CYP3A, CYP2D6 and CYP2C19) in healthy adult participants (Part 1); 2) high dose at steady state on the single dose pharmacokinetics of a combination oral contraceptive containing levonorgestrel and ethinyl estradiol in healthy female participants (Part 2); and 3) low dose at steady state on the single dose pharmacokinetics of a cocktail containing selective probes of CYP enzymes (CYP3A, CYP2D6 and CYP2C19) in healthy adult participants (Part 3).

NCT ID: NCT03546712 Not yet recruiting - Healthy Clinical Trials

Estimating Error in Locating Touch Sensation on Forearm in Healthy Middle School Going Children

Start date: September 2018
Phase:
Study type: Observational

Tactile localization stimuli are fundamental in forearm to the somatosensory perception.Tactile localization reverse the touch internal organization of the forearm and in the normal development of children.It is helpful in quick estimation of tactile localization among the children in the age group, eight to thirteen years.Study design is cross-sectional study it is conducted from September 2017 to April 2019 and use stratified random sampling. subject recruitment is healthy school going children of age group between eight and thirteen year will be included in this study.The procedure will be explained to the children's before starting the test. Ascent will be obtained from the participant. Anthropometrics will be measured before beginning the procedure. The acuity of TL will be determined by the point-to-point tactile localization (PPTL) technique. For performing PPTL, the child will be seated and the examiner will locate a point on the participants forearm of the blinded child by a black pen marker. Then the child will be asked to relocate the point with the help of red pen marker in blindfolded state. The distance between black point and red point (in mm) will be noted this distance will be measure by measuring tape as the acuity of tactile localization. Mean of three readings will be used for estimating the normative reference value of tactile localization by PPTL technique.

NCT ID: NCT03540836 Not yet recruiting - Healthy Clinical Trials

A Study to Determine the Relative Bioavailability of Two New Relacorilant Capsule Variants

Start date: May 25, 2018
Phase: Phase 1
Study type: Interventional

This is an open-label, randomized, 3 treatment, 3-period, 6-sequence, crossover study conducted at a single study center to characterize the relative bioavailability of relacorilant administered as 3×100-mg softgel capsules (Treatment A), 3×100 mg hard-shell capsules (Treatment B), and 6×50-mg hard shell capsules (Treatment C/reference) in healthy, fasted, adult subjects. Eligible subjects will participate in 3 treatment periods. During each treatment period, subjects will receive a single 300-mg relacorilant dose. An equal number of subjects will be randomized to each of 6 sequences.

NCT ID: NCT03539666 Not yet recruiting - Healthy Clinical Trials

Effect of Diets on the Gut Microbiota Composition and Cardiometabolic Wellbeing

Start date: June 15, 2018
Phase: N/A
Study type: Interventional

The project will characterize human gut microbiome response to two different diets and the possible physiological and biochemical implications of such response on cardiometabolic risk factors. The study will use controlled-feeding, systems-biology, metagenomic, and metabolomic approaches to examine American dietary patterns.

NCT ID: NCT03537326 Not yet recruiting - Healthy Clinical Trials

Study to Detect Oral Administration of Besonide in Women.

WADA
Start date: May 28, 2018
Phase: Phase 1
Study type: Interventional

This study aims at identifying analisis strategies to detect oral administration of Budesonide in women; in order for them to be used by the accredited laboratories of the Worl Anti-Doping Agency (WADA).

NCT ID: NCT03536325 Not yet recruiting - Healthy Clinical Trials

A Study to Assess the Safety, Tolerability and Pharmacokinetics of Guselkumab Following a Single Intravenous Administration in Healthy Japanese Participants

Start date: May 31, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of guselkumab following single-dose intravenous (IV) infusion in Japanese healthy male participants.

NCT ID: NCT03527316 Not yet recruiting - Healthy Clinical Trials

Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear Extinction

MFE
Start date: August 2018
Phase: Early Phase 1
Study type: Interventional

Serotonin and oxytocin play a role in fear conditioning and fear extinction learning, psychological processes that are critically involved in psychiatric disorders such as posttraumatic stress disorder (PTSD). Specifically, administration of oxytocin has been shown to facilitate fear extinction in humans. Similarly, substances that release serotonin and oxytocin such as MDMA have been shown to enhance the extinction of fear memory in animals. However, there are no data on the effects of MDMA on fear extinction in humans. Therefore, the primary aim of this study is to investigate the role of acute serotonin release in the effects of fear extinction. MDMA will be used as pharmacological tool to induce serotonin release in this study.