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NCT ID: NCT03468543 Terminated - Healthy Clinical Trials

Study Determining Gastric-Retentive and Modified Release Properties of Prototype Capsules in Healthy Subjects

Start date: July 26, 2017
Phase: Early Phase 1
Study type: Interventional

To assess how long modified release (MR) memantine hydrochloride prototype capsule formulations stay in the stomach as determined by magnetic resonance imaging (MRI).

NCT ID: NCT03297008 Terminated - Healthy Clinical Trials

Biomarkers in Saliva and Stool

Start date: March 11, 2015
Phase: N/A
Study type: Observational

To collect saliva and stool samples using the salimetrics swab and self-stool collection kit, process and store samples in a standardized manner. Following this, perform immunological assays such as enzyme-linked immunosorbent assay, multiplex bead assay and Immunocap to correlate the salivary and fecal levels of biomarkers in healthy donors. As this method is non-invasive, we believe that more people will be willing to donate samples.

NCT ID: NCT03180762 Terminated - Healthy Clinical Trials

A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-64140284 in Healthy Participants

Start date: May 30, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the safety and tolerability of JNJ-64140284 versus placebo after single oral dose administration (ascending dose levels) under fasted condition, to characterize the pharmacokinetics (PK) of JNJ-64140284 in plasma, cerebrospinal fluid (CSF) and urine after single oral dose administration and to investigate the effect of food (high fat/high calorie) on the PK of JNJ-64140284 following single oral dose administration.

NCT ID: NCT03126097 Terminated - Healthy Clinical Trials

A Study to Investigate the Interaction Between JNJ-64155806 and Ethinylestradiol/Drospirenone in Healthy Females

Start date: April 13, 2017
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to evaluate the effect of single and multiple doses of JNJ-64155806 on the steady-state pharmacokinetics (PK) of ethinylestradiol and drospirenone and vice versa in healthy female participants.

NCT ID: NCT03116581 Terminated - Healthy Clinical Trials

Altruistic Decisions

Start date: February 3, 2014
Phase: N/A
Study type: Interventional

The study aimed to understand how payoffs for others influence perceptual decision making. The research consists in testing how varying monetary payoffs for another modify the perceptual decision making processes. The use of drift diffusion models on a random dots task enable the characterization of the decision parameter(s) that are modulated when a decision is made to win payoffs for others as compared to decisions for self-benefits. Once the parameter revealed through behavioral experiment, neuroimaging is applied to find the neural correlates of the effects of taking others into account in the decision making process.

NCT ID: NCT03095833 Terminated - Healthy Clinical Trials

Food Intake Decisions

Start date: February 27, 2015
Phase: N/A
Study type: Interventional

Functional Magnetic resonance study on the effect of cognitive context variables on the perception and valuation of food odorants and flavor. The study is composed of two experiments; in a first experiment we address the question of how valuation of food odors are modulated by 3 cognitive conditions (indulgence, healthy, and neutral). Food odors are delivered using a custom-made olfactometer. Here we hypothesize that cognitive regulation can modulate the primary sensory processing of food odors. We expect that cortical regions related with valuation and cognitive regulation such as the ventromedial prefrontal cortex and the dorsolateral prefrontal cortex operate the modulation of primary olfactory cortex and amygdala. In a second experiment, we aim to reveal the brain areas involved in integrating food color cues with odor and taste stimuli. Here we hypothesize that color cues are capable of biasing flavor attributes of food (flavor intensity), and that this bias occurs at different cortical areas commonly associate with multisensory integration such as the orbitofrontal cortex, insula, amygdala and hippocampus.

NCT ID: NCT03095794 Terminated - Healthy Clinical Trials

Social Decision-making (SOCIAL-DECISION)

Start date: January 31, 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate neural mechanism of healthy humans underlying group decision making and compare it with that of individual decision-making. Using functional neuroimaging technology combining with computational modeling, we examine how the human brain process social information to make a decision within a group, which often guides humans to make a better decision using collective wisdom.

NCT ID: NCT03059303 Terminated - Healthy Clinical Trials

Study to Assess the Relative Bioavailability of Fixed-Dose Combination (FDC) Tablet (Simeprevir, Odalasvir and AL-335) Compared With Single Agents Administered Together, and to Assess the Effect of Multiple-Dose Lansoprazole or Omeprazole on Single-Dose Pharmacokinetics of SMV, ODV, and AL-335 (FDC)

Start date: February 20, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the relative bioavailability of single-dose Simeprevir (SMV), Odalasvir (ODV), and AL-335 when administered as a fixed-dose combination (FDC) compared with the single agents when administered together, and to assess the effect of multiple-dose lansoprazole and omeprazole on the single-dose pharmacokinetics (PK) of SMV, ODV, and AL-335 when administered as an FDC.

NCT ID: NCT03058822 Terminated - Healthy Clinical Trials

Relative Bioavailability of BMS-931699 From Prefilled Syringe Compared to Drug in Vial

Start date: January 25, 2017
Phase: Phase 1
Study type: Interventional

A Phase 1, relative bioavailability study of BMS-931699 from prefilled syringe compared to drug in vial

NCT ID: NCT03030391 Terminated - Healthy Clinical Trials

Novel Positron Emission Tomography (PET) Radiotracer to Image Phosphodiesterase-4B (PDE4B)

Start date: January 10, 2017
Phase: Phase 1
Study type: Interventional

Background: The new drug 18F-PF-06445974 has a little radioactivity. This can be seen by a positron emission tomography (PET) scan. The drug helps researchers see a protein, PDE4B, in the brain. Looking at PDE4B in the living brain might show how it is involved in psychiatric and neurological disorders. One part of the study will look at how the study drug is distributed in the brain. Another part will study how brain measures vary. Objectives: To measure the protein PDE4B in the brain. To test how a new radioactive chemical, 18F-PF-06445974, is distributed in the body. Eligibility: Healthy adults ages 18 and older Design: Participants will have 1-3 visits over a year. Each will be 2-5 hours. Women will have a pregnancy test each time.