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NCT ID: NCT03196856 Not yet recruiting - Healthy Clinical Trials

Brock Exercise And Supplement Trials

BEAST
Start date: July 1, 2017
Phase: N/A
Study type: Interventional

This study will analyze the effects of Greek yogurt consumption and an 8 week exercise intervention on muscle size, body composition and bone health in untrained, university-aged males.

NCT ID: NCT03196531 Not yet recruiting - Healthy Clinical Trials

A Study to Assess the Bioequivalence of Xisimin (Loratadine) Tablets Under Fasting and Fed Conditions in Healthy Participants Compared With Clarityne Tablets

Start date: September 25, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the bioequivalence of Xisimin (loratadine) compared with Clarityne in healthy participants receiving a single dose of 10 milligram (mg) under fasting condition as part of Cohort 1 and under fed condition as part of Cohort 2.

NCT ID: NCT03195088 Not yet recruiting - Healthy Clinical Trials

Evaluation of Safety and Tolerability of Single Rising Doses of BI 473494 in Healthy Subjects

Start date: July 7, 2017
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to investigate the safety and tolerability of single rising doses of BI 473494 in healthy male subjects. The secondary objective is the exploration of PK including dose proportionality, and PD of BI 473494 after single dosing.

NCT ID: NCT03194139 Not yet recruiting - Healthy Clinical Trials

A Study Designed to Compare the Safety and Pharmacokinetics of Intravenously Administered Superoxide Dismutase Mimetic GC4711 and GC4419 in Healthy Volunteers

Start date: September 2017
Phase: Phase 1
Study type: Interventional

The study will be a double-blind, randomized, crossover, single-dose assessment of IV-administered GC4711 compared to GC4419 in healthy volunteers. Consenting subjects will undergo screening procedures within 28 days of the start of dosing. Pharmacokinetics (parent drug and major metabolites) will be assessed in plasma and urine from all subjects. Initially, a sentinel cohort of 4 subjects, will be enrolled; each eligible subject will receive single dose of GC4711 IV at dose of 30 mg over one hour. Following a clinical safety review by the Galera study team , if no safety concerns are identified after the last subject completes study participation, enrollment will continue in 2 stages to a crossover study design. In stage 1, 12 subjects will be enrolled and in stage 2, if no safety concerns are identified in stage 1 following a clinical safety review by the Galera study team, 20 subjects will be enrolled. In both enrollment stages, eligible subjects in the crossover design will be randomized in 1:1 ratio to one of two treatment sequences: Test (GC4711) -> Ref (GC4419) or Ref (GC4419) -> Test (GC4711). On Day 1, subjects will receive the first treatment they were randomized to, and on Day 4 (following a washout), they will receive the second treatment. Subjects will be followed up for 2 days after the second treatment.

NCT ID: NCT03193580 Not yet recruiting - Healthy Clinical Trials

Accelerating Motor Learning in Pediatrics

AMPED
Start date: June 20, 2017
Phase: N/A
Study type: Interventional

Non-invasive brain stimulation can both study and potentially treat neurological disorders. Transcranial direct-current stimulation (tDCS) is an emerging safe and tolerability form of stimulation and has been used increasingly over the last decade. The purpose of this research is to see if two different types of tDCS can improve motor function in healthy children. tDCS has been shown to safely enhance hand motor function in healthy adults, and those that have suffered stroke and other conditions. Recently the investigators demonstrated that tDCS may enhance hand motor function in healthy children, however, how it does so is unknown. In addition to assessing changes in motor function when tDCS is given during motor skill training, the investigators will perform various tests before and after stimulation to understand the changes that happen in the brain accompanying motor skill learning and brain stimulation. The investigators hypothesize that there will be an accelerated acquisition of motor skill, when training is paired with conventional anodal tDCS, HD-tDCS, or sham tDCS.

NCT ID: NCT03193307 Not yet recruiting - Healthy Clinical Trials

This Study Tests in Healthy Korean Women Which Effects BI 409306 and a Birth-control Pill Have on Each Other

Start date: July 5, 2017
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to investigate the effect of multiple doses of ethinylestradiol / levonorgestrel (Microgynon®) on single dose pharmacokinetics of BI 409306 and the effect of single dose of BI 409306 on multiple dose pharmacokinetics of ethinylestradiol / levonorgestrel (Microgynon®)

NCT ID: NCT03192436 Not yet recruiting - Healthy Clinical Trials

Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound

Start date: September 2017
Phase: N/A
Study type: Interventional

Neuromodulation is a fast growing field that offers a wide range of applications for both understanding and treating the brain. Future research for non-invasive neuromodulation will need to elucidate the optimal frequency, duration, and intensity of stimulation for a variety of technologies and diseases. Closed loop stimulation is thus a promising research area that allows for responsive stimulation and real time symptom management. Our project is proposed to develop and test a novel noninvasive neuromodulation integrating transcranial focused ultrasound stimulation (tFUS) with electrophysiological source imaging (ESI-tFUS) to allow evidence-based neuromodulation for brain research and the management of brain conditions. Despite the recent developments and attention surrounding tFUS, relatively little is known about the mechanisms and optimal parameters of this stimulation technology. The addition of ESI neuroimaging, aimed at providing biomarkers to assess the effects of tFUS neuromodulation, could provide crucial necessary information regarding the neural response to the applied stimulation in real-time. In order for tFUS to be further developed and transformed into a robust neuromodulation technology, an integrated electrophysiological source-imaging-guided tFUS system to allow for individualized and responsive stimulation is needed. The purpose of this study is to develop and evaluate the proposed ESI-tFUS in human subjects using motor and somatosensory paradigms.

NCT ID: NCT03191045 Not yet recruiting - Healthy Clinical Trials

In Vivo Predictive Dissolution 1

iPD1
Start date: July 1, 2017
Phase: N/A
Study type: Observational

This study will: 1. validate MRI motility method with concomitant perfused manometry method in healthy adult participants. 2. measure exploratory endpoints of interest including GI fluid volumes in 21 adult healthy volunteers studied twice.

NCT ID: NCT03188510 Not yet recruiting - Healthy Clinical Trials

A Study of Two Different Formulations of LY3074828 in Healthy Participants

Start date: June 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to look at the amount of the study drug, LY3074828, that gets into the blood stream and how long it takes the body to get rid of LY3074828 when given as different formulations. The tolerability of LY3074828 will also be evaluated and information about any side effects experienced will be collected. Screening is required within 28 days prior to the start of the study. For each participant, the total duration of the clinical trial will be approximately 13 weeks, not including screening.

NCT ID: NCT03187665 Not yet recruiting - Healthy Clinical Trials

Alarms Due to Loss of Signal Integrity in Partially Wireless Versus Traditional Pulse Oximetry in Pediatric Patients

Start date: July 1, 2017
Phase: N/A
Study type: Observational

This research study will help us to learn more about a device we use when children are sick called a pulse oximeter. The pulse oximeter lets us know how much oxygen is inside your blood without taking blood from you. It is non-invasive meaning it does not enter the body. The device has a cable attached to it. At the end of the cable is a wrap that looks like a Band-Aid with a red light on it. This wrap is placed around a finger or toe. The red light gives us a reading of how much oxygen you have in your blood and your heart rate. Having a pulse oximeter connected to you is painless. This device is used in many places. Besides hospitals, it is used in doctors' offices and in fitness centers. This study will help us learn more about whether a partially wireless, more portable pulse oximeter that connects to a small device worn on the child's arm or leg will give us a more reliable signal/reading while letting children move more easily. We will compare this device with the traditional wall-connected unit. Movement of the cable or a child moving may give a false oxygen reading. We will ask the child to do activities that create movement. We will look at the readings when your child moves. We think the partially wireless pulse oximeter will be more reliable during movement than the traditional wall-connected unit. Subjects will have two continuous pulse oximeter probes placed on them. These soft probes will go on a finger, toe, foot or hand and will be attached to two different pulse oximeter monitors. The child will then be asked to do common childhood activities based on their age for about 20 minutes. Examples of things a child may be asked to do include grabbing a rattle or drawing with crayons or kicking a ball. Anything the child doesn't want to do he/she does not have to do. These activities will be play activities the child already does. Continuous pulse oximetry data will be recorded during the testing and will be stored in a way that it cannot be linked to the subject after the testing is complete.