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Breast Cancer clinical trials

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NCT ID: NCT05326165 Not yet recruiting - Breast Cancer Clinical Trials

Early Intervention

Start date: May 2024
Phase: N/A
Study type: Interventional

This research study is a Pilot Study examining the use of a compression sleeve with embedded sensor to prevent lymphedema.

NCT ID: NCT05313737 Not yet recruiting - Breast Cancer Clinical Trials

Opt-in vs. Opt-out for Breast Cancer Screening

Start date: April 18, 2022
Phase: N/A
Study type: Interventional

This is a randomized controlled trial that will evaluate the effectiveness two different outreach strategies for a population-based breast cancer screening program at the VA Puget Sound among average risk female Veterans who are due for breast cancer screening.

NCT ID: NCT05298072 Not yet recruiting - Breast Cancer Clinical Trials

Identification of Novel Inflammation-related Biomarkers for Early Detection of Anthracycline-induced Cardiotoxicity in Breast Cancer Patients

Start date: April 2022
Phase:
Study type: Observational

This study aims to identify possible set of inflammatory biomarkers before, during and after anthracycline-based chemotherapy in breast cancer patients to identify (sub)clinical chemotherapy-related cardiac dysfunctionCRCD to identify patients who would benefit from additional cardioprotective therapy.

NCT ID: NCT05291910 Not yet recruiting - Breast Cancer Clinical Trials

Inetetamab Combined With Anti-PD-1 Monoclonal Antibody and Albumin-Bound Paclitaxel for HER2+ Metastatic Breast Cancer

Start date: March 12, 2022
Phase: Phase 4
Study type: Interventional

This is a multi-center, prospective, interventional, single-arm clinical trial. In the study, patients with her2-positive recurrent or metastatic breast cancer who were initially treated were included. The purpose of this study is to evaluate the efficacy and safety of Inetetamab combined with anti-PD-1 monoclonal antibody and albumin-bound paclitaxel for HER2+ Metastatic Breast Cancer.

NCT ID: NCT05287308 Not yet recruiting - Breast Cancer Clinical Trials

Adjuvant Albumin-bound Paclitaxel Versus Taxanes in Breast Cancer: a Real-world Study

Start date: March 2022
Phase: N/A
Study type: Interventional

This is a prospective, multi-center, real-world study designed to evaluate the efficacy and safety of albumin-bound paclitaxel versus paclitaxel or docetaxel in adjuvant treatment of breast cancer.

NCT ID: NCT05268913 Not yet recruiting - Breast Cancer Clinical Trials

Towards Early Detection of Breast Cancer in High Risk Population

READ RISK
Start date: March 1, 2022
Phase:
Study type: Observational

Breast cancer is a major and growing health challenge, and the leading cause of cancer in women. As population obesity rates increase, the number of new breast cancer diagnosis continues to rise. Despite treatment advances, breast cancer remains an important cause of premature mortality, taking women in the prime of life. Although underlying susceptibility caused by mutation in the genes including BRCA1/2 is increasingly identified, current pre-symptomatic screening for the general population and those at high genetic risk remains sub-optimal, with high false negative and positive rates. Alteration of breast lipid composition has been observed by us and others in patients with breast cancer and is thought to precede onset. We have developed and tested a novel method to allow a standard 3T MRI scanner to perform quantitative 3D mapping of specific lipid molecules in the breast. We will investigate if this method can detect very early breast cancers, and compare the amount and spread of lipid composition in breast tissue of premenopausal women with very high genetic risk of breast cancer, women with breast cancer and women with obesity.

NCT ID: NCT05258461 Not yet recruiting - Breast Cancer Clinical Trials

An Innovative Smartphone Application for Adverse Event Management During Breast Cancer Adjuvant Chemotherapy

Start date: March 7, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate benefits of the app in breast cancer patients receiving the docetaxel, doxorubicin, and cyclophosphamide (TAC) chemotherapy. The investigators hypothesized that the addition of the app to conventional adverse event management would increase quality of life (QoL) scores and reduce adverse events.

NCT ID: NCT05258383 Not yet recruiting - Breast Cancer Clinical Trials

Personalized Estimation of Doses Delivered During Image Guided Radiation Therapy Tests

ELISA
Start date: May 15, 2023
Phase:
Study type: Observational

In image-guided radiotherapy (IGRT), the repeated and increasingly intensive use of on-board positioning imaging, using 2D or 3D Mega-Volt (MV) or kilo-Volt (kV) imaging devices (cone-beam or CBCT scanners), is leading the international medical community to question the potential impact of these additional doses delivered to the patient, especially in at-risk populations such as children and young adults. The doses delivered to the patient by positioning imaging are still relatively unknown, due to the lack of experimental means and software available in clinical routine to easily and accurately evaluate these doses. The main objective is to estimate by personalized Monte Carlo calculation the physical doses delivered to the patient's organs by the onboard imaging systems during their radiotherapy treatment. The obtained imaging doses will be compared according to different irradiation scenarios commonly used in clinical routine as well as according to the treated location.

NCT ID: NCT05253170 Not yet recruiting - Breast Cancer Clinical Trials

Hypo Versus Conventional Fractionation in Reconstructed-Breast Cancer Mastectomy Patients

Start date: April 1, 2022
Phase: Phase 3
Study type: Interventional

This randomized Phase III study aims to show major complication rate of hypofractionation radiation therapy is not inferior, compared to conventional fractionation radiation therapy in breast cancer patients undergoing mastectomy and reconstruction surgery.

NCT ID: NCT05251766 Not yet recruiting - Breast Cancer Clinical Trials

Nab-paclitaxel Compared With Docetaxel in the Neoadjuvant Chemotherapy Breast Cancer

Start date: April 20, 2022
Phase: Phase 1
Study type: Interventional

Comparison of docetaxel and Nab-paclitaxel in neoadjuvant chemotherapy for breast cancer