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NCT ID: NCT03768609 Not yet recruiting - Healthy Clinical Trials

A Study to Evaluate the Effect of Cyclosporine, a P-Glycoprotein, Breast Cancer Resistance Protein, and Organic-Anion-Transporting Polypeptide Inhibitor, on Pimodivir in Healthy Adults

Start date: December 10, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the effect of a single oral dose of cyclosporine on the pharmacokinetics of a single oral dose of pimodivir when coadministered to healthy adult participants under fasted conditions.

NCT ID: NCT03764774 Not yet recruiting - Healthy Clinical Trials

A Study of LY3463251 in Healthy Participants

Start date: December 6, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and tolerability (side effects) of single (Part A) and multiple (Part B) doses of the study drug when it is administered subcutaneously (under the skin) into the abdomen. This is a two-part study. Participants will enroll in only one part. For each participant, Part A will last about 10 weeks and Part B will last about 13 weeks, including screening.

NCT ID: NCT03762837 Not yet recruiting - Healthy Clinical Trials

Multicenter Prospective Cohort Study of Risk Factors for Gallbladder Cancer

Start date: January 1, 2019
Phase:
Study type: Observational [Patient Registry]

This trial is a prospective study, the main purpose of the study is to investigate the association between benign gallbladder disease and gallbladder carcinoma; to explain the timing of intervention, intervention and early prevention of benign gallbladder disease; according to the national epidemiology of gallbladder cancer Center Clinical Research (unpublished), 2000 National Cholecystoma Clinical Epidemiology Report, and 2005 Clinical Analysis of 2379 Cases of Gallbladder Carcinoma in 17 Hospitals in Five Northwest Provinces, Pre-experimental data, using samples The volume estimation formula, α = 0.05, β = 0.1, plans to enroll 100,000 people.Half of participants is someone with Biliary benign disease,while the other half is healthy.

NCT ID: NCT03762135 Not yet recruiting - Healthy Clinical Trials

Location Initiated Individualized Texts for Adolescent Health (LIITAH)

Start date: February 15, 2019
Phase: N/A
Study type: Interventional

The goal of this study is to test whether the mobile application (app.) helps adolescents make healthy food choices, decreasing calories purchased from restaurants, fewer number of visits to restaurants, and if it has an impact on their body mass index (BMI). Eligible adolescents will be enrolled in the study along with a parent for approximately 6 months.

NCT ID: NCT03762031 Not yet recruiting - Healthy Clinical Trials

A Study Designed to Evaluate the Safety and Pharmacokinetics of Intravenously Administered Superoxide Dismutase Mimetic GC4711 in Healthy Volunteers

Start date: April 2019
Phase: Phase 1
Study type: Interventional

The study will be a Phase 1, randomized, double-blind, placebo-controlled, single dose escalation study designed to evaluate the safety and PK of intravenously administered superoxide dismutase mimetic GC4711 in healthy volunteers.

NCT ID: NCT03759522 Not yet recruiting - Healthy Clinical Trials

Assessment of Neuroinflammation in Central Inflammatory Disorders Using [18F]DPA-714.

DPA-714
Start date: February 1, 2019
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [18F]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer [18F]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-invasive measure of neuroinflammation. The primary objective of this study is to determine if pain and fatigue patients have higher levels of neuroinflammation than HC individuals as measured with [18F]DPA-714-PET/MRI.

NCT ID: NCT03756584 Not yet recruiting - Healthy Clinical Trials

Probing TBS-induced Neural Plasticity and Associated Effects on Learning

Start date: December 3, 2018
Phase: N/A
Study type: Interventional

Recent animal research indicates that excitatory brain stimulation opens a time window of increased neural plasticity that permits remodeling of neural representations. Repetitive transcranial magnetic stimulation (rTMS) may thus facilitate learning of new associations by reducing proactive interference but human research is missing. Therefore, it is the aim of this study to investigate the effects of intermittent theta-burst stimulation (iTBS), a potent form of excitatory brain stimulation, on associative memory. Twenty right handed healthy participants will receive 3 minutes of iTBS or sham stimulation of the left lateral parietal cortex after memorizing a set of 20 face-word associations. Recall capacity will be tested directly before and after stimulation. Participants will then learn a new combination of associations using the same set of stimuli, followed by an evaluation of their recall capacity. We hypothesize that iTBS compared to sham stimulation will reduce recall capacity directly after the stimulation but increase recall capacity of the newly learned associations due to reduced proactive interference. This study may not only pave the way towards a new understanding of the mechanism of action of brain stimulation, but can also help in developing new treatment strategies for neuropsychiatric disorders.

NCT ID: NCT03756246 Not yet recruiting - Healthy Clinical Trials

Influenza Vaccine as a Novel Experimental Model of the Behavioral Immune Response in Depression

Start date: January 2019
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine differences between the immune responses in healthy and depressed people. Participants will receive the influenza vaccine and their responses will be monitored. This study will recruit 15 healthy and 60 depressed participants.

NCT ID: NCT03755232 Not yet recruiting - Healthy Clinical Trials

Acute Glycemic and Insulinemic Response of FOSSENCE™

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Short chain fructooligosaccharide (FOS) is known as a prebiotic fiber/nutrient and has been documented to demonstrate different health benefits including glucose control, gut health, mineral absorption, weight and immunity. FossenceTM is a short chain fructo-oligosaccharide (scFOS), sweet tasting, soluble prebiotic dietary fibre which is produced through Tata Chemicals Limited's patented process and is currently US GRAS notified (safe for consumption). The formulation and properties of scFOS suggest that the molecule may potentially play a role in glucose and insulin metabolism. The purpose of this study is to explore the rise of glucose and insulin in the blood after consuming FossenceTM that has been added or substituted into a sugar drink or white bread.

NCT ID: NCT03754959 Not yet recruiting - Healthy Clinical Trials

This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 1358894 Affects the Way the Body Breaks Down Midazolam

Start date: December 18, 2018
Phase: Phase 1
Study type: Interventional

The primary objective of the trial is to investigate the safety and tolerability of BI 1358894 in healthy male subjects following oral administration of multiple rising doses over 14 days.