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NCT ID: NCT03316820 Not yet recruiting - Healthy Clinical Trials

Bioavailability Study of K0706 in Healthy Subjects

Start date: December 1, 2017
Phase: Phase 1
Study type: Interventional

This is single-center, single-dose, randomized, open-label, four-period, four sequence crossover study to evaluate the relative bioavailability of K0706 24 mg tablet formulation relative to 24 mg capsule formulation under fasted conditions and to evaluate the food-effect for tablet formulation in healthy subjects.

NCT ID: NCT03315936 Not yet recruiting - Healthy Clinical Trials

This Study in Healthy Men Tests How Different Doses of BI 894416 Are Taken up in the Body and How Well BI 894416 is Tolerated

Start date: November 2, 2017
Phase: Phase 1
Study type: Interventional

This first-in man trial is designed to investigate the safety and tolerability of BI 894416 in healthy male subjects following oral administration of single rising doses. Pharmacokinetics (PK) including dose proportionality after single dosing of BI 894416 will be explored.

NCT ID: NCT03315273 Not yet recruiting - Healthy Clinical Trials

Measuring Motor Imagery Ability in Patients With Traumatic Brain Injury.

Start date: October 23, 2017
Phase: N/A
Study type: Interventional

1. Validation of translated Motor Imagery ability questionnaire MIQ-RS 2. Investigating the Motor Imagery ability in patients with traumatic brain injury

NCT ID: NCT03313141 Not yet recruiting - Healthy Clinical Trials

Study of the Diaphragmatic Function by Transient Elastography (ELASTODIAPH)

ELASTODIAPH
Start date: October 25, 2017
Phase: N/A
Study type: Interventional

The study of diaphragmatic function is usually measured by the pressures and volumes generated by contraction of the diaphragm, which is often difficult (cumbersome technique, difficulty to obtain a perfect cooperation of the subjects, and difficulty to specifically analyze the diaphragm compared to other accessory respiratory muscle groups). In this study, the investigators aimed at analysing diaphragmatic function by measuring the shortening, stiffness, strain and thickening of the diaphragm by ultrasound.

NCT ID: NCT03310970 Not yet recruiting - Healthy Clinical Trials

Pharmacokinetics of Lidocaine in Healthy Adults

Start date: November 2017
Phase: Phase 4
Study type: Interventional

The study to be performed will utilize already FDA-approved marketed products in healthy adults for the purpose to generate data for establishing rate of drug delivery of Lidoderm® topical patch (manufactured by Endo Pharmaceuticals) and the lidocaine 5% patch (manufactured by Mylan Pharmaceuticals) in healthy adults, and to ensure the safety of individuals utilizing these types of products.

NCT ID: NCT03310411 Not yet recruiting - Healthy Clinical Trials

A Study of Lasmiditan When Given With Sumatriptan in Healthy Participants

Start date: October 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess whether taking lasmiditan and sumatriptan together will have any additional effects on heart rate and blood pressure compared to taking lasmiditan and sumatriptan individually. This study will also look at the amount of study drug that gets into the blood stream and how long it takes the body to get rid of it when these two drugs are taken together. This study will last about 21 days, not including the screening. Participants will spend 16 days/15 nights in the clinical research unit (CRU) followed by follow-up. Screening is required within 28 days prior to the start of the study.

NCT ID: NCT03309124 Not yet recruiting - Healthy Clinical Trials

Effect of White Potatoes on Glycemic Response and Satiety in Older Adults

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

The purpose of the present study is to explore the influence of cooking methods on post-prandial glycaemia and its impact on satiety across the lifespan in healthy older adults.

NCT ID: NCT03308669 Not yet recruiting - Healthy Clinical Trials

A Study of Lasmiditan in Healthy Participants When Co-administered With Topiramate

H8H-MC-LAHT
Start date: October 2017
Phase: Phase 1
Study type: Interventional

This study will assess the safety, tolerability and blood concentrations of lasmiditan and topiramate together compared to lasmiditan and topiramate separately. Information about any side effects that may occur will be collected. Participants will be admitted to the Clinical Research Unit (CRU) one day prior to the start of the study and will remain through Day 14. This study is expected to last approximately 25 days, not including screening. Screening is required within 28 days prior to the start of the study.

NCT ID: NCT03308383 Not yet recruiting - HEALTHY Clinical Trials

Normal Echocardiographic Parameters of Indian Population and Comparison With the ASE Reference Range

TTE IN INDIAN
Start date: October 2017
Phase: N/A
Study type: Interventional

Echocardiography forms one of the most used modality in the evaluation of cardiac anatomy and functions in both patients with cardiac symptoms and in healthy individuals for occupational and research purpose. The interpretation of any medical investigation including echocardiographic report is based on its comparison with the normal range for that parameter, which is known to vary depending on the age, sex, body surface area (BSA), ethnicity and race. Since most of the medical/surgical treatment decisions are made based on the echocardiographic reports, the interpretation of results should be accurate. Even though there are many studies defining reference ranges of echocardiographic parameters, most of them were based on studies conducted in Western and European population, who shows considerable difference in their anthropometric measurements from the Indian population. Hence for the accurate diagnosis of any cardiac abnormalities, the reference values should have been derived from studies conducted in population of that particular race and ethnicity who are free of risk factors for the cardiac disease. Hence the investigator planned to conduct a study to determine the normal Echocardiographic parameters and compare it with the reference range of established by American society of echocardiography (ASE).

NCT ID: NCT03307681 Not yet recruiting - Healthy Clinical Trials

Effect of White Potatoes on Glycemic Response and Satiety in Children

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

The purpose of the present study is to explore the influence of cooking methods on post-prandial glycaemia and its impact on satiety in children.